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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | MicroRNA-204/ 211 alters epithelial physiology显示文摘 | Wang FE Zhang C Maminishkis A | 2010 | FASEBJ2010，24，5： | 1 |
| 3 | Electrophysiological observations in hippocampal slices from rats treated with the ketogenic diet 显示文摘 | Stafstrom CE Wang C Jensen FE | 1999 | Dev Neurosci1999，21，35： | 1 |
| 4 | Surgical risk factors, morbid- ity,and mortality in elderly patients显示文摘 | Turrentine FE Wang H Simpson VB | 2006 | J Am Coil Surg2006，203，6： | 1 |
| 5 | Desialylation induces apoptosis and phagncytosis of platelets in patients with prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation 显示文摘 | Wang QM Zhang XH Feng FE | 2014 | Blood ( ASH annual meeting Abstracts )2014，124，21： | 1 |
| 6 | MicroRNA-204/211 alters epithelial physiology 显示文摘 | Wang FE Zhang C Maminishkis A Dong L Zhi C Li R | 2010 | Faseb J2010，24，5： | 1 |
| 7 | PDGF - C and - D induced proliferation / migration of human RPE is abolished by inflammatoryeytok ines 显示文摘 | L i R Maminishkis A Wang FE | 2007 | Invest Ophthalmol2007，48，12： | 1 |
| 8 | Hypoxia-induced hyperexcitability in vivo and in vitro in the immature hippocampus显示文摘 | Jensen FE Wang C | 1996 | Epilepsy Res1996，26，1： | 1 |
| 9 | PDGF-C and -D induced proliferation/ migration of human RPE is abolished by inflammatory cytokines显示文摘 | Li R Maminishkis A Wang FE | 2007 | Invest Ophthalmol Vis Sci2007，48，： | 1 |
| 10 | 13 alloy 显示文摘 | WANG L MA J Q YANG J Dry-sliding tribological prop- erties of a nano-eutectic Fe i s7 C 0 | 2010 | Wear2010，268，： | 1 |
| 11 | Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models显示文摘 | Wang N Docherty FE Brown HK | 2014 | J Bone Miner Res2014，29，12： | 1 |
| 12 | PDGF-C and-D induced proliferation/ migration of human RPE is abolished by inflammatory cytokines显示文摘 | Li R Maminishkis A Wang FE | | 0，，： | 1 |
| 13 | Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo 显示文摘 | Wang X Paulin FE Campbell LE | 2001 | EMBO J2001，20，16： | 1 |
| 14 | Surgical risk factors, morbidity, and mortality in elderly patients 显示文摘 | Turrentine FE Wang H Simpson VB | 2006 | J Am Coll Surg2006，203，6： | 1 |
| 15 | MicroRNA-204/211 alters epithelial physiology 显示文摘 | Wang FE Zhang C Maminishkis A Dong L Zhi C Li R | 2010 | FASEB J2010，24，5： | 1 |
| 16 | On the concept new of solutions and existence results for impul- sive fractional evolution equations 显示文摘 | WANG Jinrong FE KAN M ZHOU Yong | 2011 | Dynamics of PDE2011，8，4： | 1 |
| 17 | Neuronal differentiation of bone marrow-derived stromal stem cells involves suppression of discordant phenotypes through gene silencing 显示文摘 | Egusa H Sehweizer FE Wang CC | 2005 | J Biol Chem2005，280，23： | 1 |
| 18 | Effects and mechanisms of berber- inE on hyperlipidemic and insulin resistant rats显示文摘 | Lu FE He MK Wang KF | 2004 | The Proceedings of the China Association for Science and Technology2004，1，1： | 1 |
| 19 | Surgical risk factors,morbidity,and mortality in elderly patients显示文摘 | Turrentine FE Wang H Simpson VB | 2006 | J Am Coll Surg2006，203，6： | 1 |
| 20 | Surgical risk factors, morbidity, and mortality in elderly patients 显示文摘 | Turrentine FE Wang H Simpson VB | 2006 | J Am Coll Surg2006，203，6： | 1 |
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