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| 1 | Experimental Studies on The Mechanism and Control of Secondary Flow Losses in Turbine Cascades显示文摘This paper summarizes the results of the authors' 4 year experimental studies on the secondary flow losses in turbine cascades.cascade wind tunnel experiments were carried out concerning the influence of aspect rations,incidence,turning angles and outer endwall divergent angles in order to unveil the evolution mechanism of secondary flow losses in turbine cascades without end clearance.Some methods for controlling the secondary flows are investigated including the blade leaning,blade cambering,endwall convergence and leading edge extension at two ends of the blade. | Wang Zhongqi Han Wanjin Xu Wenyuan Harbin Institute of Technology | 1992 | Journal of Thermal Science1992，1，3： | 7 |
| 2 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 3 | Effects of Hot Steam Injection from the Slot at the Trailing Edge on Turbine Nozzle Vane Flow Field显示文摘Moisture removal slot configurations with three different opening widths are in turn set at the trailing edges of a turbine hollow guide vane.The flow fields are analyzed by two-phase flow numerical simulation of solving the steady three dimensional Reynolds averaged Navier-Stokes equations on the basis of the real water vapor thermo-physical properties,and the blade temperature field is solved by the fluid-solid coupling.Exergy parame- ter is introduced as a measure to evaluate the economic cost of energy conversion process.The results indicate that the bigger slot allow lower quality of hot steam in the case of the equivalent injected quantity,while it has a higher exergy effective efficiency of the mixing process in the cascade channels.The hot steam injecting at the trailing edges has an optimal injected mass flow rate for a relatively large slot,on this point the exergy effective efficiency is the maximum,namely the flow loss is the minimum. | Liang Xu Peigang Yan Hongyan Huang Wanjin Han | 2008 | Journal of Thermal Science2008，17，4： | 3 |
| 4 | Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response显示文摘RIPK1 is a master regulator of multiple cell death pathways,including apoptosis and necroptosis,and inflammation.Importantly,activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells undergoing necroptosis,in animal models of amyotrophic lateral sclerosis(ALS)and Alzheimer's disease(AD),and in human ALS and AD.Rare human genetic carriers of non-cleavable RIPK1 variants(D324V and D324H)exhibit distinct symptoms of recurrent fevers and increased transcription of proinflammatory cytokines.Multiple RIPK1 inhibitors have been advanced into human clinical trials as new therapeutics for human inflammatory and neurodegenerative diseases,such as ALS and AD.However,it is unclear whether and how RIPK1 kinase activity directly mediates inflammation independent of cell death as the nuclear function of RIPK1 has not yet been explored.Here we show that nuclear RIPK1 is physically associated with the BAF complex.Upon RIPK1 activation,the RIPK1/BAF complex is recruited by specific transcription factors to active enhancers and promoters marked by H3K4me1 and H3K27ac.Activated nuclear RIPK1 mediates the phosphorylation of SMARCC2,a key component of the BAF complex,to promote chromatin remodeling and the transcription of specific proinflammatory genes.Increased nuclear RIPK1 activation and RIPK1/BAF-mediated chromati n-remodeling activity were found in cells expressi ng non-cleavable RIPK1,and in creased enrichment of activated RIPK1 on active enhancers and promoters was found in an animal model and human pathological samples of ALS.Our results suggest that RIPK1 kinase serves as a transcriptional coregulator in nucleus that can transmit extracellular stimuli to the BAF complex to modulate chromatin accessibility and directly regulate the transcription of specific genes involved in mediating inflammatory resp onses. | Wanjin Li Bing Shan Chengyu Zou Huibing Wang Meng-Meng Zhang Hong Zhu Masanori Gomi Naito Daichao Xu Vica Jean Manuel Lauren Mifflin Zhaodong Hou John Ravits Junying Yuan | 2022 | Cell Research2022，32，7： | 1 |
| 5 | Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks显示文摘象通过代的压抑的 histone 修正那样的 epigenetic 信息的忠诚传播或恢复为房间身份的维护是批评的。我们这里报导那 chromodomain 象 Y 一样蛋白质(CDYL ) ,包含 chromodomain 抄写 corepressor,身体上与染色质集会因素 1 被联系(CAF-1 ) 并且 replicative helicase 看建筑群。我们证明 CDYL 衔接 CAF-1 和看,便于在 DNA 复制期间的 histone 转移和免职。我们证明到复制的 CDYL 成员修改 histone 酶 G9a, SETDB1,和 EZH2 分叉,导致最新扔的 histone H3 上的 H3K9me2/3 和 H3K27me2/3 的增加。显著地, CDYL 的弄空阻碍早 S 阶段前进并且敏化房间到 DNA 损坏。我们的数据显示 CDYL 在压抑的 histone 标记的传播 / 恢复起一个重要作用,从而为房间身份的维护保存 epigenetic 风景。 | Yongqing Liu Shumeng Liu Shuai Yuan Huajing Yu Yu Zhang Xiaohan Yang Guojia Xie Zhe Chen Wanjin Li Bosen Xu Luyang Sun Yongfeng Shang Jing Liang | 2017 | Journal of Molecular Cell Biology2017，9，3： | 0 |
| 6 | Direct synthesis of high-quality perovskite nanocrystals on a flexible substrate and deterministic transfer显示文摘Solid-state perovskite nanocrystals are promising coherent light sources, as there is optical feedback within the crystal structure. In order to utilize the high performance of perovskites for on-chip applications, or observe new physical phenomena, these crystals must be integrated with pre-fabricated electronic or photonic structures. However, the material's fragility has made the deterministic transfer a great challenge thus far. Here, we report the first deterministic transfer of perovskite nanocrystals with sub-micron accuracy. Cesium lead halide(CsPbI_3) nanocrystals were directly synthesized on flexible polydimethylsiloxane(PDMS) stamps via chemical vapor deposition(CVD) and subsequently transferred onto arbitrary substrates/structures. We demonstrated the transfer of a CsPbI_3 crystalline nanoplate(NP)onto an 8 mm fiber core and achieved single-mode whispering gallery mode lasing. Our method can be extended to a variety of other arbitrary substrates(e.g., electrodes, photonic structures, micromechanical systems), laying the foundations for previously unattainable opportunities in perovskites-based devices. | Yilun Wang Xing Cheng Kai Yuan Yi Wan Pan Li Yuhao Deng Haoran Yu Xiaolong Xu Yi Zeng Wanjin Xu Yanping Li Renmin Ma Kenji Watanabe Takashi Taniguchi Yu Ye Lun Dai | 2018 | Science Bulletin2018，63，23： | 0 |
| 7 | CDYL作为丁烯酰辅酶A水合酶调控组蛋白丁烯酰化及精子发生显示文摘文章简介本研究发现,转录辅抑制因子CDYL具有负调控组蛋白赖氨酸丁烯酰化的功能。有趣的是,CDYL负调控组蛋白丁烯酰化并不是通过直接从底物赖氨酸上去除丁烯酰基的方式实现的,而是利用CDYL的丁烯酰辅酶A水合酶活性。 | Shumeng Liu Huajing Yu Yongqing Liu Xinhua Liu Yu Zhang Chen Bu Shuai Yuan Zhe Chen Guojia Xie Wanjin Li Bosen Xu Jianguo Yang Lin He Tong Jin Yundong Xiong Luyang Sun Xiaohui Liu Chunsheng Han Zhongyi Cheng 梁静 尚永丰 | 2018 | 科学新闻2018，0，4： | 0 |
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