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| 1 | Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis显示文摘Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis. | Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian Zhou Peiran Yang Tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 2 | Safety and effectiveness of Traditional Chinese Medicinal herbs for diabetic foot:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the safety and effectiveness of traditional Chinese medicinal herbs(TCMHs) as an adjunctive treatment for diabetic foot(DF).METHODS: The sources used were Pub Med(1966 to August 2015), the Cochrane Library(1988 to August 2015), the Excerpta Medica Database(1974 to August 2015), Wiley(1807 to August 2015), Ovid(1988 to August 2015), Clinical Trials.gov(1993 to August 2015), the Cochrane Central Register of Controlled Trials(1966 to August 2015), China Science and Technology Journal Database(1994 to August2015), Chi CTR(2007 to August 2015), Sino Med(1978 to August 2015), the China National Knowledge Infrastructure(1984 to August 2015), Wanfang Data Knowledge Service Platform(1998 to August 2015), and the Traditional Chinese Medical Literature Analysis and Retrieval System(TCMLARS)(1984 to August 2015). Studies were identified and selected, and the data were extracted by two independent reviewers. The Cochrane Risk of Bias tool was used to assess the quality of studies. Revman 5.2 software was used for data synthesis and analysis.RESULTS: Sixteen studies were included based on the selection criteria. Of these, seven studies had low bias risk and one had high bias risk. In the overall analysis, TCMHs resulted in a significantly higher total effective rate(OR 5.08; 95% CI 3.50 to7.36; P < 0.000 01), cure rate(OR 2.12; 95% CI1.63 to 2.77; P < 0.000 01), and shorter time to ulcer healing(SMD-0.64; 95% CI-0.89 to-0.40;P < 0.000 01) when compared with non-TCMHs treated DF. The analysis also revealed that significantly fewer amputations occurred in TCMHs patients(OR 0.36; 95% CI 0.20 to 0.65; P = 0.0007).Sensitivity analysis indicated that the findings of the Meta-analysis were robust to study quality,and the funnel plot of the Egger test showed no publication bias.CONCLUSION: TCMHs intervention appears to be more effective for DF, with a similar safety profile,when compared with non-TCMHs treatments, although this result requires further verification with more well-designed studies. | Chen Shuo Ma Jianwei Xu Limei Niu Tianhui Dong Jing Liu Wenjun Han Qi | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 5 |
| 3 | Six-dimensional potential energy surface of the dissociative chemisorption of HCl on Au(111) using neural networks显示文摘We constructed a six-dimensional potential energy surface(PES)for the dissociative chemisorption of HCl on Au(111)using the neural networks method based on roughly 70000 energies obtained from extensive density functional theory(DFT)calculations.The resulting PES is accurate and smooth,based on the small fitting errors and good agreement between the fitted PES and the direct DFT calculations.Time-dependent wave packet calculations show that the potential energy surface is very well converged with respect to the number of DFT data points,as well as to the fitting process.The dissociation probabilities of HCl initially in the ground rovibrational state from six-dimensional quantum dynamical calculations are quite diferent from the four-dimensional fixed-site calculations,indicating it is essential to perform full-dimensional quantum dynamical studies for the title molecule-surface interaction system. | LIU TianHui FU BiNa ZHANG Dong H | 2014 | Science China Chemistry2014，57，1： | 2 |
| 4 | The Tribochemical Study of Some N-Containing Heterocyclic Compounds as Lubricating Oil Additives显示文摘 | Zhongyi He Wenqi Rao Tianhui Ren Weimin Liu Qunji Xue | 2002 | Tribology Letters2002，，2： | 1 |
| 5 | Overexpression of S100A4 is closely associated with the progressionand prognosis of gastric cancer in young patients显示文摘 | Hua Li Ziquan Liu Chuanxiang Xu Yunyun Chen Jianwei Zhang Bo Cui Xuewei Chen Gaihong An Xiaojun She Hongtao Liu Zifeng Jiang Tianhui Wang | 2013 | Oncology Letters2013，，5： | 1 |
