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| 1 | CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target显示文摘The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in TME.Over-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer patients.In TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and metastasis.The CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in TME.Blocking the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor progression.CXCL5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the treatment.In this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in TME.The possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed. | Wen Zhang Huishan Wang Mingyang Sun Xueting Deng Xueru Wu Yilan Ma Mengjing Li Said Maisam Shuoa Qiang You Lin Miao | 2020 | Cancer Communications2020，40，2： | 19 |
| 2 | Ovary cancer incidence and mortality in China, 2011显示文摘Objective: To evaluate and analyze ovary cancer incidence and mortality in China in 2011 using ovary cancer data from population-based cancer registration in China, and to provide scientific information for its control and prevention.Methods: Invasive cases of ovary cancer were extracted and analyzed from the overall Chinese cancer database in 2011, which were based on data from 177 population-based cancer registries distributing in 28 provinces. The crude, standardized, and truncated incidences and mortalities et al. were calculated and new and deaths cases from ovary cancer throughout China and in different regions in 2011 were estimated using Chinese practical population.Results: The estimates of new ovary cancer cases and deaths were 45,223 and 18,430, respectively, in China in 2011. The crude incidence rate, age-standardized rate by Chinese standard population(ASR-C) and agestandardized rate by world standard population(ASR-W) incidence were 6.89/100,000, 5.35/100,000 and 5.08/100,000, respectively; the crude, ASR-C and ASR-W mortalities were 2.81/100,000, 2.01/100,000 and 1.99/100,000, respectively. The incidence and mortality in urban areas were higher than those in rural areas. The age-specific incidence and mortality increased rapidly from age 35-39 and peaked at age 60-64 or 75-79 years. After age 45 or 55, the age-specific incidence and death rates in urban were much higher than those in rural areas. Conclusions: Compared with GLOBOCAN 2012 data, the ovary cancer incidence in China in 2011 was at middle level, but its mortality was at low level worldwide. | Kuangrong Wei Yuanming Li Rongshou Zheng Siwei Zhang Zhiheng Liang Huishan Cen Wanqing Chen | 2015 | Chinese Journal of Cancer Research2015，27，1： | 14 |
| 3 | MHD and kinetic analysis of flow bursts in the Earth's plasma sheet显示文摘In an attempt to study the flow bursts in the Earth’s plasma sheet we select an event that took place on August 7,2004 in the expansion phase of a substorm,using data from the geomagnetic index,solar wind data,plasma and magnetic field observations from C1 Cluster satellite(the Cluster mission has 4 satellites)and from Double Star TC-1 satellite.In MHD approach,TC-1 firstly observed the tailward flow,then the earthward,and finally the flow alternated in two directions.C1 firstly observed the earthward plasma flow,and then the tailward plasma flow.Before flow bursts are observed by TC-1 and C1,there are disturbances in local entropy with their tailward local entropy larger than those of the earthward.The kinetic features of the plasma flow observed by C1 are similar to those in MHD.However,kinetic characteristics of the plasma flow observed by TC-1 are far more than the description in MHD.The inadequacy mainly exists in two cases:(i)the firstly enhanced tailward flows given in MHD are found without significant increase of the energetic tailward flux;(ii)the almost stagnant flow in MHD is composed of the enhanced energetic ion flux in both earthward and tailward directions.The earthward flow burst observed by TC-1 might be multiple overshoots and rebounds.The earthward flow burst observed by C1 might be simply rebounded in the near-Earth.The pulsation observed by C1 is earlier than that observed by TC-1 with the former intensity less than that of the latter.After the energetic ion flux in the tailward direction is significantly enhanced,the power spectrum intensity of the ULF wave commences to increase obviously,which may suggest that the stream instability is closely correlated with ULF pulsations. | MA YuDuan CAO JinBin FU HuiShan REME H. DANDOURAS I. YANG JunYing WANG ZhiQiang TAO Dan YANG Jian | 2014 | Science China(Technological Sciences)2014，57，1： | 7 |
