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| 1 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 2 | Development and validation of a nomogram for predicting the survival of patients with non-metastatic nasopharyngeal carcinoma after curative treatment显示文摘Background: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival(OS) of non-metastatic nasopharyngeal carcinoma(NPC) patients after curative treatments.Methods: We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003. The clinical data of a separate cohort of 464 patients who received intensity-modulated radiation therapy(IMRT) between 2001 and 2010 were also retrieved to examine the extensibility of the model. Cox regression analysis was used to identify the prognostic factors for building the nomogram. The predictive accuracy and discriminative ability were measured using the concordance index(c-index).Results: We identiied and incorporated 12 independent clinical factors into the nomogram. The calibration curves showed that the prediction of OS was in good agreement with the actual observation in the internal validation set and IMRT cohort. The c-index of the nomogram was statistically higher than that of the 7th edition TNM staging system for predicting the survival in both the primary cohort(0.69 vs. 0.62) and the IMRT cohort(0.67 vs. 0.63).Conclusion: We developed and validated a novel nomogram that outperformed the TNM staging system in predicting the OS of non-metastatic NPC patients who underwent curative therapy. | Wenhua Liang Guanzhu Shen Yaxiong Zhang Gang Chen Xuan Wu Yang Li Anchuan Li Shiyang Kang Xi Yuan Xue Hou Peiyu Huang Yan Huang Hongyun Zhao Ying Tian Chong Zhao Li Zhang | 2016 | Chinese Journal of Cancer2016，35，12： | 6 |
| 3 | MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1显示文摘糖尿病和许多另外的新陈代谢症候群是仔细与肥胖有关。揭示胖免职的内在的机制,越来越多的研究在 adipocytes 开发期间正在集中于 miRNAs 的功能。以前的研究 haveproved 那出 miR-15a/b 戏在多重生理的过程的重要角色;然而,他们的功能在 adipogenesisremain 期间不清楚。揭示这,我们在猪的 pre-adipocyte 在 adipogenesis 期间检测了 miR-15a/b 的表示侧面,并且发现那他们层次在 adipocyte 区别的早阶段增加了并且在白天 4 .Moreover 以后落下的表示,在猪的 pre-adipocytes 的 miR-15a/b 的在表示上支持了 adipocyte 区别, miR-15a/b 的类脂化合物 accumulation.Target 基因被预言并且检验,它表明 Forkhead 盒子蛋白质 O1 ( FoxO1 )是目标 geneof miR-15a/b 。表示水平由 miR-15a/b 在表示上引起了的 FoxO1 的抑制在 adipogenesis.Thus 上有积极效果,我们断定 miR-15a/b 经由镇压在猪的 pre-adipocyte 支持 adipogenesis FoxO1。 | Peiyue Dong Yin Mai Zhenyu Zhang Lin Mi Guofang Wu Guiyan Chu Gongshe Yang Shiduo Sun | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 6 |
| 4 | Heterogeneously integrated,superconducting silicon-photonic platform for measurementdevice-independent quantum key distribution显示文摘Integrated photonics provides a route to both miniaturization of quantum key distribution(QKD)devices and enhancing their performance.A key element for achieving discrete-variable QKD is a singlephoton detector.It is highly desirable to integrate detectors onto a photonic chip to enable the realization of practical and scalable quantum networks.We realize a heterogeneously integrated,superconducting silicon-photonic chip.Harnessing the unique high-speed feature of our optical waveguide-integrated superconducting detector,we perform the first optimal Bell-state measurement(BSM)of time-bin encoded qubits generated from two independent lasers.The optimal BSM enables an increased key rate of measurement-device-independent QKD(MDI-QKD),which is immune to all attacks against the detection system and hence provides the basis for a QKD network with untrusted relays.Together with the timemultiplexed technique,we have enhanced the sifted key rate by almost one order of magnitude.With a 125-MHz clock rate,we obtain a secure key rate of 6.166 kbps over 24.0 dB loss,which is comparable to the state-of-the-art MDI-QKD experimental results with a GHz clock rate.Combined with integrated QKD transmitters,a scalable,chip-based,and cost-effective QKD network should become realizable in the near future. | Xiaodong Zheng Peiyu Zhang Renyou Ge Liangliang Lu Guanglong He Qi Chen Fangchao Qu Labao Zhang Xinlun Cai Yanqing Lu Shining Zhu Peiheng Wu Xiao-Song Ma | 2021 | Advanced Photonics2021，3，5： | 5 |
| 5 | Differential expression of meat quality and intramuscular fat deposition related genes in Hanjiang black pigs显示文摘 | Guofang Wu Xin'e Shi Jiping Zhou Lei Wang Yuefeng Li Chengchuang Song Aoqi Xiang Peiyue Dong Shiduo Sun | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 3 |
