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| 1 | Effects of d-Phenylalanine as a biocide enhancer of THPS against the microbiologically influenced corrosion of C1018 carbon steel显示文摘Microbiologically influenced corrosion(MIC) is caused by biofilms such as those of sulfate reducing bacteria(SRB). To mitigate MIC, biocide treatment is often needed. Tetrakis(hydroxymethyl) phosphonium sulfate(THPS) is an environmentally friendly biocide that is often used in the oil and gas industry. However, its prolonged use leads to biocide resistance, leading to dosage escalation. A biocide enhancer can be used to slow down the trend. In recent years, d-amino acids have been investigated as an enhancer for THPS and other biocides. Published works used anaerobic vials and flow devices, which could not reveal the real-time changes of the biocide treatment on corrosion. In this work, it was proven that the biocide enhancement effects of d-Phenylalanine(d-Phe) on THPS against the Desulfovibrio vulgaris biofilm on C1018 carbon steels could be assessed in real time using linear polarization resistance and electrochemical impedance spectroscopy to collaborate sessile cell count, weight loss and pitting depth data. The results showed that 500 ppm(w/w) d-Phe effectively enhanced 80 ppm THPS against MIC by the D. vulgaris(a corrosive SRB) biofilm. The sessile cell count and pit depth were all reduced with the enhancement of d-Phe. | Jin Xu Ru Jia Dongqing Yang Cheng Sun Tingyue Gu | 2019 | Journal of Materials Science & Technology2019，35，1： | 6 |
| 2 | Laparoscopic distal gastrectomy with D2 dissection for advanced gastric cancer显示文摘The successful application of the laparoscopic distal gastrectomy with D2 dissection for gastric cancer requires adequate understanding of the anatomic characteristics of peripancreatic and intrathecal spaces, the role of pancreas and vascular bifurcation as the surgical landmarks, as well as the variations of gastric vascular anatomy. The standardized surgical procedures based on distribution of regional lymph node should be clarified. | Jiang Yu Yanfeng Hu Tao Chen Tingyu Mou Xia Cheng Guoxin Li | 2013 | Chinese Journal of Cancer Research2013，25，4： | 6 |
| 3 | An intelligent approach for dimensioning completeness inspection in 3D based on transient geometric elements显示文摘 | Yalong Cheng Zhonghua Ni Tingyu Liu Xiaojun Liu | 2014 | Computer-Aided Design2014，，： | 1 |
| 4 | NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation显示文摘NDFIP1 has been previously reported as a tumor suppressor in multiple solid tumors,but the function of NDFIP1 in NSCLC and the underlying mechanism are still unknown.Besides,the WW domain containing proteins can be recognized by NDFIP1,resulted in the loading of the target proteins into exosomes.However,whether WW domain-containing transcription regulator 1(WWTR1,also known as TAZ)can be packaged into exosomes by NDFIP1 and if so,whether the release of this oncogenic protein via exosomes has an effect on tumor development has not been investigated to any extent.Here,we first found that NDFIP1 was low expressed in NSCLC samples and cell lines,which is associated with shorter OS.Then,we confirmed the interaction between TAZ and NDFIP1,and the existence of TAZ in exosomes,which requires NDFIP1.Critically,knockout of NDFIP1 led to TAZ accumulation with no change in its mRNA level and degradation rate.And the cellular TAZ level could be altered by exosome secretion.Furthermore,NDFIP1 inhibited proliferation in vitro and in vivo,and silencing TAZ eliminated the increase of proliferation caused by NDFIP1 knockout.Moreover,TAZ was negatively correlated with NDFIP1 in subcutaneous xenograft model and clinical samples,and the serum exosomal TAZ level was lower in NSCLC patients.In summary,our data uncover a new tumor suppressor,NDFIP1 in NSCLC,and a new exosome-related regulatory mechanism of TAZ. | Yirui Cheng Xin Lu Fan Li Zhuo Chen Yanshuang Zhang Qing Han Qingyu Zeng Tingyu Wu Ziming Li Shun Lu Cecilia Williams Weiliang Xia | 2023 | Protein & Cell2023，14，2： | 0 |
| 5 | makeTwin:A reference architecture for digital twin software platform显示文摘Digital twin is currently undergoing a significant transformation from the conceptual and theoretical research phase to the implementation and application phase.However,a universally adaptable research and development platform for digital twin is critically needed to meet the development requirements.Specifically,a publicly accessible simulation,testing,and validation platform which can support digital twin model building,data processing,algorithm design,configuration,etc.,is urgently required for researchers.Furthermore,for developers from the industry,a lowcode development platform that can offer a customizable suite of functions such as model creation,data management,protocol configuration,and visualization is urgently needed.Meanwhile,for enterprise users,there is a lack of an application management platform that can be configured and migrated for various application scenarios,functions,and modes.Therefore,based on the system research of digital twin theories and key technologies by the authors(such as the five-dimension digital twin model,digital twin modeling and digital twin data theory,digital twin standards,and so on),a digital twin software platform reference architecture,namely make Twin,is proposed and designed,as well as its ten core functions.The workflow of the make Twin and the interaction mechanisms among its core functions are described.Finally,a digital twin application system for a chemical fiber textile shop floor(CFTS)which was developed according to make Twin,is introduced,which validates the proposed reference architecture. | Fei TAO Xuemin SUN Jiangfeng CHENG Yonghuai ZHU Weiran LIU Yong WANG Hui XU Tianliang HU Xiaojun LIU Tingyu LIU Zheng SUN Jun XU Jinsong BAO Feng XIANG Xiaohui JIN | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 6 | Experimental study on the mitigation effect of mangroves during tsunami wave propagation显示文摘Mangroves are crucial for protecting coastal areas against extreme