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| 1 | Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis显示文摘 | Chaoying Hu Liu Qian Yi Miao Qiuyu Huang Ping Miao Ping Wang Qiwen Yu Hong Nie Jiying Zhang Dongyi He Rong Xu Xuehua Chen Bingya Liu Dongqing Zhang | 2012 | Cellular & Molecular Immunology2012，9，3： | 18 |
| 2 | COP9 signalosome: Discovery, conservation,activity, and function显示文摘The COP9 signalosome(CSN)is a conserved protein complex,typically composed of eight subunits(designated as CSN1 to CSN8)in higher eukaryotes such as plants and animals,but of fewer subunits in some lower eukaryotes such as yeasts.The CSN complex is originally identified in plants from a genetic screen for mutants that mimic light-induced photomorphogenic development when grown in the dark.The CSN complex regulates the activity of cullin-RING ligase(CRL)families of E3 ubiquitin ligase complexes,and play critical roles in regulating gene expression,cell proliferation,and cell cycle.This review aims to summarize the discovery,composition,structure,and function of CSN in the regulation of plant development in response to external(light and temperature)and internal cues(phytohormones). | Nanxun Qin Dongqing Xu Jigang Li Xing Wang Deng | 2020 | Journal of Integrative Plant Biology2020，62，1： | 6 |
| 3 | Suppressing the formation of SRZ in a Ni-based single crystal superalloy by RuNiAl diffusion barrier | Zhiming Bai Dongqing Li Hui Peng Juan Wang Hongbo Guo Shengkai Gong | 2012 | Progress in Natural Science:Materials International2012，22，2： | 6 |
| 4 | Magnetic resonance study of the structure and function of the hippocampus and amygdala in patients with depression显示文摘 | Li Yuefeng Yan Jinchuan Wang Dongqing Sun Meifang Zhu Yan Zhu Xiaolan Jiang Ping Yin Ruigen Zhao Liang | 2014 | Chinese Medical Journal2014，，20： | 6 |
| 5 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 6 | A new similarity computing method based on concept similarity in Chinese text processing显示文摘The paper proposes a new text similarity computing method based on concept similarity in Chinese text processing. The new method converts text to words vector space model at first,and then splits words into a set of concepts. Through computing the inner products between concepts,it obtains the similarity between words. The new method computes the similarity of text based on the similarity of words at last. The contributions of the paper include:1) propose a new computing formula between words;2) propose a new text similarity computing method based on words similarity;3) successfully use the method in the application of similarity computing of WEB news;and 4) prove the validity of the method through extensive experiments. | PENG Jing YANG DongQing TANG ShiWei WANG TengJiao GAO Jun | 2008 | Science in China(Series F)2008，51，9： | 4 |
| 7 | Polymeric microsphere injection in large pore-size porous media显示文摘High water-cut has become a worldwide challenge for oil production.It requires extensive efforts to process and dispose.This entails expanding water handling facilities and incurring high power consumption costs.Polymeric microsphere injection is a cost-effective way to deal with excessive water production from subterranean formations.This study reports a laboratory investigation on polymeric microsphere injection in a large volume to identify its in-depth fluid diversion capacity in a porous media with large pore/particle size ratio.The performance of polymeric microsphere injection was evaluated using etched glass micromodels based on the pore network of a natural carbonate rock,which were treated as water-wet or oil-wet micromodels.Waterflooding was conducted to displace oil at reservoir temperature of 95°C,followed by one pore volume of polymeric microsphere injection.Three polymeric microsphere samples with median particle size of 0.05,0.3,and 20μm were used to investigate the impact of particle size of the polymeric microspheres on incremental oil production capacity.Although the polymeric microspheres were much smaller than the pores,additional oil production was observed.The incremental oil production increased with increasing polymeric microsphere concentration and particle size.As a comparison,polymeric microsphere solutions were injected into oil-wet and water-wet micromodels after waterflooding.It was observed that the oil production in oil-wet micromodel was much higher than that in water-wet micromodel.The wettability of micromodels affected the distribution patterns of the remaining oil after waterflooding and further dominated the performance of the microsphere injection.The study supports the applicability of microsphere injection in oil-wet heterogeneous carbonates. | Dongqing Cao Ming Han Jinxun Wang Amar J.Alshehri | 2020 | Petroleum2020，6，3： | 3 |
