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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species显示文摘 | Chen-chun ZHONG Feng CHEN Jun-ling YANG Wei-wei JIA Li LI Chen CHENG Fei-fei DU Su-ping ZHANG Chengying XIE Na-ting ZHANG Olajide E OLALEYE Feng-qing WANG Fang XU Li-guang LOU Dong-ying CHEN Wei NIU Chuan LI | 2018 | Acta Pharmacologica Sinica2018，39，6： | 24 |
| 3 | Study of heteroserum-induced rat liver fibrosis model and its mechanism显示文摘StudyofheteroseruminducedratliverfibrosismodelanditsmechanismHUANGZhiGang,ZHAIWeiRong,ZHANGYueEandZHANGXiuRongSubjecthea... | HUANG Zhi Gang, ZHAI Wei Rong, ZHANG Yue E and ZHANG Xiu Rong | 1998 | World Journal of Gastroenterology1998，4，3： | 22 |
| 4 | Effects of acid deposition on terrestrial ecosystems and their rehabilitation strategies in China显示文摘South China has become the third largest region associated with acid deposition following Europe and North America, the area subject to damage by acid deposition increased from 1.75 million km 2 in 1985 to 2.8 million km 2 in 1993. Acid deposition has caused serious damage to ecosystem. Combined pollution of acid rain and SO 2 showed the obvious multiple effects on crops. Vegetable was more sensitive to acid deposition than foodstuff crops. Annual economic loss of crops due to acid deposition damage in eleven provinces of south China was 4.26 billion RMB Yuan. Acid deposition caused serious damage to forest. Annual economic loss of wood volume was about 1.8 billion RMB Yuan and forest ecological benefit loss 16.2 billion in eleven provinces of south China. Acid deposition in south China was typical “sulfuric acid type”. According to the thoughts of sustainable development, some strategies were brought forward as follows: (1) enhancing environmental management, specifying acid\|controlling region, controlling and abating the total emission amount of SO 2; (2) selecting practical energy technologies of clean coal, for example, cleansing and selecting coal, sulfur\|fixed\|type industrial briqutting, abating sulfur from waste gas and so on; (3) developing other energy sources to replace coal, including water electricity, atomic energy and the new energy such as solar energy, wind energy and so on; (4) in acid deposition region of south China, selecting acid\|resistant type of crop and tree to decrease agricultural losses, planting more green fertilizer crops, using organic fertilizers and liming, in order to improve buffer capacities of soil. | FENG Zong\|wei, MIAO Hong, ZHANG Fu\|zhu, HUANG Yi\|zong (Research Center for Eco\|Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. E\|mail: FZW@mail.rcees.ac.cn) | 2002 | Journal of Environmental Sciences2002，14，2： | 15 |
| 5 | Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice显示文摘 | Shi-Jiang Lu Feng Li Hong Yin Qiang Feng Erin A Kimbrel Eunsil Hahm Jonathan N Thon Wei Wang Joseph E ltaliano Jaehyung Cho Robert Lanza | 2011 | Cell Research2011，21，3： | 14 |
| 6 | Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer显示文摘AIM: To compare the efficacy of capecitabine and oxaliplatin (XELOX) with 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX6) in gastric cancer patients after D2 dissection. METHODS: Between May 2004 and June 2010, patients in our gastric cancer database who underwent D2 dissection for gastric cancer at the First Affiliated Hospital of Sun Yat-Sen University were retrospectively analyzed. A total of 896 patients were enrolled into this study according to the established inclusion and exclusion criteria. Of these patients, 214 received the XELOX regimen, 48 received FOLFOX6 therapy and 634 patients underwent surgery only without chemotherapy. Overall survival was compared among the three groups using Cox regression and propensity score matchedpair analyses. RESULTS: Patients in the XELOX and FOLFOX6 groups were younger at the time of treatment (median age 55.2 years; 51.2 years vs 58.9 years), had more undifferentiated tumors (70.1%; 70.8% vs 61.4%), and more lymph node metastases (80.8%; 83.3% vs 57.7%), respectively. Overall 5-year survival was 57.3% in the XELOX