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| 1 | Redox condition during Ediacaran–Cambrian transition in the Lower Yangtze deep water basin, South China: constraints from iron speciation and δ^(13) Corg in the Diben section, Zhejiang显示文摘Cherts of the Piyuancun Formation and black mudstones of the Hetang Formation in Diben Town, Kaihua County, Zhejiang were deposited in a deep water basin of the Lower Yangtze area during the Ediacaran–Cambrian transition(E–C transition), offering an opportunity to reconstruct the ancient redox condition of the deep water basin. Total 53 samples were collected and analyzed for iron speciation, including pyrite iron(FePy), carbonate associated iron(FeCarb), iron oxide and hydroxide(FeOx),magnetite iron(FeMag) and total iron(FeT) as well as d13 Corgto gain a deeper understanding of specific redox condition during the period. The results show that(1) most samples have pyrite concentration \1 %, with the FePy/FeHR ratio ranging from \0.01 to 0.81(mostly \0.5), and the FeHR/FeT ratio between 0.39 and 0.93(mostly [0.5).(2) The E–C boundary in the Diben section occurred at the maximum negative excursion of organic carbon isotope within the Piyuancun Formation, which can be correlated with other sections by using d13 Corg. We thus concluded that the relatively high content of highly reactive iron and low content of pyrite iron in the Diben section indicate a minor occurrence of H2 S and a predominance of anoxic and ferruginous environment, which is similar to other reported sections such as the Longbizui and Yanwutan sections, western Hunan. In addition, oxygen concentration in sea water showed an increasing trend in the interval corresponding to the bottom and upper layer of the Hetang Formation as indicated by the FeHR/FeT ratio, which decreased from 0.7 to 0.38, however, it was not great enough to oxidize the whole deep water. Therefore, during the E–C transition deep water basin in South China was most likely an anoxic and ferruginous enrironment, which prevented metazoon from the evolution in the deep water basin. Our work offers an important reference to better understanding of the spatiotemporal occurrence and dynamic processes of the ‘‘Cambrian Explosion''. | Yuyang Yuan Chunfang Cai Tiankai Wang Lei Xiang Lianqi Jia Yan Chen | 2014 | Chinese Science Bulletin2014，59，28： | 5 |
| 2 | Engineer- ing noble metal nanomaterials for environmental applica- tions 显示文摘 | Li Jingguo Zhao Tingting Chen Tiankai | 2015 | Nanoscale2015，7，17： | 1 |
| 3 | Improved methodology for efficient establishment of the myocardial ischemia-reperfusion model in pigs through the median thoracic incision显示文摘To investigate the feasibility and effectiveness of establishing porcine ischemia-reperfusion models by ligating the left anterior descending(LAD)coronary artery,we first randomly divided 16 male Bama pigs into a sham group and a model group.After anesthesia,we separated the arteries and veins.Subsequently,we rapidly located the LAD coronary artery at the beginning of its first diagonal branch through a mid-chest incision.Then,we loosened and released the ligation line after five minutes of pre-occlusion.Finally,we ligated the LAD coronary artery in situ two minutes later and loosened the ligature 60 min after ischemia.Compared with the sham group,electrocardiogram showed multiple continuous lead ST-segment elevations,and ultrasound cardiogram showed significantly lower ejection fraction and left ventricular fractional shortening at one hour and seven days post-operation in the model group.Twenty-four hours after the operation,cardiac troponin T and creatine kinase-MB isoenzyme levels significantly increased in the model group,compared with the sham group.Hematoxylin and eosin staining showed the presence of many inflammatory cells infiltrating the interstitium of the myocardium in the model group but not in the sham group.Masson staining revealed a significant increase in infarct size in the ischemia/reperfusion group.All eight pigs in the model group recovered with normal sinus heart rates,and the survival rate was 100%.In conclusion,the method can provide an accurate and stable large animal model for preclinical research on ischemia/reperfusion with a high success rate and homogeneity of the myocardial infarction area. | Liuhua Zhou Jiateng Sun Tongtong Yang Sibo Wang Tiankai Shan Lingfeng Gu Jiawen Chen Tianwen Wei Di Zhao Chong Du Yulin Bao Hao Wang Xiaohu Lu Haoliang Sun Meng Lv Di Yang Liansheng Wang | 2023 | The Journal of Biomedical Research2023，37，4： | 1 |
| 4 | Seismic ima- ging of the transitional crust across the northeastern margin of South China Sea 显示文摘 | Wang Tiankai Chen Mingkai Lee Chaoshing | 2006 | Tectonophysics2006，412，34： | 1 |