| 8 | Effects of exogenous ABA application on post-anthesis dry matter redistribution and grain starch accumulation of winter wheat with different staygreen characteristics显示文摘The objective of this study was to investigate whether and how exogenous abscisic acid(ABA)is involved in mediating starch accumulation in the grain and redistribution of carbohydrates during grain filling of two wheat cultivars with different staygreen characteristics.At blooming stage,plants of Wennong 6(a staygreen cultivar)and Jimai 20(control)were sprayed with10 mg L-1abscisic acid(ABA)for 3 days.The application of ABA significantly(P<0.05)increased grain filling rate,starch accumulation rate and content,remobilization of dry matters to kernels,and 1000-grain weight of the two cultivars.Exogenous ABA markedly(P<0.05)increased grain yield at maturity,and Wennong 6 and Jiami 20 showed 14.14%and 4.86%higher compared yield than the control.Dry matter accumulation after anthesis of Wennong 6 was also significantly(P<0.05)influenced by exogenous ABA,whereas that of Jimai 20 was unchanged.Application of ABA increased endogenous zeatin riboside(ZR)content 7 days after anthesis(DAA),and spraying ABA significantly increased endogenous indole-3-acetic acid(IAA)and ABA contents from 7 to 21 DAA and decreased gibberellin(GA3)content at 14 DAA,but increased GA3content from 21 to 35 DAA.The results suggested that increased yield of staygreen was due to greater starch assimilation owing to a higher filling rate and longer grain-filling duration. | Dongqing Yang Yongli Luo Yingli Ni Yanping Yin Weibing Yang Dianliang Peng Zhengyong Cui Zhenlin Wang | 2014 | The Crop Journal2014，2，Z1： | 3 |
| 9 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 10 | Influence maximization with limit cost in social network显示文摘Social networking service (SNS) applications are changing the way information spreads in online communities. As real social relationships are projected into SNS applications, word of mouth has been an important factor in the information spreading processes of those applications. By assuming each user needs a cost to accept some specific information, this paper studies the initial 'seed user' selection strategy to maximize information spreading in a social network with a cost budget. The main contributions of this paper are: 1) proposing a graphic SEIR model (gSEIR) by extending the epidemic compartmental model to simulate the dynamic information spreading process between individuals in the social network; 2) proposing a formal definition for the influence maximization problem with limit cost (IMLC) in social networks, and proving that this problem can be transformed to the weighted set-cover problem (WSCP) and thus is NP-Complete; 3) providing four different greedy algorithms to solve the IMLC problem; 4) proposing a heuristic algorithm based on the method of Lagrange multipliers (HILR) for the same problem; 5) providing two parts of experiments to test the proposed models and algorithms in this paper. In the first part, we verify that gSEIR can generate similar macro-behavior as an SIR model for the information spreading process in an online community by combining the micro-behaviors of all the users in that community, and that gSEIR can also simulate the dynamic change process of the statuses of all the individuals in the corresponding social networks during the information spreading process. In the second part, by applying the simulation result from gSEIR as the prediction of information spreading in the given social network, we test the effectiveness and efficiency of all provided algorithms to solve the influence maximization problem with cost limit. The result show that the heuristic algorithm HILR is the best for the IMLC problem. | WANG Yue HUANG WeiJing ZONG Lang WANG TengJiao YANG DongQing | 2013 | Science China(Information Sciences)2013，56，7： | 3 |
