|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm显示文摘RUNX1 绝对为 RUNX1b/c 的权威的造血作用,而是功能被要求,人的 RUNX1 的二 isoforms,是不清楚的。我们建立了可诱导的 RUNX1b/c-overexpressing 人的胚胎的干细胞(hESC ) 线,在 RUNX1b/c, overexpression 阻止了 CD34+ 房间的出现早舞台,急速地从而减少造血的干细胞的生产。同时,造血作用相关的因素的表示是 downregulated。然而,如此的阻塞效果从在 hESC/AGM-S3 房间合作文化的白天 6 消失了,证明阻塞发生在 hemogenic endothelial 房间的产生前。这阻塞被 RepSox 部分救,转变生长因素(TGF ) 的一个禁止者 - 发信号的小径,显示在 RUNX1b/c 和 TGF- 小径之间的一种靠近的关系。我们的结果在早造血作用的开发建议 RUNX1b/c 的一个唯一的禁止的函数并且可以在正常和 diseased 模型帮助它的生物函数的进一步的理解。 | Bo Chen Jiawen Teng Hongwei Liu Xu Pan Ya Zhou Shu Huang Mowen Lai Guohui Bian Bin Mao Wencui Sun Qiongxiu Zhou Shengyong Yang Tatsutoshi Nakahata Feng Ma | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 2 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 2 |
| 3 | Human Umbilical Cord-Derived Mesenchymal Stromal Cells Differentiate Into Functional Schwann Cells That Sustain Peripheral Nerve Regeneration显示文摘 | Dai Matsuse Masaaki Kitada Misaki Kohama Kouki Nishikawa Hideki Makinoshima Shohei Wakao Yoshinori Fujiyoshi Toshio Heike Tatsutoshi Nakahata Hidenori Akutsu Akihiro Umezawa Hideo Harigae Jun-ichi Kira Mari Dezawa | 2010 | Journal of Neuropathology and Experimental Neurology2010，，9： | 1 |
| 4 | Increased Susceptibility to Severe Chronic Liver Damage in CXCR4 Conditional Knock-Out Mice显示文摘 | Atsunori Tsuchiya Michitaka Imai Hiroteru Kamimura Masaaki Takamura Satoshi Yamagiwa Tatsuki Sugiyama Minoru Nomoto Toshio Heike Takashi Nagasawa Tatsutoshi Nakahata Yutaka Aoyagi | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 5 | Single-shot tomography by means of VIPA and spatial phase modulator installed optical interfer- ometer 显示文摘 | TATSUTOSHI S TAKASHI M HIROSHI O | 2011 | Optics Communications2011，284，1： | 1 |
| 6 | Cytokines regulate development of human mast cells from hematopoietic progenitors显示文摘 | Tatsutoshi Nakahata Hano Toru | 2002 | International Journal of Hematology2002，，4： | 1 |
| 7 | CpG inhibits IgE class switch recombination through suppression of NFκB activity, but not through Id2 or Bcl6显示文摘 | Takashi Kusunoki Manabu Sugai Hiroyuki Gonda Yukiko Nambu Natsuki Nagata-Nakajima Tomoya Katakai Mariko Kusunoki Akemi Sakamoto Takeshi Tokuhisa Tatsutoshi Nakahata Yoshifumi Yokota Akira Shimizu | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 8 | CD34^+CD7^+ leukemic progenitor cells may be involved in maintenance and clonal evolution of chronic myeloid leukemia显示文摘 | Nobuharu Kosugi Yasuhiro Ebihara Tatsutoshi Nakahata | 2005 | Clin Cancer Res2005，11，： | 1 |
| 9 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 1 |
| 10 | 重组人白细胞介素11对小鼠巨核细胞生成的促进作用显示文摘应用干细胞培养及集落形成法观察到白细胞介素11(IL-11)虽不能单独使小鼠骨髓细胞形成集落,但和白细胞介素3(IL-3)合用时,对正常及5-FU处理后小鼠骨髓细胞的集落形成有明显的促进作用,其中含巨核细胞的集落(CFI-GMM+CFU-M)数较IL-3单独组分别增加约2.5和7倍。巨核细胞的体积测量法显示IL-11可增大成熟巨核细胞的体积。复种实验表明巨核细胞的早期集落形成受IL-3的刺激,而进一步分化和增殖需要IL-11的参与。在干细胞因子(SCF)的协同下,IL-11可使5-FU处理后小鼠骨髓细胞形成多量的未分化集落(CFU-Blast),提示IL-11在造血干细胞早期的自我更新中可能起着重要的作用。 | 马峰 Kenichi KOIKE Atsushi KOMIYAMA Tatsutoshi NAKAHATA | 1995 | 中国实验血液学杂志1995，3，1： | 0 |