| 4 | Regulation of microRNA on plant development and viral infection显示文摘MicroRNAs (miRNAs ) 是非编码规章的 RNAswhich 的约 22 nt 的一个班在优核质是通用的。他们为劈开或翻译压抑由 targetingmRNAs 充当基因表示的否定管理者。miRNAs 广泛地参予与植物联系的基因表示的规定发展过程,例如在植物的机关形态发生和 signaltransduction 小径。类似于在植物的抗病毒的 RNA silencing, miRNA 小径被 silencing 也介入压制病毒编码的 ors。在这评论,我们给调停 miRNA 的规章的小径和调停 siRNA 的 RNA silencing 之间的差别的一篇简短摘要。Inparticular,我们在 miRNA 上考察最近的研究规章的角色在种发展进程,以及干扰病毒在 miRNA 小径压制 ors,试图在真核细胞的有机体把卓见装入基因表达式规定的复杂性。 | DUAN Chengguo WANG Chunhan GUO Huishan | 2006 | Chinese Science Bulletin2006，51，3： | 7 |
| 5 | The role of virus-derived small interfering RNAs in RNA silencing in plants显示文摘Antiviral defense is one of the important roles of RNA silencing in plants. Virus-derived small interfering RNAs (vsiRNAs) are found in the infected host cells, indicating that the host RNA silencing machinery can target viral RNAs for destruction. With the development of high-throughput sequencing of vsiRNAs, recent genetic studies have shed light on the origin and composition of vsiRNAs and their potential functions in the regulation of gene expression. Here, we briefly describe the origin and biogenesis of vsiRNAs, and review the recent discoveries regarding vsiRNA-mediated RNA silencing of viral genomes and host transcripts. This will better our understanding of virus pathogenicity and RNA silencing-related host-pathogen inter- actions in plants. | ZHU Hui GUO HuiShan | 2012 | Science China(Life Sciences)2012，55，2： | 5 |
| 6 | Magnetotail dipolarization fronts and particle acceleration:A review显示文摘In this paper, the particle acceleration processes around magnetotail dipolarization fronts(DFs) were reviewed. We summarize the spacecraft observations(including Cluster, THEMIS, MMS) and numerical simulations(including MHD, testparticle, hybrid, LSK, PIC) of these processes. Specifically, we(1) introduce the properties of DFs at MHD scale, ion scale, and electron scale,(2) review the properties of suprathermal electrons with particular focus on the pitch-angle distributions,(3)define the particle-acceleration process and distinguish it from the particle-heating process,(4) identify the particle-acceleration process from spacecraft measurements of energy fluxes, and(5) quantify the acceleration efficiency and compare it with other processes in the magnetosphere(e.g., magnetic reconnection and radiation-belt acceleration processes). We focus on both the acceleration of electrons and ions(including light ions and heavy ions). Regarding electron acceleration, we introduce Fermi,betatron, and non-adiabatic acceleration mechanisms;regarding ion acceleration, we present Fermi, betatron, reflection, resonance, and non-adiabatic acceleration mechanisms. We also discuss the unsolved problems and open questions relevant to this topic, and suggest directions for future studies. | Huishan FU Elena EGRIGORENKO Christine GABRIELSE Chengming LIU San LU KJHWANG Xuzhi ZHOU Zhe WANG Fang CHEN | 2020 | Science China Earth Sciences2020，63，2： | 4 |
| 7 | Zircon U-Pb-Hf Isotopic Systematics and Geochemistry of the Granites in the Wurinitu Molybdenum Deposit, Inner Mongolia, China: Implications for Tectonic Setting and Genetic Type of Mineralization显示文摘The Wurinitu Mo deposit is one of the newly found molybdenum deposits in the southwestern part of the late Paleozoic–Mesozoic Erenhot–Dong-Ujimqin metallogenic belt(S-EDMB),Inner Mongolia,China. In the present study,the mineralization age of the Wurinitu deposit is constrained to 137.3 ± 1.3 to 131.9 ± 1.5 Ma based on a combination of the laser ablation–inductively coupled plasma–mass spectrometry(LA–ICP–MS) zircon U–Pb dating of the mineralization related fine-grained monzonitic granite and the post-mineralization granite porphyry. The results of zircon Lu–Hf isotopes,combined with the geochemical characteristics of the granites in the S-EDMB,suggest that the Wurinitu Mo deposit was formed in an extensional environment in relation to the subduction of the Paleo-Pacific plate in late Mesozoic. The Wurinitu deposit shares similarities with the classical Climaxtype porphyry molybdenum deposits in tectonic setting,mineral assemblages,and metal zonation. | ZHANG Zhenjie CHENG Qiuming YAO Lingqing BAI Huishan LI Cheng | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 3 |
