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| 1 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 2 | Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice显示文摘 | ChuanYing Fang Hua Zhang Jian Wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang Wang WenSheng Wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo | 2016 | Molecular Plant2016，9，10： | 14 |
| 3 | Exosome-mediated metabolic reprogramming:the emerging role in tumor microenvironment remodeling and its influence on cancer progression显示文摘Metabolic reprogramming is reported to be one of the hallmarks of cancer,which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands.Recently,extracellular vesicles(EVs)known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment(TME).Meanwhile,the TME is a highly heterogeneous ecosystem incorporating cancer cells,fibroblasts,adipocytes,endothelial cells,mesenchymal stem cells,and extracellular matrix.Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells,which facilitate cancer progression,angiogenesis,metastasis,drug resistance,and immunosuppression by reprogramming the metabolism of cancer cells and their surrounding stromal cells.In this review,we present the role of exosomes in the TME and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.In addition,we will also discuss the potential role of exosomes targeting metabolic process as biomarkers for tumor diagnosis and prognosis,and exosomes-mediated metabolic reprogramming as potential targets for cancer therapy.Furthermore,a better understanding of the link between exosomes and metabolic reprogramming,and their impact on cancer progression,would provide novel insights for cancer prevention and treatment in the future. | Enli Yang Xuan Wang Zhiyuan Gong Miao Yu Haiwei Wu Dongsheng Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 4 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 5 | Conversion of female germline stem cells from neonatal and prepubertal mice into pluripotent stern cells显示文摘 | Hu Wang Manxi Jiang Haiwei Bi Xuejin Chen Lin He Xiaoyong Li Ji Wu | 2014 | Journal of Molecular Cell Biology2014，8，2： | 3 |
| 6 | Effects of pioglitazone on proliferation and differentiation of human preadipocytes显示文摘Objective: To explore the effects of thiazolidinediones(TZDs) pioglitazone on proliferation and differentiation of human preadipocytes. Methods:Omental adipose tissue biopsies were obtained from 15 patients who were undergoing elective open-abdominal surgery. The primary culture and differentiated induction of human preadipocytes were performed, and the human preadipo-cytes were treated with pioglitazone at different concentrations at proper moments. Dynamic morphological changes of the human preadipocytes were observed, and their proliferation and differentiation were assessed with Colorimetric MTT Assay and Oil Red O Staining. Results:After 24 hours and 72 hours with pioglitazone, 0.1 μmol/L(μmol/ml) pioglitazone increased the MTT values of the human preadipocytes by 25.3% and 34.8%,respectively(P < 0.05), while 1 μmol/L pioglitazone by 27.4% and 26.6%(P < 0.05), compared with the control group without pioglitazone. The human preadipocytes with pioglitazone cumulated more adipose in the endochylema than those without pioglitazone obviously. 0.1 μmol/L pioglitazone increased the differentiation degree of the human preadipocytes differentiated for 8-10 days by 44.81% and 1 μmol/L pioglitazone by 53.76%(P < 0.05). Conclusion:Thiazolidinediones pioglitazone may significantly promote the proliferation and differentiation of the human omental preadipocytes. | Jianying Zhou Minjuan Ge Yamei Wang Haiwei Wu Jie Shen Xianghua Ma | 2007 | Journal of Nanjing Medical University2007，21，2： | 2 |
| 7 | Association Between IgE Antibody Against Soluble Egg Antigen and Resistance to Reinflection with Schistosoma aponicum 显示文摘 | Zhang Zhaosong Wu Haiwei Chen Suchen H | 1997 | Transaction of the Royal Society Tropical Medition and Hygiene1997，91，： | 1 |
| 8 | Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection显示文摘COVID-19 caused by SARS-CoV-2 infection has caused substantial morbidity and mortality worldwide and paralyzed the international economy.Understanding the magnitude and duration of the antibody response to SARS-CoV-2 is important to achieve a balance between curbing the pandemic and minimizing adverse effects on society.1 Although the antibody response to SARS-CoV-2 within 9 months has been extensively studied,2,3,4,5,6 little is known about the magnitude and kinetics of antibody responses for over 9 months.Moreover,with limited observations over 9 months(n<100),2,7,8 several studies have produced inconsistent conclusions about antibody dynamics,suggesting different rates of antiviral antibody positivity at the last follow-up.2,7,8 These studies have been limited by a lack of measurement of neutralizing antibodies(NAbs),7 of inclusion of mild or asymptomatic cases,2,8 and of further exploration of potential predisposing factors for antibody dynamics.2,7 Considering the individual heterogeneity(such as disease severity)8 and time-dependent nature1 of the immune response,in-depth characterization of SARS-CoV-2 antibody kinetics across disease severity groups over a long period is urgently needed.Therefore,we repeatedly tested IgM,IgG,viral spike protein receptor-binding dom(anti-RBD)IgG,and NAb titers in COVID-19 patients during a follow-up period of up to 10 months and explored potential predisposing factors of antibody titers during follow-up. | Hao Wang Yu Yuan Mingzhong Xiao Li Chen Youyun Zhao Haiwei Zhang Pinpin Long Yana Zhou Xi Xu Yanshou Lei Bihao Wu Tingyue Diao Hao Cai Li Liu Zuoyu Shao Jingzhi Wang Yansen Bai Kai Wang Miao Peng Linlin Liu Shi Han Fanghua Mei Kun Cai Yake Lei An Pan Chaolong Wang Rui Gong Xiaodong Li Tangchun Wu | 2021 | Cellular & Molecular Immunology2021，18，7： | 1 |