| 11 | Docking and molecular dynamics studies on CYP2D6显示文摘Drug-metabolizing enzymes,also known as cytochrome P450s,are a superfamily of hemoglobin responsible for metabolizing more than 90% clinical drugs.Cytochrome P450 2D6(CYP2D6) is a significant member of cytochrome P450s for the reason of metabolizing about 20% clinical drugs.In this paper,molecular docking and molecular dynamic simulations are used to investi-gate the active site of CYP2D6,roles of essential amino acids within the active site and time-dependent protein energy changes.The results suggest that amino acids Glu216,Asp301,Ser304 and Ala305 in the active site are likely to form hydrogen bonding interactions with substrates;the benzene ring of Phe120 and aromatic ring in the substrates form Π-Π interactions.In addition,molecular dynamics simulations prove that the catalytic conformation of CYP2D6 without ligands can be obtained by their own atomic fluctuations.The impact of ligands on protein system energy and large conformational shift is not very large.Cytochrome P450s is known for their genetic polymorphisms,which will result in severe adverse drug reactions.Ideally,we hope to use mo-lecular modeling to investigate the differences between the substrates of wild-type and mutants while they are bonded with drugs,and predict the drug metabolizing ability of mutants.Reduce the possibility for people taking drugs that they can not metabolize,therefore reduce the rate of adverse drug reactions,and eventually establish a platform of personalized drugs to largely benefit human health. | WANG JingFang ZHANG ChengCheng WEI DongQing LI YiXue | 2010 | Chinese Science Bulletin2010，55，18： | 2 |
| 12 | Multiple dimensions of urban design development from a practice perspective:A case study of an institute in Nanjing显示文摘The rapid urbanization process in China has promoted the active state of urban design practice.In the process of solving complex problems,the practical scope of urban design has gradually expanded.This paper took a design institution in Nanjing as a case study and sorted the trends in design project types and themes over the past 20 years,which presented a partial and diverse state of evolution in urban design practice.Concept,technology and management were extracted as the three main dimensions of cognitive urban design practice development.The relative positions and relationships of different types of urban design work were interpreted through mapping analysis of these three dimensions.This study provided a foundation for the practical orientation of urban design in China and a platform for communication a mong managers,urban design practitioners,scholars of related disciplines,and the public. | Dongqing Han Yacheng Song Enqi Wang Hua Liu Rong Fang | 2021 | Frontiers of Architectural Research2021，10，1： | 2 |
| 13 | A Positive Feedback Loop of BBX11–BBX21–HY5 Promotes Photomorphogenic Development in Arabidopsis显示文摘Light is the most important environmental factor affecting many aspects of plant development.In this study,we report that B-box protein 11(BBX11)acts as a positive regulator of red light signaling.BBX11 loss-of-function mutant seedlings display significantly elongated hypocotyls under conditions of both red light and long day,whereas BBX11 overexpression causes markedly shortened hypocotyls under various light states.BBX11 binds to the HY5 promoter to activate its transcription,while both BBX21 and HY5 associate with the promoter of BBX11 to positively regulate its expression.Taken together,our results reveal positive feedback regulation of photomorphogenesis consisting of BBX11,BBX21,and HY5,thus substantiating a transcriptional regulatory mechanism in the response of plants to light during normal development. | Xianhai Zhao Yueqin Heng Xuncheng Wang Xing Wang Deng Dongqing Xu | 2020 | Plant Communications2020，1，5： | 2 |
| 14 | Different role of second phase in the micro-galvanic corrosion of WE43 Mg alloy in NaCl and Na_(2)SO_(4) solution显示文摘Effect of the second phase in the micro-galvanic corrosion of a commercial Mg alloy containing rare earth elements, cast WE43 alloy,was investigated in 0.6 M NaCl solution and 0.6 M Na_(2)SO_(4)solution by scanning electron microscopy(SEM) observations, scanning Kelvin probe force microscopy(SKPFM) analysis, hydrogen evolution, weight loss measurement, and electrochemical techniques. It is confirmed that the second phase of cast WE43 alloy is more active than Mg matrix and exhibits an anodic role in the micro-galvanic corrosion with α-Mg matrix as cathode and dissolves preferentially in Na_(2)SO_(4)solution, in contrast to the situation in NaCl solution. The corrosion rate of cast WE43 alloy in Na_(2)SO_(4)solution is much higher than that in NaCl solution, which is different from the conventional wisdom and could be attributed to the different role of the second phase in the micro-galvanic corrosion in two solutions. | Baojing Feng Guonan Liu Peixu Yang Sensen Huang Dongqing Qi Peng Chen Chengduo Wang Jiang Du Shaojun Zhang Jinhui Liu | 2022 | Journal of Magnesium and Alloys2022，10，6： | 2 |
