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| 1 | Phosphorus speciation in the sediment profile of Lake Erhai, southwestern China: Fractionation and ^(31)P NMR显示文摘The distribution characteristics of phosphorus(P) forms in the sediment profile of Lake Erhai,in southwestern China has been investigated by sequential extraction and 31P nuclear magnetic resonance spectroscopy(NMR) of NaOH extracts to understand P dynamics and its potential contribution to lake eutrophication.Contents of P fractions varied in the order of NH4Cl extracted P(NH4ClP) < bicarbonate-dithionite extracted P(BD-P) < HCl-P,Residual-P < NaOH extracted P(NaOH-P).The highly available NH4Cl-P represented less than 1% of total P(TP).BD-P and NaOH extracted reactive P(NaOH-rP) averaged 39%,while the ratio of Fe/P was higher than 15,indicating low P release from the sediments under permanent oxic condition.The less bio-available HCl-P,NaOH extracted nonreactive P(NaOH-nrP) and residual-P contributed 61% of TP.Regression analysis revealed that BD-P,NaOH-rP and HCl-P were positively correlated with the contents of Fe and Mn,Al and Fe,and Ca,respectively.The investigation of P compound groups in NaOH extracts by 31 P NMR showed that ortho-P and monoester-P were the largest two constituents of the P pool,followed by diester-P,phosphonate and pyro-P.A comparison of vertical variations of P groups in the sediment profile suggested that these compounds were involved in the P recycling to different extents in Lake Erhai.In particular,the lake exhibits high potential for labile P release from the surface sediments,which should be taken into consideration even after the outsourced P runoff ceased. | Runyu Zhang Liying Wang Fengchang Wu Baoan Song | 2013 | Journal of Environmental Sciences2013，25，6： | 7 |
| 2 | The cellular labeling and pH-sensitive responsive-drug release of celastrol in cancer cells based on Cys-CdTe QDs显示文摘As one of the active compounds derived from Traditional Chinese Medicine,Celastrol(CSL)had cytotoxicity for human leukemia cancer cells K562 and its multidrug-resistant cell line K562/A02.Here,we introduced cysteamine-modified CdTe QDs as the labeling and drug carrier into CSL research and found that the self-assembly and conjugation of anticancer molecular CSL with the Cys-CdTe QDs could significantly increase the drug’s cytotoxicity for K562 cells.More important,these CSL-Cys-CdTe nanocomposites could overcome the multidrug resistance of K562/A02 cells and efficiently inhibit the cancer cell proliferation by realizing the pH-sensitive responsive release of CSL to cancer cells.The enhanced cytotoxicity was caused by the increase of the G2/M phase arrest for K562/A02 cells as well as for K562 cells.Cys-CdTe QDs can readily bind on the cell plasma membranes and be internalized into cancer cells to trace and detect human leukemia cancer cells in real time.In addition,these Cys-CdTe QDs can facilitate the inhibition of the multidrug resistance of K562/A02 cells and readily induce apoptosis.As a good photosensitizer for the therapy,labeling,and tracing of cancer cells,the combination of CSL with Cys-CdTe QDs can optimize the use of and a new potential therapy method for CSL and yield new tools to explore the mechanisms of active compounds from Traditional Chinese Medicine. | LI JingYuan SHI LiXin SHAO YiXiang SELKE Matthias CHEN BaoAn JIANG Hui WANG XueMei | 2014 | Science China Chemistry2014，57，6： | 6 |
| 3 | Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives显示文摘 | Jixiang Chen Xiuhai Gan Chongfen Yi Shaobo Wang Yuyuan Yang Fangcheng He Deyu Hu Baoan Song | 2018 | Chinese Journal of Chemistry2018，36，10： | 5 |