| 6 | Probability Analysis of the Wave-Slamming Pressure Values of the Horizontal Deck with Elastic Support显示文摘This paper presents the probability distribution of the slamming pressure from an experimental study of regular wave slamming on an elastically supported horizontal deck. The time series of the slamming pressure during the wave impact were first obtained through statistical analyses on experimental data. The exceeding probability distribution of the maximum slamming pressure peak and distribution parameters were analyzed, and the results show that the exceeding probability distribution of the maximum slamming pressure peak accords with the three-parameter Weibull distribution. Furthermore, the range and relationships of the distribution parameters were studied. The sum of the location parameter D and the scale parameter L was approximately equal to 1.0, and the exceeding probability was more than 36.79% when the random peak was equal to the sample average during the wave impact. The variation of the distribution parameters and slamming pressure under different model conditions were comprehensively presented, and the parameter values of the Weibull distribution of wave-slamming pressure peaks were different due to different test models. The parameter values were found to decrease due to the increased stiffness of the elastic support. The damage criterion of the structure model caused by the wave impact was initially discussed, and the structure model was destroyed when the average slamming time was greater than a certain value during the duration of the wave impact. The conclusions of the experimental study were then described. | ZUO Weiguang LIU Ming FAN Tianhui WANG Pengtao | 2018 | Journal of Ocean University of China2018，17，3： | 1 |
| 7 | 基于MFD及实时路况的城市道路机动车排放计算方法显示文摘本文提出了基于交通流宏观基本图(MFD)以及实时路况数据的城市道路机动车排放计算方法,并以环境保护部发布的指导方法为参照,对所述方法进行了对比验证。以2015年3月北京市五环路高速,国道京福路,省道京周路的氮氧化物排放为例,两种方法计算结果平均偏差分别为?27.7%,?12.9%,?12.0%。因此,基于MFD及实时路况数据对交通流量及机动车排放的估算,可以较好地反映道路机动车的运行情况及排放特征,在构建应用于街区尺度模型的排放清单,城市区域道路机动车排放的时空分布特征等方面具有非常好的应用潜力。 | WANG Kun TONG Yali CAO Tianhui WANG Chenlong WANG Renjie GAO Jiajia LIU Yuan | 2020 | Atmospheric and Oceanic Science Letters2020，13，2： | 1 |
| 8 | Effect of Amines on the Antiwear Properties of P-Containing Compounds as Oil Additives显示文摘 | Wan Yong Liu WeiMin Ren TianHui | 1994 | Lubrication Science1994，6，： | 1 |
| 9 | The tribological study of tetrazole derivative as additive in liquid paraffin显示文摘 | Jiusheng Li Tianhui Ren Hong Liu | 2000 | Wear2000，246，： | 1 |
| 10 | The tribological study of tetrazole derivative as additive in liquid paraffin显示文摘 | Jiusheng Li Tianhui Ren Hong Liu | 2000 | Wear2000，246，： | 1 |
| 11 | Clinical Effect of Posterior Internal Fixation and Fusion in the Treatment of Thoracolumbar Fractures显示文摘Objective:To evaluate the clinical effect of posterior internal fixation and fusion in the treatment of thoracolumbar fractures.Methods:36 patients with thoracolumbar fractures from January 2018 to December 2020 were selected and divided into study group and control group according to the random number table model.The control group was treated with anterior internal fixation,while the study group was treated with posterior internal fixation and fusion.The indexes of the two groups were compared and analyzed.Results:Compared with the operation related indexes of the two groups,the study group had more advantages(P<0.05);The postoperative kyphosis Cobb angle,height of anterior and posterior vertebral body,wedge index of the two groups were better than those before operation(P<0.05),and there was no significant difference between the two groups(P>0.05);There was no significant difference between the two groups(P>0.05).Conclusion:The clinical effect of posterior internal fixation and fusion in the treatment of thoracolumbar fractures is significant,and the body damage is slight,which is worthy of comprehensive promotion. | Tianhui Liu Jianmin Cui | 2021 | Journal of Clinical and Nursing Research2021，5，2： | 1 |
| 12 | Clinical Effect of Transforaminal Endoscopic Surgery in the Treatment of Lumbar Disc Herniation显示文摘Objective:Objective to explore the curative effect of transforaminal endoscopic surgery in the treatment of lumbar disc herniation.Methods:From October 2018 to October 2020,36 patients with lumbar disc herniation were randomly divided into group A and group B.the curative effect,pain,lumbar function and quality of life were analyzed.Results:The curative effect of group A was 94.44%,better than that of group B 61.11%,P<0.05;The visual analogue scale(VAS)of group A was lower than that of group B on 3D,5D and 7d after operation(P<0.05);The KSS of group A was higher than that of group B(P<0.05);The score of quality of life in group A was better than that in group B(P<0.05).Conclusion:Lumbar disc herniation patients underwent transforaminal endoscopic surgery,the effect is good,can improve lumbar function,relieve pain,improve the quality of life of patients. | Tianhui Liu Jianmin Cui | 2021 | Journal of Clinical and Nursing Research2021，5，2： | 1 |
| 13 | Study of the tribological behaviors of S, P-containing triazine derivatives as additives in rapeseed oil显示文摘 | Zhongyi He Jinliang Lu Xiangqiong Zeng Heyang Shao Tianhui Ren Weimin Liu | 2004 | Wear2004，，3： | 1 |
