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| 1 | The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations. | Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 2 | Analysis of Microstructure and Mechanical Properties of Ultrafine Grained Low Carbon Steel显示文摘A novel design scheme of hot stamping, quenching and partitioning process was conducted in a quenchable boron steel to obtain the nanometric duplex microstructure comprising ultrafine retained austenite and martensite. It is shown that the materials possess excellent mechanical properties and the ductility can be further improved without compromising the strength. The newly treated steel shows excellent mechanical properties and the total elongation of the steel increases from 6.6% to 14.8% compared with that of hot stamped and quenched steel. Therefore, this kind of steel has become another group of advanced high-strength steels. The microstructure which is mainly responsible for such excellent mechanical properties was investigated. | 刘和平 SUN Feng'er SUN Hu'er LIU Bin WANG Yi JIN Xuejun | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 2 |
| 3 | Hot Deformation Behavior of Low Carbon Steel during Compression at Elevated Temperature显示文摘Hot compression tests of low carbon steel were carried out on Gleeble-3500 system in the temperature range from 750 to 900 ℃ and in the strain rate range from 0.001 to 1.0 s-1, and the associated microstructural evolution was studied by observations with a metallographic microscope. The results show that the stress-strain curves exhibit a peak stress at critical strain, after which the fl ow stresses decrease monotonically until reaching high strains, showing a dynamic fl ow softening. The peak stress level decreases with increasing deformation temperature and decreasing strain rate, which can be represented by the Zener-Hollomon parameter Z in the hyperbolic sine equation. The fl ow stress increases with increasing strain rate and decreasing deforming temperature. The fl ow stress can be described by constitutive equation in hyperbolic sine function and can also be described by a Zener–Hollomon parameter Z. With increasing deformation temperature and decreasing strain rate, the grain size as well as the volume fraction of the recrystallized grains increase. The safe region for hot working of the alloy has been determined according to the processing map and microstructure at the true strain of 0.5, which is the deformation temperature of 840-940 ℃ and the strain rate of 0.001-1.0 s-1. | 刘和平 LIU Bin LI Dazhao SUN Hu'er SUN Feng'er JIN Xuejun ZHANG Yongtao | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 2 |
| 4 | Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo显示文摘Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic Classification System(BCS) category was determined using equilibrium solubility, intrinsic dissolution rate, and intestinal permeability to evaluate intestinal absorption mechanisms of baicalein in rats in vitro. Physiologically based pharmacokinetic(PBPK) model commercial software GastroPlus~(TM) was used to predict oral absorption of baicalein in vivo.Results: Based on equilibrium solubility, intrinsic dissolution rate, and permeability values of main absorptive segments in the duodenum, jejunum, and ileum, baicalein was classified as a drug with low solubility and high permeability. Intestinal perfusion with venous sampling(IPVS) revealed that baicalein was extensively metabolized in the body, which corresponded to the low bioavailability predicted by the PBPK model. Further, the PBPK model predicted the key indicators of BCS, leading to reclassification as BCS-II. Predicted values of peak plasma concentration of the drug(C_(max)) and area under the curve(AUC)fell within two times of the error of the measured results, highlighting the superior prediction of absorption of baicalein in rats, beagles, and humans. The PBPK model supported in vitro and in vivo evidence and provided excellent prediction for this BCS class II drug.Conclusion: BCS and PBPK are complementary methods that enable comprehensive research of BCS parameters, intestinal absorption rate, metabolism, prediction of human absorption fraction and bioavailability, simulation of PK, and drug absorption in various intestinal segments across species. This combined approach may facilitate a more comprehensive and accurate analysis of the absorption characteristics of active ingredients of Chinese medicine from in vitro and in vivo perspectives. | Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 2 |
| 5 | Iron and the restless legs syndrome显示文摘 | Sun ER Chen CA Ho G | 1998 | Sleep1998，21，4： | 1 |
| 6 | Analysis of joint action of insecticides against house flies显示文摘 | Sun YP Johnson ER | 1960 | J Econ Ent1960，53，887： | 1 |
| 7 | Clock-turning gait synthesis for humanoid robots显示文摘Turning gait is a basic motion for humanoid robots. This paper presents a method for humanoid turning, i.e. clock-turning. The objective of clock-turning is to change robot direction at a stationary spot. The clock-turning plan-ning consists of four steps: ankle trajectory generation, hip trajectory generation, knee trajectory generation, and inverse kinematics calculation. Our proposed method is based on a typical humanoid structure with 12 DOFs (degrees of freedom). The final output of clock-turning planning is 12 reference trajectories, which are used to control a humanoid robot with 12 DOFs. ZMP (zero moment point) is used as stability criterion for the planning. Simulation experiments are conducted to verify the effectiveness of our proposed clock-turning method. | Zhe TANG Zengqi SUN Hongbo LIU Meng Joo ER | 2007 | 控制理论与应用(英文版)2007，5，1： | 1 |