| 5 | Lipid Evidence for Oil Depletion by Sulfate-Reducing Bacteria during U Mineralization in the Dongsheng Deposit显示文摘Fatty acids were extracted from fluid inclusions, and analyzed for distribution and individual δ13 C values to determine if there exists sulfate-reducing bacteria(SRB) and what substrates SRB depleted during U mineralization in the Dongsheng deposit. The 10-methylhexadecanoic acid(10 Me16:0) has been detected from most of the samples using GC-MS based on relative retention time and co-injection of standard 10 Me16:0 compound. Samples with higher 10 Me16:0 concentrations, show higher U contents. The presence of 10 Me16:0 along with iso-ω7-cis-heptadecenoic acid(i17:1ω7 c) and ω7-cisoctadecenoic acid(18:1ω7 c) in the fluid inclusions may indicate the occurrence of SRB during the U mineralization. Saturated fatty-acids and unsaturated fatty-acids detected in this study have individual δ13 C values from-30.3‰ to-28.5‰ and-30.5‰ to-27.9‰, respectively. These values are close to those of n-alkanes of the associated oils and the bulk oils, but significantly distinct from methane, thus the oils are concluded to have been used as substrate for the microorganisms to survive on. This proposal is supported by oil biodegradation and ore-stage calcite cement with δ13 C values from-1.4‰ to-17.2‰. | Tiankai Wang Lei Jiang Chunfang Cai Yuyang Yuan Yongdong Zhang Lianqi Jia Shuangling Chen | 2018 | Journal of Earth Science2018，29，3： | 1 |
| 6 | Identification of chemical compositions from“featureless”optical absorption spectra:Machine learning predictions and experimental validations显示文摘Rapid and accurate chemical composition identification is critically important in chemistry.While it can be achieved with optical absorption spectrometry by comparing the experimental spectra with the reference data when the chemical compositions are simple,such application is limited in more complicated scenarios especially in nano-scale research.This is due to the difficulties in identifying optical absorption peaks(i.e.,from“featureless”spectra)arose from the complexity.In this work,using the ultraviolet-visible(UV-Vis)absorption spectra of metal nanoclusters(NCs)as a demonstration,we develop a machine-learningbased method to unravel the compositions of metal NCs behind the“featureless”spectra.By implementing a one-dimensional convolutional neural network,good matches between prediction results and experimental results and low mean absolute error values are achieved on these optical absorption spectra that human cannot interpret.This work opens a door for the identification of nanomaterials at molecular precision from their optical properties,paving the way to rapid and high-throughput characterizations. | Tiankai Chen Jiali Li Pengfei Cai Qiaofeng Yao Zekun Ren Yixin Zhu Saif Khan Jianping Xie Xiaonan Wang | 2023 | Nano Research2023，16，3： | 0 |
| 7 | Active cell-matrix coupling regulates cellular force landscapes of cohesive epithelial monolayers显示文摘Epithelial cells can assemble into cohesive monolayers with rich morphologies on substrates due to competition between elastic,edge,and interfacial effects.Here we present a molecularly based thermodynamic model,integrating monolayer and substrate elasticity,and force-mediated focal adhesion formation,to elucidate the active biochemical regulation over the cellular force landscapes in cohesive epithelial monolayers,corroborated by microscopy and immunofluorescence studies.The predicted extracellular traction and intercellular tension are both monolayer size and substrate stiffness dependent,suggestive of cross-talks between intercellular and extracellular activities.Our model sets a firm ground toward a versatile computational framework to uncover the molecular origins of morphogenesis and disease in multicellular epithelia. | Tiankai Zhao Yao Zhang Qiong Wei Xuechen Shi Peng Zhao Long-Qing Chen Sulin Zhang | 2018 | npj Computational Materials2018，，1： | 0 |
| 8 | Protein kinases in cardiovascular diseases显示文摘Cardiovascular disease(CVD)remains the leading cause of death worldwide.Therefore,exploring the mechanism of CVDs and critical regulatory factors is of great significance for promoting heart repair,reversing cardiac remodeling,and reducing adverse cardiovascular events.Recently,significant progress has been made in understanding the function of protein kinases and their interactions with other regulatory proteins in myocardial biology.Protein kinases are positioned as critical regulators at the intersection of multiple signals and coordinate nearly every aspect of myocardial responses,regulating contractility,metabolism,transcription,and cellular death.Equally,reconstructing the disrupted protein kinases regulatory network will help reverse pathological progress and stimulate cardiac repair.This review summarizes recent researches concerning the function of protein kinases in CVDs,discusses their promising clinical applications,and explores potential targets for future treatments. | Jiawen Chen Yafei Li Chong Du Tianwen Wei Tiankai Shan Liansheng Wang | 2022 | Chinese Medical Journal2022，，5： | 0 |
