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| 1 | Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-β induction by disrupting the VISA-associated complex显示文摘Viral RNAs produced during viral infection are recognized by the cytoplasmic RNA helicases retinoic acid-inducible gene-I(RIG-I)and melanoma differentiation-associated gene 5(MDA5).A central adapter protein downstream of RIG-I and MDA5 is the mitochondrial membrane protein virus-induced signaling adaptor(VISA),which mediates the induction of type I interferons(IFNs)through the activation of transcription factors such as nuclear factor-kappaB(NF-kB)and IFN-regulatory factor-3(IRF3).Here we found that hepatitis B virus(HBV)-encoded X protein(HBx)acts as an inhibitor of virus-triggered IRF3 activation and IFN-b induction.Reporter and plaque assays indicate that HBx inhibits signaling by components upstream but not downstream of VISA.Immunoprecipitation experiments indicate that HBx interacts with VISA and disrupts the association of VISA with its upstream and downstream components.These findings suggest that HBx acts as a suppressor of virus-triggered induction of type I IFNs,which explains the observation that HBV causes transient and chronic infection in hepatocytes but fails to activate the pattern recognition receptor-mediated IFN induction pathways. | Xianmiao Wang Ying Li Aiping Mao Chao Li Yongkui Li Po Tien | 2010 | Cellular & Molecular Immunology2010，7，5： | 13 |
| 2 | FN-λ: A new spotlight in innate immunity against influenza virus infection显示文摘 | Yeping Sun Jingwen Jiang Po Tien Wenjun Liu Jing Li | 2018 | Protein & Cell2018，9，10： | 5 |
| 3 | Preparation and mechanical properties of artificial transversely isotropic rock显示文摘 | Yong Ming Tien Po Fong Tsao | 2000 | International Journal of Rock Mechanics and Mining Sciences2000，，6： | 2 |
| 4 | Cloning of M and NP Gene of H5N1 Avian Influenza Virus and Immune Efficacy of their DNA Vaccines显示文摘H5N1 鸟的流行性感冒病毒(A/chicken/Hubei/489/2004 ) 的 M 和 NP 基因被 RT-PCR 从病毒的 RNA 放大,并且分别地克隆向量进 pMD18-T。包含 M 基因(pHM6-m ) 或 NP 基因(pHM6-np ) 的表示 plasmid 然后被把 M 或 NP 基因插入到 pHM6 优核质表示向量构造;构造 plasmid 然后被定序。32 只 BALB/c 老鼠(6-week-old ) 在随机被划分成四个组。三组 BALB/c 老鼠被接种一次有 plasmid pHM6-m, plasmid pHM6-np 的 30 渭 g 或 plasmid pHM6-m (15 渭 g ) 和 pHM6-np (15 渭 g ) 的混合的任何一个 30 渭 g 的肌内的线路分别地。老鼠的一个另外的组作为控制与 100 渭 l PBS 被注射。二个星期以后,所有老鼠与相应 H5N1 鸟的流行性感冒病毒被质问,并且在下列 12 天内观察了。在 pHM6-m 组, pHM6-np 组和混合 plasmids 组的老鼠的幸存率分别地是 62.5% , 25.0% 和 50.0% 。结果证明有效保护能被 pHM6-m 或 pHM6-np 提供,但是 pHM6-m 比 pHM6-np 提供了更好保护的效果。关键词 H5N1 流行性感冒病毒 - M 基因 - NP 基因 - 克隆 - DNA 疫苗的 CLC 数字 S852.65 基础条款:国家基本科学才能训练资助(NSFC J0630648 ) | Po Tien | 2007 | 中国病毒学2007，22，1： | 2 |
| 5 | Mitochondria Redistribution in Enterovirus A71 Infected Cells and Its Effect on Virus Replication显示文摘Enterovirus A71(EV-A71)is one of the main causative agents of hand,foot and mouth disease(HFMD)and it also causes severe neurologic complications in infected children.The interactions between some viruses and the host mitochondria are crucial for virus replication and pathogenicity.In this study,it was observed that EV-A71 infection resulted in a perinuclear redistribution of the mitochondria.The mitochondria rearrangement was found to require the microtubule network,the dynein complex and a low cytosolic calcium concentration.Subsequently,the EV-A71 non-structural protein 2BC was identified as the viral protein capable of inducing mitochondria clustering.The protein was found localized on mitochondria and interacted with the mitochondrial Rho GTPase 1(RHOT1)that is a key protein required for attachment between the mitochondria and the motor proteins,which are responsible for the control of mitochondria movement.Additionally,suppressing mitochondria clustering by treating cells with nocodazole,EHNA,thapsigargin or A23187 consistently inhibited EV?A71 replication,indicating that mitochondria recruitment played a crucial role in the EV-A71 life cycle.This study identified a novel function of the EV-A71 2BC protein and provided a potential model for the regulation of mitochondrial motility in EV-A71 infection. | Yang Yang Haolong Cong Ning Du Xiaodong Han Lei Song Wenliang Zhang Chunrui Li Po Tien | 2019 | Virologica Sinica2019，34，4： | 2 |