group which was higher than that (47.5%) in the surgery only group (P = 0.062) and that (34.5%) in the FOLFOX6 group (P = 0.022). Multivariate analysis showed that XELOX therapy was an independent prognostic factor (hazard ratio = 0.564, P < 0.001). After propensity score adjustment, XELOX significantly increased overall 5-year survival compared to surgery only (58.2% vs 44.2%, P = 0.025) but not compared to FOLFOX6 therapy (48.5% vs 42.7%, P = 0.685). The incidence of grade 3/4 adverse reactions was similar between the XELOX and FOLFOX6 groups, and more patients suffered from hand-foot syndrome in the XELOX group (P = 0.018). CONCLUSION: Adjuvant XELOX therapy is associated with better survival in patients after D2 dissection, but does not result in a greater survival benefit compared with FOLFOX6 therapy. | Ying Wu Zhe-Wei Wei Yu-Long He Roderich E Schwarz David D Smith Guang-Kai Xia Chang-Hua Zhang | 2013 | World Journal of Gastroenterology2013，19，21： | 14 |
| 7 | Intravenous formulation of Panax notoginseng root extract:human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions显示文摘XueShuanTong,a lyophilized extract of Panax notoginseng roots(Sanqi)for intravenous administration,is extensively used as add-on therapy in the treatment of ischemic heart and cerebrovascular diseases and comprises therapeutically active ginsenosides.Potential for XueShuanTong-drug interactions was determined;the investigation focused on cytochrome P450(CYP)3A induction and organic anion-transporting polypeptide(OATP)1 B inhibition.Ginsenosides considerably bioavailable for drug interactions were identifed by dosing XueShuanTong in human subjects and their interaction-related pharmacokinetics were determined.The CYP3A induction potential was determined by repeatedly dosing XueShuanTong for 15 days in human subjects and by treating cryopreserved human hepatocytes with circulating ginsenosides;midazolam served as a probe substrate.Joint inhibition of OATP1B by XueShuanTong ginsenosides was assessed in vitro,and the data were processed using the Chou-Talalay method,Samples were analyzed by liquid chromatography/mass spectrometry.Ginsenosides Rb1,Rd,and Rg1 and notoginsenoside R were the major circulating XueShuanTong compounds;their interaction-related pharmacokinetics comprised compound dose-dependent levels of systemic exposure and,for ginsenosides Rb,and Rd,long terminal hal-lives(32-57 and 58-307 h,respectively)and low unbound fractions in plasma(0.8%-2.9%and 0.4%-3.0%,respectively).Dosing XueShuanTong did not induce CYP3A.Based on the pharmacokinetics and inhibitory potency of the ginsenosides,XueShuanTong was predicted to have high potential for OATP1B3-mediated drug interactions(attributed chiefly to ginsenoside Rb,)suggesting the need for further model-based determination of the interaction potential for XueShuanTong and,if necessary,a clinical drug interaction study.Increased awareness of ginsenosides'pharmacokinetics and XueShuanTong-drug interaction potential will help ensure the safe use of XueShuanTong and coadministered synthetic drugs. | Salisa Pintusophon Wei Niu Xiao-na Duan Olajide E Olaleye Yu-hong Huang Feng-qing Wang Yan-fen Li Jun-ling Yang Chuan Li | 2019 | Acta Pharmacologica Sinica2019，40，10： | 13 |
| 8 | Down-Regulation of CD44 Contributes to the Differentiation of HL-60 Cells Induced by ATRA or HMBA显示文摘CD44 is highly expressed in human acute myeloid leukemia (AML) cells. Some experiments had shown that it was possible to reverse differentiation blockage in AML cells by CD44 ligation with specific antibodies, indicating that CD44 was closely related to the differentiation of leukemia cells. The differentiation of acute promyelocytic leukemia cell line HL-60 cells could be induced by all trans-retinoic acid (ATRA) and hexamethylene bisacetamide (HMBA), but so far the mechanism was not demonstrated clearly. In the present study, we investigated whether ATRA or HMBA induced the growth arrest of HL-60 cells by down-regulating the expression of CD44. The results indicated that the proliferation of HL-60 cells was obviously