| 4 | Effects of antioxidants on homocysteine thiolactone-induced apoptosis in human umbilical vein endothelial cells显示文摘Background and objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine thiolactone (HcyT), one of the homocysteine metabolites in vivo, is toxic both in vivo and in vitro. The aim of this study was to investigate the effect of HcyT on apoptotic damage in human umbilical vein endothelial cells (HUVECs) and the role of antioxidants in the reduction of HcyT-induced apoptosis. Methods HUVECs were cultured in DMEM supplemented with 20% heat inactivated fetal bovine serum cell cultures were maintained in a humidified 5% CO2 atmosphere at 37 ℃. Cytotoxicity was determined by MTT assay,which consists of hypodiploid cells with propidium iodide labeling and intracellular reactive oxygen species levels using 2',7'-dichlorofluorescein diacetate as the probe by flow cytometry. Results HcyT (250-2000μM) induced HUVECs apoptosis in a time- and concentration-dependent manner. Reactive oxygen species levels rose in response to increasing HcyT concentrations at 24-h incubation.The reduction of cell apoptosis by N-acetylcysteine, vitamin E, or pyrrolidine dithiocarbamate, occurred simultaneously with a significant decrease in intracellular reactive oxygen species levels. Conclusion HcyT exerts its cytotoxic effects on endothelial cells through an apoptotic mechanism involving cellular reactive oxygen species production. The capacity of N-acetylcysteine, vitamin E, and pyrrolidine dithiocarbamate to scavenge HcyT-induced cellular reactive oxygen species correlates well with their efficiency to protect against HcyT-promoted apoptotic damage. The protective effect of pyrrolidine dithiocarbamate on cell apoptosis indicates HcyT-generated hydrogen peroxide may provoke cell apoptosis via activating nuclear factor-kappa binding protein. | Weijun GU Juming LU Guoqing YANG Qinghua GUO Baoan WANG Yiming MU Changyu PAN | 2006 | Journal of Geriatric Cardiology2006，3，2： | 3 |
| 5 | Fabrication and characterization of superhydrophobic poly (vinylidene fluoride) membrane for direct contact membrane distillation显示文摘 | Jing Zhang Zhenyu Song Baoan Li Qin Wang Shichang Wang | 2013 | Desalination2013，，： | 2 |
| 6 | Applications of F-expansion Method to Class of Nonlinear Klein-Gordon Equation显示文摘 | LI BAOAN CHEN JINLAN WANG MINGLING | 2005 | J of Henan Univ of Sci & Technol(natural science)2005，26，5： | 1 |
| 7 | Synthesis and antitumor efficacy of daunorubicin-loaded magnetic nanoparticles 显示文摘 | Wang Jun Chen Baoan Chen Jian | 2011 | Int J Nanomedicine2011，6，： | 1 |
| 8 | Selecting an Appropriate Experimental Animal Model for Cholangiocarcinoma Research显示文摘Cholangiocarcinoma(CCA)is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic sub-types that differ in molecular pathogeneses,epidemiology,clinical manifestations,treatment,and prognosis.The over-all prognosis and patient survival remains poor because of lack of early diagnosis and effective treatments.Preclini-cal in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer.Recent advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical,infection-induced inflammatory,implantation,and genetically engineered animal models.This review is intended to help investigators understand the particular strengths and weaknesses of the currently used in vivo animal models of human CCA and their related mod-eling techniques to aid in the selection of the one that is the best for their research needs. | Man Li Xueli Zhou Wei Wang Baoan Ji Yu Shao Qianyu Du Jinghao Yao Yan Yang | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 1 |
| 9 | Surface plasmon resonance sensor for profenofos detection using molecularly imprinted thin film as recognition element显示文摘 | Jianwei Dong Na Gao Yuan Peng Chun Guo Zhiqiang Lv Ying Wang Caihong Zhou Baoan Ning Ming Liu Zhixian Gao | 2011 | Food Control2011，，2： | 1 |
| 10 | An NF-[kappa]B pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice显示文摘 | Daniluk Jaroslaw Liu Yan Deng Defeng Chu Jun Huang Haojie Gaiser Sebastian Cruz-Monserrate Zobeida Wang Huamin Ji Baoan Logsdon Craig D | 2012 | EN2012，，4： | 1 |
