|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Mechanically induced Ca^(2+) oscillations in osteocytes release extracellular vesicles and enhance bone formation显示文摘The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin(OPG). However, the mechanisms of osteocyte mechanotransduction remain poorly understood. We've previously shown that osteocyte mechanosensitivity is encoded through unique intracellular calcium (Ca^(2+) ) dynamics. Here, by simultaneously monitoring Ca^(2+) and actin dynamics in single cells exposed to fluid shear flow, we detected actin network contractions immediately upon onset of flow-induced Ca^(2+) transients, which were facilitated by smooth muscle myosin and further confirmed in native osteocytes ex vivo. Actomyosin contractions have been linked to the secretion of extracellular vesicles(EVs), and our studies demonstrate that mechanical stimulation upregulates EV production in osteocytes through immunostaining for the secretory vesicle marker Lysosomal-associated membrane protein 1(LAMP1) and quantifying EV release in conditioned medium, both of which are blunted when Ca^(2+) signaling was inhibited by neomycin. Axial tibia compression was used to induce anabolic bone formation responses in mice, revealing upregulated LAMP1 and expected downregulation of sclerostin in vivo. This load-related increase in LAMP1 expression was inhibited in neomycin-injected mice compared to vehicle.Micro-computed tomography revealed significant load-related increases in both trabecular bone volume fraction and cortical thickness after two weeks of loading, which were blunted by neomycin treatment. In summary, we found mechanical stimulation of osteocytes activates Ca^(2+) -dependent contractions and enhances the production and release of EVs containing bone regulatory proteins. Further, blocking Ca^(2+) signaling significantly attenuates adaptation to mechanical loading in vivo, suggesting a critical role for Ca^(2+) -mediated signaling in bone adaptation. | Andrea E.Morrell Genevieve N.Brown Samuel T.Robinson Rachel L.Sattler Andrew D.Baik Gehua Zhen Xu Cao Lynda F.Bonewald Weiyang Jin Lance C.Kam X.Edward Guo | 2018 | Bone Research2018，6，1： | 13 |
| 3 | A correlation study of the expression of resistin and glycometabolism in muscle tissue after traumatic brain injury in rats显示文摘 | Jin Peng Zhu Lielie Zhang Jiasheng Xie Songling Pan Da Wen Hao Meng Weiyang Lin Luyang Chen Daqing | 2014 | Chinese Journal of Traumatology2014，17，3： | 5 |
| 4 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 5 | An efficient protein preparation for proteomic analysis of developing cotton fibers by 2‐DE显示文摘 | YuanYao Yi‐WeiYang Jin‐YuanLiu | 2006 | ELECTROPHORESIS2006，，22： | 1 |
| 6 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 7 | Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway显示文摘Taurolidine(TRD),a derivative of taurine,has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls,endotoxins and exotoxins to inhibit the adhesion of microorganisms.However,its application in antiviral therapy is seldom reported.Here,we reported that TRD significantly inhibited the replication of influenza virus H5N1 in MDCK cells with the half-maximal inhibitory concentration(EC_(50))of 34.45μg/mL.Furthermore,the drug inhibited the amplification of the cytokine storm effect and improved the survival rate of mice lethal challenged with H5N1(protection rate was 86%).Moreover,TRD attenuated virus-induced lung damage and reduced virus titers in mice lungs.Administration of TRD reduced the number of neutrophils and increased the number of lymphocytes in the blood of H5N1 virus-infected mice.Importantly,the drug regulated the NF-κB signaling pathway by inhibiting the separation of NF-κB and IκBa,thereby reducing the expression of inflammatory factors.In conclusion,our findings suggested that TRD could act as a potential anti-influenza drug candidate in further clinical studies. | Chaoxiang Lv Yuanguo Li Tiecheng Wang Qiqi Zhang Jing Qi Mingwei Sima Entao Li Tian Qin Zhuangzhuang Shi Fangxu Li Xuefeng Wang Weiyang Sun Na Feng Songtao Yang Xianzhu Xia Ningyi Jin Yifa Zhou Yuwei Gao | 2023 | Virologica Sinica2023，38，1： | 0 |