inhibited and the differentiation was induced by both ATRA and HMBA. The decreased expression of CD44 and cyclin E mRNA, and the increased expression of p27 and p21 at mRNA levels were observed. Furthermore, there was a negative correlation between the expression of CD44 and p27. It was concluded that ATRA and HMBA played a role in the differentiation induction of HL-60 cells, which was mediated by the down-regulation of CD44, accompanied by down-regulation of cyclin E, and up-regulation of p27 and p21 mRNA. | Jianing Liu1, Gaofeng Bi1, Pei’e Wen1, Weihua Yang1, Xia Ren1, Tianhua Tang1, Chao Xie1, Wei Dong1 and Guosheng Jiang1, 21Department of Hemato-oncology, Institute of Basic Medicine, Shandong Academy of Medical Sciences Key Laboratory for Modern Medicine and Technology of Shandong Province Key Medical Laboratory for Tumor Immunology & Traditional Chinese Medicine Immunology of Shandong Province, Jinan, Shandong 250062, China | 2007 | Cellular & Molecular Immunology2007，4，1： | 12 |
| 9 | Grassland degradation in Northern Tibet based on remote sensing data显示文摘This study selected vegetation cover as the main evaluation index, calculated the grassland degradation index (GDI) and established the remote sensing monitoring and evaluation system for grassland degradation in Northern Tibet, according to the National Standard (GB19377-2003), based on the remote sensing data such as NDVI data derived from NOAA/AVHRR with a spatial resolution of 8 km of 1981-2000, from SPOT/VGT with a spatial resolution of 1 km of 2001 and from MODIS with a spatial resolution of 0.25 km of 2002-2004 respectively in this area, in combination with the actual condition of grassland degradation. The grassland degradation processes and their responses to climate change during 1981-2004 were discussed and analyzed in this paper. The result indicated that grassland degradation in Northern Tibet is very serious, and the mean value of GDI in recent 20 years is 2.54 which belongs to the serious degradation grade. From 1981 to 2004, the GDI fluctuated distinctly with great interannual variations in the proportion of degradation degree and GDI but the general tendency turned to severe-grade during this period with the grassland degradation grade changed from light degraded to serious degraded in Northern Tibet. The extremely serious degraded and serious degraded grassland occupied 1.7% and 8.0% of the study area, the moderate and light degraded grassland accounted for 13.2% and 27.9% respectively, and un-degraded grassland occupied 49.2% of the total grassland area in 2004. The grassland degradation was serious, especially in the conjunctive area of Naqu, Biru and Jiali counties, the headstream of the Yangtze River lying in the Galadandong snow mountain and glaciers, the area along the Qinghai-Tibet highway and railway, and areas around the Tanggula and Nianqingtanggula snow mountains and glaciers. So the snow mountains and glaciers as well as their adjacent areas in Northern Tibet were sensitive to climate change and the areas along the vital communication line with frequent human activities experienced relatively serious grassland degradation. | GAO Qingzhu LI Yu'e WAN Yunfan LIN Erda XIONG Wei JIANGCUN Wangzha WANG Baoshan LI Wenfu | 2006 | Journal of Geographical Sciences2006，16，2： | 10 |
| 10 | Pore throat characteristics of tight sandstone of Yanchang Formation in eastern Gansu,Ordos Basin显示文摘An important factor to evaluate reservoir quality is the pore-throat size.However,the strong heterogeneity makes it difficult to characterize the pore-throat distribution in tight reservoirs.The field emission scanning electron microscope(FESEM),high pressure mercury injection and rate-controlled mercury injection are used to investigate the pore-throat size distribution in tight sandstone reservoirs of Member 7 of the Yanchang Formation in eastern Gansu,Ordos Basin,and studies of the pore throat size controlling on physical property of the tight sandstone reservoirs are also carried out.The result shows that the pore type is mainly dominated by the residual intergranular