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| 1 | Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A显示文摘支持骨头形成是在骨质疏松症治疗的基本策略之一,破裂修理。作为骨头形成上的激发器之一, osteogenic 生长肽(OGP ) 在 vitro 并且在 vivo, osteoprotegerin (OPG ) 在被建议了被包含增加造骨细胞的增长和区别。在这研究,我们在骨头髓上评估了 OGP 的效果从在由 3-(4,5-dimethylthiazol-2-yl ) 的 vitro 的 OPG 缺乏的老鼠的间充质的干细胞(MSC )-2,5-diphenyltetrazolium 溴化物试金,碱的磷酸酶(高山) 活动试金,即时聚合酶链反应,和西方的污点分析。结果证明 OGP 刺激了 MSC 增长并且在 mRNA 和蛋白质层次两个都在 MSC 增加了 CDK2 和 cyclin A 的表示。然而, OGP 的 differentiative 效果都没作为高山活动和 Runx2 的表示层次被显示出, Osterix 没被 OGP 显著地增加。我们的学习建议 OGP 可以由刺激 MSC 增长而非区别在 OPG 缺乏的老鼠增加骨头形成,并且可能由触发 CDK2/cyclin 一条小径。 | Qinming Fei Changjun Guo Xiaoya Xu Jianjun Gao Jian Zhang Tongyi Chen Dafu Cui | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 11 |
| 2 | Size-dependent elastic properties of thin films: surface anisotropy and surface bonding显示文摘Surface eigenstress and eigendisplacement models were used to investigate the surface stress,surface relaxation and surface elasticity of thin films with different surface orientations.Molecular dynamics simulations and first-principles calculations were conducted on face-centered cubic Au films with the focus on relaxation induced nonlinear initial deformation.The simulation results verify the theoretical predictions of the size dependency of surface energy density and surface stress,and the nonlinear scaling law of the size-dependent Young’s modulus of thin films.The mechanism of the size-dependent behaviors was further explored at the atomic bonding level with the charge density field.The Au atomic bonding at surfaces is enhanced compared to its interior counterpart and therefore the nominal Young’s modulus of the Au thin films is larger when the film thickness is smaller. | ZHOU XiaoYe REN Hang HUANG BaoLing ZHANG TongYi | 2014 | Science China(Technological Sciences)2014，57，4： | 5 |
| 3 | Machine learning of mechanical properties of steels显示文摘Knowledge of the mechanical properties of structural materials is essential for their practical applications. In the present work,three-hundred and sixty data samples on four mechanical properties of steels—fatigue strength, tensile strength, fracture strength and hardness—were selected from the Japan National Institute of Material Science database, comprising data on carbon steels and low-alloy steels. Five machine learning algorithms were used to predict the mechanical properties of the materials represented by the three-hundred and sixty data samples, and random forest regression showed the best predictive performance.Feature selection conducted by random forest and symbolic regressions revealed the four most important features that most influence the mechanical properties of steels: the tempering temperature of steel, and the alloying elements of carbon, chromium and molybdenum. Mathematical expressions were generated via symbolic regression, and the expressions explicitly predicted how each of the four mechanical properties varied quantitatively with the four most important features. This study demonstrates the great potential of symbolic regression in the discovery of novel advanced materials. | XIONG Jie ZHANG TongYi SHI SanQiang | 2020 | Science China(Technological Sciences)2020，63，7： | 4 |
