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| 1 | Positive impact of adding No.14v lymph node to D2 dissection on survival for distal gastric cancer patients after surgery with curative intent显示文摘Background:D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer(GC),while the necessity of No.14 v lymph node(14v) dissection for distal GC is still controversial.Methods:A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer,Tianjin Medical University Cancer Institute and Hospital were enrolled in this study,of whom,243 patients also had the 14 v dissected.Other 677 patients without 14 v dissection were used for comparison.Results:Forty-five(18.5%) patients had 14 v metastasis.There was no significant difference in 3-year overall survival(OS) rate between patients with and without 14 v dissection.Following stratified analysis,in TNM stages I,II,IIIa and IV,14 v dissection did not affect 3-year OS;in contrast,patients with 14 v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc.In multivariate analysis,14 v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio(HR),1.568;95% confidence interval(CI):1.186-2.072;P=0.002].GC patients with 14 v dissection had a significant lower locoregional,especially lymph node,recurrence rate than those without 14 v dissection(11.7 % vs.21.1%,P=0.035).Conclusions:Adding 14 v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM Ⅲb/Ⅲc. | Yuexiang Liang Liangliang Wu Xiaona Wang Xuewei Ding Hongmin Liu Bin Li Baogui Wang Yuan Pan Rupeng Zhang Ning Liu Han Liang | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 2 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 3 | The determination of 52 elements in marine geological samples by an inductively coupled plasma optical emission spectrometry and an inductively coupled plasma mass spectrometry with a high-pressure closed digestion method显示文摘An improved analytical method to determine the content of 52 major, minor and trace elements in marine geological samples, using a HF-HCl-HNO_3 acid system with a high-pressure closed digestion method(HPCD), is studied by an inductively coupled plasma optical emission spectrometry(ICP-OES) and an inductively coupled plasma mass spectrometry(ICP-MS). The operating parameters of the instruments are optimized, and the optimal analytical parameters are determined. The influences of optical spectrum and mass spectrum interferences, digestion methods and acid systems on the analytical results are investigated. The optimal spectral lines and isotopes are chosen, and internal standard element of rhodium is selected to compensate for matrix effects and analytical signals drifting. Compared with the methods of an electric heating plate digestion and a microwave digestion, a high-pressure closed digestion method is optimized with less acid, complete digestion,less damage for digestion process. The marine geological samples are dissolved completely by a HF-HCl-HNO_3 system, the relative error(RE) for the analytical results are all less than 6.0%. The method detection limits are 2–40μg/g by the ICP-OES, and 6–80 ng/g by ICP-MS. The methods are used to determine the marine sediment reference materials(GBW07309, GBW07311, GBW07313), rock reference materials(GBW07103, GBW07104,GBW07105), and cobalt-rich crust reference materials(GBW07337, GBW07338, GBW07339), the obtained analytical results are in agreement with the certified values, and both of the relative standard deviation(RSD) and the relative error(RE) are less than 6.0%. The analytical method meets the requirements for determining 52 elements contents of bulk marine geological samples. | GAO Jingjing LIU Jihua LI Xianguo YAN Quanshu WANG Xiaojing WANG Hongmin | 2017 | Acta Oceanologica Sinica2017，36，1： | 13 |
| 4 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 5 | Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer显示文摘Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A(JDA) is a natural compound isolated from Jiyuan Rabdosia rubescens with anti-tumor activity,unclear anti-tumor mechanisms and limited water solubility hamper its clinical application.Here,we showed a2,a new JDA derivative,inhibited the growth of gastric cancer cells.Subsequently,we discovered for the first time that a2 induced ferroptosis.Importantly,compound a2 decreased GPX4 expression and overexpressing GPX4 antagonized the anti-proliferative activity of a2.Furthermore,we demonstrated that a2 caused ferrous iron accumulation through the autophagy pathway,prevention of which rescued a2 induced ferrous iron elevation and cell growth