pore,dissolution pore,micropore and a few micro-fractures;the high-pressure mercury injection experiment indicates that the pore-throat size ranges from 0.0148 μm to 40mm,the pore throat more than 1 mm is less;the ratecontrolled mercury injection experiment reveals that for samples with different physical properties,the pore radius mainly varies from 80 μm to 350 μm;the throat radius exhibits the strong heterogeneity,and is from 0.12 μm to 30μm;the pore-throat size can be effectively characterized by combination of high-pressure and rate-controlled mercury injections,and it varies from 0.0148 μm to 350 μm.The permeability is mainly controlled by the large pore throat(>R_(50))which accounts for a small proportion;in the tight sandstone with the permeability greater than 0.1 mD,the permeability is mainly controlled by the micropore and mesopore;in the tight sandstone with the permeability smaller than 0.1 mD,the permeability is mainly controlled by the nanopore and micropore;the proportion of small pore throat increases with reduction of permeability,it is important that the small pore throat influences the reservoir storage property though its effect on permeability are small. | Hao Wu Chunlin Zhang Youliang Ji Rui'e Liu Shang Cao Sheng Chen Yunzhao Zhang Ye Wang Wei Du Gang Liu | 2018 | Petroleum Research2018，3，1： | 7 |
| 11 | Combined remediation of DDT congeners and cadmium in soil by Sphingobacterium sp.D-6 and Sedum alfredii Hance显示文摘Combined pollution of 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane (DDT) and cadmium (Cd) in agricultural soils is of great concern because they present serious risk to food security and human health.In order to develop a cost-effective and safe method for the removal of DDTs and Cd in soil,combined remediation of DDTs and Cd in soil by Sphingobacterium sp.D-6 and the hyperaccumulator,Sedum alfredii Hance was investigated.After treatment for 210 days,the degradation half-lives of DDTs in soils treated by strain D-6 decreased by 8.1% to 68.0% compared with those in the controls.The inoculation of strain D-6 into soil decreased the uptake of DDTs by pak choi and S.alfredii.The shoots/roots ratios of S.alfredii for the Cd accumulation ranged from 12.32 to 21.75.The Cd concentration in soil decreased to 65.8%-71.8% for S.alfredii treatment and 14.1%-58.2% for S.alfredii and strain D-6 combined treatment,respectively,compared with that in the control.The population size of the DDTs-degrading strain,Simpson index (1/D) and soil respiratory rate decreased in the early stage of treatment and then gradually increased,ultimately recovering to or exceeding the initial level.The results indicated that synchronous incorporation of strain D-6 and S.alfredii into soil was found to significantly (p 0.05) enhance the degradation of DDTs in soil and the hyperaccumulation of Cd in S.alfredii.It was concluded that strain D-6 and S.alfredii could be used successfully to control DDTs and Cd in contaminated soil. | Hua Fang Wei Zhou Zhengya Cao Feifan Tang Dandan Wang Kailin Liu Xiangwei Wu Xiao'e Yang Yongge Sun Yunlong Yu | 2012 | Journal of Environmental Sciences2012，24，6： | 5 |
| 12 | A comparison of surgical efficacy between a 1.8-mm microincision and 3.2-mm and 5.5-mm incisions for phacoemulsification显示文摘Phacoemulsification is a commonly used surgical method in cataract surgery. This paper observes and compares the surgical efficacy of three incisions of different length for phacoemulsification to identify the optimal method for cataract surgery. Ninety patients were enrolled in the present study and divided into three groups. The 1.8-mm group received Bausch & Lomb MI60 foldable intraocular lens(IOL) implantation(n=30), 3.2-mm group received Bausch & Lomb Akreos AO foldable lens implantation(n=30), and 5.5-mm group received Alcon TYPE 05 rigid IOL implantation(n=30). Visual acuity, Oculyzer-based anterior segment analysis, and corneal endothelial cell count before surgery, and 3, 7, 30, and 90 d after surgery were recorded and compared. Pseudophakic accommodation three days, one week, one month, and three months after surgery was determined. Intraoperative ultrasound time and ultrasonic energy were recorded. It was finally concluded that for phacoemulsification with the same phaco tip, a 1.8-mm microincision can lead to quicker recovery of visual acuity, more stable astigmatism, and higher pseudophakic accommodation than conventional incision. | E Song Xin Li Ming-Chao Bi Hua Ren Dan Wang Zhi-Hua Cui Wei Yang Hui Shi Ya-Bin Sun | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 4 |
