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| 1 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 2 | Deep structure beneath the southwestern section of the Longmenshan fault zone and seimogenetic context of the 4.20 Lushan M_S7.0 earthquake显示文摘Magnetotelluric measurements were carried out along two profiles across the middle and southwestern sections of the Longmenshan fault zone(LMSf)from 2009 to 2011,after the 2008 Wenchuan MW7.9 earthquake.The former profile crosses the Wenchuan event epicenter and the latter one crosses 2013 Lushan MS7.0 event epicenter.The data were analyzed using advanced processing techniques,including phase tensor and two-dimensional inversion methods,in order to obtain reliable 2-D profiles of the electrical structure in the vicinity of the two earthquakes.A comparison of the two profiles indicates both similarities and differences in the deep crustal structure of the LMSf.West of the southwestern section,a crustal high conductivity layer(HCL)is present at about 10 km depth below the Songpan-Garzêblock;this is about 10 km shallower than that under the middle section of the LMSf.A high resistivity body(HRB)is observed beneath the southwestern section,extending from the near surface to the top of upper mantle.It has a smaller size than the HRB observed below the middle section.In the middle section,there is a local area of decreased resistivity within the HRB but there is absence of this area.The 2013 Lushan earthquake occurred close to the eastern boundary of HRB and the Shuangshi-Dachuan fault,of which the seismogenic context has both common and different features in comparison with the 2008 Wenchuan event.On a large scale,the 2013 Lushan earthquake is associated with the HCL and deformation in the crust including HCL of the eastern Tibetan Plateau.In order to assess seismic risk,it is important to consider both the stress state and the detailed crustal structure in different parts of the LMSf. | ZHAN Yan ZHAO GuoZe UNSWORTH Martyn WANG LiFeng CHEN XiaoBin LI Tao XIAO QiBin WANG JiJun TANG Ji CAI JunTao WANG YanZhao | 2013 | Chinese Science Bulletin2013，58，28： | 39 |
| 3 | The regulatory role of AT 1 receptor on activated HSCs in hepat,c fibrogenesis,effects of RAS inhibitors on hepatic fibrosis induced by CCl_4显示文摘AIM To assess the effect of ACE inhibitor andAng Ⅱ type Ⅰ(AT1)receptor antagonist inpreventing hepatic fibrosis caused by CCl4administration in rats;to investigate whether ornot there are expression of AT 1 receptors onhepatic stellate cells;and to observe the effectof Ang Ⅱ on proliferation and ECM synthesis ofcultured HSCs.METHODS Studies were conducted in maleSprague-Dawley rats.Except for thehepatofibrotic model group and the controlgroup,in three treated groups,either enalapril(5 mg/kg),or Iosartan(10 mg/kg),or enalapril+Iosartan were given to the fibrotic rats bydaily gavage,and saline vehicle was given tomodel and normal control rats.After 6 weeks,liver fibrosis was assessed directly by hepaticmorphometric analysis,which has beenconsidered the gold standard for thequantification of fibrosis.The expressions of AT1 receptors and(α-mooth muscle actin,α-SMA)in liver tissue or isolated hepatic stellate cells(HSCs)were detected by immunohistochemicaltechniques.The effect of Ang Ⅱ on HSCproliferation was determined by MTT method.Effect of Ang Ⅱ on collagen synthesis of HSCswas determined by 3H-proline incorporation.RESULTS Contrasted to the fibrosis in rats ofthe model group,groups of rats treated with either enalapril or Iosartan,or a combination oftwo drugs showed a limited expansion of theinterstitium(4.23±3.70 vs 11.22±4.79,P<0.05),but no difference was observedamong three treated groups(5.38±3.43,4.96±2.96,4.23±2.70,P>0.05).Expression of AT 1receptors was found in fibrotic interstitium offibrotic rats,whereas in normal control rats theywere limited to vasculature only to a very slightdegree.AT 1 receptors were also expressed onactivated HSCs in the culture.At concentrationsfrom 10-9to 10-5mol/L,Ang Ⅱ stimulated HSCproliferation in culture in a dose-dependentmanner.Increasing Ang Ⅱ concentrationsproduced corresponding increases in 3H-prolineincorporation.Differences among groups were significant.CONCLUSION Angiotensin-converting enzyme inhibitors and AT I blocker may slow the progression of hepatic fibrosis; activated HSCs express AT 1 receptors, and Ang Ⅱ can stimulate the proliferation and collagen synthesis of HSCs in a dose-dependent manner; and activation of RAS may be related to hepatic fibrogenesis induced by CCI4. | Hong Shan Wei Han Ming Lu Ding Guo Li Yu Tao Zhan Zhi Rong Wang Xin Huang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，6： | 27 |