| 8 | High density lipoproteinuptake by scavenger receptor SR-BII 显示文摘 | Eckhardt ER Cai L Sun B | 2004 | J Biol Chem2004，279，14： | 1 |
| 9 | JAK 2 V 617 F mutation and 46/1 haplotype in C hinese B udd‐ C hiari syndrome patients显示文摘 | Hui Wang Guixiang Sun Peijin Zhang Jing Zhang Er Gui Maoheng Zu Enzhi Jia Hao Xu Lichun Xu Jinpeng Zhang Zhaojun Lu | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 10 | Analysis of joint action of insecticides against house flies显示文摘 | Sun YP Johnson ER | 1960 | J Econ Ent1960，53，： | 1 |
| 11 | Design for diagnosability of muhistation manufacturing systems based on sensor allocation optimization 显示文摘 | SUN Jiwen XI Lifeng PAN Er'shun | 2009 | Computers in Industry2009，69，7： | 1 |
| 12 | Analysis of joint action of insecticides against house flies 显示文摘 | Sun YP Johnson ER | 1960 | Journal of Economic Entomology1960，53，5： | 1 |
| 13 | Iron and the restless legs syndrome 显示文摘 | Sun ER Chen CA Ho G | 1998 | Sleep1998，21，4： | 1 |
| 14 | Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model 显示文摘 | Suarez ER Chang DK Sun J | 2016 | Oncotar- get2016，，： | 1 |
| 15 | Endoscopic diagnosis of early-stage primary esophageal small cell carcinoma: Report of two cases显示文摘BACKGROUND Primary esophageal small cell carcinoma(PESCC)is a highly aggressive malignancy,and its detailed clinical behaviors have remained virtually unknown.Because of the rapid tumor progression,the diagnosis of esophageal small cell carcinoma at early stage is extremely difficult in clinical practice.Currently,only a handful of PESCC cases have been reported.CASE SUMMARY Case 1:A 62-year-old man was diagnosed with an esophageal submucosal tumor by endoscopy.Endoscopic ultrasonography showed a 0.8 cm low echo nodule in the muscularis mucosa.As the patient refused to undergo endoscopic resection,neoplasia was detected by endoscopy 1 year later.Case 2:A 68-year-old woman was diagnosed as having an esophageal submucosal tumor by endoscopy at a local hospital.About 2 wk later,we performed endoscopic ultrasonography and found a 1 cm low echo nodule in the muscularis mucosa;the submucosal was thinner than normal but still continuous;mucosal hyperemia and erosion were found on the surface of the tumor.Endoscopic submucosal dissection(ESD)was performed and the histopathological finding showed a small cell carcinoma invading the submucosal layer.CONCLUSION Early esophageal small cell carcinoma shows submucosal infiltrating growth with a hypoechoic mass in the muscularis mucosa as diagnosed by endoscopic ultrasonography.It is easily misdiagnosed as submucosal masses.Endoscopic manifestations should be identified and pathological biopsies should beemployed. ESD may be performed to provide an opportunity for early treatmentof PESCC. | Li-Mian Er Yan Ding Xiao-Fang Sun Wen-Qian Ma Li Yuan Xiu-Li Zheng Na-Na An Ming-Li Wu | 2021 | World Journal of Clinical Cases2021，9，11： | 1 |
| 16 | Isomeric C24^·+ carbon cluster qions de- rived from perchlorocoronene reactions of carboncluster ions with pyridine显示文摘 | SUN J CALTAPANIDES S GRLITZMATCH- ER H F | 1998 | J Phys Chem A1998，102，： | 1 |
| 17 | Early-life antibiotic use is associated with wheezing among children with high atopic risk:a prospective European study 显示文摘 | Sun W Svendsen ER Karmaus WJ | 2014 | J Asthma2014，24，： | 1 |
| 18 | Consensus‑based multidimensional due diligence of fintech‑enhanced green energy investment projects显示文摘The purpose of this study is to provide a hybrid group decision-making approach to evaluate fintech-based financial alternatives for green energy investment projects.First,the multidimensional factors of due diligence for fintech-based financing alternatives of green energy investment projects are identified.In this regard,the balanced scorecard perspectives are considered.Next,consensus-based group decision-making analysis is performed.Second,impact-relation directions for fintech-based financing alternatives of green energy investment projects are defined.For this purpose,the spherical fuzzy Decision-Making Trial and Evaluation Laboratory(DEMATEL)methodology is applied.The novelty of this study is its proposal of a new outlook to due diligence of fintech-project financing for renewable energy investments by using the group and integrated decision-making approaches with spherical fuzzy DEMATEL.The findings indicate that customer expectations are the most essential factor for the revenue sharing and rewarding models.Additionally,this study identified that organizational competency plays the most important role with respect to the peer-to-business debt model.In contrast,the conclusion was reached that financial returns have the greatest importance for the equity sharing model. | Wei Liu Youfa Sun Serhat Yuksel Hasan Dinçer | 2021 | Financial Innovation2021，7，1： | 1 |
| 19 | Deletion,mutation,and loss of expression of KLF6 in human prostate cancer显示文摘 | Chen C Hyytinen ER Sun X | 2003 | Am J Pathol2003，162，4： | 1 |
| 20 | Clinicaland molecular evaluation of SH0X/PAR1 duplications in Leri -Weill dyschondrosteosis ( LWD) and idiopathic short stature(ISS )显示文摘 | Benito - Sanz S Barroso E Heine - Sun er D | 2011 | J Clin Endocrinol Metab2011，96，2： | 1 |
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