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| 1 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 2 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 3 | Recent advances of MXene as promising catalysts for electrochemical nitrogen reduction reaction显示文摘Electrochemical reduction of N2,as an eco-friendly alternative,not only allows the use of protons in water as a source of hydrogen under mild conditions but also can be driven by renewable electric energy.The major challenge is to identify high-efficiency electrocatalysts.MXene is a new class of 2D transition metal carbides,nitrides,and carbonitrides that have received significant attention in electrocatalysis.The investigations on MXene in electrocatalytic nitrogen fixation are rapidly proceeding,and some breakthroughs have emerged ve ry recently due to MXenes’satisfacto ry catalytic activity.Here,the recent progress concerning the MXene-based catalysts for electrochemical N2 reduction reaction(NRR)is highlighted.In regards to giving guidelines for exploring more efficient MXene-based catalysts for the NRR,the fabrication and surface modification of MXene are discussed.Besides,the shortcomings and challenges of current research are summarized and the future research directions are prospected. | Jie Sun Wenhan Kong Zhaoyong Jin Yaqian Han Liangyu Ma Xiaoteng Ding Yusheng Niu Yuanhong Xu | 2020 | Chinese Chemical Letters2020，31，4： | 2 |
| 4 | Structural optimization and evaluation of butenolides as potent antifouling agents: modification of the side chain affects the biological activities of compounds显示文摘 | Yongxin Li Fengying Zhang Ying Xu Kiyotaka Matsumura Zhuang Han Lingli Liu Wenhan Lin Yanxing Jia Pei-Yuan Qian | 2012 | Biofouling2012，，8： | 1 |
| 5 | Glioma stem cells and neural stem cells respond differently to BMP4 signaling显示文摘Malignant glioma is a highly heterogeneous and invasive primary brain tumor characterized by high recurrence rates,resistance to combined therapy,and dismal prognosis.Glioma stem cells(GSCs)are likely responsible for tumor progression,resistance to therapy,recurrence,and poor prognosis owing to their high self-renewal and tumorigenic potential.As a family member of BMP signaling,bone morphogenetic protein4(BMP4)has been reported to induce the differentiation of GSCs and neural stem cells(NSCs).However,the molecular mechanisms underlying the BMP4-mediated effects in these two cell types are unclear.In this study,we treated hGSCs and hNSCs with BMP4 and com-pared the phenotypic and transcriptional changes between these two cell types.Phenotypically,we found that the growth of hGSCs was greatly inhibited by BMP4,but the same treatment only increased the cell size of hNSCs.While the RNA sequencing results showed that BMP4 treatment evoked significantly transcriptional changes in both hGSCs and hNSCs,the profiles of differentially expressed genes were distinct between the two groups.A gene set that specifically targeted the proliferation and differentiation of hGSCs but not hNSCs was enriched and then validated in hGSC culture.Our results suggested that hGSCs and hNSCs responded differently to BMP4 stimulation.Understanding and investigating different responses between hGSCs and hNSCs will benefit finding partner factors working together with BMP4 to further suppress GSCs proliferation and stemness without disturbing NSCs. | Xin-Xin Han Chunhui Cai Li-Ming Yu Min Wang Wenhan Yang Dai-Yu Hu Jie Ren Lu-Ying Zhu Jia-Jia Deng Qing-Qing Chen Hua He Zhengliang Gao | 2022 | Cell Regeneration2022，11，1： | 1 |
| 6 | Propelling polysulfide redox by Fe_(3)C-FeN heterostructure@nitrogendoped carbon framework towards high-efficiency Li-S batteries显示文摘Lithium-sulfur(Li-S) batteries hold great promise in next-generation high-energy-density energy storage systems,but the intractable shuttle effect and the sluggish redox kinetics of polysulfides hinder the practical implementation of Li-S batteries.Here,heterostructured Fe_(3)C-FeN nanoparticles dotted in the threedimensional-ordered nitrogen-doped carbon framework(Fe_(3)C-FeN@NCF) were synthesized by molecular engineering combined with heterointerface engineering,and were applied to regulate the immobilization-diffusion-conversion behavior of polar polysulfides.It is experimentally and theoretically demonstrated that the heterointerface between Fe_(3)C and FeN exhibits high sulfiphilicity and high electronic/ionic conductivity,thus effectively capturing polysulfides and accelerating the bidirectional conversion of sulfur species.Meanwhile,the holey carbon framework functions as the scaffold to highly disperse binary nanoparticles,ensuring the sufficient exposure of active sites and the easy accessibility for lithium ions and electrons.By virtue of these synergistic merits,the Li-S batteries based on Fe_(3)CFeN@NCF-modified separators afford excellent electrochemical performances including a high rate capacity of 858 mA h g^(-1)at 2 C and a low capacity decay rate of 0.07% per cycle after 800 cycles at 1C This work provides inspiration for the design of heterostructured compounds and sheds light on the potential of heterostructure in high-efficiency Li-S batteries. | Mengdi Zhang Jiawei Mu Yanan Li Yuanyuan Pan Zhiliang Dong Bei Chen Shiwei Guo Wenhan Yuan Haiqiu Fang Han Hu Mingbo Wu | 2023 | Journal of Energy Chemistry2023，，3： | 1 |