| 4 | Augmented reality and virtual reality displays:emerging technologies and future perspectives显示文摘With rapid advances in high-speed communication and computation,augmented reality(AR)and virtual reality(VR)are emerging as next-generation display platforms for deeper human-digital interactions.Nonetheless,to simultaneously match the exceptional performance of human vision and keep the near-eye display module compact and lightweight imposes unprecedented challenges on optical engineering.Fortunately,recent progress in holographic optical elements(HOEs)and lithography-enabled devices provide innovative ways to tackle these obstacles in AR and VR that are otherwise difficult with traditional optics.In this review,we begin with introducing the basic structures of AR and VR headsets,and then describing the operation principles of various HOEs and lithography-enabled devices.Their properties are analyzed in detail,including strong selectivity on wavelength and incident angle,and multiplexing ability of volume HOEs,polarization dependency and active switching of liquid crystal HOEs,device fabrication,and properties of micro-LEDs(light-emitting diodes),and large design freedoms of metasurfaces.Afterwards,we discuss how these devices help enhance the AR and VR performance,with detailed description and analysis of some state-of-the-art architectures.Finally,we cast a perspective on potential developments and research directions of these photonic devices for future AR and VR displays. | Jianghao Xiong En-Lin Hsiang Ziqian He Tao Zhan Shin-Tson Wu | 2021 | Light(Science & Applications)2021，10，11： | 27 |
| 5 | Management Recommendations on Sleep Disturbance o Patients with Parkinson's Disease显示文摘INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD).Sleep disturbance affects 40-98% of PD patients in the world. In China, the prevalence of PD patients with sleep disturbance ranges from 47.66% to 89.10%. Sleep disturbance usually has adverse impact on the quality of life of PD patients. Apossible pathogenesis of PD with sleep disturbance include thalamocortical pathway degeneration and changes of neurotransmitter systems. The etiology of sleep disturbance is multifactorial,involving degeneration of areas regulating sleep,sleep structure affected by drugs,sleep disturbance induced by drug,and sleep fragmentation by multiple factors. | Chun-Feng Liu Tao Wang Shu-Qin Zhan De-Qin Geng Jian Wang Jun Liu Hui-Fang Shang Li-Juan Wang Piu Chan Hai-Bo Chen Sheng-Di Chen Yu-Ping Wang Zhong-Xin Zhao K Ray Chaudhuri | 2018 | Chinese Medical Journal2018，，24： | 26 |
| 6 | Modeling the relationship of land use change and some geophysical indicators for the interlock area of farming and pasturing in China显示文摘This paper discusses land-use changes in the interlock area of farming and pasturing (IAFP)in northern China. It presents detailed analyses of land-use features in the IAFP, which are controlled by the macro geomorphic units and geophysical conditions-constraints or advantages. Additionally, it selects some indicators, according to the availability in acquiring and processing their quantitative data, to analyze the canonical correlations between the typical conversion of grassland and geophysical conditions. The preliminary study indicates that the physical conditions are of great advantages to the development of grassland. There exists significant correlation between land use change and some geophysical conditions. | DENG Xiangzheng, LIU Jiyuan, ZHUANG Dafang, ZHAN Jinyan, ZHAO Tao(Inst. of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, China) | 2002 | Journal of Geographical Sciences2002，12，4： | 19 |
