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| 1 | Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A显示文摘支持骨头形成是在骨质疏松症治疗的基本策略之一,破裂修理。作为骨头形成上的激发器之一, osteogenic 生长肽(OGP ) 在 vitro 并且在 vivo, osteoprotegerin (OPG ) 在被建议了被包含增加造骨细胞的增长和区别。在这研究,我们在骨头髓上评估了 OGP 的效果从在由 3-(4,5-dimethylthiazol-2-yl ) 的 vitro 的 OPG 缺乏的老鼠的间充质的干细胞(MSC )-2,5-diphenyltetrazolium 溴化物试金,碱的磷酸酶(高山) 活动试金,即时聚合酶链反应,和西方的污点分析。结果证明 OGP 刺激了 MSC 增长并且在 mRNA 和蛋白质层次两个都在 MSC 增加了 CDK2 和 cyclin A 的表示。然而, OGP 的 differentiative 效果都没作为高山活动和 Runx2 的表示层次被显示出, Osterix 没被 OGP 显著地增加。我们的学习建议 OGP 可以由刺激 MSC 增长而非区别在 OPG 缺乏的老鼠增加骨头形成,并且可能由触发 CDK2/cyclin 一条小径。 | Qinming Fei Changjun Guo Xiaoya Xu Jianjun Gao Jian Zhang Tongyi Chen Dafu Cui | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 11 |
| 2 | Size-dependent elastic properties of thin films: surface anisotropy and surface bonding显示文摘Surface eigenstress and eigendisplacement models were used to investigate the surface stress,surface relaxation and surface elasticity of thin films with different surface orientations.Molecular dynamics simulations and first-principles calculations were conducted on face-centered cubic Au films with the focus on relaxation induced nonlinear initial deformation.The simulation results verify the theoretical predictions of the size dependency of surface energy density and surface stress,and the nonlinear scaling law of the size-dependent Young’s modulus of thin films.The mechanism of the size-dependent behaviors was further explored at the atomic bonding level with the charge density field.The Au atomic bonding at surfaces is enhanced compared to its interior counterpart and therefore the nominal Young’s modulus of the Au thin films is larger when the film thickness is smaller. | ZHOU XiaoYe REN Hang HUANG BaoLing ZHANG TongYi | 2014 | Science China(Technological Sciences)2014，57，4： | 5 |
| 3 | Machine learning of mechanical properties of steels显示文摘Knowledge of the mechanical properties of structural materials is essential for their practical applications. In the present work,three-hundred and sixty data samples on four mechanical properties of steels—fatigue strength, tensile strength, fracture strength and hardness—were selected from the Japan National Institute of Material Science database, comprising data on carbon steels and low-alloy steels. Five machine learning algorithms were used to predict the mechanical properties of the materials represented by the three-hundred and sixty data samples, and random forest regression showed the best predictive performance.Feature selection conducted by random forest and symbolic regressions revealed the four most important features that most influence the mechanical properties of steels: the tempering temperature of steel, and the alloying elements of carbon, chromium and molybdenum. Mathematical expressions were generated via symbolic regression, and the expressions explicitly predicted how each of the four mechanical properties varied quantitatively with the four most important features. This study demonstrates the great potential of symbolic regression in the discovery of novel advanced materials. | XIONG Jie ZHANG TongYi SHI SanQiang | 2020 | Science China(Technological Sciences)2020，63，7： | 4 |
| 4 | FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR显示文摘Filamin A (FLNa ) 是无所不在地表示的细胞质的蛋白质,它 24 次象 Ig 一样重复跟随的一个 N 终端肌动朊绑定领域(ABD ) 创作。FLNa 作为连接 transmembrane 受体的细胞骨架蛋白质工作,包括 integrins,到 F 肌动朊并且用作发信号的中介。最近的研究作为与超过 90 蛋白质交往并且在细胞的发信号的 transduction 起重要作用的支架蛋白质识别了 FLNa。在人的 FLNa 基因的变化或缺点被显示了引起众多的发展缺点。而且, FLNa 的异常表示在许多癌症被观察了例如甲状旁腺的肿瘤,颈的癌症,和乳癌。然而,它在肺腺癌的角色很少被讨论了。在现在的学习,我们的在里面 vitro 并且在 vivo,研究证明在肺癌症房间线 A549 房间的那 silencing FLNa 表情由提高表皮的生长因素受体和英皇家空军之阶级最低之兵发信号小径的激活支持了 A549 房间的增长,移植,和侵略。这些结果在肺癌症和揭开的新奇机制使 FLNa 的新奇功能清楚些,这些结果为肺腺癌为预言和治疗提供了可能的目标。 | Yuna Zhang Tienian Zhu Jingpu Liu Jiankun Liu Dongmei Gao Tongyi Su Ruijing Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 5 | Intersubband optical absorption in a step asymmetric semiconductor quantum well driven by a terahertz field显示文摘 | Zhu Haiyan Zhang Tongyi Zhao Wei | 2009 | J Appl Phys2009，105，04： | 1 |
