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| 1 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 2 | Implementing IMRT in clinical practice: a joint document of the American Society for Therapeutic Radiology and Oncology and the American Association of Physicists in Medicine显示文摘 | James M Galvin Gary Ezzell Avraham Eisbrauch Cedric Yu Brian Butler Ying Xiao Isaac Rosen Julian Rosenman Michael Sharpe Lei Xing Ping Xia Tony Lomax Daniel A Low Jatinder Palta | 2004 | International Journal of Radiation Oncology Biology Physics2004，，5： | 1 |
| 3 | A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation显示文摘Triazolopyridines are an important kind of fused-ring compounds.A HOCl-promoted triazolopyridine formation strategy is reported here for the first time in which hypochlorous acid(HOCl)mildly and efficiently promotes the formation of 1,2,4-triazolo[4,3-a]pyridines NT1-NT6 from various 2-pyridylhydrazones N1-N6.N6,a rhodol-pyridylhydrazone hybrid,was developed into a fluorescent probe for the selective detection of HOCl,and successfully applied to probe endogenous HOCl in living cells and zebrafish in situ and in real time.The present intramolecular cyclization reaction is selective and atom-economical,thereby not only providing an important approach for the convenient synthesis of triazolopyridines,but also offering a general strategy for sensitive,selective and biocompatible detection of endogenous HOCl in complex biosystems. | Yanhui Zhang Hao Teng Ying Gao Muhammad Wasim Afzal Jingye Tian Xi Chen Haoyang Tang Tony D.James Yuan Guo | 2020 | Chinese Chemical Letters2020，31，11： | 0 |
| 4 | 银币模压加工过程中表面发蓝的发生机理及克服方法显示文摘在银币的生产过程中,硬币表面发蓝是非常普遍的现象。许多硬币收藏者用放大镜,甚至是显微镜去观察硬币发蓝。如果不满意硬币的外观,收藏者将退还硬币给造币厂。为了清除银币表面的发蓝,造币生产线必须被中断,以抛光或清洗压印的模具。如果毛胚没有处于良好的准备状态,抛光一副冲模的时间就超过了压印硬币的时间。文中分析了硬币表面发蓝的原因,揭示了在模压过程中值得注意的摩擦学现象,并且提出了无需人工抛光冲模去除发蓝的方法,实现了银币的高效生产,清洗模具周期由冲压80次,提高到800次以上。 | Tony Ying Uvon Tolbert Paul Lewis Ron Harrigal | 2009 | 中国表面工程2009，22，2： | 0 |
| 5 | Exploring the impact of a coordinated variable speed limit control on congestion distribution in freeway显示文摘Over the past few decades,urban freeway congestion has been highly recognized as a serious and worsening traffic problem in the world.To relieve freeway congestion,several active traffic and demand management(ATDM) methods have been developed.Among them,variable speed limit(VSL) aims at regulating freeway mainline flow upstream to meet existing capacity and to harmonize vehicle speed.However,congestion may still be inevitable even with VSL implemented due to extremely high demand in actual practice.This study modified an existing VSL strategy by adding a new local constraint to suggest an achievable speed limit during the control period.As a queue is a product of the congestion phenomenon in freeway,the incentives of a queue build-up in the applied coordinated VSL control situation were analyzed.Considering a congestion occurrence(a queue build-up)characterized by a sudden and sharp speed drop,speed contours were utilized to demonstrate the congestion distribution over a whole freeway network in various scenarios.Finally,congestion distributions found in both VSL control and non-VS control situations for various scenarios were investigated to explore the impact of the applied coordinated VSL control on the congestion distribution.An authentic stretch of Whitemud Drive(WMD),an urban freeway corridor in Edmonton,Alberta,Canada,was employed to implement this modified coordinated VSL control strategy;and a calibrated micro-simulation VISSIM model(model functions) was applied as the substitute of the real-world traffic system to test the above mentioned performance.The exploration task in this study can lay the groundwork for future research on how to improve the presented VSL control strategy for achieving the congestion mitigation effect on freeway. | Jing Cao Dawei Hu Ying Luo Tony Z.Qiu Zhuanglin Ma | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，3： | 0 |
| 6 | Mechanisms of prostate carcinogenesis and its prevention by a γ-tocopherolrich mixture of tocopherols in TRAMP mice显示文摘Tocopherols belong to a subgroup of the vitamin E family. Dietary feeding of a γ-tocopherol-rich mixture of tocopherols(γ-Tm T) inhibits prostate tumorigenesis in TRAMP mice. In this study, we aimed to investigate mechanisms of prostate carcinogenesis in TRAMP mice by identifying differentially expressed pathways and effects of γ-Tm T on these pathways. Eight-week-old TRAMP and age-matched C57BL/6 mice were administered either 600 mg/kg of γ-Tm T or a control vehicle via oral gavage. Twelve hours after dosing, prostate tissues were collected for RNA extraction. Whole genome mouse microarrays were used to examine gene expression profiles. The expression of the selected genes were validated using quantitative PCR. Thousands of genes and various pathways were altered in the prostates of TRAMP mice. Compared to C57BL/6 mice, TRAMP mice exhibited enhanced proliferation, suppressed expression of antioxidant and phase II detoxification enzymes, and metabolic reprogramming in the prostate. γ-Tm T differentially regulated the gene expression profiles of TRAMP and C57BL/6 mice, with only a small percentage of genes overlapping. γ-Tm T inhibited genes involved in proliferation and glucose metabolism and induced several antioxidant/phase II detoxification genes in TRAMP mice. γ-Tm T modulates multiple aberrant pathways in the prostate of TRAMP mice, which might represent important mechanisms for prostate cancer prevention. | Ying Huang Zhengyuan Su Tienyuan Wu Constance Lay-Lay Saw Ah-Ng Tony Kong | 2016 | Journal of Chinese Pharmaceutical Sciences2016，25，3： | 0 |
| 7 | Risk Perception and Knowledge in Fire Risk Reduction in a Dong Minority Rural Village in China: A Health-EDRM Education Intervention Study显示文摘Fire is one of the major disasters in rural communities but evidence of the effectiveness of education interventions against fire risks is limited. This was a 2-year study assessed the effectiveness of face-to-face Health Emergency and Disaster Risk Management(HealthEDRM) education interventions for raising fire risk reduction knowledge in a fire-prone rural ethnic minority community. The study was conducted in various pre-set time points of an intervention-based project in a Dongbased community in Nanjiang Village, Guizhou Province in 2015 and 2016 to increase knowledge among the villagers about how to reduce general-and electrical-fire risks. Pre-and post-intervention questionnaires were used to evaluate the effectiveness of increasing fire risk-related knowledge through these interventions, immediately after the 2015 and 2016 interventions, and 17 months after the 2015 intervention. The knowledge of using fire blanket,recalling the correct emergency telephone number,unplugging unused electrical appliances, and not using water to extinguish electrical fires had immediately improved after the interventions. Subjects demonstrated a better understanding that fire blankets can fight a blaze if used appropriately, and that knowledge was sustained for 17 months. The interventions were effective in improving fire prevention and response knowledge. Targeted interventions should be organized according to communities' culture, the evolution of economic prosperity and lifestyle practices. | Emily Ying Yang Chan Holly Ching Yu Lam Phoebe Pui Wun Chung Zhe Huang Tony Ka Chun Yung Kelvin Wai Kit Ling Gloria Kwong Wai Chan Cheuk Pong Chiu | 2018 | International Journal of Disaster Risk Science2018，9，3： | 0 |
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