| 7 | Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein显示文摘AIM: To evaluate the efficacy of transcatheter arterial chemoembolisation(TACE) compared with surgical intervention and sorafenib for treatment of hepatocellular carcinoma(HCC) in patients with tumor thrombus extending to the main portal vein.METHODS: From 2009 to 2013, a total of 418 HCC patients with tumor thrombus extending to the main portal vein were enrolled in this study and divided into four groups. These groups underwent different treatments as follows: TACE(n = 307), surgical intervention(n = 54), sorafenib(n = 15) and palliativetreatment(n = 42). Overall survival rates were determined by Kaplan-Meier method, and differences between the groups were identified through log-rank analysis. Cox's proportional hazard model was used to identify the risk factors for survival.RESULTS: The mean survival periods for patients in the TACE, surgical intervention, sorafenib and palliative treatment groups were 10.39, 4.13, 5.54 and 2.82 mo, respectively. For the TACE group, the 3-, 6-, 12-and 24-mo survival rates were 94.1%, 85.9%, 51.5% and 0.0%, respectively. The corresponding rates were 60.3%, 22.2%, 0.0% and 0.0% for the surgical intervention group and 50.9%, 29.5%, 0.0% and 0.0% for the sorafenib group. Evidently, the results in the TACE group were significantly higher than those in the other groups(P < 0.0001). Furthermore, no significant difference among survival rates was observed between TACE with/without sorafenib(10.22 mo vs 10.52 mo, P = 0.615). No significant difference in survival rates was also found among the surgical intervention, sorafenib and palliative treatment groups(P > 0.05). These values significantly increased after TACE with/without sorafenib compared with other treatments(P < 0.05).CONCLUSION: For HCC patients with tumor thrombus extending to the main portal vein, TACE can yield a higher survival rate than surgical intervention or sorafenib treatment. | Hai-Hong Ye Jia-Zhou Ye Zhi-Bo Xie Yu-Chong Peng Jie Chen Liang Ma Tao Bai Jun-Ze Chen Zhan Lu Hong-Gui Qin Bang-De Xiang Le-Qun Li | 2016 | World Journal of Gastroenterology2016，22，13： | 14 |
| 8 | 我国不同地区稻田甲烷排放量及控制措施研究显示文摘1993—1995连续3年在天津模拟微型小区进行了4组水稻对比试验,1995年又在武汉和广州大田上进行了两组早晚稻验证试验,研究不同地区稻田甲烷排放通量及其控制措施,包括:施用沼渣代替普通堆肥(A),施用包被复合肥(B)、硫铵(C)、硝铵(D)代替尿素,稻田间歇落干(E),以及施用氧化硅粉(F)等农作措施,对减少稻田甲烷排放量的作用。每种设计措施重复2—3年。试验结果表明:①不施或轻施堆肥(主要施用化肥)的稻田甲烷排放通量中值范围为0.66—13.39(天津一季稻0.66—1.70,南方早稻5.67,晚稻13.39)mg/(m2·h),可代表我国稻田一般情况。特别重施堆肥的稻田甲烷排放量中值范围分别为18.80—28.48mg/(m2·h)(包括晚稻),与国外报告的平均范围相当;但重施腐熟沼渣的与单施尿素的甲烷排放通量无差异。②6项设计控制甲烷的措施比同等无控制措施农作方法减少稻田甲烷排放量11%—90%以上,水稻产量无显著增减。综合归纳各种设计措施减少稻田甲烷排放通量中值依次排列为:A(97.9%)>B(44.0%)>F(43.5%)>C,D(41.1%)>E(33.6%)。 | Tao Zhan et al.(Agro-environ.Prot.Inst., Tianjin, 300191) , | 1998 | 农业环境保护1998，17，1： | 12 |
| 9 | The impact of climate change on forest fire danger rating in China’s boreal forest显示文摘The Great Xing'an Mountains boreal forests were focused on in the northeastern China.The simulated future climate scenarios of IPCC SRES A2a and B2a for both the baseline period of 1961-1990 and the future scenario periods were downscaled by the Delta Method and the Weather Generator to produce daily weather data.After the verification with local weather and fire data,the Canadian Forest Fire Weather Index System was used to assess the forest fire weather situation under climate change in the study region.An increasing trend of fire weather severity was found over the 21st century in the study region under the both future climate change scenarios,compared to the 1961-1990 baseline period.The annual mean/maximum fire weather index was predicted to rise continuously during 2010-2099,and by the end of the 21st century it is predicted to rise by 22%-52% across much of China's boreal forest.The significant increases were predicted in the spring from of April to June and in the summer from July to August.In the summer,the fire weather index was predicted to be higher than the current index by as much as 148% by the end of the 21st century.Under the scenarios of SRES A2a and B2a,both the chance of extremely high fire danger occurrence and the number of days of extremely high fire danger occurrence was predicted to increase in the study region.It is anticipated that the number of extremely high fire danger days would increase from 44 days in 1980s to 53-75 days by the end of the 21st century. | YANG Guang DI Xue-ying GUO Qing-xi SHU Zhan ZENG Tao YU Hong-zhou WANG Chao | 2011 | Journal of Forestry Research2011，22，2： | 12 |
