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| 1 | Regulation and function of DNA methylation in plants and animals显示文摘DNA methylation 是涉及多样的生物过程的一个重要 epigenetic 标记。在植物, DNA methylation 能通过指导 RNA 的 DNA methylation 小径被建立,为 transcriptional 基因 silencing (TGS ) 的一条 RNA 干扰小径,它要求 24-nt 小介入 RNA。在哺乳动物, de novo DNA methylation 首先在二个发展阶段发生:在早 embryogenesis 期间并且在 gametogenesis 期间。当在哺乳动物的 DNA methylation 模式的建立是否一般来说包含 RNA 干扰,不是清楚的时,在细菌房间的 transposons 的 de novo DNA methylation 和抑制要求 24-32-nt 交往 piwi 小 RNA。DNA methylation 地位被 DNA methylation 和 demethylation 反应动态地调整。在植物,活跃 DNA demethylation 依靠 silencing 的抑压者 bifunctional DNA glycosylases 的 1 个家庭,移开 5-methylcytosine 底然后在 abasic 地点劈开 DNA 脊梁,开始一个基础切除修理(BER ) 小径。在动物,活跃 DNA demethylation 的多重机制被建议了,包括脱氨基酶 -- 并且 DNA 开始 glycosylase 的 BER 小径。有关在 DNA methylation 的建立和维护以后的各种各样的 histone 修正的效果的新信息拓宽了我们 DNA methylation 的规定的理解。在植物和动物的 DNA methylation 的功能也在这评论被讨论。 | Xin-Jian He Taiping Chen Jian-Kang Zhu | 2011 | Cell Research2011，21，3： | 52 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for PDAC progression, we employed single-cell RNA-seq (scRNA-seq) to acquire the transcriptomic atlas of 57,530 individual pancreatic cells from primary PDAC tumors and control pancreases, and identified diverse malignant and stromal cell types, including two ductal subtypes with abnormal and malignant gene expression profiles respectively, in PDAC. We found that the heterogenous malignant subtype was composed of several subpopulations with differential proliferative and migratory potentials. Cell trajectory analysis revealed that components of multiple tumor-related pathways and transcription factors (TFs) were differentially expressed along PDAC progression. Furthermore, we found a subset of ductal cells with unique proliferative features were associated with an inactivation state in tumor-infiltrating T cells, providing novel markers for the prediction of antitumor immune response. Together, our findings provide a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncover a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy. | Junya Peng Bao-Fa Sun Chuan-Yuan Chen Jia-Yi Zhou Yu-Sheng Chen Hao Chen Lulu Liu Dan Huang Jialin Jiang Guan-Shen Cui Ying Yang Wenze Wang Dan Guo Menghua Dai Junchao Guo Taiping Zhang Quan Liao Yi Liu Yong-Liang Zhao Da-Li Han Yupei Zhao Yun-Gui Yang Wenming Wu | 2019 | Cell Research2019，29，9： | 24 |
| 4 | Late Mesozoic magmatism and tectonic evolution in the Southern margin of the North China Craton显示文摘Late Mesozoic granitic magmatism(158–112 Ma) are widespread in the southern margin of the North China Craton(NCC), contemporary with many world-class Mo-Au-Ag-Pb-Zn polymetallic deposits. There are abrupt changes in the elements and isotopic compositions of these granites at about 127 Ma. The early stage(158–128 Ma) granites show slightly or no negative Eu anomalies, large ion lithophile elements enriched and heavy REE depleted(such as Y and Yb), belonging to typical I-type granite. The late stage(126–112 Ma) granites are characterized by A-type and/or highly fractionated I-type granite, with higher contents of SiO2, K2 O, Y, Yb and Rb/Sr ratio and lower contents of Sr, δEu value and Sr/Y ratio than that of the early-stage granites.Moreover, the whole rock Nd and Hf isotopic compositions of the granites younger than 127 Ma show more depleted than those of the older one. The two stages of Late Mesozoic granites were derived from a source region of the ancient basement of the southern margin of the NCC incorporated the mantle material. The late stage(126–112 Ma) granites contain more fractions of mantle material with depleted isotopic composition than the early ones. The granites record evidence for a strong crust-mantle interaction. They formed in an intracontinental extensional setting which was related to lithospheric thinning and asthenospheric upwelling in this region, which was possibly caused by westward subduction of the Paleo-Pacific plate. 127 Ma is an critical period of the transformation of the tectonic regime. | GAO XinYu ZHAO TaiPing | 2017 | Science China Earth Sciences2017，60，11： | 14 |