| 9 | Visualizing the role of applied voltage in non-metal electrocatalysts显示文摘Understanding how applied voltage drives the electrocatalytic reaction at the nanoscale is a fundamental scientific problem,particularly in non-metallic electrocatalysts,due to their low intrinsic carrier concentration.Herein,using monolayer molybdenum disulfide(MoS_(2))as a model system of non-metallic catalyst,the potential drops across the basal plane of MoS_(2)(△V_(sem))and the electric double layer(△V_(edl))are decoupled quantitatively as a function of applied voltage through in-situ surface potential microscopy.We visualize the evolution of the band structure under liquid conditions and clarify the process of EF keeping moving deep into Ec,revealing the formation process of the electrolyte gating effect.Additionally,electron transfer(ET)imaging reveals that the basal plane exhibits high ET activity,consistent with the results of surface potential measurements.The potential-dependent behavior of kf and ns in the ET reaction are further decoupled based on the measurements of△V_(sem)and△V_(edl).Comparing the ET and hydrogen evolution reaction imaging results suggests that the low electrocatalytic activity of the basal plane is mainly due to the absence of active sites,rather than its electron transfer ability.This study fills an experimental gap in exploring driving forces for electrocatalysis at the nanoscale and addresses the long-standing issue of the inability to decouple charge transfer from catalytic processes. | Ziyuan Wang Jun Chen Chenwei Ni Wei Nie Dongfeng Li Na Ta Deyun Zhang Yimeng Sun Fusai Sun Qian Li Yuran Li Ruotian Chen Tiankai Bu Fengtao Fan Can Li | 2023 | National Science Review2023，10，9： | 0 |
| 10 | The synthesis of fluorescent nanoclusters based on the etching reaction显示文摘Thiolate-protected atomically precise nanoclusters(NCs)demonstrate a series of unique luminescent characteristics attributed to their various peculiar electronic structures.Therefore,fluorescent NCs present extraordinary practical values in biosensing and bioimaging research fields.Nevertheless,restricted by the types of fluorescent NCs,there are great difficulties in promoting the development of NCs in fluorescent research areas.As a result,it is of significant necessity for researchers to develop new synthetic pathways to produce high-quality fluorescent NCs.According to the analysis about the structural characteristics of fluorescent NCs,some general features like longer motif and higher ligand-to-metal ratio can be found,consistent to some presented regularities in etching reaction.Consequently,in this work,we used Au_(25)(MHA)_(18)(MHA=6-mercaptohexanoic acid)as a model nanocluster and utilized the etching reaction to systematically explore etching products and their corresponding luminescent properties.Moreover,we also identified three main reaction processes in the entire etching reaction process,which can generate new metal nanocluster species with various fluorescent properties.Hence,the etching reaction will provide a good platform to produce new luminescent metal NC species. | Hongbin Lin Yitao Cao Qiaofeng Yao Tiankai Chen Huiting Shan Jianping Xie | 2024 | Nano Research2024，17，5： | 0 |
| 11 | Autophagy and circadian rhythms:interactions and clinical implications显示文摘Autophagy is a widespread biological process that controls cellular growth,survival,development,and death.Circadian rhythm is a recurring reaction of living organisms and behaviors to variations in surrounding brightness and obscurity.Most of the fundamental physiological processes in mammals,such as the sleep-wake pattern and the rhythm of nutrition and energy metabolism,are governed by circadian rhythms.Research has indicated that autophagy exhibits a specific circadian pattern in both normal and abnormal conditions.Autophagy can modulate circadian rhythms by breaking down proteins that regulate the circadian clock.The potential regulatory connection between the two has been a popular subject of clinical and fundamental research.Understanding the interaction between circadian rhythm and autophagy could potentially lead to the development of novel approaches for disease treatment in the future.The present analysis presented a summary of the molecular processes implicated in the interplay between autophagy and circadian rhythm,as well as the pathological importance of the disrupted regulatory association between these two phenomena. | TIANKAI DI ZHIFEI ZHOU FEN LIU YUJIANG CHEN LULU WANG | 2024 | BIOCELL2024，48，1： | 0 |
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