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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Internet-based collaborative pseudo-dynamic testing of multi-span bridge structure显示文摘In this paper, the first Internet-based collaborative pseudo-dynamic testing of a multi-span bridge system in China's Mainland is presented in detail, which has been carried out by the collaboration of Hunan University (HNU), Harbin Institute of Technology (HIT) and Tsinghua University (TU) in China's Mainland, and the University of Southern California (USC) in the USA. The prototype system of Russion River Bridge at Southern California in America is illustrated. Different testing specimens, testing equipments and substructure boundary conditions at HNU and HIT laboratories are described. A network protocol platform for collaborative pseudo-dynamic testing, called NetSLab, and some function modules developed on the use of its standardized interface are introduced. Aiming at the MTS system widely used in structural testing, two approaches are presented to implement the communication interface between NetSLab and testing equipment, respectively, studied by HNU and HIT. The integrated networked testing system and collaborative testing procedures are presented. The testing results manifest that the networked collaborative testing system with powerful capability provides a testing platform with good coordination for complex models or actual structures, and achieves remote sharing of testing equipments. | Dapeng Wang a, Shizhu Tiana, Xinjiang Caia, Yunlei Fan b, Yan Xiaob,c a School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China b School of Civil Engineering, Hunan University, Changsha 410082, China c Department of Civil Engineering, University of Southern California, Los Angeles, CA 90089, USA | 2009 | Progress in Natural Science:Materials International2009，19，5： | 4 |
| 3 | Correlation between adhesion of diamond-like carbon film on LiTaO3 substrate and SAW velocity 显示文摘 | Tiana Jingze Zhang Qing Zhou Q | 2005 | Surface & Coatings Technology2005，198，： | 1 |
| 4 | Numerical simulation and optimization on valve-induced water hammer characteristics for parallel pump feedwater system显示文摘 | Tiana Wenxi Sua G H Wanga Gaopeng | 2008 | Annals of Nuclear Energy2008，35，12： | 1 |
| 5 | Investigation on characteristics of leachate and concentrated leachate in three landfill leachate treat- ment plants显示文摘 | Zhang Q Q Tiana B H Zhanga X | 2013 | Waste Management2013，33，11： | 1 |
| 6 | Implementing Key Competenees in Basic Education: reflections on curriculum design and development in Spain 显示文摘 | Alejandro Tiana Jos6 Moya & Florencio Luengo | 2011 | European Journal of Education2011，，： | 1 |
| 7 | Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma显示文摘 | Asunción Fernández-Barral Jose Luis Orgaz Pablo Baquero Zaheer Ali Alberto Moreno María Tiana Valentí Gómez Erica Riveiro-Falkenbach Carmen Ca?adas Sandra Zazo Corine Bertolotto Irwin Davidson Jose Luis Rodríguez-Peralto Ignacio Palmero Federico Rojo Lass | 2014 | Neoplasia2014，，： | 1 |
| 8 | Precipitation Behavior of Nitrides in LIO?ordered TiAl显示文摘 | W H Tiana M Nemoto | 2005 | lntermetallics2005，13，： | 1 |
| 9 | Modeling the alpha-helix to beta-hairpin transition mechanism and the formation of oligomeric aggregates of the fibrillogenic peptide Abeta (12-28):insights from all-atom molecular dynamics simulations显示文摘 | SIMONA F TIANA G BROGLIA RA | 2004 | J Mol Graph Model2004，23，3： | 1 |
| 10 | Effects of NaAlO2 on structure and corrosion resistance of micro-are oxidation coatings formed on AM6OB magnesium alloy in phosphateKOH electrolyte显示文摘 | Lianga J Tiana J Guoa B G | 2005 | Surface & Coatings Technology2005，199，23： | 1 |
| 11 | Correlation between adhesion of diamond-like carbon fill on LiTaO3 subslxate and SAW velocity显示文摘 | Tiana Jingze Zhang Qing Zhou Q | 2005 | Surface & Coatings Technology2005，198，： | 1 |
| 12 | Quaternary ammonium sah-functionalized chitosan: An easily recyclable catalyst for efficient synthesis of cyclic carbonates from epoxides and carbon dioxide显示文摘 | Zhao Y Tiana J S Qi X H | 2007 | J Mol Catal A2007，271，12： | 1 |
| 13 | Hybrid processes based on plasma immersion ion implantation : A brief review 显示文摘 | Tiana X B Chub P K Fub R | 2004 | Surface & Coatings Technology2004，，186： | 1 |
| 14 | Similar folds with different stabilization mechanisms:the cases of Prion and Dop pel proteins显示文摘 | COLACINO S TIANA G COLOMBO G | 2006 | BMC Struct Biol2006，21，6： | 1 |
| 15 | Properties and precipitates of the high strength and electrical conductivity Cu-Ni-Co-Si-Cr alloy显示文摘In this paper,a novel Cu-1.5 Ni-1.1 Co-0.6 Si-0.1 Cr(wt.%)alloy with high strength and electrical conductivity was designed.After aging,excellent properties of 857±12 MPa yield strength,300±8 HV microhardness,42.8±2.5%IACS conductivity,and 7±0.5%elongation were obtained.According to the atomic structure,part of Ni atoms in Ni_(2)Si can be replaced by Co atoms to form nano-precipitates(Ni,Co)_(2)Si.The alloy’s high strength and conductivity are mainly attributed to the fine and uniformly distributed(Ni,Co)_(2)Si and Cr nano precipitates.The alloy strength was also enhanced by twins,dislocations,and grain refining strengthening.Based on the investigations of deformation microstructure and the orientation relationship between the(Ni,Co)_(2)Si precipitates and the Cu matrix,the main reason for elongation increase is attributed to the formation of deformation twins and the small lattice mismatch strain at the coherent interfaces of precipitates and the Cu matrix. | Yijie Ban Yongfeng Geng Jinrui Hou Yi Zhang Meng Zhou Yanlin Jia Baohong Tiana Yong Liua Xu Li Alex A.Volinsky | 2021 | Journal of Materials Science & Technology2021，，34： | 1 |
| 16 | Improvement of cultivation medium for enhanced production of coenzyme Q10 by photosynthetic Rhodospirillum rubrum 显示文摘 | TIANA Y YUEA T YUANA Y | 2010 | Biochemical Engineering Journal2010，51，： | 1 |
| 17 | A fieldbus-based intelligent sensor显示文摘 | Tiana G Y Zhaob Z X Bainesb R W | 2000 | Mechatronics2000，10，8： | 1 |
| 18 | Implementing Blended Learning at a Developing University : Obstacles in theway显示文摘 | MswaziTshabalala Charity Ndeya-Ndereya Tiana van der Merwe | 2014 | Electronic Journal of e-Learning2014，，12： | 1 |
| 19 | Phase III trial of induction gemcitabine or paclitaxel plus carboplatin followed by paclitaxel consolidation in ovarian cancer显示文摘 | Alan N. Gordon Michael Teneriello Mike F. Janicek Jeffrey Hines Peter C. Lim M. Dwight Chen Luis Vaccarello Howard D. Homesley Scott McMeekin Tiana L. Burkholder Yanping Wang Luping Zhao Mauro Orlando Coleman K. Obasaju John F. Gill Datchen F. Tai | 2011 | Gynecologic Oncology2011，，3： | 1 |
| 20 | Research on the Function and Performance Evaluation Systems of Community Health Services显示文摘 | Bingqiang Tiana Shouzhong Hua | 2012 | IERI Procedia2012，，： | 1 |
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