| 5 | New Fossil Xyelidae(Insecta,Hymenoptera) from the Yixian Formation of Western Liaoning,China显示文摘In this paper one new genus and two new species,Brachyoxyela brevinodia sp.nov.and Brachyoxyela gracilenta sp.nov.,in the subfamily Macroxyehnae of the family Xyelidae,are described and illustrated.The specimens were collected from the Yixian Formation,the Upper Jurassic to Lower Cretaceous,of Beipiao City,Liaoning Province,northeastern China.The new genus is established based on the characters that vein Sc meets R only beyond origin of Rs,third antennal segment is almost equal in length to the rest flagellomeres combined,terminal flagellomeres increasingly shortened toward apex,and vein 2r-rs inclined toward the apex of wing. | GAO Taiping ZHAO Yunyun REN Dong | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 5 |
| 6 | Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation显示文摘Pancreatic ductal adenocarcinoma(PDAC)has poor prognosis due to limited therapeutic options.This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets.We have identified HNF4G gene whose silencing most effectively repressed PDAC cell invasiveness.HNF4G overexpression is induced by the deficiency of transcriptional factor and tumor suppressor SMAD4.Increased HNF4G are correlated with SMAD4 deficiency in PDAC tumor samples and associated with metastasis and poor survival time in xenograft animal model and in patients with PDAC(log-rank P=0.036;HR=1.60,95%CI=1.03–2.47).We have found that Metformin suppresses HNF4G activity via AMPK-mediated phosphorylation-coupled ubiquitination degradation and inhibits in vitro invasion and in vivo metastasis of PDAC cells with SMAD4 deficiency.Furthermore,Metformin treatment significantly improve clinical outcomes and survival in patients with SMAD4-deficient PDAC(log-rank P=0.022;HR=0.31,95%CI=0.14–0.68)but not in patients with SMAD4-normal PDAC.Pathway analysis shows that HNF4G may act in PDAC through the cell-cell junction pathway.These results indicate that SMAD4 deficiency-induced overexpression of HNF4G plays a critical oncogenic role in PDAC progression and metastasis but may form a druggable target for Metformin treatment. | Chengcheng Wang Taiping Zhang Quan Liao Menghua Dai Junchao Guo Xinyu Yang Wen Tan Dongxin Lin Chen Wu Yupei Zhao | 2021 | Protein & Cell2021，12，2： | 5 |
| 7 | Provenance and tectonic setting transition as recorded in the Neoproterozoic strata, western Jiangnan Orogen:Implications for South China within Rodinia显示文摘The Neoproterozoic Tonian strata (ca.870-725 Ma) in the western Jiangnan Orogen archive the records of sedimentary provenance and tectonic setting which can be used to understand the geological evolution of the South China Continent.These strata are separated into the basement and cover sequences by a regional angular unconformity.The basement sequence can be subdivided into the lower and the upper parts by the widespread interbedded ca.840 Ma basalt with pillow structure.In the present work,234 concordant detrital zircon analyses are obtained from three Tonian sandstone samples in the Fanjingshan district,Guizhou Province.Combined with previous results,a total of 1736 analyses of detrital zircon U-Pb ages derived from 12 formations of Tonian strata in the western Jiangnan Orogen are used to decipher the integrated sedimentary and tectonic histories.The zircons from the lowermost part of the basement sequence (the Yujiagou Formation) show oval morphology and display two Paleoproterozoic age peaks at 2325 Ma and 1845 Ma which are similar with the detrital zircon age peaks from the Late Paleoproterozoic to Early Mesoproterozoic Dongchuan/Dahongshan/Hekou groups,suggesting a passive margin basin in which the sediments were mainly sourced from the southwestern Yangtze Block.However,the zircon age population of the lower part of the basement sequence (the Xiaojiahe,Huixiangping formations and their equivalents) indicates the sedimentary derivation from bidirectional sources (the ca.870 Ma arc materials in the south and the old detritus from the southwestern Yangtze Block) which is consistent with a back arc setting for the deposition of the sediments.Zircons from the upper part of the basement sequence (the Duyantang Formation and its equivalent) show euhedral and subangular morphology and display a unimodal age peak at ca.835 Ma.This sequence was possibly deposited in a convergent setting and the detritus were came from the locally distributed syn-collisional igneous rocks.The lower part of the cover sequence (the Xinzhai and Wuye formations and their equivalents) shows a distinct zircon age peak at 815-809 Ma and two subordinate peaks at 2485 Ma and 2018 Ma,suggesting that the basin had gradually transformed into a continental rift basin and received the detritus from the ca.815 Ma post-collisional magmatic rocks as well as from different Paleoproterozoic source rocks in the northern Yangtze Block.We propose a tectonic evolution model that envisages eruption of ca.840 Ma basalt in a back arc basin that existed during ca.870-835 Ma,an angular unconformity was formed during amalgamation of the Yangtze Block and the Cathaysia Block at ca.835-820 Ma and the rifting of the South China Continent was initiated at ca.800 Ma.Our study concludes that the South China Continent was formed on the periphery of the Rodinia supercontinent. | Jiawei Zhang Taiping Ye Yaran Dai Jianshu Chen Hui Zhang Chuangu Dai Guohua Yuan Kaiyuan Jiang | 2019 | Geoscience Frontiers2019，10，5： | 4 |