inhibition.Moreover,a2 exhibited more potent anti-cancer activity than 5-fluorouracil in gastric canc er cell line-derived xenograft mice models.Patient-derived tumor xenograft models from different patients displayed varied sensitivity to a2,and GPX4 downregulation indicated the sensitivity of tumors to a2.Finally,a2 exhibited well pharmacokinetic characteristic s.Overall,our data suggest that inducing ferroptosis is the major mechanism mediating anti-tumor activity of a2,and a2 will hopefully serve as a promising compound for gastric cancer treatment. | Ying Liu Zan Song Yajie Liu Xubin Ma Wang Wang Yu Ke Yichao Xu Dequan Yu Hongmin Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 6 | Tailoring bimodal grain structure of Mg-9Al-1Zn alloy for strength-ductility synergy:Co-regulating effect from coarse Al_(2)Y and submicron Mg_(17)Al_(12) particles显示文摘Grain boundary strengthening is an effective strategy for increasing mechanical properties of Mg alloys.However,this method offers limited strengthening in bimodal grain-structured Mg alloys due to the difficultly in increasing the volume fraction of fine grains while keeping a small grain size.Herein,we show that the volume fraction of fine grains(FGs,~2.5μm)in the bimodal grain structure can be tailored from~30 vol.%in Mg-9 Al-1 Zn(AZ91)to~52 vol.%in AZ91-1Y(wt.%)processed by hard plate rolling(HPR).Moreover,a superior combination of a high ultimate tensile strength(~405 MPa)and decent uniform elongation(~9%)is achieved in present AZ91-1Y alloy.It reveals that a desired bimodal grain structure can be tailored by the co-regulating effect from coarse Al_(2)Y particles resulting in inhomogeneous recrystallization,and dispersed submicron Mg_(17)Al_(12)particles depressing the growth of recrystallized grains.The findings offer a valuable insight in tailoring bimodal grain-structured Mg alloys for optimized strength and ductility. | Yong-Kang Li Min Zha Hai-Long Jia Si-Qing Wang Hongmin Zhang Xiao Ma Teng Tian Pinkui Ma Hui-Yuan Wang | 2021 | Journal of Magnesium and Alloys2021，9，5： | 6 |
| 7 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 8 | A Master-Slave Blockchain Paradigm and Application in Digital Rights Management显示文摘Upon flaws of current blockchain platforms of heavyweight, large capacity of ledger, and time-consuming of synchronization of data, in this paper, we proposed a new paradigm of master-slave blockchain scheme(MSB) for pervasive computing that suitable for general PC, mobile device such as smart phones or PADs to participants in the working of mining and verification, in which we separated traditional blockchain model in 2 layer defined as master node layer and a series of slavery agents layer, then we proposed 2 approaches for partially computing model(PCM) and non-computing of model(NCM) in the MSB blockchain, Finally large amounts of simulations manifest the proposed master-slave blockchain scheme is feasible, extendible and suitable for pervasive computing especially in the 5 G generation environment, and can apply in the DRM-related applications. | Zhaofeng Ma Weihua Huang Wei Bi Hongmin Gao Zhen Wang | 2018 | China Communications2018，15，8： | 5 |
| 9 | Two-dimensional porphyrin- and phthalocyanine-based covalent organic frameworks显示文摘Covalent organic frameworks(COFs) represent an emerging class of porous crystalline materials and have recently shown interesting applications from catalysis to optoelectronic devices.In this review,by covering most of the reported work,we summarized the research progress of two-dimensional(2D)porphyrin- and phthalocyanine-based COFs,with highlighting the synthesis of these 2D COFs via various dynamic covalent reactions and emphasizing their potential applications in different areas. | Hongmin Wang Huimin Ding Xiangshi Meng Cheng Wang | 2016 | Chinese Chemical Letters2016，27，8： | 5 |
| 10 | Release characteristics of mercury in chemical looping combustion of bituminous coal显示文摘This study evaluated the release characteristics of mercury from bituminous coal in chemical looping combustion(CLC)using Australian iron ore as the oxygen carrier in a fixed bed reactor.The effects of several parameters,such as temperature in the fuel reactor(FR)and air reactor(AR),gasification medium in the FR,and reaction atmosphere in the AR,on mercury release characteristics,were investigated.The mercury speciation and release amount in the FR and AR under different conditions were further explored.The results indicate that most of the mercury in coal was released in the FR,while the rest of it was