| 10 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 11 | Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia显示文摘 | Li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang Bin Zhang Tao Wang Chun-Feng Liu Hui Lu Xiao-Ping Dong Zhi-Ying Wu Jie-Wen Zhang Ji-Hui Zhang Zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier Jian-Ping Jia Yu-Ping Wang | 2018 | Chinese Medical Journal2018，，13： | 10 |
| 12 | Tumor necrosis factor-α mediates JNK activation response to intestinal ischemia-reperfusion injury显示文摘AIM:To investigate whether tumor necrosis factor-α(TNF-α)mediates ischemia-reperfusion(I/R)-induced intestinal mucosal injury through c-Jun N-terminal kinase(JNK)activation.METHODS:In this study,intestinal I/R was induced by 60-min occlusion of the superior mesenteric artery in rats followed by 60-min reperfusion,and the rats were pretreated with a TNF-α inhibitor,pentoxifylline,or the TNF-α antibody infliximab.After surgery,part of the intestine was collected for histological analysis.The mucosal layer was harvested for RNA and protein extraction,which were used for further real-time polymerase chain reaction,enzyme-linked immunosorbent assay and Western blotting analyses.The TNF-α expression,intestinal mucosal injury,cell apoptosis,activation of apoptotic protein and JNK signaling pathway were analyzed.RESULTS:I/R significantly enhanced expression of mucosal TNF-α at both the mRNA and protein levels,induced severe mucosal injury and cell apoptosis,activated caspase-9/caspase-3,and activated the JNK signaling pathway.Pretreatment with pentoxifylline markedly downregulated TNF-α at both the mRNA and protein levels,whereas infliximab pretreatment did not affect the expression of TNF-α induced by I/R.However,pretreatment with pentoxifylline or infliximab dramatically suppressed I/R-induced mucosal injury and cell apoptosis and significantly inhibited the activation of caspase-9/3 and JNK signaling.CONCLUSION:The results indicate there was a TNFα-mediated JNK activation response to intestinal I/R injury. | Qi Yang Feng-Ping Zheng Ya-Shi Zhan Jin Tao Si-Wei Tan Hui-Ling Liu Bin Wu | 2013 | World Journal of Gastroenterology2013，19，30： | 9 |
| 13 | Enhanced methane production in an anaerobic digestion and microbial electrolysis cell coupled system with co-cultivation of Geobacter and Methanosarcina显示文摘The anaerobic digestion(AD)and microbial electrolysis cell(MEC)coupled system has been proved to be a promising process for biomethane production.In this paper,it was found that by co-cultivating Geobacter with Methanosarcina in an AD–MEC coupled system,methane yield was further increased by 24.1%,achieving to 360.2 m L/g-COD,which was comparable to the theoretical methane yield of an anaerobic digester.With the presence of Geobacter,the maximum chemical oxygen demand(COD)removal rate(216.8 mg COD/(L·hr))and current density(304.3 A/m_3)were both increased by 1.3 and 1.8 fold compared to the previous study without Geobacter,resulting in overall energy efficiency reaching up to 74.6%.Community analysis demonstrated that Geobacter and Methanosarcina could coexist together in the biofilm,and the electrochemical activities of both were confirmed by cyclic voltammetry.Our study observed that the carbon dioxide content in total gas generated from the AD reactor with Geobacter was only half of that generated from the same reactor without Geobacter,suggesting that Methanosarcina may obtain the electron transferred from Geobacter for the reduction of carbon dioxide to methane.Taken together,Geobacter not only can improve the performance of the MEC system,but also can enhance methane production. | Qi Yin Xiaoyu Zhu Guoqiang Zhan Tao Bo Yanfei Yang Yong Tao Xiaohong He Daping Li Zhiying Yan | 2016 | Journal of Environmental Sciences2016，28，4： | 9 |
| 14 | Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo显示文摘Fucoidan 是从棕色的海草孤立的主要 sulfated 多糖之一。在这研究,我们在弥漫的大 B 房间淋巴瘤(DLBCL ) 上决定了 fucoidan 的反癌症活动在 vitro 并且在 vivo 的房间。Fucoidan 在一个剂量依赖者和时间依赖者举止禁止了 DLBCL 细胞的生长,并且 fucoidan 治疗挑起了 G 0/G1 细胞周期拘捕,它被 p21 伴随起来规定和 cyclin D1, Cdk4,和 Cdk6 下面规定。Fucoidan 也在 DLBCL 房间线和主要 DLBCL 房间导致了 caspase 依赖的房间 apoptosis。另外, fucoidan 治疗从线粒体引起了 mitochondrial 膜潜力的损失和细胞色素 c 和导致 apoptosis 因素的版本进 cytosol。Fucoidan 也加强了在杀死 DLBCL 房间的 carfilzomib 的活动。fucoidan 的口头的管理有效地在异种皮移植老鼠模型禁止了肿瘤生长。我们的调查结果作为一个 anti-DLBCL 代理人揭示 fucoidan 的新奇功能,它能在 DLBCL 的临床的治疗被使用。 | Guang Yang Qianqiao Zhang Yuanyuan Kong Bingqian Xie Minjie Gao Yi Tao Hongwei Xu Fenghuang Zhan Bojie Dai Jumei Shi Xiaosong Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 15 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