| 8 | Pancreatic head cancer: Open or minimally invasive pancreaticoduodenectomy?显示文摘Pancreatic head cancer still represents an insurmountable barrier for patients and pancreatic surgeons.Pancreaticoduodenectomy(PD)continues to be the operative standard of care and potentially curative procedure for pancreatic head cancer.Despite the rapid development of minimally invasive techniques,whether the efficacy of minimally invasive pancreaticoduodenectomy(MIPD)is noninferior or superior to open pancreaticoduodenectomy(OPD)remains unclear.In this review,we summarized the history of OPD and MIPD and the latest staging and classification information for pancreatic head cancer as well as the proposed recommendations for MIPD indications for patients with pancreatic head cancer.By reviewing the MIPD-vs.OPD-related literature,we found that MIPD shows noninferiority or superiority to OPD in terms of safety,feasibility,enhanced recovery after surgery(ERAS)and several short-term and long-term outcomes.In addition,we analyzed and summarized the different MIPD outcomes in the USA,Europe and China.Certain debates over MIPD have continued,however,selection bias,the large number of low-volume centers,the steep MIPD learning curve,high conversion rate and administration of neoadjuvant therapy may limit the application of MIPD for pancreatic head cancer. | Mengyu Feng Zhe Cao Zhiwei Sun Taiping Zhang Yupei Zhao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
| 9 | MiR-135a biogenesis and regulation in malignancy:a new hope for cancer research and therapy显示文摘MicroRNAs(miRNAs)are evolutionarily conserved small non-coding RNAs that affect posttranscriptional regulation by binding to the 3′-untranslated region of target messenger RNAs.MiR-135a is a critical miRNA that regulates gene expression,and many studies have focused on its function in cancer research.MiR-135a is dysregulated in various cancers and regulates cancer cell proliferation and invasionvia several signaling pathways,such as the MAPK and JAK2/STAT3 pathways.MiR-135a has also been found to promote or inhibit the epithelial-mesenchymal transition and chemoresistance in different cancers.Several studies have discovered the value of miR-135a as a novel biomarker for cancer diagnosis and prognosis.These studies have suggested the potential of therapeutically manipulating miR-135a to improve the outcome of cancer patients.Although these findings have demonstrated the role of miR-135a in cancer progression and clinical applications,a number of questions remain to be answered,such as the dual functional roles of miR-135a in cancer.In this review,we summarize the available studies regarding miR-135a and cancer,including background on the biogenesis and expression of miR-135a in cancer and relevant signaling pathways involved in miR-135a-mediated tumor progression.We also focus on the clinical application of miR-135a as a biomarker in diagnosis and as a therapeutic agent or target in cancer treatment,which will provide a greater level of insight into the translational value of miR-135a. | Zhe Cao Jiangdong Qiu Gang Yang Yueze Liu Wenhao Luo Lei You Lianfang Zheng Taiping Zhang | 2020 | Cancer Biology & Medicine2020，17，3： | 4 |
