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| 1 | Inhibition of lung cancer cell proliferation mediated by human mesenchymal stem cells显示文摘人的间充质的干细胞(hMSCs ) 主要为他们的潜在的临床的使用被学习。最近,癌症研究的领域里的许多注意对 hMSCs 被给予了。在这研究,我们由使用一个合作文化系统和调节 hMSCs 的媒介在 vitro 并且在 vivo 在肺癌症房间线 SK-MES-1 和 A549 的增长上调查了 hMSCs 的影响。我们的结果证明 hMSCs 能禁止 SK-MES-1 和 A549 房间的增长,并且经由一些可溶的因素在 vitro 导致肿瘤房间的 apoptosis。动物学习证明从 hMSCs 的这些可溶的因素能由 preliminarily 与调节 hMSCs 的媒介对待肿瘤细胞压制 tumorigenesis 和肿瘤 angiogenesis。在肿瘤房间的脉管的 endothelial 生长因素的 downregulated 表示可能是在肿瘤 angiogenesis 的干扰的机制,它被西方的污点分析和 immunohistochemistry 试金验证。一起拿,我们的结果建议 hMSCs 能由 secreting 一些禁止肿瘤细胞生长可溶的因素。 | Lin Li Hui Tian Zhitao Chen Weiming Yue Shuhai Li Wenjun Li | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 11 |
| 2 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 3 | Growth of the Sayram Lake and retreat of its water-supplying glaciers in the Tianshan Mountains from 1972 to 2011显示文摘Inland lakes and alpine glaciers are important constituents of water resources in arid and semiarid regions. Understanding their variations is critical for both an accurate evaluation of the dynamic changes of water resources and the retrieval of climatic information. On the basis of earlier researches, this study investigated the growth of the Sayram Lake and the retreat of its water-supplying glaciers in the Tianshan Mountains using long-term sequenced remote sensing images. Our results show that over the past 40 years, the surface area and the water level of the lake has increased by 12.0±0.3 km2 and 2.8 m, respectively, and the area of its water-supplying glaciers has decreased continuously since the early 1970 s with a total reduction of about –2.13±0.03 km2. Our study has indicative significance to the research of regional climate change. | CHENG Weiming WANG Nan ZHAO Shangmin FANG Yue ZHAO Min | 2016 | Journal of Arid Land2016，8，1： | 6 |
| 4 | Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo显示文摘肺癌症是在整个世界的癌症相关的死亡的领先的原因。在最近的年里,肺的腺癌在频率超过了有鳞的房间癌并且是在许多国家的肺癌症的占优势的形式。流行病学的调查显示出在消费和死亡从许多癌症评估的大蒜(瞀或蒜之类 sativum ) 之间的一种反的关系。Diallyl trisulfide (DATS ) 是导出大蒜的混合物之一(是也知道:organosulfer 混合物,振荡) 。DATS 能导致 apoptosis 并且禁止许多癌症细胞线的生长。我们的学习证明 DATS 导致的 apoptotic 事件是通过导致了 Bax/Bcl-2 和 caspase-3, -8, 和 -9 的活动的比率的起来规定的 anti-apoptotic Bcl-2 的重要减少的线粒体依赖者 caspase 串联。最后, DATS 导致了 apoptosis 并且在一个集中依赖者和时间依赖者举止禁止了增长。由与 A549 异种皮移植建立女 BALB/c 裸体老鼠的一个动物模特儿,没有与控制组相比引起重量损失或任何另外的副作用,而且,我们在裸体老鼠发现 DATS 的那口头的 gavage A549 异种皮移植的显著地延迟的生长。在 vitro 并且在 vivo 的所有证据建议 DATS 能是理想的反癌症药。 | Wenjun Li Hui Tian Lin Li Shuhai Li Weiming Yue Zhitao Chen Lei Qi Wensi Hu Yingchao Zhu Bin Hao Cun Gao Libo Si Fei Gao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 5 | Human mesenchymal stem cells with adenovirus-mediated TRAIL gene transduction have antitumor effects on esophageal cancer cell line Eca-109显示文摘apoptotic ligand TNF 相关的导致 apoptosis ligand (小道) 被相信是癌症 genetherapy 的一个有希望的候选人,然而,全身地处理这疾病的基因治疗策略被 thevector 的低效的交货经常损害到肿瘤组织。间充质的干细胞(MSC ) 被显示出到家到肿瘤地点并且能潜在地 actas 为 antitumor 基因治疗向量的盾和车辆。这里,我们使用了表示小道到 transduceMSCs 的 adenoviral 向量并且在食道的癌症房间 Eca-109 上学习了这些带小道的 MSC 的导致 apoptosis 活动。我们在 vitro,表示小道的 MSC 能禁止增长并且由 MTT 试金, co-cultureexperiments 和流动 cytometry 分析在 Eca-109 房间导致 apoptosis 的 resultsshowed。在 vivo,表示小道的 MSC 也显示了一个能力在一个 Eca-109 异种皮移植老鼠模型禁止肿瘤生长。一起, ourfindings 显示基于 MSCs 的小道基因交货的基因治疗策略为食道的癌症的 improvingthe 治疗有宽潜在的价值。 | Lin Li Fengling Li Hui Tian Weiming Yue Shuhai Li Guanqing Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 5 |