| 6 | Preparation and mechanical properties of artificial transversely isotropic rock显示文摘 | Yong Ming Tien Po Fong Tsao | 2000 | International Journal of Rock Mechanics and Mining Sciences2000，，6： | 1 |
| 7 | Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients显示文摘 | Lun Cai Zheng Zhang Lin Zhou Haiyan Wang Junliang Fu Shuye Zhang Min Shi Hui Zhang Yongping Yang Hao Wu Po Tien Fu-Sheng Wang | 2008 | Clinical Immunology2008，，： | 1 |
| 8 | Evaluation of abdominal ultrasonography mass screening for hepatocellular carcinoma in Taiwan显示文摘 | Yen‐Po Yeh Tsung‐Hui Hu Po‐Yuan Cho Hsiu‐Hsi Chen Amy Ming‐Fang Yen Sam Li‐Sheng Chen Sherry Yueh‐Hsia Chiu Jean Ching‐Yuan Fann Wei‐Wen Su Yi‐Jen Fang Shih‐Tien Chen Hsiao‐Ching San Hung‐Pin Chen Chao‐Sheng Liao | 2014 | Hepatology2014，，5： | 1 |
| 9 | Antibodies against analogous heptad repeat peptide HR212 of Newcastle Disease Virus inhibit virus-cell membrane fusion显示文摘膜熔化是在包的病毒入口的关键步。纽卡斯尔的高度保存的七个重复区域(HR1 和 HR2 ) 疾病病毒(NDV ) 熔化蛋白质(F) 是为病毒的膜熔化的批评功能的领域。他们处于膜熔化状态显示不同符合构造并且为抵销抗体回答被看作候选人目标。我们以前报导七个的类似物重复肽 HR2-HR1-HR2 (HR212 ) , HR2 能禁止 NDV 导致的房间房间膜熔化。这里,我们证明 HR212 能导致生产高度在能认出 HR1 和 HR2 的完整的长度肽并且禁止 NDV 红血球凝聚和 NDV 入口的使免疫的兔子的有势力抗体。这些建议 HR212 或它的抗体能是导致病毒的房间房间膜熔化的一个禁止者。 | LI Ying TIEN Po | 2007 | Progress in Natural Science:Materials International2007，17，2： | 1 |
| 10 | A novel minicircle vector based system for inhibting the replication and gene expression of Enterovirus 71 and Coxsackievirus A16显示文摘 | Zhuo Yang Guodong Li Yingqiu Zhang Xiaoman Liu Po Tien | 2012 | Antiviral Research2012，，2： | 1 |
| 11 | Ribozyme-mediated resistance to rice dwarf virus and the transgene silencing in the progeny of transgenic rice plants显示文摘 | Shengcheng Han Zujian Wu Huaiyi Yang Rong Wang Yin Yie Lianhui Xie Po Tien | 2000 | Transgenic Research2000，，3： | 1 |
| 12 | Identification of the Myelin Oligodendrocyte Glycoprotein as a Cellular Receptor for Rubella Virus显示文摘 | Cong Haolong Jiang Yue Tien Po | 2011 | Journal of virology2011，85，11： | 1 |
| 13 | Discovery of novel src homology region 2 domain‐containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma显示文摘 | Wei‐Tien Tai Chung‐Wai Shiau Pei‐Jer Chen Pei‐Yi Chu Hsiang‐Po Huang Chun‐Yu Liu Jui‐Wen Huang Kuen‐Feng Chen | 2014 | Hepatology2014，，1： | 1 |
| 14 | Hepatitis B virus e antigen induces activation of rat hepatic stellate cells显示文摘 | Yanlu Zan Yuxia Zhang Po Tien | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 1 |
| 15 | Identification of the Myelin Oligodendrocyte Glycoprotein as a Cellular Receptor for Rubella Virus显示文摘 | Cong Haolong Jiang Yue Tien Po | 2011 | JOURNAL OF VIROLOGY2011，85，11： | 1 |
| 16 | Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells显示文摘 | Canhui Liu Lun-Quan Sun Po Tien | 2000 | Cancer Gene Therapy2000，7，5： | 1 |
| 17 | PREFACE显示文摘First of all, I would like to introduce the predecessor of 'Virologica Sinica (to be published in English) and its history of development. I was honored to participate in it. ' Acta Virologica Sinica' (in Chinese with English abstract), which was first published in 1980, was the first virological journal issued in China. The editor in chief was Prof. Dr. Shangyin Gao (1909-1989), who was a famous virologist. He was the director | Po Tien | 2007 | 中国病毒学2007，22，1： | 0 |
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