| 10 | Zircon U-Pb geochronology of tuffite beds in the Baishugou Formation:Constraints on the revision of Ectasian System at the southern margin of the North China Craton显示文摘The Xiamaling Formation of 1.4–1.35 Ga in Jixian Section and adjoining areas represents a unique Ectasian Period(Mesoproterozoic)sedimentary sequence in the North China Craton(NCC).Studies carried out during the last decade have contributed significantly in improving our understanding about the Ectasian sedimentation tectonics in the NCC during this transitional interval between the breakup of Supercontinent Columbia and the assembly of Rodinia.The present study reports,for the first time,tuffite beds interlayered with carbonaceous-siliceous slate-phyllite in the upper Baishugou Formation(western Henan Province),at the southern margin of NCC.The LA-MC-ICPMS U-Pb geochronology of zircons from two tuffite samples has yielded almost identical ages of 1330±10 Ma(MSWD=0.43,N=38)and 1332±10 Ma(MSWD=0.90,N=24),that constrain a 1.33 Ga depositional age(Ectasian Period)for the Baishugou Formation.A close similarity in lithological characteristics and their respective superimposed lithostratigraphic relationships of the Baishugou and Xiamaling formations,underline a comparable depositional environment for them.The high-precision geochronology data on the Baishugou Formation would stimulate a relook into the Meso-Neoproterozoic chronostratigraphic framework of the NCC,and further research would lead to a comprehensive understanding of the geological evolution of the NCC during Ectasian Period and its correlation with analogous global events. | Xiyan ZHU Shiyan WANG Wenbo SU Taiping ZHAO Lanyin PANG Mingguo ZHAI | 2020 | Science China Earth Sciences2020，63，11： | 4 |
| 11 | Current epidemiology of pancreatic cancer: Challenges and opportunities显示文摘Pancreatic cancer(PC) is an increasingly common disease worldwide. Having a better understanding of worldwide and regional epidemiologic features and risk factors of PC is essential to identify new approaches for prevention,early diagnosis, surveillance, and treatment. In this article, we review the epidemiologic features and risk factors for PC and discuss opportunities and challenges of PC future treatment. | Wenhao Luo Jinxin Tao Lianfang Zheng Taiping Zhang | 2020 | Chinese Journal of Cancer Research2020，32，6： | 3 |
| 12 | Protective effects of ginkgo biloba leaves extract on peroxide-induced oxidative stress damage in PC12 cells显示文摘BACKGROUND: Extracts of ginkgo biloba leaves (EGB) and its metabolites have been reported to enhance brain function and nerve behavior. It has also been hypothesized that they can protect neurons from oxidative stress. OBJECTIVE: To investigate protective effects of EGB on peroxide (H2O2)-induced oxidative stress damage in PC12 cells. DESIGN: Observational contrast study. SETTING: Department of Pathophysiology,Guangdong Pharmacological College. MATERIALS: EGB was provided by Xi'an Fujie Biotechnological Development Company; 1640 culture medium,methylthiazolyl tetrazolium (MTT),trypsin and dimathyl sulfoxide (DMSO) by Sigma Company; PC12 cell strain by Cell Center of Medical College of Zhongshan University; calf serum by Hangzhou Sijiqing Bioengineering Company; lactate dehydrogenase (LDH) kit by Nanjing Jiancheng Bioengineering Research Institute. METHODS: The experiment was carried out in Department of Cell Biology of Guangdong Pharmacological College from June to December 2005. ① Cell culture: PC12 cells were cultured in 1640 medium containing 200 g/L fetal calf serum. The cells were diluted to 1×107 L-1 and washed every two days. Those cells were used to experiment until they grew in logarithm on solid wall. ② Grouping and intervention: PC12 cells (1×108 L-1) were plated in 96-well plates with the density of 200 μL/hole and divided into three groups: normal control group (routinely adding media),H2O2 group (treating with media and H2O2 for 20 hours) and EGB group (adding media,100 μmol/L EGB and 100 μmol/L H2O2). ③ MTT assay: PC12 cells (1× 108 L-1) were plated in 96-well plates and divided into three groups with 8 holes for each group. Under sterile condition,cells were added with 5 g/L MTT (100 μL) and cultured for 4 hours. And then,200 μL DMSO fluid was added and shaken for 30 minutes until blue crystal products formed were dissolved soundly. ④ Experimental evaluation: Absorbance (A) at 630 nm was measured and LDH activity was measured at the same time. MAIN OUTCOME MEASURES: Results of MTT assay and LDH activity. RESULTS: ① Results of MTT assay: A value was lower in the H2O2 group than that in the normal control group (P < 0.01),while A value was higher in the EGB group than that in the H2O2 group (P < 0.01). ② LDH activity: LDH activity was higher in the H2O2 group than that in the normal control group (P < 0.01),while LDH activity was lower in the EGB group than that in the H2O2 group (P < 0.01). CONCLUSION: EGB can inhibit H2O2-induced oxidative stress damage in PC12 cells possibly by preventing damage to the cell membrane. | Weiqiang Chen Taiping Hu Ying Liu | 2007 | Neural Regeneration Research2007，2，6： | 3 |
