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| 1 | Treatment of young patients with lupus nephritis using calcineurin inhibitors显示文摘Recent advances in the management of lupus nephritis,together with earlier renal biopsy and selective use of aggressive immunosuppressive therapy,have contributed to a favorable outcome in children and adolescents with systemic lupus erythematosus(SLE).Nevertheless,we believe that a more effective and less toxic treatment is needed to attain an optimal control of the activity of lupus nephritis.Recent published papers and our experiences regarding treatment of young patients with lupus nephritis using calcineurin inhibitors are reviewed.Although it has been reported that intermittent monthly pulses of intravenous cyclophosphamide(IVCY)are effective for preserving renal function in adult patients,CPA is a potent immunosuppressive agent that induces severe toxicity,including myelo-and gonadal toxicity,and increases the risk of secondary malignancy.Thus,treatment for controlling lupus nephritis activity,especially in children and adolescents,remains challenging.Cyclosporine A(Cs A)and tacrolimus(Tac)are T-cell-specific calcineurin inhibitors that prevent the activation of helper T cells,thereby inhibiting thetranscription of the early activation genes of interleukin(IL)-2 and suppressing T cell-induced activation of tumor necrosis factor-α,IL-1βand IL-6.Therefore,both drugs,which we believe may be less cytotoxic,are attractive therapeutic options for young patients with lupus nephritis.Recently,a multidrug regimen of prednisolone(PDN),Tac,and mycophenolate mofetile(MMF)has been found effective and relatively safe in adult lupus nephritis.Since the mechanisms of action of MMF and Tac are probably complementary,multidrug therapy for lupus nephritis may be useful.We propose as an alternative to IVCY,a multidrug therapy with mizoribine,which acts very similarly to MMF,and Tac,which has a different mode of action,combined with PDN for pediatric-onset lupus nephritis.We also believe that a multidrug therapy including Cs A and Tac may be an attractive option for young patients with SLE and lupus | Hiroshi Tanaka Kazushi Tsuruga Tomomi Aizawa-Yashiro Shojiro Watanabe Tadaatsu Imaizumi | 2012 | World Journal of Nephrology2012，1，6： | 8 |
| 2 | Increased Incidence of Follicular Lymphoma in the Duodenum显示文摘 | Tadashi Yoshino Kenji Miyake Koichi Ichimura Tomohiko Mannami Nobuya Ohara Shuji Hamazaki Tadaatsu Akagi | 2000 | The American Journal of Surgical Pathology2000，，5： | 1 |
| 3 | Functions and potential applications of glycolipid biosurfactants from energy-saving materials to gene delivery carriers 显示文摘 | Dai Kitamoto Hiroko Isoda Tadaatsu Nakahara | 2002 | Bioscience & Bioengineering2002，94，3： | 1 |
| 4 | Microendoscopic discectomy (MED) for lumbar disc prolapse显示文摘 | Hiroyuki Nakagawa Mikio Kamimura Shigeharu Uchiyama Kenji Takahara Toshiro Itsubo Tadaatsu Miyasaka | 2003 | Journal of Clinical Neuroscience2003，，2： | 1 |
| 5 | Functions and Potential Applications of Glycolipid Biosurfactants from Energy Saving Materials to Gene Delivery Carriers显示文摘 | DAI K HIROKO I TADAATSU N | 2002 | J Biosci Bioeng2002，94，3： | 1 |
| 6 | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population显示文摘 | Yoshiji Yamada Hidemi Yoshida Sahoko Ichihara Tadaatsu Imaizumi Kei Satoh Mitsuhiro Yokota | 2000 | Atherosclerosis2000，，1： | 1 |
| 7 | A Mutation in Plasma Platelet-Activating Factor Acetylhydrolase (Val sup 279 [right arrow] Phe) is a Genetic Risk Factor for Stroke显示文摘 | Makoto Hiramoto Hidemi Yoshida Tadaatsu Imaizumi Nobuhiro Yoshimizu Kei Satoh | 1997 | Stroke: A Journal of Cerebral Circulation1997，，12： | 1 |