| 8 | mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration显示文摘Hair follicles(HFs)undergo cycles of degeneration(catagen),rest(telogen),and regeneration(anagen)phases.Anagen begins when the hair follicle stem cells(HFSCs)obtain sufficient activation cues to overcome suppressive signals,mainly the BMP pathway,from their niche cells.Here,we unveil that mTOR complex 1(mTORC1)signaling is activated in HFSCs,which coincides with the HFSC activation at the telogen-to-anagen transition.By using both an inducible conditional gene targeting strategy and a pharmacological inhibition method to ablate or inhibit mTOR signaling in adult skin epithelium before anagen initiation,we demonstrate that HFs that cannot respond to mTOR signaling display significantly delayed HFSC activation and extended telogen.Unexpectedly,BMP signaling activity is dramatically prolonged in mTOR signaling-deficient HFs.Through both gain-and loss-of-function studies in vitro,we show that mTORC1 signaling negatively affects BMP signaling,which serves as a main mechanism whereby mTORC1 signaling facilitates HFSC activation.Indeed,in vivo suppression of BMP by its antagonist Noggin rescues the HFSC activation defect in mTORC1-null skin.Our findings reveal a critical role for mTOR signaling in regulating stem cell activation through counterbalancing BMP-mediated repression during hair regeneration. | Zhili Deng Xiaohua Lei Xudong Zhang Huishan Zhang Shuang Liu Qi Chen Huimin Hu Xinyue Wang Lina Ning Yujing Cao Tongbiao Zhao Jiaxi Zhou Ting Chen Enkui Duan | 2015 | Journal of Molecular Cell Biology2015，7，1： | 3 |
| 9 | Reconstructing the flux-rope topology using the FOTE method显示文摘With high-resolution data of the Magnetospheric Multiscale(MMS) mission, we observe a magnetic flux rope(MFR) in the Earth's magnetosheath. This MFR, showing a clear bipolar variation of the magnetic field in the normal component to local current sheet, contains a strong core field. We use the FOTE method to reconstruct the topology of this MFR and find it is consistent with previous expectation. For the first time, the spiral field and core field of the MFR are both revealed from the FOTE method. Comparing topologies reconstructed at different times, we suggest that the axis of the MFR rotates about 88° at different spatial location. Shape and size of the normal projection to axis vary with the spatial location as well. Inside the MFR, a significant increase of plasma density from 40 to 80 cm^(-3), a sharp decrease of ion temperature from 200 to 50 eV, an enhancement of cold ions and a series of filamentary currents are found. | CHEN ZuZheng FU HuiShan WANG TieYan CAO Dong PENG FangZheng YANG Jian XU Yin | 2019 | Science China(Technological Sciences)2019，62，1： | 3 |
| 10 | Variation in assimilable organic carbon formation during chlorination of Microcystis aeruginosa extracellular organic matter solutions显示文摘This study investigated the chlorination of Microcystis aeruginosa extracellular organic matter(EOM) solutions under different conditions, to determine how the metabolites produced by these organisms affect water safety and the formation of assimilable organic carbon(AOC). The effects of chlorine dosages, coagulant dosage, reaction time and temperature on the formation of AOC were investigated during the disinfection of M.aeruginosa metabolite solutions. The concentration of AOC followed a decreasing and then increasing pattern with increasing temperature and reaction time. The concentration of AOC decreased and then increased with increasing chlorination dosage, followed by a slight decrease at the highest level of chlorination. However, the concentration of AOC decreased continuously with increasing coagulant dosage. The formation of AOC can be suppressed under appropriate conditions. In this study, chlorination at 4 mg/L, combined with a coagulant dose of 40 mg/L at 20°C over a reaction time of 12 hr, produced the minimum AOC. | Xingbin Sun Ting Yuan Huishan Ni Yanpeng Li Yang Hu | 2016 | Journal of Environmental Sciences2016，28，7： | 2 |