disasters such as tsunamis and storm surges.An experimental study was conducted to determine how mangroves can mitigate the tsunami wave propagation.The test was performed in a flume, where mangrove models were installed on a slope, and dam-burst waves were used to simulate tsunami waves. To study how mangrove forests reduce the impact of tsunamis, this paper measured the heights of the incoming waves under different initial conditions(tsunami wave intensity and initial water depth) and plant factors(arrangement and distribution density) and described the reduction process. The results show that, after passing through the mangrove, the tsunami bore height will decrease within a certain range as the initial water depth increases. However, there is no correlation between the increase of inundation level and the drop of water level. The bore height attenuation is more significant at higher density of mangroves,but after tsunami passing through the mangroves, the relative bore height will decrease. When the distribution density of mangroves is constant, the wave attenuation at different locations(before, on and after the slope)shows different relationships with the initial water depth and wave height for different models. The transmission coefficient(K_(i)) shows a parabolic correlation with its density. The proportion of the energy loss caused by the mangrove resistance to the total energy(E_(b)) is defined as C_(m2). The variation trend of C_(m2) corresponds to the tsunami wave energy attenuation rate(C_(a)) and K_(i). | Cheng Chen Chen Peng Hui Yan Minjian Wei Tingyu Wang | 2023 | Acta Oceanologica Sinica2023，42，7： | 0 |
| 7 | Flexible computational photodetectors for self-powered activity sensing显示文摘Conventional vision-based systems,such as cameras,have demonstrated their enormous versatility in sensing human activities and developing interactive environments.However,these systems have long been criticized for incurring privacy,power,and latency issues due to their underlying structure of pixel-wise analog signal acquisition,computation,and communication.In this research,we overcome these limitations by introducing in-sensor analog computation through the distribution of interconnected photodetectors in space,having a weighted responsivity,to create what we call a computational photodetector.Computational photodetectors can be used to extract mid-level vision features as a single continuous analog signal measured via a two-pin connection.We develop computational photodetectors using thin and flexible low-noise organic photodiode arrays coupled with a self-powered wireless system to demonstrate a set of designs that capture position,orientation,direction,speed,and identification information,in a range of applications from explicit interactions on everyday surfaces to implicit activity detection. | Dingtian Zhang Canek Fuentes-Hernandez Raaghesh Vijayan Yang Zhang Yunzhi Li Jung Wook Park Yiyang Wang Yuhui Zhao Nivedita Arora Ali Mirzazadeh Youngwook Do Tingyu Cheng Saiganesh Swaminathan Thad Starner Trisha L.Andrew Gregory D.Abowd | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 8 | Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22显示文摘MEIOB is a vital protein in meiotic homologous recombination and plays an indispensable role in human gametogenesis.In mammals,MEIOB and its partner SPATA22 form a heterodimer,ensuring their effective localization on single-strand DNA(ssDNA)and proper synapsis processes.Mutations in human MEIOB(hMEIOB)cause human infertility attributed to the failure of its interaction with human SPATA22(hSPATA22)and ssDNA binding.However,the detailed mechanism is still unclear.In our study,truncated or full-length hMEIOB and hSPATA22 are traced by fused expression with fluorescent proteins(i.e.,copGFP or mCherry),and the live cell imaging system is used to observe the expression and localization of the proteins.When transfected alone,hMEIOB accumulates in the cytoplasm.Interestingly,a covered NLS in the OB domain of hMEIOB is identified,which can be exposed by hSPATA22 and is necessary for the nuclear localization of hMEIOB.When hSPATA22 loses its hMEIOB interacting domain or NLS,the nuclear localization of hMEIOB is aborted.Collectively,our results prove that the NLS in the OB domain of hMEIOB and interaction with hSPATA22 are required for hMEIOB nuclear localization. | Yating Xu Zhen Chen Panfeng Wu Wei Qu Hanqing Shi Muyang Cheng Yumin Xu Tingyu Jin Cong Liu Cong Liu Yi Li Mengcheng Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 9 | Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway显示文摘Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment.The cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous repair.These proteins are thus candidate targets for spinal cord injury therapy.Our previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model animals.However,the specific mechanism and potential targets involved remain to be clarified.In this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive days.We found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal cord.Bioinformatics analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed molecules.Immunofluorescence staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord tissue.The expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve rsican.Furthermore,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB 202190.This suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulation.In summary,our findings show that photobiomodulation modulates the expression of chondroitin sulfate proteoglycans,and versican is one of the key target molecules of photo biomodulation.MAPK/Sox9 and Smad3/Sox9 pathways may play a role in the effects of photo biomodulation on chondroitin sulfate proteoglycan accumulation after spinal cord injury. | Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu Xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu Wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu | 2024 | Neural Regeneration Research2024，19，1： | 0 |
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