released in the AR.Hg0 was found to be the major species in the released mercury.The results also indicate that a higher temperature in the FR led to an increase in the total mercury release amount and a decrease in Hg0 proportion.However,a higher temperature in the AR resulted in a decrease in the total mercury release amount and Hg 0 proportion.The increase in the H2O/CO2 ratio of gasification mediums in the FR was beneficial for the increase in the total mercury release amount and Hg 0 proportion.A higher O2 concentration in reaction atmosphere in AR had a negligible effect on the total mercury release amount,but a positive effect on Hg0 oxidization. | Ling Ji Qianwen Wang Zhiyue Zhang Hao Wu Changsong Zhou Hongmin Yang | 2020 | Journal of Environmental Sciences2020，32，8： | 5 |
| 11 | The influence of intimacy on the ’iterative reactions’ during OX-ZEO process for aromatic production显示文摘The oxide-zeolite process provides a promising way for one-step production of aromatics from syngas,whereas the reasons for the dramatic effect of intimacy between oxide and zeolite in the composite catalyst on the product selectivity are still unclear. In order to explore the optimal intimacy and the essential influence factors, ZnCrOxcombined with ZSM-5 are employed to prepare the composite catalysts with different distances between the two components by changing the mixing methods. An aromatic selectivity of 74%(with CO conversion to be 16%) is achieved by the composite catalyst when the intimacy is in the range of nanometer. A so-called ‘iterative reactions’ mechanism of intermediates over oxides is then proposed and studied: the intermediate chemical can undergo a hydrogenation reaction on oxide.So the shorter the intermediates stay on oxide, the more of chance for C-C coupling takes place on zeolite to form aromatics. Moreover, the aero-environments of reaction is found to impact on the extent of iterative reaction as well. Therefore, when the intimacy between the two components changes, the extent of iterative reactions vary, resulting in alteration of product distribution. This work provides new insight in understanding the mechanisms during the complex process of OX-ZEO composite catalysis and sheds light to the design of a high-yield catalyst for synthetization of aromatics from syngas. | Xiaoli Yang Ting Sun Junguo Ma Xiong Su Ruifeng Wang Yaru Zhang Hongmin Duan Yanqiang Huang Tao Zhang | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 12 | Electrochemical Deposition and Nucleation of Aluminum on Tungsten in Aluminum Chloride-Sodium Chloride Melts显示文摘Electrochemical deposition and nucleation of aluminum on tungsten electrode from AlCl_3-NaCl melts were studied by cyclic voltammetry,chronopotentiometry and chronoamperometry.Cyclic voltammetry and chronopo- tentiometry analyses showed that Al(Ⅲ) was reduced at 200℃in two consecutive steps in an electrolyte of molten AlCl_3-NaCl system with a composition 52:48 molar ratio.The current-time characteristics of nucle- ation aluminum on tungsten showed a strong dependence on overpotentials.Chronoamperometry showed that the deposition process of aluminum on tungsten was controlled by an instantaneous nucleation with a hemispherical diffusion-controlled growth mechanism.The results could lead to a better understanding of the AlCl_3-NaCl melt system that has technological importance in electrodeposition of metals as well as in rechargeable batteries. | Zhaowen WANG Hongmin KAN Zhongning SHI Bingliang GAO Yungang BAN Xianwei HU | 2008 | Journal of Materials Science & Technology2008，24，6： | 4 |
| 13 | δ-Opioid receptor as a potential therapeutic target for ischemic stroke显示文摘Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the use of thrombolytic and clot removal medicine,significant numbers of stroke patients are still left out without option for treatment.In this review,we summarize recent research work on the activation ofδ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury.Moreover,as activation ofδ-opioid receptor by a non-peptidicδ-opioid receptor agonist also modulates the expression,maturation and processing of amyloid precursor protein andβ-secretase activity,the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed. | Kalpana Subedi Hongmin Wang | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 14 | Nitrogen-doped hierarchically porous carbon spheres for low concentration CO_(2) capture显示文摘Synthesis of spherical carbon beads with effective CO_2 capture capability is highly desirable for large scale application of CO2 sorption, but