|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21^(st) century显示文摘Restitution of normal fat absorption in exocrine pancreatic insufficiency remains an elusive goal. Although many patients achieve satisfactory clinical results with enzyme therapy, few experience normalization of fat absorption, and many, if not most, will require individualized therapy. Increasing the quantity of lipase administered rarely eliminates steatorrhea but increases the cost of therapy. Enteric coated enzyme microbead formulations tend to separate from nutrients in the stomach precluding coordinated emptying of enzymes and nutrients. Unprotected enzymes mix well and empty with nutrients but are inactivated at pH 4 or below. We describe approaches for improving the results of enzyme therapy including changing to, or adding, a different product, adding non-enteric coated enzymes,(e.g., giving unprotected enzymes at the start of the mealand acid-protected formulations later), use of antisecretory drugs and/or antacids, and changing the timing of enzyme administration. Because considerable lipid is emptied in the first postprandial hour, it is prudent to start therapy with enteric coated microbead prior to the meal so that some enzymes are available during that first hour. Patients with hyperacidity may benefit from adjuvant antisecretory therapy to reduce the duodenal acid load and possibly also sodium bicarbonate to prevent duodenal acidity. Comparative studies of clinical effectiveness of different formulations as well as the characteristics of dispersion, emptying, and dissolution of enteric-coated microspheres of different diameter and density are needed; many such studies have been completed but not yet made public. We discuss the history of pancreatic enzyme therapy and describe current use of modern preparations, approaches to overcoming unsatisfactory clinical responses, as well as studies needed to be able to provide reliably effective therapy. | Tony Trang Johanna Chan David Y Graham | 2014 | World Journal of Gastroenterology2014，20，33： | 17 |
| 2 | Dental and periodontal phenotype in sclerostin knockout mice显示文摘Sclerostin is a Wnt signalling antagonist that controls bone metabolism.Sclerostin is expressed by osteocytes and cementocytes;however,its role in the formation of dental structures remains unclear.Here,we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography(mCT)imaging.mCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls.mCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice.No significant differences were observed for the tooth and pulp chamber volume.Descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width.Taken together,these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin. | Ulrike Kuchler Uwe Y Schwarze Toni Dobsak Patrick Heimel Dieter D Bosshardt Michaela Kneissel Reinhard Gruber | 2014 | International Journal of Oral Science2014，6，2： | 7 |
| 3 | On generation source sites of internal waves in the Luzon Strait显示文摘This effort aims to determine the generation source sites in the Luzon Strait for energetic,long-crest,transbasin internal waves(IW)observed in the northern South China Sea(NSCS).The roles of islands distributed on eastern side of the strait,Kuroshio,submarine ridges,shoaling thermocline,and strait configuration played in the IW generation are examined using the cruise data analysis,satellite data interpretation,and dynamical analysis.The islands and channels on eastern side of the strait are excluded from a list of possible IW source sites owing to their unmatched horizontal dimensions to the scale of IW crest line length,and the relative low Reynolds number.The Kuroshio has a potential to be a radiator for the long-crest IW disturbances,meanwhile,the Kuroshio west(east)wing absorbs the eastward(westward)propagating IW disturbance.Namely,the Kuroshio blockades the outside west-east propagating IW disturbances.The 3-D configuration of the Luzon Strait is characterized by a sudden,more than one order widening of the cross-section areas at the outlets on both sides,providing a favorable condition for IW type initial disturbance formation.In the Luzon Strait,the thermocline is featured by a westward shoaling all the year around,providing the dynamical conditions for the amplitude growth(declination)to the westward(eastward)propagating IW type disturbance.Thus,the west slope of western submarine ridge at the western outlet of the Luzon Strait is a high possibility source sites for energetic,long-crest,transbasin IWs in the NSCS.The interpretation results of satellite SAR images during a 13 a period from 1995 to 2007 provide the convincing evidence for the conclusions. | ZHENG Quanan SONG Y Tony LIN Hui HU Xiaomin MENG Junmin WANG Dan | 2008 | Acta Oceanologica Sinica2008，27，3： | 5 |