| 9 | The Ailao Shan/Red River metamorphic belt: Tertiary left-lateral shear between Indochina and South China显示文摘 | Tapponnier P Lacassin R Leloup P H Sch~irer U Zhong Dalai Wu Haiwei Liu Xiaohan Ji Shaocheng Zhang Lianshang Zhong Jiayou | 1990 | Nature1990，343，6257： | 1 |
| 10 | Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover显示文摘 | Yinyue Deng Nadine Schmid Chao Wang Jianhe Wang Gabriella Pessi Donghui Wu Jasmine Lee Claudio Aguilar Christian H. Ahrens Changqing Chang Haiwei Song Leo Eberl Lian-Hui Zhang | 2012 | Proceedings of the National Academy of Sciences2012，，38： | 1 |
| 11 | Culex pipiens pallens:identification of genes differentially expressed in deltamethrin-resistant and-susceptible strains显示文摘 | Haiwei WU Haisheng TIAN Guangling WU | 2004 | Pestic Biochem Phys2004，79，： | 1 |
| 12 | High‐Performance Electrocatalysts for Oxygen Reduction Derived from Cobalt Porphyrin‐Based Conjugated Mesoporous Polymers显示文摘 | Zhong‐Shuai Wu Long Chen Junzhi Liu Khaled Parvez Haiwei Liang Jie Shu Hermann Sachdev Robert Graf Xinliang Feng Klaus Müllen | 2014 | Adv. Mater2014，，9： | 1 |
| 13 | Low-cost and low-density carbonized facial tissue supported uniform NiCo_(2)S_(4)nanotubes for high capacity flexible solid-state supercapacitors显示文摘Recently,rapid development of intelligent wearable electronic equipment has triggered great needs for flexible and lightweight portable energy storage systems.Here,we demonstrate a low-cost($0.5 m^(-2))and low density carbonized facial tissue paper(FCP)for high-conductive NiCo_(2)S_(4)nanotubes assisted novel ultra-flexible solid-state supercapacitors(SSCs).The hydrothermal synthesized FCP-900@NiCo_(2)S_(4)electrodes in this paper only have a density of 5 mg cm^(-2)and show large specific capacitance of 3115 mF cm^(-2)at 2 mA cm^(-2).Based on the high performance of FCP-900@NiCo_(2)S_(4)electrodes,the as assembled SSCs can deliver an energy density of 1.2 mWh cm^(-3),high power density of 58.16 mW cm-3.It also shows great bending-state capacitive performance with high capacitance retention after 5000 cycles,providing a new opportunity for developing high-performance flexible wearable energy storage devices. | Haiwei Wu Jingxuan Bi Yiyi Li Li Wang Xiaofei Pang Chuanyin Xiong Zhijian Li | 2021 | Journal of Materiomics2021，7，1： | 1 |
| 14 | Erythropoietin attenuates ischemia-reperfusion induced lung injury by inhibiting tumor necros-is factor-αand matrix metalloproteinase-9expression显示文摘 | Haiwei Wu Guohua Dong Hua Jing | 2009 | European Journal of Pharmacology2009，602，23： | 1 |
| 15 | CdS quantum dots/2+ electrochemiluminescence resonance energy transfer system for sensitive cytosensing显示文摘 | WU Meisheng SHI Haiwei XU Jingiuan | 2011 | Chem Commun2011，47，27： | 1 |
| 16 | Microchip device with 64-site electrode array for multiplexed immunoassay of cell surface antigens based on electrochemiluminescence resonance energy transfer 显示文摘 | WU Meisheng SHI Haiwei HE Lijing | 2012 | Anal Chem2012，84，9： | 1 |
| 17 | Cultivar and insecticide applications affect the physiological develop- ment of the brown planthopper, Nialaprvata lugens ( Stal ) (Homoptera: Delphacidae) 显示文摘 | YIN Jianli XU Haiwei WU Jincai | 2008 | Environmental Entomolog2008，37，： | 1 |
| 18 | Brain natriuretic peptide limits myocardial infarct size dependent of nitric oxide synthase in rats显示文摘 | Binhui Ren Yi Shen Hongtao Shao Jianjun Qian Haiwei Wu Hua Jing | 2006 | Clinica Chimica Acta2006，，1： | 1 |
| 19 | The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies显示文摘Dear Editor, Many forms of sight-threatening diseases, including retinitis pigmentosa (RP) and age-related macular degeneration (AMD), are caused by the dysfunction, degeneration and loss of the retinal pigment epithelium (RPE)(Strauss, 2005). RPE cell transplantation may potentially recover or halt disease progression, in which human embryonic stem cells (hESCs) could serve as an unlimited donor source for RPE differentiation, and a few clinical trials have shown the safety and effective of transplantation of hESCs-derived RPE (hESC-RPE) for AMD patients (Schwartz et al., 2012;Schwartz etal., 2015;Song etal., 2015;da Cruz et al., 2018;Kashani et al., 2018;Liu et al., 2018). | Lei Wang Wei Wu Qi Gu Zengping Liu Qiyou Li Zhongwen Li Jinhui Fang Wenjing Liu Jun Wu Ying Zhang Liu Wang Haiwei Xu Wei Li Baoyang Hu Qi Zhou Zhengqin Yin Jie Hao | 2019 | Protein & Cell2019，10，6： | 1 |
| 20 | Pretreatment with recombined human erythropoietin attenuates ischemia–reperfusion-induced lung injury in rats显示文摘 | Haiwei Wu Binhui Ren Jiaquan Zhu Guohua Dong Biao Xu Changtian Wang Xiaogang Zheng Hua Jing Binhui Ren Jiaquan Zhu Guohua Dong Biao Xu Changtian Wang Xiaogang Zheng Hua Jing | 2006 | European Journal of Cardio-Thoracic Surgery2006，，6： | 1 |
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