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| 1 | Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation显示文摘通过 ubiquitination 小径的 p53 蛋白质周转是在它的 transcriptional 活动的规定的重要机制;然而,很少通过 proteasome 独立的小径对 p53 周转被知道。消化机关扩大因素(Def ) 蛋白质为消化机关的发展是必要的。在 zebrafish, def 的功能的损失有选择地 upregulates p53 反应基因的表示,它提出至于是在 Def 和 p53 之间的关系的一个问题。我们这里报导 Def 是核仁的蛋白质并且 def 的功能的损失导致 p53 蛋白质的 upregulation,它令人惊讶地在 nucleoli 积累。我们的广泛的研究证明了 Def 能调停这个过程是的 p53 蛋白质和那的降级在 Calpain3 的活动独立于 proteasome 小径,却依赖,半胱氨酸朊酶。我们的调查结果定义调整 p53 的周转功能的一条新奇核仁的小径,它将在 organogenesis 和 tumorigenesis 推进我们 p53 的角色的理解。 | Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng | 2013 | Cell Research2013，23，5： | 8 |
| 2 | On Discount Weighting Grey Modeling of GM(1,1)显示文摘In allusion to the different sample value the different influences on forecast values, this paper putsforward a kind of discount weighting grey modeling method and establishes a kind of discount coefficient grey modelof GM (1, 1 ). It means much as respect to improve the validity and rationalics of forecast model in the course offorecast modeling. | WU Cheng-mao ZHANG Tao GAO Xiang-peng(Xi’an Institute of Posts and Telecommunications, Xi’an, 710061, P R. China) | 1999 | The Journal of China Universities of Posts and Telecommunications1999，6，2： | 4 |
| 3 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 4 | Assessing impacts of different land use scenarios on water budget of Fuhe River,China using SWAT model显示文摘The Soil and Water Assessment Tool(SWAT)model was used to assess the impacts of different land use scenarios on hydrological processes in the Fuhe watershed in Poyang Lake Basin,East China.A total of 12 model parameters were calibrated with observed monthly runoff data for 1982-1988 and validated for 1991-1998 for baseline conditions.The baseline test results of R2 and Nash-Sutcliffe model efficiency(NSE)values ranged between 0.88 and 0.94 across the calibration and validation periods,indicating that SWAT accurately replicated the Fuhe watershed streamflow.Several different land use scenarios were then simulated with the model,focusing on the impacts of land use change on the hydrology of the watershed.The results of hypothetical scenario simulations revealed that surface runoff declined while groundwater recharge and evapotranspiration(ET)increased,as forest land,agriculture land and/or grassland areas increased,as well as when paddy field and urban areas decreased.These results further showed that forest land has a higher capacity to conserve the water as compared to pasture land.The results of the real scenario simulations revealed that urbanization is the strongest contributor to changes in surface runoff,water yield,and ET.Urbanization can be considered as a potential major environmental stressor controlling hydrological components. | Tao Can Chen Xiaoling Lu Jianzhong Philip W.Gassman Sauvage Sabine Sanchez Pérez José-Miguel | 2015 | International Journal of Agricultural and Biological Engineering2015，8，3： | 4 |
| 5 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 6 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 7 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 8 | Extracellular heat shock protein 72 protects schwann cells from hydrogen peroxide-induced apoptosis 显示文摘 | Luo X Tao L Lin P | 2012 | J Neurosci Res2012，90，： | 1 |
| 9 | The thermal sensation difference between Chinese and American people显示文摘 | Tao P | 1991 | Indoor air1991，，4： | 1 |
| 10 | Peptide with angiotensin Ⅰ-converting enzyme inhibitory activity from hydrolyzed corn gluten meal显示文摘 | Yang Y J Tao G J Liu P J | | 0，，19： | 1 |
| 11 | Two-dimensional channel ending scheme for MCTF-based scalable video coding 显示文摘 | WANG YU FANG TAO CHAU L P | 2007 | IEEE Transactions On Multimedia2007，9，1： | 1 |
| 12 | Determination of huerzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector显示文摘 | Yue P Tao T Zhao Y | | 0，，： | 1 |
| 13 | Specular surface measurement by using least squares light tracking technique显示文摘 | GUO H FENG P TAO T | 2010 | Optics and Lasers in Engineering2010，48，2： | 1 |
| 14 | Transparent dispensible high- refractive index ZrO2/epoxy nanocomposites for led encapsulation 显示文摘 | Tao P Li Y Siegel R W | 2013 | Journal of Applied Polymer Science2013，130，5： | 1 |
| 15 | Perfluorinated Compounds in Aquatic Organisms at Various Trophic Levels in a Great Lakes Food Chain显示文摘 | Kurunthachalam Kannan Lin Tao Ewan Sinclair Stephanie D Pastva Dave J Jude John P Giesy | 2005 | Archives of Environmental Contamination and Toxicology2005，，4： | 1 |
| 16 | 显示文摘 | Tao C Zheng S P Mohwald H | 2003 | Langmuir2003，19，21： | 1 |
| 17 | Machine visior for color inspect ion of potatoes and apples显示文摘 | Heinemann P H Varghese Z | 1992 | Trans of the ASAE1992，38，6： | 1 |
| 18 | Machine vision for color inspection of potatoes and apples显示文摘 | Tao Y Heinemann P H Varghese Z et a1 | 1995 | Transactions of the ASAE1995，38，5： | 1 |
| 19 | Adaptive control of plants with unknown dead-zones显示文摘 | TAO G Recker D A Kokotovic P V | 1994 | IEEE Trans on Automatic Control1994，39，1： | 1 |
| 20 | Co-delivery of GM-CSF gene enhances the immune responses of hepatitis C viral core protein-expressing DNA vaccine:Role of dendritic cells显示文摘 | Ouyang P Hwang LH Tao MH | 2002 | J Med Virol2002，66，3： | 1 |
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