| 11 | Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo显示文摘Antrodia cinnamomea is extensively used as a traditional medicine to prevention and treatment of liver cancer.However,its comprehensive chemical fingerprint is uncertain,and the mechanisms,especially the potential therapeutic target for anti-hepatocellular carcinoma(HCC)are still unclear.Using UPLC-Q-TOF/MS,139 chemical components were identified in A.cinnamomea dropping pills(ACDPs).Based on these chemical components,network pharmacology demonstrated that the targets of active components were significantly enriched in the pathways in cancer,which were closely related with cell proliferation regulation.Next,HCC data was downloaded from Gene Expression Omnibus database(GEO).The Cancer Genome Atlas(TCGA)and Dis Ge NET were analyzed by bioinformatics,and 79 biomarkers were obtained.Furtherly,nine targets of ACDP active components were revealed,and they were significantly enriched in PI3 K/AKT and cell cycle signaling pathways.The affinity between these targets and their corresponding active ingredients was predicted by molecular docking.Finally,in vivo and in vitro experiments showed that ACDPs could reduce the activity of PI3 K/AKT signaling pathway and downregulate the expression of cell cycle-related proteins,contributing to the decreased growth of liver cancer.Altogether,PI3 K/AKT-cell cycle appears as the significant central node in anti-liver cancer of A.Cinnamomea. | Yan Zhang Pin Lv Junmei Ma Ning Chen Huishan Guo Yan Chen Xiaoruo Gan Rong Wang Xuqiang Liu Sufang Fan Bin Cong Wenyi Kang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 12 | Multi-Component and Multi-Point Trace Gas Sensing in Wavelength Modulation Spectroscopy Based on Wavelength Stabilization显示文摘Multi-component and multi-point trace gas sensing in the wavelength modulation spectroscopy is demonstrated based on the frequency-division multiplexing and time-division multiplexing technology.A reference photodetector is connected in series with a reference gas cell with the constant concentration to measure the second-harmonics peak of the components for wavelength stabilization in real time.The central wavelengths of the distributed feedback lasers are locked to the target gas absorption centers by the reference second-harmonics signal using a digital proportional-integral-derivative controller.The distributed feedback lasers with different wavelengths and modulation frequencies are injected into the gas cell to achieve multi-components gas measurement by the frequency-division multiplexing technology.In addition,multi-point trace gas sensing is achieved by the time-division multiplexing technology using a photoswitch and a relay unit.We use this scheme to detect methane(CH4)at 1650.9 nm and water vapor(H2O)at 1368.597 nm as a proof of principle with the gas cell path length of 10 cm.The minimum detection limits achieved for H2O and CH4 are 1.13 ppm and 11.85 ppm respectively,with three-point gas cell measurement;thus 10.5-fold and 10.1-fold improvements are achieved in comparison with the traditional wavelength modulation spectroscopy.Meanwhile,their excellent R-square values reach 0.9983 and 0.99564 for the concentration ranges of 500 ppm to 2000 ppm and 800 ppm to 2700 ppm,respectively. | Zongliang WANG Jun CHANG Huishan YU Cunwei TIAN Hao ZHANG Xiukun ZHANG Longfei TANG Qinduan ZHANG Yiwen FENG | 2019 | Photonic Sensors2019，9，4： | 2 |
| 13 | Transplantation of sendai viral angiopoietin-I-modified mesenchymal stem cells for ischemic limb disease显示文摘 | Wenhua Piao Huishan Wang Makoto Inoue | 2010 | Angiogenesis2010，13，： | 1 |
| 14 | The pedicled latissimus dorsi myocutaneous flap in head and neck reconstruction显示文摘 | Huishan Wang Chenping ZHANG | 2014 | Oral and Maxillofacial Surgery Clinics of North America2014，26，3： | 1 |
| 15 | About the upper chromatic number of a C- hypergraph显示文摘 | Diao Kefeng Zhao Ping Zhou Huishan | 2000 | Discrete Mathematics2000，220，1： | 1 |
| 16 | Crystallization behaviors of bi odegradable poly( I:lactic acid)/graphene oxide nanocompo- sites from the amorphous state显示文摘 | Wang Huishan Qiu Zhaobin | 2011 | Thermoehim Acta2011，526，12： | 1 |
| 17 | Reversing the Trend: The Recent Expansion of the Reverse Mortgage Market显示文摘 | HuiShan | 2011 | Real Estate Economics2011，，4： | 1 |
| 18 | Boshan tone sandhi 显示文摘 | Lin Huishan | 2004 | Tai- wan Journal of Linguistics2004，，2： | 1 |
| 19 | A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes显示文摘 | Weiquan Wang Yaorong Wu Yin Li Jiaying Xie Zhonghui Zhang Zhiyong Deng Yiyue Zhang Cuiping Yang Jianbin Lai Huawei Zhang Hongyan Bao Sanyuan Tang Chengwei Yang Peng Gao Guixian Xia Huishan Guo Qi Xie | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 20 | About the upper chromaticnumber of a C-hypergraph显示文摘 | Kefeng Diao Ping Zhao Huishan Zhou | 2000 | Discrete Mathematics2000，220，： | 1 |
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