| 13 | Genome-wide association mapping of vitamins B1 and B2 in common wheat显示文摘Vitamin B is essential for maintaining normal life activities in humans and animals who have to intake the microelement from the outside, especially from cereal products. In the present study 166 Chinese and foreign wheat cultivars planted in two environments were characterized for variation in vitamin B1 and B2 contents. A genome-wide association study(GWAS) using the wheat 90 K SNP assay identified 17 loci for vitamin B1 and 7 for vitamin B2 contents. Linear regression analysis showed a significantly positive correlation of the number of favorable alleles with vitamin B1 and B2 contents. Marker-trait associations(MTAs) at IWB43809(6AS, 0cM) and IWB69903(6AS, 13cM) were new and stable, and significantly associated with vitamin B1 content across two environments. The loci identified in this study and associated SNP markers could be used for improvement of vitamin B1 and B2 contents to obtain superior quality along with grain yield in wheat. | Jieyun Li Jindong Liu Wei'e Wen Pingzhi Zhang Yingxiu Wan Xianchun Xia Yan Zhang Zhonghu He | 2018 | The Crop Journal2018，6，3： | 4 |
| 14 | Characterization of the Yeast Transcriptome显示文摘 | Victor E Velculescu Lin Zhang Wei Zhou Jacob Vogelstein Munira A Basrai Douglas E Bassett Phil Hieter Bert Vogelstein Kenneth W Kinzler | 1997 | Cell1997，，2： | 4 |
| 15 | Effect of garlic and garlic-green tea mixture on serum lipids in MNNG-induced experimental gastriccarcinoma and precancerous lesion显示文摘EfectofgarlicandgarlicgreenteamixtureonserumlipidsinMNNGinducedexperimentalgastriccarcinomaandprecancerouslesionSUQi,LUOZh... | SU Qi, LUO Zhao Yang, TENG Hua, YUN Wei Dong, Li Yi Qing and HE Xin E Institute of Oncology, Hengyang Medical College, Hengyang 421001, Hunan Province, China | 1998 | World Journal of Gastroenterology1998，4，1： | 4 |
| 16 | Highly sensitive solar-blind deep ultraviolet photodetector based on graphene/PtSe_(2)/β-Ga_(2)O_(3)2D/3D Schottky junction with ultrafast speed显示文摘There is an emerging need for high-sensitivity solar-blind deep ultraviolet(DUV)photodetectors with an ultra-fast response speed.Although nanoscale devices based on Ga_(2)O_(3)nanostructures have been developed,their practical applications are greatly limited by their slow response speed as well as low specific detectivity.Here,the successful fabrication of two-/three-dimensional(2D/3D)graphene(Gr)/PtSe2/β-Ga_(2)O_(3)Schottky junction devices for high-sensitivity solar-blind DUV photodetectors is demonstrated.Benefitting from the high-quality 2D/3D Schottky junction,the vertically stacked structure,and the superior-quality transparent graphene electrode for effective carrier collection,the photodetector is highly sensitive to DUV light illumination and achieves a high responsivity of 76.2 mA/W,a large on/off current ratio of~105,along with an ultra-high ultraviolet(UV)/visible rejection ratio of 1.8×104.More importantly,it has an ultra-fast response time of 12µs and a remarkable specific detectivity of~1013 Jones.Finally,an excellent DUV imaging capability has been identified based on the Gr/PtSe2/β-Ga_(2)O_(3)Schottky junction photodetector,demonstrating its great potential application in DUV imaging systems. | Di Wu Zhihui Zhao Wei Lu Lukas Rogée Longhui Zeng Pei Lin Zhifeng Shi Yongtao Tian Xinjian Li Yuen Hong Tsang | 2021 | Nano Research2021，14，6： | 4 |