| 6 | Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo显示文摘Heparanase 是降级的哺乳动物的 endoglycosidase 在房间表面并且在细胞外的矩阵的 heparan 硫酸盐。heparanase 的表示在许多人的恶意的肿瘤被检测并且仔细把侵略,转移,和 angiogenesis 与肿瘤联系了。然而, heparanase 的特定的角色和它调整非小的房间肺癌症(NSCLC ) 的恶意的潜力的机制房间仍然保持不清楚。在现在的学习, heparanase 的表示在由 antisense oligodeoxynucleotide 的 NSCLC 房间线是下面调整的。结果证明 heparanase 的下面规定导致了重要抑制侵略并且在 vitro 并且在 vivo 的 A549 房间的 proliferative 潜力。进一步的研究证明 heparanase 的下面规定显著地禁止了 A549 房间的 angiogenic 潜力,它可能是为在在 vivo 的 BALB/c 裸体老鼠的 A549 房间增长的抑制负责的机制。这些调查结果证明 heparanase 在调整 A549 房间的侵略,增长,和 angiogenesis 起必要作用。 | Zhitao Chen Liangming Zhu Xiaohua Li Hui Tian Yusong Fang Haibo Liu Shuhai Li Lin Li Weiming Yue Wenjun Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 7 | Oxidative Dehydrogenation of 1-Butene to 1,3-Butadiene Using CO2 over Cr-SiO2 Catalysts Prepared by Sol-gel Method显示文摘 | GAO Biao LUO Yajun MIAO Changxi YUE Yinghong YANG Weimin HUA Weiming GAO Zi | 2018 | Chemical Research in Chinese Universities2018，34，4： | 2 |
| 8 | Down-regulation of MTA1 protein leads to the inhibition of migration, invasion, and angiogenesis of non-small-cell lung cancer cell line显示文摘联系转移的蛋白质 1 (MTA1 ) 高表示在许多人的好攻击的肿瘤被检测了并且在象侵略,转移,和 angiogenesis 那样的恶意的生物行为起重要作用。然而,在调整 non-small-cell 肺癌症(NSCLC ) 的恶意的行为的 MTA1 蛋白质的特定的角色和机制房间仍然保持不清楚。阐明 MTA1 蛋白质的详细函数,我们下面调整在由在 vitro 的 RNA 干扰(RNAi ) 的 NSCLC 房间线的 MTA1 蛋白质表达式,并且发现 MTA1 蛋白质的下面规定显著地禁止了 95D 房间的移植和侵略潜力。进一步的研究表明 MTA1 蛋白质的下面规定显著地减少了矩阵 metalloproteinase-9 的活动,它能是为 95D 房间移植和侵略的抑制负责的机制。另外,试管形成试金证明 MTA1-siRNA 95D 房间的调节媒介导致的完全的试管的数字比 95D 房间的显著地小。这些调查结果证明那 MTA1 蛋白质在调整 95D 房间的迁居,侵略,和 angiogenesis 潜力起重要作用,由 RNAi 建议那条 MTA1 蛋白质下面规定可能是一条新奇治疗学的途径禁止 NSCLC 的前进。 | Shuhai Li Hui Tian Weiming Yue Lin Li Cun Gao Libo Si Wenjun Li Wensi Hu Lei Qi Ming Lu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 2 |
| 9 | Dynamic interaction of neutrophils and RFP-labelled Vibrio parahaemolyticus in zebrafish(Danio rerio)显示文摘Vibrio parahaemolyticus(Vp)is an aquatic zoonotic pathogen that causes vibriosis in marine animals as well as sepsis,gastroenteritis and wound infection in human.In vertebrates,the innate immune system plays a critical defense mechanism against Vp infection including transmigration of neutrophils.In this study,we have examined the genetic recombination and infectious process of Vp in the zebrafish(Danio rerio),a vertebrate model system extensively used for studying host-pathogen interactions.A pathogenic Vp strain,Vp57,tagged with red fluorescent protein(RFP)(Vp57^(RFP))was introduced into larval zebrafish at 3 days post fertilization(dpf),in which the innate immunity is present whereas the adaptive immunity has not yet