remains challenging. Herein, a facile and efficient strategy to prepare nitrogen-doped hierarchically porous carbon spheres was developed via co-pyrolyzation of poly(vinylidene chloride) and melamine in alginate gel beads. In this approach, melamine not only serves as the nitrogen precursor, but also acts as a template for the macropores structures. The nitrogen contents in the hierarchically porous carbon spheres reach a high level, ranging from 11.8 wt% to 14.7 wt%, as the melamine amount increases. Owing to the enriched nitrogen functionalities and the special hierarchical porous structure, the carbon spheres exhibit an outstanding CO_2 capture performance, with the dynamic capacity of as much as about 7 wt% and a separation factor about 49 at 25 °C in a gas mixture of CO_2/N_2(0.5:99.5, v/v). | Yang Li Jing Wang Sisi Fan Fanan Wang Zheng Shen Hongmin Duan Jinming Xu Yanqiang Huang | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 15 | Extraction mechanism of rare earths from chloride acidic solution with ammonium-bifunctionalized ionic liquid extractants显示文摘A series of ammonium-bifunctionalized ionic liquid extractants(ammonium-Bif-ILEs) combined with a number of anions, including carboxylic acids and 1,3-diketonates, have been prepared and studied in this report. Their extraction behavior and properties toward rare earth ions(REs(Ⅲ)) are systematically investigated in chloride media as a function of important parameters such as aqueous phase p H, salting-out agent concentrations, and extraction temperature. The separation performance of ammonium-Bif-ILEs toward REs(Ⅲ) are systematically discussed. The results demonstrate that ammonium-Bif-ILEs have a synergistic effect between the cation and anions in separation of REs(Ⅲ). The influences of different anions on separation factor(b) values are further studied. By comparison, ammonium-Bif-ILEs containing 1,3-diketonates have more potential applications in La(Ⅲ)/RE(Ⅲ) separation than those containing carboxylic acids. | Hualing Yang Ji Chen Wei Wang Hongmin Cui Wengang Liu Yu Liu | 2016 | Science China Chemistry2016，59，5： | 2 |
| 16 | Experimental Study on the Mechanical Performance of Mortise-Tenon Joints Reinforced with Replaceable Flat-Steel Jackets显示文摘The mortise-tenon joint is an important hub transmitting and distributing external loads for load-bearing components(beams,columns et al.)in the ancient-timber frame structure system.However,the conventional steel hoop reinforcement methods often insert wood screws into the timber components.When the reinforced joint rotates greatly,the anchoring failure of the screws will cause damage to the timber joint.To solve this problem,this study proposes a detachable and replaceable non-destructive flat-steel jacket reinforcement method in which horizontal flat steel is placed in the center of the joint,and the bolt is extended to the outside of the timber beam.Nine 1:3.52 scaled straight-tenon joint specimens were subjected to monotonic loading of beam ends,including three unreinforced reference joints,three joints with flat-steel jacket and three carbon fiber-reinforced plastic(CFRP)reinforced joints.The mechanical behaviors of the novel joints with flat-steel jacket were experimentally studied by comparing with those of the joints without strengthening and retrofitted with CFRP,based on the failure modes,the initial stiffness,the ultimate bearing capacity,and the moment-rotation relationship curves.Results indicated that the mortise-tenon joints reinforced with flat-steel jackets maintain the original semi-rigid properties of the unreinforced mortise-tenon joints and can effectively prevent the tenon from pulling out.The initial stiffness and ultimate bearing capacity were improved markedly.The column and beam of the reinforced joints remain intact providing the reference for the practical application of joints reinforcement.The mortisetenon joints reinforced with CFRP lose the semi-rigid properties of the unreinforced tenon-mortise joints.The joints reinforced with CFRP have the largest initial stiffness,while the unreinforced joints have the lowest stiffness.The initial stiffness of the proposed joint is in between the joints reinforced with CFRP and unreinforced joints.The ultimate bearing capacity of the joints reinforced with flat-steel jacket is larger than the other two joints,whereas the unreinforced joints have the lowest ultimate bearing capacity. | Hongmin Li Hongxing Qiu Wenbo Wang | 2021 | Journal of Renewable Materials2021，9，6： | 2 |