| 17 | Differently sized cuckoos pose different threats to hosts显示文摘Hole-nesting tits Parus spp.have been classified as'unsuitable'hosts for cuckoo parasitism because cuckoos cannot enter a cavity if the entrance is too small.However,Chinese tits could re-ject alien eggs and egg ejection rate increased with the local diversity of parasitic cuckoo species.Antiparasitic behavior among Chinese tits may have evolved due to greater size variation among sympatric cuckoo species.This raises the question of whether differently sized parasitic cuckoos pose different threats to Chinese tits.A green-backed tit Parus monticolus population that is sym-patric with Asian emerald cuckoo Chrysococcyx maculatus(eme-cuckoo,small-sized parasite)and common cuckoo Cuculus canorus(com-cuckoo,large-sized parasite),and a cinereous tit P.cinereus population that is only sympatric with com-cuckoo were chosen as study organisms.We observed behavioral response and recorded alarm calls of the 2 tit species to eme-cuckoo,com-cuckoo,chipmunk Tamias sibiricus(a nest predator)and dove Streptopelia orientalis(a harm-less control),and subsequently played back alarm calls to conspecific incubating females.In dummy experiments,both tit species performed intense response behavior to chipmunk,but rarely responded strongly to the 3 avian species.In playback experiments,both tit species responded strongly to conspecific chipmunk alarm calls,but rarely responded to dove alarm calls.The inten-sity of response of incubating female green-backed tits to eme-cuckoo and com-cuckoo alarm calls were similar to that of chipmunk alarm calls,while the intensity to eme-cuckoo alarm calls was higher than the intensity to dove alarm calls which was similar to that of com-cuckoo alarm calls.In contrast,few female cinereous tits responded to eme-cuckoo and com-cuckoo alarm calls.These findings indicated that the threat level of eme-cuckoo was slightly greater than that of com-cuckoo for sympatric green-backed tits,but not for allopatric cinereous tits. | Jiangping YU Mingju E Wei SUN Wei LIANG Haitao WANG Anders Pape MΦLLER | 2020 | Current Zoology2020，66，3： | 4 |
| 18 | Chlorophyll Fluorescence and Photosynthesis: The Basics显示文摘 | G H Krause E Weis | 1991 | Annual Review of Plant Physiology and Plant Molecular Biology1991，，： | 4 |
| 19 | Ecological rebuilding and land reclamation in surface mines in Shanxi Province, China显示文摘It is well known that the mining industry produces a large amount of derelict land, and causes pollution of water loss and soil erosion as well as other environmental damage in China. As land is under pressure in China, it is now policy to restore or reclaim land despoiled by mining, the aim being to develop sustainable and healthy arable land ecosystems. This paper outlines the principles and approaches of ecological restoration, which have been adopted in Shanxi Province with reference to three typical surface mines. In the research, the principles of ecological engineering and ecological succession are considered as the critical theories of ecological restoration in mine degraded land. Meanwhile, the paper made a comparative research on main links of ecological rebuilding in three surface mines in Shanxi Province, which include new land construction, treatment of toxic substances, control of soil erosion, fertility management, irrigation, ecological planning and the establishment of legislation systems. As the research demonstrated, for successful restoration, new land construction is the fundamental framework, but it must be integrated with ecological engineering including ecological planning, the control of soil erosion and vegetation establishment and ecosystem creation in order to optimise land productivity and soil fertility. In addition, the establishment of the legislation systems and organization of administration are also indispensable aspects of ecological rebuilding in mined land. | MIAO Ze wei 1, BAI Zhong ke 2, GAO Lin 1 (1. Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China E\|mail: miaozewei@yahoo.com 2. Department of Soil Science, Shanxi Agricultural University Taigu, 03 | 2000 | Journal of Environmental Sciences2000，12，4： | 3 |
| 20 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
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