| 13 | Wavelength-tunable infrared light emitting diode based on ordered ZnO nanowire/Si1-xGex alloy heterojunction显示文摘 | Taiping Zhang Renrong Liang Lin Dong Jing Wang Jun Xu Caofeng Pan | 2015 | Nano Research2015，8，8： | 2 |
| 14 | Advantage of dual wavelength light-emitting diodes with dip-shaped quantum wells显示文摘Dual-wavelength light-emitting diodes (DW-LEDs) with dip-shaped quantum wells have been studied by numerical simulation.The emission spectra,light output power,carrier concentration in the quantum wells and internal quantum efficiency are investigated.The simulation results indicate that the DW-LEDs with dip-shaped quantum wells perform better than conventional LEDs with rectangular quantum wells in terms of light output power,leakage current and efficiency droop.These improvements in the electrical and optical characteristics are mainly attributed to the alleviation of the electrostatic field in the dip-shaped quantum wells. | XU YiQin FAN GuangHan ZHOU DeTao LI Xin LU TaiPing ZHAO Fang ZHANG YunYan ZHENG ShuWen GONG ChangChun | 2012 | Chinese Science Bulletin2012，57，20： | 2 |
| 15 | PHYSICAL MODELING OF HYDRAULIC DESILTATION IN TAPU RESERVOIR显示文摘A movable bed physical model was constructed to investigate hydraulic desiltation by flushing and lateral erosion in the Tapu reservoir, Taiwan. The model scaling is based on the requirement for dynamic similarity of cohesive sediment deposit initiation in flushing processes. For model scaling, flume experiments investigating the initiation of cohesive sediment deposits were carried out to establish the relationship between critical shear stress of the flow and dry density of the deposit. Experiments in the physical model were then performed to measure the variations of the reservoir water level, the outlet discharge and the outflow sediment discharge. The processes of emptying and flushing were observed and analyzed in the main flushing channel. One of the experiments was conducted to simulate the on-site flushing operations on June 11, 1997. The results showed that the total 0cumulative flushed sediment volume by physical modeling was close to that by numerical simulation. To deal with the fioodplain deposits, experiments of lateral erosion as an auxiliary method were also conducted in the physical model to investigate the effectiveness and applicability for the0 Tapu reservoir. | Jihn-Sung LAI and Fi-John CHANG Assistant Research Fellow, Hydrotech Research Institute, National Taiwan University, Taipei, 10617, Taiwan Professor, Department of Agriculture Engineering and Hydrotech Research Institute, National Taiwan University, Taipe | 2001 | International Journal of Sediment Research2001，16，3： | 2 |
| 16 | The Effect of CD3-Specific Monoclonal Antibody on Treating Experimental Autoimmune Myasthenia Gravis显示文摘CD3-specific monoclonal antibody was the first one used for clinical practice in field of transplantation. Recently,renewed interests have elicited in its capacity to prevent autoimmune diabetes by inducing immune tolerance. In this study, we tested whether this antibody can also be used to treat another kind of autoimmune disease myasthenia gravis (MG) and explored the possible mechanisms. MG is caused by an autoimmune damage mediated by antibody- and complement-mediated destruction of AChR at the neuromuscular junction. We found that administration of CD3-specific antibody (Fab)2 to an animal model with experimental autoimmune myasthenia gravis (EAMG) (B6 mice received 3 times of AChR/CFA immunization) could not significantly improve the clinical signs and clinical score. When the possible mechanisms were tested, we found that CD3 antibody treatment slightly down-regulated the T-cell response to AChR, modestly up-regulation the muscle strength. And no significant difference in the titers of IgG2b was found between CD3 antibody treated and control groups. These data indicated that CD3-specific antibody was not suitable for treating MG, an antibody- and complementmediated autoimmune disease, after this disease has been established. The role of CD3-specific antibody in treating this kind of disease remains to be determined. | Ruonan Xu~1 Jianan Wang~1 Guojiang Chen~1 Gencheng Han~1 Renxi Wang~1 Beifen Shen~1 Yan Li~(1,2) ~1Institute of Basic Medical Science,Academy of military Medical Science,Beijing 100850,China ~2Department of Molecular Immunology,Institute of Basic Medical Science,27 Taiping Road,Beijing 100850,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 2 |