| 8 | Traveling-wave parametric amplifiere-induced qubit dephasing:analysis and mitigation显示文摘The mitigation of dephasing poses a significant challenge toimproving the performance of error-prone superconducting quantum computing systems.Here,the dephasing of a transmon qubit ina dispersive readout regime was investigated by adopting aJosephson traveling-wave parametric amplifier as the preamplifier.Our findings reveal that the potent pump leakage from the preamplifier may lead to severe dephasing.This could be attributed to amixture of measurement-induced dephasing,ac Stark effect,andheating.It is showed that pulse-mode readout is a promising measurement scheme to mitigate qubit dephasing while minimizing theneed for bulky circulators.Our work provides key insights intomitigating decoherence from microwave-pumped preamplifiers,which will be critical for advancing large-scale quantum computers. | Yingshan Zhang Huikai Xu Yu Song Yuqun Xu Shuang Yang Ziyue Hua Shoukuan Zhao Weiyang Liu Guangming Xue Yirong Jin Haifeng Yu | 2023 | Chip2023，2，4： | 0 |
| 9 | The Application of a Safe Neutralization Assay for Ebola Virus Using Lentivirus-Based Pseudotyped Virus显示文摘Dear Editor,Zaire Ebola virus(EBOV)is a negative-sense singlestranded RNA virus that is capable of causing acute hemorrhagic fever with a frightening fatality rate that can reach up to 90%.Due to its high lethality and frequent recurrence,EBOV is a substantial threat to public health.Research about live EBOV is restricted to BSL-4 laboratories;therefore,conventional serological detection methods do not provide a safe way to evaluate neutralizing activity,resulting in a bottleneck in antibody-based detection of viruses such as EBOV.Here,we aim to develop and apply a neutralization assay for EBOV using a generated lentivirus-based pseudotyped EBOV bearing GP on its surface. | Zengguo Cao Hongli Jin Gary Wong Ying Zhang Cuicui Jiao Na Feng Fangfang Wu Shengnan Xu Hang Chi Yongkun Zhao Tiecheng Wang Weiyang Sun Yuwei Gao Songtao Yang Xianzhu Xia Hualei Wang | 2021 | Virologica Sinica2021，36，6： | 0 |
| 10 | Measurement of Linear Momentum Transfer in Ar+Bi and Ar+Ag Systems at 25MeV/u显示文摘Measurement of Linear Momentum Transfer in Ar+Bi and Ar+Ag Systems at 25MeV/uMeasurementofLinearMomentumTransferinAr+BiandAr+... | Wu Enjiu Jin Genming Zheng Jiwen Yin Shuzhi Tan Jilian Zhang Chun Jin Weiyang Song Mingtao Li Zuyu Wu Heyu Wang Sufang He Zhiyoap Jiang DongXing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 11 | Light Charged Particles Emitted from Central Collision in Reaction of 25MeV/u ^(40)Ar on ^(nat)Ag显示文摘Light Charged Particles Emitted from Central Collision in Reaction of 25MeV/u ^(40)Ar on ^(nat)AgLightChargedParticlesEmittedf... | Yin Shuzhi Jin Weiyang Jin Genming Zhang Chun Zheng Jiwen Wu Enjiu Tan Jilian Song Mingtao Li Zuyu Wang Sufang Wu Heyu He Ziyong Jiang Doughing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 12 | Relation of Temperature and Excitation Energies of Hot Nuclei in Reactions of ^(40)Ar+^(nat)Ag at 25MeV/u显示文摘Relation of Temperature and Excitation Energies of Hot Nuclei in Reactions of ^(40)Ar+^(nat)Ag at 25MeV/uRelationofTemperature... | Yin Shuzhi Jin Weiyang Jin Genming Zhang Chun Zheng Jiwen Wu Enjiu Tan Jilian Song Mingtao Li Zuyu Wang Sufang Wu Heyu He Zhiyong Jiang Dongxing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 13 | Light Charged Particle Measurement in Coincidence with Fission Fragments in Reaction of 25MeV/u ^(40)Ar+^(209)Bi显示文摘Light Charged Particle Measurement in Coincidence with Fission Fragments in Reaction of 25MeV/u ^(40)Ar+^(209)BiLightChargedPa... | Zhang Chun Zheng Jiwen Wu Enjiu Yin Shuzhi Wang Sufang Jin Weiyang Jin Genming Tan Jilian Song Mingtao Li Zuyu Wu Heyu He Zhiyong Jiang Dongxing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 14 | Production and Characterization of Hot Nuclei in Ar Induced Reactions at 25 MeV/u | Wu, Enjiu Jing, Genming Zheng, Jiwen Yin, Shuzhi Tan, Jilian Zhang, Chun Jin, Weiyang Song, Mintao Li, Zhuyu Wu, Heyu Wang, Shufang He, Zhiyong Jiang, Dongxing Qian, Xing | 1996 | Chinese journal of nuclear physics1996，，3： | 0 |
| 15 | Correlative Measurements of Fission Fragments and Light Particles(α,p)in Reactions of ^(40)Ar+^(209)Bi,^(nat)Ag at 25MeV/u显示文摘Correlative Measurements of Fission Fragments and Light Particles(α,p)in Reactions of ^(40)Ar+^(209)Bi,^(nat)Ag at 25MeV/u￥WuE?.. | Wu Enjiu Jing Genming Yin Shuzhi Zheng Jiwen Tan Jilian Song Mintao Jin Weiyang Zhang Chun Li Zhuyu Wu Heyu Guo Zhongyan Wang Shufang He Zhiyong Jiang Dongxing and Qian Xing | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员