| 11 | Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells显示文摘Mast cells (MCs) play a pivotal role in the hypersensitivity reaction by regulating the innate and adaptive immune responses. Humans have two types of MCs. The first type, termed MCTC, is found in the skin and other connective tissues and expresses both tryptase and chymase, while the second, termed MCT, which only expresses tryptase, is found primarily in the mucosa. MCs induced from human adult-type CD34+ cells are reported to be of the MCT type, but the development of MCs during embryonic/fetal stages is largely unknown. Using an efficient coculture system, we identified that a CD34+c-kit+ cell population, which appeared prior to the emergence of CD34+CD45+ hematopoietic stem and progenitor cells (HSPCs), stimulated robust production of pure Tryptase+Chymase+ MCs (MCTCs). Single-cell analysis revealed dual development directions of CD34+c-kit+ progenitors, with one lineage developing into erythro-myeloid progenitors (EMP) and the other lineage developing into HSPC. Interestingly, MCTCs derived from early CD34+c-kit+ cells exhibited strong histamine release and immune response functions. Particularly, robust release of IL-17 suggested that these early developing tissue-type MCTCs could play a central role in tumor immunity. These findings could help elucidate the mechanisms controlling early development of MCTCs and have significant therapeutic implications. | Guohui Bian Yanzheng Gu Changlu Xu Wenyu Yang Xu Pan Yijin Chen Mowen Lai Ya Zhou Yong Dong Bin Mao Qiongxiu Zhou Bo Chen Tatsutoshi Nakathata Lihong Shi Min Wu Yonggang Zhang Feng Ma | 2021 | Journal of Molecular Cell Biology2021，13，2： | 0 |
| 12 | Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts显示文摘The aryl hydrocarbon receptor(AHR)plays an important role during mammalian embryo development.Inhibition of AHR signaling promotes the development of hematopoietic stem/progenitor cells.AHR also regulates the functional maturation of blood cells,such as T cells and megakaryocytes.However,little is known about the role of AHR modulation during the development of erythroid cells.In this study,we used the AHR antagonist StemRegenin 1(SR1)and the AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin during different stages of human erythropoiesis to elucidate the function of AHR.We found that antagonizing AHR signaling improved the production of human embryonic stem cell derived erythrocytes and enhanced erythroid terminal differentiation.RNA sequencing showed that SR1 treatment of proerythroblasts upregulated the expression of erythrocyte differentiation-related genes and downregulated actin organization-associated genes.We found that SR1 accelerated F-actin remodeling in terminally differentiated erythrocytes,favoring their maturation of the cytoskeleton and enucleation.We demonstrated that the effects of AHR inhibition on erythroid maturation were associated with F-actin remodeling.Our findings help uncover the mechanism for AHRmediated human erythroid cell differentiation.We also provide a new approach toward the large-scale production of functionally mature human pluripotent stem cell-derived erythrocytes for use in translational applications. | Yijin Chen Yong Dong Xulin Lu Wanjing Li Yimeng Zhang Bin Mao Xu Pan Xiaohong Li Ya Zhou Quanming An Fangxin Xie Shihui Wang Yuan Xue Xinping Cai Mowen Lai Qiongxiu Zhou Yan Yan Ruohan Fu Hong Wang Tatsutoshi Nakahata Xiuli An Lihong Shi Yonggang Zhang Feng Ma | 2022 | Journal of Molecular Cell Biology2022，14，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员