| 15 | The optimization of hydrothermal process of MoS2 nanosheets and their good microwave absorption performances显示文摘In this study,flower-like MoS2 constructed by nanosheets was synthesized by a simple hydrothermal method.The hydrothermal process was optimized and the effects of hydrothermal condition,including reaction temperature,reaction time and the ratio of Mo source to S source(Mo:S)in precursor,on microwave absorption performances and dielectric properties were investigated.Our results showed that when the reaction temperature was 180℃,the reaction time was 18 h,and the Mo:S was 1:3.5,the synthesized MoS2 had the best performance:Its minimum reflection loss could reach-55.78 dB,and the corresponding matching thickness was 2.30 mm with a wide effective bandwidth of 5.17 GHz.Further researches on the microwave absorption mechanism revealed that in addition to the destructive interference of electromagnetic waves,various polarization phenomena such as defect dipole polarization were the main reasons for microwave loss.We believe that MoS2 is a candidate for a practical microwave absorbent. | Xiaoyu Lin Jing Wang Zengyong Chu Dongqing Liu Taotao Guo Lingni Yang Zhenyu Huang Sitong Mu Shun Li | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 16 | MBA:A market-based approach to data allocation and dynamic migration for cloud database显示文摘With the coming shift to cloud computing,cloud database is emerging to provide database service over the Internet.In the cloud-based environment,data are distributed at Internet scale and the system needs to handle a huge number of user queries simultaneously without delay.How data are distributed among the servers has a crucial impact on the query load distribution and the system response time.In this paper,we propose a market-based control method,called MBA,to achieve query load balance via reasonable data distribution.In MBA,database nodes are treated as traders in a market,and certain market rules are used to intelligently decide data allocation and migration.We built a prototype system and conducted extensive experiments.Experimental results show that the MBA method significantly improves system performance in terms of average query response time and fairness. | WANG TengJiao LIN ZiYu YANG BiShan GAO Jun HUANG Allena YANG DongQing ZHANG Qi TANG ShiWei NIU JinZhong | 2012 | Science China(Information Sciences)2012，55，9： | 2 |
| 17 | Molecular dynamics simulations exploring drug resistance in HIV-1 proteases显示文摘Although HIV-1 subtype B still dominates the epidemic AIDS in developed countries,an increasing number of people in developing countries are suffering from an epidemic of non-subtype B viruses.What is worse,the efficacy of the combinational use of antiretroviral drugs is gradually compromised by the rapid development of drug resistance.To gain an insight into drug resistance, 10-ns MD simulations were simultaneously conducted on the complexes of the TL-3 inhibitor with 4 different proteases(Bwt,Bmut, Fwt and Fmut),among which the complex of the Bwt protease with the TL-3 inhibitor was treated as the control group.Detailed analyses of MD data indicated that the drug resistance of Bmut against TL-3 mainly derived from loss of an important hydrogen bond and that of Fwt was caused by the decrease of hydrophobic interactions in S1/S1'pocket,while both of the two reasons mentioned above were the cause of the Fmut protease's resistance.These results are in good agreement with the previous experiments, revealing a possible mechanism of drug resistance for the aforementioned protease subtypes against the TL-3 inhibitor.Additionally,another indication was obtained that the mutations of M36I,V82A and L90M may induce structural transforms so as to alter the inhibitor's binding mode. | GU Hui CHEN HaiFeng WEI DongQing WANG JingFang | 2010 | Chinese Science Bulletin2010，55，24： | 2 |
| 18 | CD133 + /CD44 + /Oct4 + /Nestin + stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic cancer显示文摘 | Dongqing Wang Haitao Zhu Ying Zhu Yanfang Liu Huiling Shen Ruigen Yin Zhijian Zhang Zhaoliang Su | 2012 | Acta Histochemica2012，，： | 1 |
| 19 | Experimental researches of thermal diffusivity and conductivity in embankment ballast under periodically fluctuating temperature显示文摘 | Binxiang Sun Xuezu Xu Yuanming Lai Dongqing Li Shuangjie Wang Jinzhao Zhang | 2004 | Cold Regions Science and Technology2004，，2： | 1 |
| 20 | Programmable metallization cells based on amorphous La 0.79 Sr 0.21 MnO 3 thin films for memory applications显示文摘 | Dongqing Liu Nannan Wang Guang Wang Zhengzheng Shao Xuan Zhu Chaoyang Zhang Haifeng Cheng | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
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