| 7 | Composite polymer electrolyte reinforced by graphitic carbon nitride nanosheets for room-temperature all-solid-state lithium batteries显示文摘By virtue of the flexibility and safety, polyethylene oxide(PEO) based electrolytes are regarded as an appealing candidate for all-solid-state lithium batteries. However, their application is limited by the poor ionic conductivity at room temperature, narrow electrochemical stability window and uncontrolled growth of lithium dendrite. To alleviate these problems, we introduce the ultrathin graphitic carbon nitride nanosheets(GCN) as advanced nanofillers into PEO based electrolytes(GCN-CPE). Benefiting from the high surface area and abundant surface N-active sites of GCN, the GCN-CPE displays decreased crystallinity and enhanced ionic conductivity. Meanwhile, Fourier transform infrared and chronoamperometry studies indicate that GCN can facilitate Li+migration in the composite electrolyte. Additionally, the GCN-CPE displays an extended electrochemical window compared with PEO based electrolytes. As a result, Li symmetric battery assembled with GCN-CPE shows a stable Li plating/stripping cycling performance, and the all-solid-state Li/LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622) batteries using GCN-CPE exhibit satisfactory cyclability and rate capability in a voltage range of 3-4.2 V at 30 ℃. | Qingyue Han Suqing Wang Wenhan Kong Bing Ji Haihui Wang | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 8 | Defect elimination to enhance photoluminescence and optical transparency of Pr-doped ceramics for self-calibrated temperature feedback windows显示文摘Pr-doped metal oxide polycrystalline transparent ceramics are highly desirable for photothermal window systems served in extreme environments;however,obtaining efficient photoluminescence(PL)together with high transparency in these ceramics is still posing serious challenges,which undoubtedly limits their applications.Here,Pr-doped Y_(2)Zr_(2)O_(7)(YZO)transparent ceramics,as an illustrative example,are prepared by a solid-state reaction and vacuum sintering method.Owing to the elimination of defect clusters[Pr_(Y)^(4+)-O^(2-)Pr_(Y)^(4+)]and[Pr_(Y)^(4+)-e′]without the introduction of impurities and additional defects,the fabricated YZO:Pr ceramics exhibit high transparency(74%)and efficient PL(39-fold enhanced)after air annealing plus vacuum re-annealing treatment.Moreover,upon 295/450 nm excitation,the emission bands(blue,green,red,and dark red)from YZO:Pr ceramics present different temperature-dependent properties due to the thermalquenching channel generated by the intervalence charge transfer(IVCT)state between Pr_(Y)^(4+)and Zr^(4+)ions.Furthermore,a self-calibrated temperature feedback window with the same fluorescence intensity ratio(FIR)model(I_(613)/I_(503),where I represents the intensity)under different excitation light sources(295 and 450 nm)is designed.The developed photothermal window operated in a wide temperature range(303-663 K)shows relatively high sensitivities(absolute sensitivity(Sa)and relative sensitivity(S)reach 0.008 K^(-1)at 663 K and 0.47%K^(-1)at 363 K,respectively),high repeatability(>98%),and low temperature uncertainty(T<3.2 K).This work presents a paradigm for achieving enhanced PL along with elevated transparency of lanthanide(Ln)-doped ceramics through vacuum re-annealing treatment engineering and demonstrates their promising potential for photothermal window systems. | Kailei Lu Yucheng Ye Wenhan Han Gang Cheng Xinghua Zhu Jianqi Qi Tiecheng Lu | 2023 | Journal of Advanced Ceramics2023，12，4： | 0 |
| 9 | Connectome-based predictive modelling can predict follow-up craving after abstinence in individuals with opioid use disorders显示文摘Background Individual differences have been detected in individuals with opioid use disorders(OUD)in rehabilitation following protracted abstinence.Recent studies suggested that prediction models were effective for individual-level prognosis based on neuroimage data in substance use disorders(SUD).Aims This prospective cohort study aimed to assess neuroimaging biomarkers for individual response to protracted abstinence in opioid users using connectome-based predictive modelling(CPM).Methods One hundred and eight inpatients with OUD underwent structural and functional magnetic resonance imaging(fMRI)scans at baseline.The Heroin Craving Questionnaire(HCQ)was used to assess craving levels at baseline and at the 8-month follow-up of abstinence.CPM with leave-one-out cross-validation was used to identify baseline networks that could predict follow-up HCQ scores and changes in HCQ(HCQtolow V-up-HCQpa baseline).Then,the follow-up aseline predictive ability of identified networks was tested in a separate,heterogeneous sample of methamphetamine individuals who underwent MRI scanning before abstinence for SUD.Results CPM could predict craving changes induced by long-term abstinence,as shown by a significant correlation between predicted and actual HCQ fllow-up(r=0.417,p<0.001)and changes in HCQ(negative:r=0.334,p=0.002;positive:r=0.233,p=0.038).Identified craving-related prediction networks included the somato-motor network(SMN),salience network(SALN),default mode network(DMN),medial frontal network,visual network and auditory network.In addition,decreased connectivity of frontal-parietal network(FPN)-SMN,FPN-DMN and FPN-SALN and increased connectivity of subcortical network(SCN)-DMN,SCN-SALNandSCN-SMN were positively correlated with craving levels.Conclusions These findings highlight the potential applications of CPM to predict the craving level of individuals after protracted abstinence,as well as the generalisation ability;the identified brain networks might be the focus of innovative therapies in the future. | Wenhan Yang Jungong Han Jing Luo Fei Tang Li Fan Yanyao Du Longtao Yang Jun Zhang Huiting Zhang Jun Liu | 2023 | General Psychiatry2023，36，6： | 0 |
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