| 14 | Experiment and Numerical Simulation on the Dynamic Response of Foam-Filled Tubes Under Lateral Blast Loading显示文摘The dynamic response and energy absorption performance of foam-filled tubes under lateral external blast loading were investigated experimentally and numerically.A series of blast tests for the foam-filled tubes with different geometric parameters were carried out by the use of the ballistic pendulum system.Experimental results were compared with the numerical simulation results employing the software ABAQUS.The results showed that the finite element(FE)analysis was in good agreement with the experimental data.The effects of the diameter and wall thickness of the outer tube,the TNT explosive charge mass,and the standoff distance on the deformation modes,the blast resistance,and the energy absorption performance of the foam-filled tubes were investigated.Three deformation modes of the foam-filled tubes were observed under the lateral external blast loading,including local plastic deformation,large plastic deformation with an elliptic shape,and the tearing of the outer tube.The result revealed that the introduction of the foam core played a vital role in the deflection and energy absorption capacity of the structure.This study provided effective guidelines for designing foam-filled tubes with high energy absorption efficiency. | Zhifang Liu Tianhui Zhang Shiqiang Li Jianyin Lei Zhihua Wang | 2021 | Acta Mechanica Solida Sinica2021，34，6： | 1 |
| 15 | The tribological study of tetrazole derivative as additive in liquid paraffin显示文摘 | Li Jiusheng Ren Tianhui Liu Hong | 2000 | Wear2000，246，： | 1 |
| 16 | Tribological evaluation of S -(1H-benzotriazole-1-yl) methyl N , N -dialkyldithiocarbamates as additives in rapeseed oil显示文摘 | Jiusheng Li Yanyan Zhang Tianhui Ren Weimin Liu Xingguo Fu | 2002 | Wear2002，，7： | 1 |
| 17 | A study of S-(1H-benzotriazol-1-yl) methyl N, N-dialkyldithiocarbamates as novel multifunctional oil additives 显示文摘 | REN Tianhui LIU Weimin XUE Qunji | 1994 | Wear1994，172，1： | 1 |
| 18 | Antithrombin gene Arg197Stop mutation-associated venous sinus thrombosis in a Chinese family显示文摘This study sought to elucidate the genetic correlation of cerebral venous sinus thrombosis caused by a hereditary antithrombin deficiency in a Chinese family,at the genetic and protein levels.A nonsense mutation from C to T on locus 6431 in exon 3B of the antithrombin gene was observed,leading to an arginine (CGA) to stop codon (TGA) change in the protein.This is the first report of this mutation in China.Ineffective heparin therapy in the propositus patient is associated with a lack of heparin binding sites after antithrombin gene mutation.Characteristic low intracranial pressure in the acute phase might be specific to this patient with cerebral venous sinus thrombosis. | Ang Li Tianhui Liu Zhandong Liu Jimei Li Chunling Zhang Jun Chen Jinmei Sun Yanfei Han Lili Wang Dexin Wang Qiming Xue Baoen Wang | 2011 | Neural Regeneration Research2011，6，20： | 1 |
| 19 | The Tribochemical Study of Some N-Containing Heterocyclic Compounds as Lubricating Oil Additives显示文摘 | Zhongyi He Wenqi Rao Tianhui Ren Weimin Liu Qunji Xue | 2002 | Tribology Letters2002，，2： | 1 |
| 20 | 全脑放疗同步或序贯替尼泊甙、顺铂治疗小细胞肺癌脑转移(英文)显示文摘Objective: The aim of the study was to compare efficacies and safeties of 2 different treatments of whole brain radiotherapy (WBRT) sequential or concomitant Vm26/DDP for small cell lung cancer (SCLC) patients with brain metastases. Methods: A total of 39 patients were randomly divided into sequential chemoradiotherapy regime (A group, 20 patients) and concomitant chemoradiotherapy regime (B group, 19 patients). The dose of WBRT was 36 Gy in 18–20 fractions, chemotherapy of Vm26/DDP regimen with teniposide 60 mg/m2 on d1 to d3 and cisplatin 20 mg/m2 on d1 to d5, repeating every 3 weeks. The response was evaluated after WBRT and 2 cycles of chemotherapy. Results: Total response rates of A and B groups were 70.0% and 78.9% respectively (P = 0.520). The median survival was 11 months in A group and 10 months in B group. Six, twelve and eighteen months cumulative survival rates of A and B groups were 75.0%, 42.5%, 26.2%, and 81.6%, 26.4%, 10.5%, respectively (χ2 = 0.383, P > 0.05). Response rate and the number of brain metastases were independent prognostic factors. Conclusion: Both sequential and concomitant chemoradiotherapy groups are effective, and the main toxicity with myelosuppression is tolerable after therapy. It can be applied firstly and effectively to the SCLC patients with brain metastases in clinic . | Mingyue Liu Yun Zhou Qian Han Tianhui Gao Zhifen Luo Wenyu Wang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 1 |
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