| 16 | Thick Miocene eolian deposits on the Huajialing Mountains:The geomorphic evolution of the western Loess Plateau显示文摘The geomorphic evolution of northwestern China during the Cenozoic has been a subject of much geological interest because of its link with the uplift of the Himalayan-Tibetan complex.Much information about these changes is recoverable from the sedimentary sequences of the region.We report here on the thick eolian deposits mantling the Huajialing Mountains,a relatively flat mountain range in the western Loess Plateau.Correlation of magnetic susceptibility stratigraphy with the QA-I Miocene eolian sequence dates a 134.7 m section(NL-VII) for the interval from 18.7 to 11.8 Ma,as confirmed by micro-mammalian fossils.These eolian deposits demonstrate a much wider distribution of the Miocene eolian deposits,and also indicate that the topography contrasts in the western Loess Plateau,including the uplifts of the Huajialing Mountains and the bedrock highlands in the Qinan region,were formed by the early Miocene.The near-continuous Miocene eolian sequence from 18.7 to 11.8 Ma indicates that the substratum of Huajialing had not experienced any intense tectonic changes during this time interval,which suggests further,the relative tectonic stability of the nearby Tibetan Plateau. | ZHAN Tao GUO ZhengTang WU HaiBin GE JunYi ZHOU Xin WU ChunLin ZENG FangMing | 2011 | Science China Earth Sciences2011，54，2： | 7 |
| 17 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 18 | Ketoconazole Associated Hepatotoxicity: A Systematic Review and Metaanalysis显示文摘Objective To evaluate the incidence of Ketoconazole associated hepatotoxicity and related factors. Methods Literature retrieval was conducted by using multi-databases for meta-analysis on Ketoconazole associated hepatotoxicity. The data were collected with a standardized form. Overall estimation of incidence of hepatotoxicity for specific study type was calculated by using a DerSimonian-Laird random-effects model owing to the substantial differences among the studies. Results Totally 204 eligible studies were included in the analysis. The incidence of Ketoconazole associated hepatotoxicity was 3.6%-4.2%. The dosage and duration specific subgroup analyses did not show any significant difference among groups, while the age specific subgroup analysis showed the incidence in children and people aged >60 years was 1.4% (95% CI: 0.5%-4.2%) and 3.2% (95% CI: 1.1%-8.7%) respectively. Additionally, the incidence of the hepatotoxicity was higher in people who had oral administration of ketoconazole beyond the provisions of the usage instructions, and the incidence was 5.7% (95% CI: 4.5%-7.2%). Conclusion Ketoconazole associated hepatotoxicity was common. Off-label use might increase the risk of liver damage. Well-designed large sample studies are needed to identify the risk factors in future. | YAN Jiang Ying NIE Xiao Lu TAO Qing Mei ZHAN Si Yan ZHANG Yan De | 2013 | Biomedical and Environmental Sciences2013，26，7： | 6 |
| 19 | Synthesis of a novel water-soluble polymeric UV-absorber for cotton显示文摘<正>A water-soluble polymeric UV-absorber with polyvinylamine as backbone and benzotriazole type UV absorber as anti-UV functional group was synthesized by grafting brominated(2'-acetoxy-5'-methylphenyl)-2H-benzotriazole onto polyvinylamine. The intermediates and synthesized polymeric UV absorber were characterized by ~1H NMR,MS,IR and UV spectroscopy.The finishing properties of the polymeric UV absorber on cotton were investigated to show good UV protection property and wash fastness. | Wei Ma Xue Jiang Yong Liu Bing Tao Tang Shu Fen Zhan | 2011 | Chinese Chemical Letters2011，22，12： | 5 |
| 20 | Exponential sums over primes in short intervals显示文摘 | LIU Jianya, Lu Guangshi & ZHAN Tao Department of Mathematics, Shandong University, Jinan 250100, China | 2006 | Science China Mathematics2006，49，5： | 5 |
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