| 11 | Progress on deuterated potassium dihydrogen phosphate(DKDP)crystals for high power laser system application显示文摘In this review,we introduce the progress in the growth of large-aperture DKDP crystals and some aspects of crystal quality including determination of deuterium content,homogeneity of deuterium distribution,residual strains,nonlinear absorption,and laser-induced damage resistance for its application in high power laser system.Large-aperture high-quality DKDP crystal with deuteration level of 70%has been successfully grown by the traditional method,which can fabricate the large single-crystal optics with the size exceeding 400 mm.Neutron diffraction technique is an efficient method to research the deuterium content and 3D residual strains in single crystals.More efforts have been paid in the processes of purity of raw materials,continuous filtration technology,thermal annealing and laser conditioning for increasing the laser-induced damage threshold(LIDT)and these processes enable the currently grown crystals to meet the specifications of the laser system for inertial confinement fusion(ICF),although the laser damage mechanism and laser conditioning mechanism are still not well understood.The advancements on growth of large-aperture high-quality DKDP crystal would support the development of ICF in China. | Mingxia Xu Baoan Liu Lisong Zhang Hongkai Ren Qingtian Gu Xun Sun Shenglai Wang Xinguang Xu | 2022 | Light(Science & Applications)2022，11，9： | 1 |
| 12 | Matrix micrestructure deteriorations resulting from diamond incorporation in electroplated metal-diamond composites显示文摘 | Li Yundong Zhan Anqing Wang Baoan | 2008 | Surface & coatings technology2008，202，： | 1 |
| 13 | Synthesis and bactericidal activities of novel pyrazole-1-carbothioamide derivatives显示文摘 | Xinhua Liu Shifan Wang Baoan Song | 2007 | Frontiers of Chemistry in China2007，2，3： | 1 |
| 14 | Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles显示文摘 | Baoan Chen Haijun Zhang Wang Cailian | 2011 | International Journal of Nanomedicine (default)2011，，： | 1 |
| 15 | Simultaneous and rapid detection of six different mycotoxins using an immunochip显示文摘 | WANG Ying LIU Nan NING Baoan | 2012 | Biosensors and Bioelectronics2012，34，1： | 1 |
| 16 | Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies显示文摘 | Baoan Chen Feng Gao Jing Chen Jun Wang Wei Hulai Jian Cheng Xia Guohua Baoan Chen Liu Lijie Chuanlu Xu Wu Weiwei Bao wen Zhang Yi Ding Jiahua Yang Liya Shen Huiling Yang Mimgming Xu Wenlin Xuemei Wang | 2010 | 2010 (defa)2010，，： | 1 |
| 17 | Design, Synthesis, and Antiviral Activity of Novel Chalcone Derivatives Containing a Purine Moiety显示文摘 | Xiuhai Gan Yanjiao Wang Deyu Hu Baoan Song | 2017 | Chinese Journal of Chemistry2017，35，5： | 1 |
| 18 | miR-34a inhibits the metastasis of osteosarcoma cells by repressingthe expression of CD44显示文摘 | Haien Zhao Baoan Ma Yucai Wang Tao Han Lianhe Zheng Cong Sun Tao Liu Yinglong Zhang Xiuchun Qiu Qingyu Fan | 2013 | Oncology Reports2013，，： | 1 |
| 19 | Butterfly-wing hierarchical metallic glassy nanostructure for surface enhanced Raman scattering显示文摘The surface-enhanced Raman spectroscopy(SERS)is a technique for the detection of analytes on the surface with an ultrahigh sensitivity down to the atomic-scale,yet the fabrication of SERS materials such as nanoparticles or arrays of coinage metals often involve multiple complex steps with the high cost and pollution,largely limiting the application of SERS.Here,we report a complex hierarchical metallic glassy(MG)nanostructure by simply replicating the surface microstructure of butterfly wings through vapor deposition technique.The MG nanostructure displays an excellent SERS effect and moreover,a superhydrophobicity and self-cleaning behavior.The SERS effect of the MG nanostructure is attributed to the intrinsic nanoscale structural heterogeneities on the MG surface,which provides a large number of hotspots for the localized electromagnetic field enhancement affirmed by the finite-difference time-domain(FDTD)simulation.Our works show that the MG could be a new potential SERS material with low cost and good durability,well extending the functional application of this kind of material. | Hongyu Jiang Jing Li Chengrong Cao Xiaozhi Liu Ming Liu Yutian Shen Yanhui Liu Qinghua Zhang Weihua Wang Lin Gu Baoan Sun | 2019 | Nano Research2019，12，11： | 1 |
| 20 | Impact of night sleep duration on glycemic and triglyceride levels in C hinese with different glycemic status 不同血糖水平的中国人群的夜晚睡眠时间对血糖和甘油三酯水平的影响显示文摘 | Yu Zheng Anping Wang Changyu Pan Juming Lu Jingtao Dou Zhaohui Lu Jianming Ba Baoan Wang Yiming Mu | 2015 | Journal of Diabetes2015，，： | 1 |
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