| 4 | FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR显示文摘Filamin A (FLNa ) 是无所不在地表示的细胞质的蛋白质,它 24 次象 Ig 一样重复跟随的一个 N 终端肌动朊绑定领域(ABD ) 创作。FLNa 作为连接 transmembrane 受体的细胞骨架蛋白质工作,包括 integrins,到 F 肌动朊并且用作发信号的中介。最近的研究作为与超过 90 蛋白质交往并且在细胞的发信号的 transduction 起重要作用的支架蛋白质识别了 FLNa。在人的 FLNa 基因的变化或缺点被显示了引起众多的发展缺点。而且, FLNa 的异常表示在许多癌症被观察了例如甲状旁腺的肿瘤,颈的癌症,和乳癌。然而,它在肺腺癌的角色很少被讨论了。在现在的学习,我们的在里面 vitro 并且在 vivo,研究证明在肺癌症房间线 A549 房间的那 silencing FLNa 表情由提高表皮的生长因素受体和英皇家空军之阶级最低之兵发信号小径的激活支持了 A549 房间的增长,移植,和侵略。这些结果在肺癌症和揭开的新奇机制使 FLNa 的新奇功能清楚些,这些结果为肺腺癌为预言和治疗提供了可能的目标。 | Yuna Zhang Tienian Zhu Jingpu Liu Jiankun Liu Dongmei Gao Tongyi Su Ruijing Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 5 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 6 | Some nutritional and functional properties of defatted wheat germ protein 显示文摘 | Yiqiang Ge Aidong Sun Yangying Ni Tongyi Cai | 2000 | Journal of Agriculture and Food chemistry2000，48，12： | 1 |
| 7 | Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats 显示文摘 | Li Quanhong Fu Caili Rui Yukui Hu Guanghui Cai Tongyi | 2005 | Plant Foods for Human Nutrition2005，60，： | 1 |
| 8 | Intersubband optical absorption in a step asymmetric semiconductor quantum well driven by a terahertz field显示文摘 | Zhu Haiyan Zhang Tongyi Zhao Wei | 2009 | J Appl Phys2009，105，04： | 1 |
| 9 | Some properties of an acidic protein-bound polysaccharide from the fruit of pumpkin显示文摘 | Fu Caili Tian Haijun Cai Tongyi Liu Yi Li Quanhong | | Food Chemistry0，，： | 1 |
| 10 | Optimizing conditions for the purification of crude octacosanol extract from rice bran wax by molecular distillation analyzed using response surface methodology显示文摘 | Fang Chen Tongyi Cai Guanghua Zhao etal | 2005 | Journal of Food Engineering2005，70，： | 1 |
| 11 | Some properties of an acidic protein-bound polysaccharide from the fruit of pumpkin显示文摘 | Fu Caili Tian Haijun Cai Tongyi | 2007 | Food Chemistry2007，100，3： | 1 |
| 12 | Fracture of Piezoelectric Ceramics 显示文摘 | Ran Fu and Tongyi Zhang | 1999 | Applied Mechanics in the Americas1999，7，： | 1 |
| 13 | Optimizing conditions for thepurification of crude octacosanol extract from rice branwax by molecular distillation analyzed using responsesurface methodology 显示文摘 | Fang Chen Tongyi Cal | 2005 | Jouranal of Food Engineering2005，，70： | 1 |
| 14 | Some nutritional and functional properties of defatted wheat germ protein显示文摘 | Yiqiang Ge Aidong Sun Yangying Ni Tongyi Cai | 2000 | Journal of Agriculture and Food Chemistry2000，48，12： | 1 |
| 15 | 生活方式对亚洲男性性激素、性活动以及老龄化的调节作用[J]显示文摘 | VictorHH GohT TongYY | | 亚洲男性学杂志(英文版)0，，： | 1 |
| 16 | Some properties ofan acidic protein-bound polysaccharide from the fruit ofpumpkin显示文摘 | Fu Caili Tian Haijun Cai Tongyi | 2007 | Food Chemistry2007，100，3： | 1 |
| 17 | Some properties of an acidic protein-bound polysaeeharide from the fruit of pumpkin显示文摘 | Caili F Haijun T Tongyi C | 2007 | Food Chemistry2007，100，3： | 1 |
| 18 | Some properties of an acidic protein-bound polysaccharide from the fruit of pumpkin显示文摘 | FU Caili TIAN Haijun CAI Tongyi | 2007 | Food Chemistry2007，100，3： | 1 |
| 19 | Some nutritional and functional properties of de-fatted wheat germ protein显示文摘 | Yiqiang Ge Aidong Sun Yangying Ni Tongyi Cai | 2000 | Journal of Agriculture and Food Chemistry2000，48，12： | 1 |
| 20 | Some properties of an acidic protein-bound polysaccharide from the fruit of pumpkin显示文摘 | Caili F Haijun T Tongyi C | 2007 | Food Chemistry2007，100，3： | 1 |
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