| 4 | Dynamical analysis of mesoscale eddy-induced ocean internal waves using linear theories显示文摘This study aims to explore generation mechanisms of the ocean internal wave using the dynamical analysis methods based on linear theories.Historical cruise measurements and recent synthetic aperture radar(SAR)observations of mesoscale eddies with diameter of several tens of kilometers to hundreds of kilometers show that the internal wave packets with wavelength of hundreds of meters to kilometer exist inside the mesoscale eddies.This coexistence phenomenon and inherent links between the two different scale processes are revealed in the solutions of governing equations and boundary conditions for the internal wave disturbance with a horizontally slowly variable amplitude in a cylindrical coordinate system.The theoretical solutions indicate that the instability of eddy current field provides the dynamical mechanism to internal wave generation.The derived dispersion relation indicates that the internal wave propagation is modified by the eddy current field structure.The energy equation of the internal waves clearly shows the internal wave energy increment comes from the eddy.The theoretical models are used to explain the observation of the mesoscale eddy-induced internal waves off the Norwegian coast.The two-dimensional waveform solution of the anticyclonic eddy-induced internal wave packet appears as ring-shaped curves,which contains the typical features of eddy stream lines.The comparison of theoretical solutions to the structure of the internal wave packets on SAR image shows a good agreement on the major features. | XU Qing ZHENG Quanan LIN Hui LIU Yuguang SONG Y Tony YUAN Yeli | 2008 | Acta Oceanologica Sinica2008，27，3： | 3 |
| 5 | Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration显示文摘在果蝇成年 midgut 的肠的干细胞(ISC ) 为维持织物动态平衡是必要的,并且他们的增长和区别加快以便为填满遇见需求响应损害的失去的房间。包括 JAK-STAT, EGFR 和河马(Hpo ) 小径的几个发信号小径在导致损坏的 ISC 增长被含有,但是集成这些小径的机制留下了逃犯。这里,我们证明 oncoprotein Myc (dMyc ) 的果蝇相当或相同的事物这些下游地工作表明小径调停他们 ISC 增长上的效果。在先锋房间的 dMyc 表示响应织物损坏被刺激,并且 dMyc 为加速的 ISC 增长和 midgut 新生是必要的。我们证明葡聚糖硫酸盐钠喂引起的那织物损坏经由 Hpo 小径刺激 dMyc 表示,而喂的 bleomycin 通过 JAK-STAT 和 EGFR 小径激活 dMyc。我们提供 dMyc 表示是的证据 transcriptionally 由多重发信号的小径的 upregulated,它响应织物为最佳的 ISC 增长被要求损坏。我们也获得了证据那织物损坏罐头 upregulate dMyc 表情 post-transcriptionally。最后,我们证明 dMyc 表示的基础水平在正常织物动态平衡期间为 ISC 维护,增长和系区别被要求。 | Fangfang Ren Qing Shi Yongbin Chen Alice Jiang Y Tony Ip Huaqi Jiang Jin Jiang | 2013 | Cell Research2013，23，9： | 2 |
| 6 | An efficient approach for locating the critical slip surface in slope stability analyses using a real-coded genetic algorithm显示文摘 | LI Y C CHEN Y M TONY L T | 2010 | Canadian Geotechnical Journal2010，47，7： | 1 |
| 7 | Shear strengthcharacterization of municipal solid waste at the Suzhou land-fill,China显示文摘 | Zhan Tony L T Chen Y M Ling W A | 2008 | Engineering Geology2008，97，34： | 1 |
| 8 | Performance of a large-scale slope model subjected to rising and lowering water levels显示文摘 | JIA G W ZHAN TONY L T CHEN Y M | 2009 | Engineering Geology2009，106，： | 1 |
| 9 | Synthetic studies on zoapatanol:construction of oxepanes via an intramolecular 1,3-dipolar cycloaddition strategy 显示文摘 | Tony KM Wong CH Ting Y | 1996 | Tetrahedron : Asymmetry1996，7，5： | 1 |
| 10 | Conditioning of aluminium- based water treatment sludge with Fenton's reagent: Effectiveness and optimising study to improve dewaterability 显示文摘 | Tony M A Zhao Y Q Fu J F | 2008 | Chemosphere2008，72，4： | 1 |
| 11 | Properties of HTS for successful U/n processing显示文摘 | Weinstein R Ren Y Sawh R Gandini A Henning W Murakami M Mochida T Chikumoto N Sakai N Krabbes G Bieger W Milliken D Dou S X Tonies S Eis terer M Weber H | | 0，，： | 1 |
| 12 | Conditioning of aluminium-based water treatment sludge with Fenton's reagent:Effectivenessand optimizing study to improve dewaterability显示文摘 | Maha A Tony Y Q Zhao J F Fu | 2008 | Chemosphere2008，72，4： | 1 |
| 13 | Performance of a large-scale slope model subjected to rising and lowering water levels 显示文摘 | G W Jia Tony L T Zhan Y M Chen D G Fredlund | 2009 | Engineering Geology2009，106，12： | 1 |
| 14 | Conditioning of aluminium-based water treatment sludge with Fenton’s reagent:Effectiveness and optimising study to improve dewaterability显示文摘 | Maha A Tony Y Q Zhao J F Fu | 2008 | Chemosphere2008，72，4： | 1 |
| 15 | Duodenal PKC-[delta] and Cholecystokinin Signaling Axis Regulates Glucose Production显示文摘 | Breen Danna M Yue Jessica T Y Rasmussen Brittany A Kokorovic Andrea Cheung Grace W C Lam Tony K T | 2011 | Diabetes2011，，12： | 1 |
| 16 | Perform- ance of a Large-scale Slope Model Subjected to Ris- ing and Lowering Water Levels 显示文摘 | Jia G W Zhan Tony L T Chen Y M | 2009 | Engineering Geology2009，106，： | 1 |
| 17 | Methionine adenosyltransferase 2B, HuR, and sirtuin protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells显示文摘 | Heping Y Yuhua Z Tony W H | 2013 | The Journal of biological chemistry2013，288，23： | 1 |
| 18 | Seizure-associated,aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling显示文摘 | Jessberger S Zhao C Toni N Clemenson GD Jr Li Y Gage FH | 2007 | J Neurosci2007，27，： | 1 |
| 19 | Extending spectral modeling synthesis with transient modeling synthesis显示文摘 | Tony S Verma Teresa H Y Meng | 2000 | Computer Music Journal2000，24，2： | 1 |
| 20 | The mechanisms of coronary restenosis: Insights from experimental models显示文摘 | Gordon A F Tony Y A | 2000 | Journal of Experimental Pathology2000，81，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员