| 6 | Exponential time differencing based efficient SC-PML for RCS simulation显示文摘To efficiently simulate and calculate the radar cross section(RCS) related electromagnetic problems by employing the finite-difference time-domain(FDTD) algorithm, an efficient stretched coordinate perfectly matched layer(ESC-PML) based upon the exponential time differencing(ETD) method is proposed.The proposed implementation can not only reduce the number of auxiliary variables in the SC-PML regions but also maintain the ability of the original SC-PML in terms of the absorbing performance. Compared with the other existed algorithms, the ETDFDTD method shows the least memory consumption resulting in the computational efficiency. The effectiveness and efficiency of the proposed ESC-PML scheme is verified through the RCS relevant problems including the perfect E conductor(PEC) sphere model and the patch antenna model. The results indicate that the proposed scheme has the advantages of the ETD-FDTD method and ESC-PML scheme in terms of high computational efficiency and considerable computational accuracy. | NIU Liqiang XIE Yongjun JIANG Haolin WU Peiyu | 2020 | Journal of Systems Engineering and Electronics2020，31，4： | 3 |
| 7 | lncRNAX-inactive-specific transcript is a potential biomarker related to changes in CD4+T cell levels in systemic lupus erythematosus显示文摘Background:Systemic lupus erythematosus(SLE)is a particularly heterogeneous autoimmune disease.This study was intended to clarify the correlations between X-inactive-specific transcript(XIST)expression and SLE clinical features and the contribution of XIST to SLE pathogenesis at the transcriptome level.Methods:XIST expression in 79 SLE patients,14 rheumatoid arthritis patients,and 23 healthy controls was determined by quantitative polymerase chain reaction.The Benjamini and Hochberg adjusted method and multivariate linear regression were applied to correct p-values and adjust confounding factors,respectively.Bioinformatic methods were used to explore the function and regulatory mechanism of XIST.Results:XIST was significantly elevated in peripheral blood mononuclear cells and CD4^(+)T cells from SLE patients compared with the levels in healthy controls and had potential diagnostic value for SLE.Notably,XIST expression was positively correlated with the SLE disease activity index and significantly reduced after effective treatment.Moreover,SLE patients with high XIST expression tended to have elevated levels of CD4^(+)T cells,but reduced levels of NK cells.Bioinformatic analyses suggested that XIST may regulate OLFM4 and CEACAM8 expression by acting as a spongy body for miR-20a,miR-92a,miR-106a,and miR-449a.Furthermore,CEACAM8 was significantly upregulated in CD4^(+)T cells from SLE patients and significantly positively correlated with XIST expression.Conclusions:lncRNA XIST,a potential diagnostic and therapeutic biomarker for SLE,is involved in the change of immune cell balance in the peripheral blood of SLE patients.Mechanistically,XIST may regulate the miR-17-92-CEACAM8 axis to achieve this in CD4^(+)T cells. | Qi Cheng Xin Chen Jieying Xu Mo Chen Peiyu Zhang Huaxiang Wu Yan Du | 2022 | Rheumatology & Autoimmunity2022，2，3： | 2 |
| 8 | Author correction to‘Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsisinduced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice'[Acta Pharmaceutica Sinica B 13(2023)1164-1179]显示文摘The authors regret that there were some picture errors in Fig.7C and Supporting Information Fig.S10B owing to the negligence of the picture typesetting and careless mistakes.In Fig.7C,the H&E picture of PBS+Lipo+CLP group was the inverted picture of CLP group in Fig.5G.In Fig.7C,the H&E picture of Clo-Lipo+CLP group was zoom-in picture of L johnsoni+CLP group in Fig.8F.In Fig.SI0B,the H&E picture of ileum in CLP group was zoom-in picture of Anti-IL-10R+CLP group in Fig.S11C.The authors revise the H&E picture of liver in PBS+Lipo+CLP group and the H&E picture of liver in Clo-Lipo+CLP group in Fig.7C.Also,the H&E picture of ileum in CLP group of Fig.S10B have been revised.The correct figures are presented as below. | Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine Lai-Han Leung | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 2 |
