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| 1 | FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR显示文摘Filamin A (FLNa ) 是无所不在地表示的细胞质的蛋白质,它 24 次象 Ig 一样重复跟随的一个 N 终端肌动朊绑定领域(ABD ) 创作。FLNa 作为连接 transmembrane 受体的细胞骨架蛋白质工作,包括 integrins,到 F 肌动朊并且用作发信号的中介。最近的研究作为与超过 90 蛋白质交往并且在细胞的发信号的 transduction 起重要作用的支架蛋白质识别了 FLNa。在人的 FLNa 基因的变化或缺点被显示了引起众多的发展缺点。而且, FLNa 的异常表示在许多癌症被观察了例如甲状旁腺的肿瘤,颈的癌症,和乳癌。然而,它在肺腺癌的角色很少被讨论了。在现在的学习,我们的在里面 vitro 并且在 vivo,研究证明在肺癌症房间线 A549 房间的那 silencing FLNa 表情由提高表皮的生长因素受体和英皇家空军之阶级最低之兵发信号小径的激活支持了 A549 房间的增长,移植,和侵略。这些结果在肺癌症和揭开的新奇机制使 FLNa 的新奇功能清楚些,这些结果为肺腺癌为预言和治疗提供了可能的目标。 | Yuna Zhang Tienian Zhu Jingpu Liu Jiankun Liu Dongmei Gao Tongyi Su Ruijing Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 2 | Intersubband optical absorption in a step asymmetric semiconductor quantum well driven by a terahertz field显示文摘 | Zhu Haiyan Zhang Tongyi Zhao Wei | 2009 | J Appl Phys2009，105，04： | 1 |
| 3 | Optimizing conditions for the purification of crude octacosanol extract from rice bran wax by molecular distillation analyzed using response surface methodology显示文摘 | Fang Chen Tongyi Cai Guanghua Zhao etal | 2005 | Journal of Food Engineering2005，70，： | 1 |
| 4 | Optimizing conditions for the purification of crude oetacosanol extract from rice bran wax by molecular distillation analyzed using response surface methodology 显示文摘 | CHEN Fang CA1 Tongyi ZHAO Guanghua | 2005 | Journal of Food Engineering2005，70，1： | 1 |
| 5 | 显示文摘 | Chen Fang Cai Tongyi Zhao Guanghua | 2005 | Journal of Food Engineering2005，70，： | 1 |
| 6 | Optimizing conditions for the purification of crude octacosanol extract from rice bran wax by molecular distillation analyzed using response surface methodology 显示文摘 | CHEN Fang CAI Tongyi ZHAO Guanghua | 2005 | Journal of Food Engineering2005，70，1： | 1 |
| 7 | Optimizing conditions for the purification of crude octacosanol extract from rice bran wax by molecular distillation analyzed using response surface methodology显示文摘 | Chen Fang Cai Tongyi Zhao Guanghua | 2005 | Food Engineering2005，，70： | 1 |
| 8 | Highly selective adsorption of light hydrocarbons in a HKUST-like MOF constructed from spirobifluorene-based octacarboxylate ligand by a substitution strategy显示文摘Metal-organic frameworks(MOFs)with HKUST-like tbo structures have been paid specific attention for gas sorption and separation because of their specific pore features.According to the geometric similarity of spirobifluorene and[Cu_(2)(O_(2)CR)_(4)]paddlewheel secondary building units(Cu_(2)SBUs)in HKUST-1,we attempted to rationally construct a HKUST-like MOF by a substitution strategy.Using a judiciously designed octatopic carboxylate ligand,a copper-organic framework,JUC-220,was synthesized.The crystals of JUC-220 exhibited characteristic features in cubic with disorder,possibly due to the disorder substitution and high symmetry of tbo topology.Two related HKUST-like structure models were considered.Thanks to the suitable pore size and specific pore shapes,the adsorption selectivities of JUC-220 for C_(3)H_(8)/CH_(4)(5/85)and C_(2)H_(6)/CH_(4)(10/85)gas mixtures were as high as 736 and 46 respectively at 298 K and 1 bar.Specially,JUC-220 exhibited excellent trace adsorption performance of C_(3)H_(8)and C_(2)H_(6)as well as reverse adsorption behavior of C_(2)H_(6)/C_(2)H_(4).Thus,JUC-220 serves as an example of HKUST-like MOF with disorder for light hydrocarbons separation and the implementation of substitution which can be used to explore more porous MOFs. | Xinli Shi Yucong Zu Xilin Li Tongyi Zhao Hao Ren Fuxing Sun | 2023 | Nano Research2023，16，7： | 1 |
| 9 | Fracture of piezoelectric ceramics显示文摘 | Zhang Tongyi Zhao Minghao Tong P | 2001 | Advances in Applied Mechanics2001，38，： | 1 |
| 10 | Unravelling the enhanced vaccine immunity by heterologous KCONVAC/Ad5-nCoV COVID-19 vaccination显示文摘Dear Editor,Growing evidence has indicated that heterologous COVID-19 vaccination could generate higher antibody(Ab)and cellmediated immune(CMI)responses than homologous vaccination regimen.1–3 However,fundamental understanding of immunological mechanisms dictating the enhanced vaccine immunity is still lacking.To gain mechanistic insights,we comprehensively profiled the immune responses generated by homologous or heterologous booster vaccination in mice(Fig.1a). | Weijun Zhao Huajun Zhao Baoying Huang Tongyi Zhao Limei Wang Jian Zhang Yong Yang Xinying Tang Wenjie Tan Ang Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 11 | Single-Photon Lidar for Fast Imaging at Low SBR and Few Photons显示文摘In low-light conditions,the single-photon light detection and ranging(Lidar)technique based on timecorrelated single-photon counting(TCSPC)is suited for collecting a three-dimensional(3D)profile of the target.We present a rapid 3D reconstruction approach for single-photon Lidar with low signal-to-background ratio(SBR)and few photons based on a combination of short-duration range gate selection,photon accumulation of surrounding pixels,and photon efficiency algorithm in this paper.We achieve the best noise filtering and 3D image reconstruction by choosing the optimal combined order of simple methods.Experiments were carried out to validate the various depth estimation algorithms using simulated data and single-photon avalanche diode(SPAD)array data under varying SBR.The experimental results demonstrate that our proposed method can achieve high-quality 3D reconstruction with a faster processing speed compared to the existing algorithms.The proposed technology will encourage the use of single-photon Lidar to suit practical needs such as quick and noise-tolerant 3D imaging. | Xue Ruikai Kang Yan Zhang Tongyi Meng Fanxing Wang Xiaofang Li Weiwei Li Lifei Zhao Wei | 2023 | 激光与光电子学进展2023，60，8： | 0 |
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