developed.Vp57 and Vp57^(RFP)showed similar LD50 and induced similar symptoms and pathological changes in the hosts.We microinjected 579 colony-forming units(CFU)Vp57^(RFP)into the zebrafish caudal vein,and observed that neutrophils were recruited to the injection site and within 3 h post infection(hpi)Vp57^(RFP)were mainly distributed in the tail,eyes,heart and optic vesicle.After 3 hpi,the fish died with slight spine bending.Several Vp57^(RFP)were also detected in somites,the phagocytosis of neutrophils was activated through the progress of bacterial infections.We found that chemotaxis and phagocytosis of neutrophils occurs when zebrafish is infected by Vp57^(RFP),whereas Vp57^(RFP)can escape from neutrophils and colonize other remote regions using the blood circulation system. | Qiuyue Zhang An Ding Qianwen Yue Weiming Li Yao Zu Qinghua Zhang | 2017 | Aquaculture and Fisheries2017，2，6： | 1 |
| 10 | Promoting effect of A1 on SO4^2-/MxOy(M =Zr, Ti, Fe) catalysts显示文摘 | HUA Weiming XIA Yongde YUE Yinghong | 2000 | Journal of Catalysis2000，196，1： | 1 |
| 11 | Acidity enhancement of SBA mesoporous molecular sieve by modification with SO4^2-/ZrO2 显示文摘 | Hua Weiming Yue Yinghong Gao Zi | 2001 | J Mol Catal A: Chemical2001，170，： | 1 |
| 12 | Hydrogenation of Methyl Benzoate over Mn/Al Catalysts: Comparison among Catalyst Preparation Routes显示文摘 | Aimin Chen Hualong Xu Weiming Hua Wei Shen Yinghong Yue Zi Gao | 2005 | Topics in Catalysis (-)2005，，1： | 1 |
| 13 | Acidity enhancement of SBA mesoporous molecular sieve by modification with SO42-/ZrO2 显示文摘 | Hua Weiming Yue Yinghong Gao Zi | 2001 | J Mol Catal A: Chemical2001，170，： | 1 |
| 14 | Catalytic ac tivities and properties of sulfated zirconia supported on meso structured γ-Al2O3 显示文摘 | Zhao Jie Yue Yinghong Hua Weiming | 2008 | Applied Catalysis2008，，： | 1 |
| 15 | Dehydroge- nation of propane to propene over different polymorphs of gallium oxide显示文摘 | Zheng Bo Hua Weiming Yue Yinghong | 2005 | J Catal2005，232，1： | 1 |
| 16 | Dehydrogenation of ethane to ethylene over a highly efficient Ga 2 O 3 /HZSM-5 catalyst in the presence of CO 2显示文摘 | Zhenhao Shen Jian Liu Hualong Xu Yinghong Yue Weiming Hua Wei Shen | 2009 | Applied Catalysis A General2009，，2： | 1 |
| 17 | Nanosized titania and zirconia as catalysts for hydrolysis of carbon disulfide显示文摘 | Yinghong Yue Xiping Zhao Weiming Hua | 2003 | Appl Catal B2003，46，3： | 1 |
| 18 | Characterization and Catalytic Activities of Al2O3-Promoted Sulfated Tin Oxides显示文摘 | Jie Zhao Yinghong Yue Dewei Zhai Changxi Miao Jianyi Shen Heyong He Weiming Hua Zi Gao | 2009 | Catalysis Letters (-)2009，，1： | 1 |
| 19 | Promoting effect of AI on SO-/MxOy (M-- Zr,Ti,Fe) catalysts显示文摘 | Hua Weiming Xia Yongde Yue Yinghong | 2000 | Journal of Catalysis2000，196，1： | 1 |
| 20 | Acidity enhancement of SBA mesoporous molecular sieve by modification with SO4^2-/ZrO2 显示文摘 | Weiming Hua Yinghong Yue Zi Gao | 2001 | Journal of Molecular catalysts A :Chemical2001，170，1： | 1 |
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