| 6 | Fracture of Piezoelectric Ceramics 显示文摘 | Ran Fu and Tongyi Zhang | 1999 | Applied Mechanics in the Americas1999，7，： | 1 |
| 7 | Removal of Mercury by an Aminated Fiber Prepared by Irradiation Grafting Copolymerization显示文摘 | Nianfang Ma Shuixia Chen Tongyi Li Qikun Zhang | 2012 | Separation Science and Technology2012，，6： | 1 |
| 8 | Residual-stress Relaxation in Polysilicon Thin Films by High-temperature Rapid Thermal Annealing 显示文摘 | Zhang Xin Zhang TongYi Wong Man | 1998 | Sensors and Actuators A1998，64，： | 1 |
| 9 | Residual-stress Relaxation in Polysilicon Thin Films by High-temperature Rapid Thermal Annealing显示文摘 | Zhang Xin Zhang Tongyi Wong Man | 1998 | Sensors and Actuators1998，64，： | 1 |
| 10 | Residual Stress Relaxation in Polysilicen Thin Films by High-temperature Rapid Thermal Annealing显示文摘 | Zhang Xin Zhang Tongyi Wongman | 1998 | Semors and Actuators A1998，64，： | 1 |
| 11 | Temperature dependent Grüneisen parameter显示文摘Grüneisen parameter is one of the most valuable quantities in thermodynamics, which links the material properties of bulk modulus, heat capacity at constant volume, thermal expansion coefficient, and volume together. A new thermodynamic model of temperature-dependent potential energy is proposed here to investigate the temperature dependent Grüneisen parameter of bulk material. The newly developed thermodynamic model leads to temperature dependent analytical solutions of Grüneisen parameter and other thermo-mechanical properties including the Grüneisen equation of state. Molecular dynamics simulations are conducted on single crystalline Ni, Cu, and Au bulk crystals and the simulation results verify the newly developed thermodynamic model and quantitively evaluate the theoretically derived physical quantities. In addition, the Debye model is also employed in the study of temperature dependent Grüneisen parameter and the results also verify the theoretical approach. | ZHANG Xun SUN Sheng XU Tao ZHANG TongYi | 2019 | Science China(Technological Sciences)2019，62，9： | 1 |
| 12 | Measurements of residual stresses in thin films using micro-rotating-structures显示文摘 | ZHANG Xin ZHANG Tongyi | 1998 | Thin Solid Films1998，335，： | 1 |
| 13 | P, esidual-stress Relaxation in Polysilicon Thin Films by High-temperature Rapid Thermal Annealing显示文摘 | Zhang Xin Zhang Tongyi WongMan | 1998 | Sensors and Actuators1998，64，： | 1 |
| 14 | Fracture of piezoelectric ceramics显示文摘 | Zhang Tongyi Zhao Minghao Tong P | 2001 | Advances in Applied Mechanics2001，38，： | 1 |
| 15 | Mechanically assisted electroplating of Ni-P coatings on carbon steel 显示文摘 | Ping Zhaoxia He Yedong Gu Changdong Zhang Tongyi | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 16 | First-principles study of multiple-site substitutions of alloying elements in Ni-based single crystal superalloys显示文摘The development of Ni-based single crystal superalloys relies heavily on the composition design with the addition of critical alloying elements,e.g.,Re and Ru.Understanding the role of alloying effects require to know the configurations of the alloying element distribution betweenγ-Ni andγ′-Ni3Al phases and among various non-equivalent sites.This work employed firstprinciples density functional theory calculations to study the preference of phase and site occupancy of 11 alloying elements including Al and transition metal elements:3d (Ti,Cr,Co,Ni),4d (Mo,Ru),and 5d (Hf,Ta,W,Re) in Ni and Ni3Al.We calculated the substitution energies of 1298 triple-site doping configurations including 286 Ni Ni Ni site doping of Ni,726 Al Ni Ni site doping,and 286 Ni Ni Ni site doping of Ni3Al with alloying elements Ni,Co,Ru,Cr,Re,Mo,W,Al,Ti,Ta,and Hf.In the dual-site and triple-site doping of Ni and Ni3Al,all studied alloying elements preferred to occupy Ni phase rather than Ni3Al phase.We found that the most stable defect complexes often contained the favorable substitutions of Al,Ti,Ta,and Hf for the Ni sites that stabilized the alloying elements doping at the other one or two nearest neighbor sites.The co-substitutions of various alloying elements at multiple sites are critical to understanding the strengthening mechanism of alloying elements in Ni-based single crystal superalloys. | SUN JunXi DU Wan XIAO Bin WU YuQin LIU Yi ZHANG TongYi | 2021 | Science China(Technological Sciences)2021，64，6： | 1 |