| 17 | Resuscitation of Septic Patients with Target-and-endpoint Protocol:A Retrospective Study from a Chinese Tertiary Hospital ICU显示文摘Objective To investigate the effect of target-and-endpoint protocol on the resuscitation of septic patients.Methods This is a retrospective study performed at the Peking Union Medical College Hospital Intensive Care Unit.We enrolled 545 septic patients who needed vasopressors on at least the first day of ICU admission.The general characteristics,blood lactate level,mean arterial pressure(MAP),central venous pressure(CVP)and saturation of central venous oxygen(ScvO2)at admission and 6,24 hours after admission were collected.The parameters at different time points were compared.Lactate clearance rate and in-hospital mortality were analyzed.Results The 6-hour lactate clearance rate was 21.6%(IQR,8.6%-39.0%),and in-hospital mortality was 9.4%.For patients with low CVP values(<8 mm Hg,1 mm Hg=0.133 kPa)at admission,CVP increased significantly at 6 hours after admission(5.4±1.6 mm Hg vs.7.7±2.6 mm Hg,P<0.001).For patients with low MAP(<75 mm Hg)at admission,the MAP values increased significantly at 6 hours(64.2±7.1 mm Hg vs.82.2±13.1 mm Hg,P<0.001).For patients with low ScvO2 value(<70%)at admission,the ScvO2 value increased significantly at 6 hours(61.9%±7.0%vs.71.9%±7.8%,P<0.001).No difference was found between the values at 6 hours and the corresponding values at 24 hours after admission.For patients with high CVP values(≥8 mm Hg)at admission,CVP decreased significantly at 6 hours(11.3±4.0 mm Hg vs.10.3±2.9 mm Hg,P<0.001).For patients with high MAP(≥75 mm Hg)at admission,the MAP values decreased significantly at 6 hours(94.2±13.9 mm Hg vs.89.4±11.4 mm Hg,P<0.001).For patients with high ScvO2 value(≥70%)at admission,the ScvO2 values decreased significantly at 6 hours(76.8%±4.2%vs.72.9%±7.3%,P<0.001).No difference was found between the values at 6 hours and the corresponding values at 24 hours.Conclusions This study suggested that in the resuscitation of sepsis and septic shock patients in the ICU,the target values did not need to be within the“normal range”recommended by early-goal directed therapy.The“target-and-endpoint”protocol,which aimed for personalized goals,deserves more consideration. | Hongmin Zhang Xiaoting Wang Qing Zhang Dawei Liu | 2018 | Chinese Medical Sciences Journal2018，33，3： | 2 |
| 18 | Resuscitation fluids as drugs:targeting the endothelial glycocalyx显示文摘Fluid resuscitation is an essential intervention in critically ill patients,and its ultimate goal is to restore tissue perfusion.Critical illnesses are often accompanied by glycocalyx degradation caused by inflammatory reactions,hypoperfusion,shock,and so forth,leading to disturbed microcirculatory perfusion and organ dysfunction.Therefore,maintaining or even restoring the glycocalyx integrity may be of high priority in the therapeutic strategy.Like drugs,however,different resuscitation fluids may have beneficial or harmful effects on the integrity of the glycocalyx.The purpose of this article is to review the effects of different resuscitation fluids on the glycocalyx.Many animal studies have shown that normal saline might be associated with glycocalyx degradation,but clinical studies have not confirmed this finding.Hydroxyethyl starch(HES),rather than other synthetic colloids,may restore the glycocalyx.However,the use of HES also leads to serious adverse events such as acute kidney injury and bleeding tendencies.Some studies have suggested that albumin may restore the glycocalyx,whereas others have suggested that balanced crystalloids might aggravate glycocalyx degradation.Notably,most studies did not correct the effects of the infusion rate or fluid volume;therefore,the results of using balanced crystalloids remain unclear.Moreover,mainly animal studies have suggested that plasma may protect and restore glycocalyx integrity,and this still requires confirmation by high-quality clinical studies. | Guangjian Wang Hongmin Zhang Dawei Liu Xiaoting Wang Chinese Critical Ultrasound Study Group | 2022 | Chinese Medical Journal2022，，2： | 2 |
| 19 | Preparation of porous nanorod polyaniline film and its high electrochemical capacitance performance显示文摘 | Jiguo Tu Jungang Hou Wei Wang Shuqiang Jiao Hongmin Zhu | 2011 | Synthetic Metals2011，，13： | 1 |
| 20 | Phase Evolution of BaTiO3 Nanoparticles:An Identification of BaTi20 IntermediatePhasein Calcined Stearic Acid Gel显示文摘 | Wang Liqiu Kang Hongmin Xue Dongfeng | 2008 | Journal of Physical Chemistry C2008，112，7： | 1 |
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