| 8 | A single band does not always represent single bacterial strains in denaturing gradient gel electrophoresis analysis显示文摘 | Hiroyuki Sekiguchi Noriko Tomioka Tadaatsu Nakahara Hiroo Uchiyama | 2001 | 2001，，： | 1 |
| 9 | Immunohistochemical study on the distribution of α and β subunits of S-100 protein in human neoplasm and normal tissues显示文摘 | Kiyoshi Takahashi Toshiaki Isobe Yuji Ohtsuki Tadaatsu Akagi Hiroshi Sonobe Tsuneo Okuyama | 1984 | Virchows Archiv B Cell Pathology Including Molecular Pathology1984，，1： | 1 |
| 10 | PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells显示文摘 | Fuyuki Sato Yunyan Wu Ujjal Kumar Bhawal Yang Liu Tadaatsu Imaizumi Satoko Morohashi Yukio Kato Hiroshi Kijima | 2011 | European Journal of Cancer2011，，11： | 1 |
| 11 | Interferon-γ stimulates fractalkine expression in human bronchial epithelial cells and regulates mononuclear cell adherence显示文摘 | Tadaatsu I Hidemi Y | 2002 | Am J Respir Cell Mod Biol2002，25，4： | 1 |
| 12 | IFN-[gamma] and TNF-[alpha] Synergistically Induce microRNA-155 Which Regulates TAB2/IP-10 Expression in Human Mesangial Cells显示文摘 | Imaizumi Tadaatsu Tanaka Hiroshi Tajima Atsushi Yokono Yoshikazu Matsumiya Tomoh Yoshida Hidemi Tsuruga Kazushi Aizawa-yashiro Tomomi Hayakari Ryo Inoue Ituro Ito Etsuro Satoh Kei | 2010 | American Journal of Nephrology2010，，5： | 1 |
| 13 | Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation显示文摘 | Hidemi Yoshida Junsei Mimura Tadaatsu Imaizumi Tomoh Matsumiya Akira Ishikawa Norifumi Metoki Kunikazu Tanji Ken Ota Ryo Hayakari Kunio Kosaka Ken Itoh Kei Satoh | 2011 | Neuroscience Research2011，，4： | 1 |
| 14 | Succession of bacterial community structure along the Changjiang river determined by denaturing gradient gel electrophoresis and clone library analysis显示文摘 | Hiroyuki sekiguchi Masataka Watanabe Tadaatsu Nakahara | 2002 | Applied and environmental microbiology2002，68，10： | 1 |
| 15 | Functions and potential applications of glycolipid biosurfactants:From energysaving materials to gene delivery carriers显示文摘 | Dai K Hiroko I Tadaatsu N | 2002 | Jourmal of Bioscience and Bioengineering2002，94，3： | 1 |
| 16 | Interleukin-1β stimulates galectin-9 expression in human astrocytes显示文摘 | Hidemi Yoshida Tadaatsu Imaizumi Mika Kumagai Kazuyuki Kimura Chikako Satoh Naoyuki Hanada Koji Fujimoto Nozomu Nishi Kunikazu Tanji Tomoh Matsumiya Fumiaki Mori Xue-Fan Cui Wakako Tamo Takeo Shibata Shingo Takanashi Ken Okumura Takanori Nakamura Koichi W | 2001 | Neuroreport2001，，17： | 1 |
| 17 | Functions and potential applications of glycolipid biosurfactants: From energy - saving materials to gene delivery carriers 显示文摘 | Dai K Hiroko I Tadaatsu N | 2002 | Jourmal of Bioscience and Bioengineering2002，94，3： | 1 |
| 18 | A single band does not always represent single bacterial strains in denaturing gradient gel electrophoresis analysis 显示文摘 | Hiroyuki Sekiguchi Noriko Tomioka Tadaatsu Nakahara | 2001 | Biotechnology Letters2001，23，： | 1 |
| 19 | A single band does not always represent single bacterial strains in denaturing gradient gel electrophoresis analysis显示文摘 | Hiroyuki Sekiguchi Noriko Tomioka Tadaatsu Nakahara Hiroo Uchiyama | | 0，2001，： | 1 |
| 20 | Bacterial lipopolysaccharide induces retinoic acid-inducible gene-I in vascular endothelial cells显示文摘 | Tadaatsu Imaizumi Hidemi Yoshida Kei Satoh | 2003 | International Congress Series2003，1251，： | 1 |
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