| 17 | Unravelling the enhanced vaccine immunity by heterologous KCONVAC/Ad5-nCoV COVID-19 vaccination显示文摘Dear Editor,Growing evidence has indicated that heterologous COVID-19 vaccination could generate higher antibody(Ab)and cellmediated immune(CMI)responses than homologous vaccination regimen.1–3 However,fundamental understanding of immunological mechanisms dictating the enhanced vaccine immunity is still lacking.To gain mechanistic insights,we comprehensively profiled the immune responses generated by homologous or heterologous booster vaccination in mice(Fig.1a). | Weijun Zhao Huajun Zhao Baoying Huang Tongyi Zhao Limei Wang Jian Zhang Yong Yang Xinying Tang Wenjie Tan Ang Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 18 | Surface segregation of hydrogen in free-standing Pd-H alloy nanofilms显示文摘The interaction between mechanics and chemistry plays an essential and critical role in the behaviors and properties of materials,especially in nanoscale alloys. Based on the classical Gibbs and Mc Lean adsorption isotherms, the present study takes the freestanding nanometer thick films of Pd-H solid solutions as a typic example to investigate surface segregation of hydrogen. The surface eigenstress model is further developed here to give analytic formulas, which have the capability to quantitatively predict the size-dependent surface segregation. Molecular dynamics(MD) simulations are conducted on free-standing Pd-H nanofilms.The MD simulations verify the theoretical analytic results and determine the values of parameters involved in the theoretical analysis. The integrated theoretical and numerical study exhibits that both surface excess H concentration and apparent biaxial Young’s modulus of Pd-H thin films depend on the nominal H concentration and the film thickness. The MD simulations determine the values of three parameters involved in the theoretical analysis. Especially, the parameter of the differentiation in reference chemical potential behaves like the molar free energy of segregation in the Mc Lean adsorption isotherm. | CAI Hong MAI JiaWei GAO YingXin HUANG He SUN Sheng ZHANG TongYi | 2019 | Science China(Technological Sciences)2019，62，10： | 0 |
| 19 | Definition of Planarian Mortality in an Acute Toxicity Test:A Case Study on Dugesia japonica Exposed to 1-Octyl-3-methylimidazolium Bromide显示文摘In order to define the mortality criteria of planarian objectively,a case study of Dugesia japonica exposed to 1-octyl-3-methylimidazolium bromide([C8mim]Br)was performed followed by a recovery culture.The results showed that defining planarian mortality in light of its body disintegration was appropriate.If the disintegrated tissue of a planarian was more than 1/4 of its body length,it would completely degenerate.However,a planarian would regenerate the lost tissue and return to normal after a few days’recovery culture if the disintegrated part was less than 1/4 of body length.Therefore,we propose to use body disintegration as the endpoint of planarian mortality,i.e.,1/4 body length degenerated is the critical threshold of mortality and survival of planarians when exposed to toxicants.This criterion could be adapted in the standardization of testing protocols and comparability of acute toxicity test or other toxicological research using planarian as the test animal. | Zhang Hecai Liu Tongyi Liu Yanfang Zhang Jie Wang Zhige Chen Guangwen | 2016 | 生态毒理学报2016，11，6： | 0 |
| 20 | Science China Technological Sciences: Taking the great opportunity and embracing much brighter prospects显示文摘Science China Technological Sciences(SCTS)is a multidisciplinary journal that reports research work in technological sciences and engineering sciences.Since launched in 1950 the journal series of Science China have been making considerable | Zhang tongYi | 2018 | Science China(Technological Sciences)2018，61，1： | 0 |
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