| 9 | A Broadband45°Dual-Polarized Multiple-Input Multiple-Output Antenna for 5G Base Stations with Extra Decoupling Elements显示文摘A dual-polarized multiple-input multiple-output(MIMO)antenna is proposed for 5G base stations.Each antenna element consists of two orthogonally placed fan-shaped dipole elements and45°dual-polarized feed-ing structures are used to achieve broadband operation.The resonant frequency of the array element is from 3.3 to 4.2 GHz,which covers the mainstream spectrum allocations of 5G mobile networks.H-shaped coupling elements are used to improve the isolation between the neighboring antenna elements and the mutual coupling is reduced by over 4 dB.The envelope correlation of a 2×2 array is provided for verification. | Qi Wu Peiyu Liang Xiaoming Chen | 2018 | Journal of Communications and Information Networks2018，3，1： | 2 |
| 10 | On Quasi α- semicommutative rings 显示文摘 | ZHANG Peiyu WU Jun DING Tingting | 2013 | Journal of Hangzhou Normal Uni- versity (Natural Science Edition )2013，12，5： | 1 |
| 11 | Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro显示文摘With the increasing incidence of depression worldwide,antidepressant medications are commonly used in males of reproductive age for long-term treatment of depression,as well as other disorders[1].Antidepressants are known to be associated with sexual side effects[2],such as decreased libido and impotence.Their effects on semen parameters and other markers of male fertility have been less thoroughly described,such as sperm motility and fertilization ability.Therefore,it is critical to determine the potential toxic effects of antidepressants on reproductive organs.A recent study systemically determined the effect of different drugs on the telomere-related DNA damage response of germ cells[3].In addition,another study showed that mirtazapine has less toxic effects than amitriptyline and other drugs[4].However,these studies used germ cell lines to determine the phenotype,which limits their potential translational value in toxicity studies in humans.Given the widespread and often long-term use of antidepressant medications,there is an urgent need for further data regarding their impact on semen quality and subsequent male fertility. | Sixian Wu Xiaoliang Li Peiyu Li Tongtong Li Gelin Huang Qun Sun Andras Dinnyés Lijun Shang Wenming Xu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 12 | Versioning and piracy control for digital infor- mation goods显示文摘 | Wu Shinyi Chen Peiyu | 2008 | Operation Research2008，56，1： | 1 |
| 13 | Effects of larval host plants on over-wintering preparedness and survival of the cotton bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)显示文摘 | Zhudong Liu Peiyu Gong Kujun Wu Wei Wei Jianghua Sun Dianmo Li | 2007 | Journal of Insect Physiology2007，，10： | 1 |
| 14 | Accelerate Researchon Land Creation显示文摘 | Peiyue Li Hui Qian Jianhua Wu | 2014 | Nature2014，，510： | 1 |
| 15 | Unsplit-field higher-order nearly PML for arbitrary media in EM simulation显示文摘An unsplit-field higher order nearly perfectly matched layer(NPML)based on the auxiliary differential equation approach is introduced in three-dimensional finite-difference timedomain lattices.The proposed scheme has the advantage of both the NPML scheme and the higher order concept in terms of the improved absorbing performance and considerable computational efficiency.By incorporating with the generalized material independent concept,the proposed implementation is indepen dent of the material’s type.Thus,it has the advantages of terminating arbitrary media without changing the updated equations in the PML regions.Its effectiveness and efficiency is further demonstrated through numerical examples. | JIANG Haolin XIE Yongjun WU Peiyu ZHANG Jianfeng NIU Liqiang | 2021 | Journal of Systems Engineering and Electronics2021，32，1： | 1 |
| 16 | Analysis of regional temperature variation characteristics in the Lancang River Basin in southwestern China显示文摘 | Xuan Wang Peiyu Liang Chunhui Li Feifei Wu | 2013 | Quaternary International2013，，： | 1 |
| 17 | Groundwater Quality Assessment Based on Rough Sets Attribute Reduction and TOPSIS Method in a Semi-arid Area, China显示文摘 | Li Peiyue Wu Jianhua Qian Hui | 2012 | Environmental Monitoring and Assess- ment2012，184，8： | 1 |
| 18 | Groundwater quality assessment based on rough sets attribute reduction and TOPSIS method in a semi-arid area, China 显示文摘 | Li Peiyue Wu Jianhua Qian Hui | 2012 | Environmental Monitoring and Assessment2012，184，8： | 1 |
| 19 | Groundwater quality assessment based on entropy weighted osculating value method显示文摘 | LI Peiyue Wu Jianhua Qian Hui | 2010 | International Journal of Environmental Sciences2010，1，4： | 1 |
| 20 | A service oriented implementation of distributed status monitoring and fault diagnosis systems显示文摘 | WANG Lei LI Peiyu WU Zhaohui | 2005 | Lecture Notes in Computer Science2005，3516，： | 1 |
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