| 17 | Numerical simulation of scattering wave imaging in a goaf显示文摘废矿是对安全采矿的威胁。他们另外的复杂地质的身体的成像效果或那些在常规反映的波浪图象经常是差的。因此,废矿的精确察觉成为了一个重要问题,到与紧急的一种感觉被解决。基于散布理论,我们使用了一个相等的偏移量方法提取普通散布点集合,点和普通的中间的点聚在一起以便分析在普通散布之间的不同散布波浪特征并且完成比较栈和迁居成像。我们的研究结果证明散布波浪成像方法比常规成像方法更有效并且因此是为检测废矿和另外的复杂地质的身体的一个更有效的成像方法。它为安全采矿过程和基础结构有重要含意。 | Li Juanjuan Pan Dongming Liao Taiping Hu Mingshun Wang Linlin | 2011 | Mining Science and Technology2011，21，1： | 2 |
| 18 | Reconsideration of the sediment characteristics of the second member of the Triassic Xujiahe Formation in Sanhuiba,Huaying Mountain显示文摘The second member of the Triassic Xujiahe Formation in the Sanhuiba area in Huaying Mountain is an important section of sedimentary delta facies in the Chongqing Tianfu Geological Survey and Training Base. In spite of some initial efforts on its lithology and lithofacies, the existing research is yet to be completed and suffers from contradictory conclusions and inadequate evidence. Starting from the sedimentary microfacies types and cyclic features, we analyzed the vertical sequence of a sedimentary delta model and discovered that this section is a constructional delta deposit. Eight incomplete and asymmetric regressive cycles are marked off, given that frequent erosion surfaces appeared in the section. Based on the analysis of structural characteristics of every monocycle, we summarized the system of cycles, tracts and sequence characteristics of the overall section. In view of this systematic series of cycles, we discussed the features of the syndepositional tectonic movements in the area and conclude that, due to frequent erosion, migration and diversion of a sub-channel branch was brought about by oscillating movements of the crust. In a comparison with neighboring sections, we explored the cause of erosion and the relations between erosion and cycles. This study greatly strengthens existing research and theories, makes an important and comprehensive contribution to geological surveys and training in the area and provides essential suggestions for coal exploration, oil and gas evaluation and in general to exploration and development in the target stratum. | LIAO Taiping HU Jingjing ZHANG Furong LIU Lijing | 2010 | Mining Science and Technology2010，20，4： | 2 |
| 19 | Sr speciation in producing SrCO_3 with celestite显示文摘Strontium speciation transferring in strontium residue and mixing strontium ore are investigated with extracting experiment, X-ray powder diffraction(XRD), X-ray fluorescence spectrometer(XRF) and Atomic Absorption Spectroscopy(AAS). The results show that there are strontium carbonate, strontium sulfate, strontium sulfide, and a little amount of strontium silicate and strontium ferrite in strontium residue. Impurities in strontium residue mainly contain carbonate and oxide of calcium, iron, magnesium and aluminum etc. The amount of strontium sulfide in strontium residue is larger than that in strontium ore. And a little strontium silicate and strontium ferrite are found in strontium ore. It is concluded that acid soluble method is used firstly in the process of producing strontium carbonate from mixing strontium ore. In addition, mechanical smash method and surface active treatment to strontium samples are beneficial to the ratio-leaching increase of strontium. The research achievement helps to save energy and decrease pollutants emission in strontium processing industry. | LIU Chenglun ZHANG Li XU Longjun SU Zhimin XIE Taiping WANG Yuan | 2014 | Chinese Journal Of Geochemistry2014，33，3： | 2 |
| 20 | The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation显示文摘Dear Editor,Immunodeficiency,centromeric instability,and facial anomalies(ICF)syndrome is a rare autosomal recessive disorder characterized by antibody deficiency,facial dysmorphism,failure to thrive,and mental retardation.Patients with ICF syndrome suffer from recurrent and often fatal infections in early childhood.A hallmark of ICF syndrome is loss of DNA methylation in special genomic regions,most notably satellite repeats at centromeric regions,which leads to heterochromatin decondensation and chromosomal abnormalities in lymphocytes(Ehrlich et al.,2008). | Swanand Hardikar Zhengzhou Ying Yang Zeng Hongbo Zhao Bigang Liu Nicolas Veland Kevin McBride Xiaodong Cheng Taiping Chen | 2020 | Protein & Cell2020，11，3： | 2 |
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