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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Single-cell Immune Landscape of Human Recurrent Miscarriage显示文摘t Successful pregnancy in placental mammals substantially depends on the establishment of maternal immune tolerance to the semi-allogenic fetus.Disorders in this process are tightly associated with adverse pregnancy outcomes including recurrent miscarriage(RM).However,an indepth understanding of the systematic and decidual immune environment in RM remains largely lacking.In this study,we utilized single-cell RNA-sequencing(scRNA-seq)to comparably analyze the cellular and molecular signatures of decidual and peripheral leukocytes in normal and unexplained RM pregnancies at the early stage of gestation.Integrative analysis identifies 22 distinct cell clusters in total,and a dramatic difference in leukocyte subsets and molecular properties in RM cases is revealed.Specifically,the cytotoxic properties of CD8^(+)effector T cells,nature killer(NK),and mucosal-associated invariant T(MAIT)cells in peripheral blood indicates apparently enhanced pro-inflammatory status,and the population proportions and ligand–receptor interactions of the decidual leukocyte subsets demonstrate preferential immune activation in RM patients.The molecular features,spatial distribution,and the developmental trajectories of five decidual NK(dNK)subsets have been elaborately illustrated.In RM patients,a dNK subset that supports embryonic growth is diminished in proportion,while the ratio of another dNK subset with cyto toxic and immune-active signature is significantly increased.Notably,a unique pro-inflammatory CD56^(+)CD16^(+)dNK subset substantially accumulates in RM decidua.These findings reveal a comprehensive cellular and molecular atlas of decidual and peripheral leukocytes in human early pregnancy and provide an in-depth insight into the immune pathogenesis for early pregnancy loss. | Feiyang Wang Wentong Jia Mengjie Fan Xuan Shao Zhilang Li Yongjie Liu Yeling Ma Yu-Xia Li Rong Li Qiang Tu Yan-Ling Wang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，2： | 8 |
| 3 | A new algorithm of retrieving a petroleum substances absorption coefficient in sea water based on a remote sensing image显示文摘Establishing the remote sensing algorithm of retrieving the absorption coefficient of seawater petroleum substances is an efficient way to improve the accuracy of retrieving a seawater petroleum concentration using a remote sensing technology. A remote sensing reflectance is a basic physical parameter in water color remote sensing. Apply it to directly retrieve the absorption coefficient of seawater petroleum substances is of potential advantage. The absorption coefficient of waters containing petroleum [ACWCP, a_o(λ)], consists of the absorption coefficient of pure water [ACPW, a_w(λ)], plankton [ACP, a_(ph)(λ)], colored scraps [ACCS, a_(d,g)(λ)], and petroleum substance [ACPS, a_(oil)(λ)]. Among those, ACCS consists of the absorption coefficient of nonalgal particle [ACNP, a_d(λ)] and colored dissolved organic matter [ACCDOM, a_g(λ)]. For waters containing petroleum, the retrieved ACCS using the existing method is a combination absorption coefficient of ACNP,ACCDOM and ACPA [CAC, a_(d,g,oil)(λ)]. Therefore, the principle question is how to extract ACPS from CAC.Through the analysis of the three proportion tests conducted between the year of 2013 and 2015 and the corresponding remote sensing data, an algorithm of retrieving the absorption coefficient of petroleum substances is proposed based on remote sensing reflectance. First of all, ACPS and CAC are retrieved from the reflectance using the quasi-analytical algorithm(QAA), with some parameter modified. Secondly, given the fact that the backscatter coefficient [BC, b_(bp)(555)] of total particles at 555 nm can be obtained completely from the reflectance, the relation between BC and ACNP in petroleum contaminated water can be established. As a result, ACNP can be calculated. Then, combining the remote sensing retrieving algorithm of a_g(440), the method of achieving the spectral slope of the absorption coefficient can be established, from which ACCDOM,can be calculated. Finally, ACPS can be computed as the residual. The accuracy of ACPS based on this algorithm is 86% compared with the in situ measurements. | HUANG Miaofen XING Xufeng SONG Qingjun LIU Yang DONG Wentong | 2016 | Acta Oceanologica Sinica2016，35，11： | 7 |
| 4 | NEW SCALING METHOD FOR COMPRESSOR MAPS USING AVERAGE INFINITESIMAL STAGE显示文摘存在的精确表演的评价煤气的汽轮机引擎的多级式的轴流动的压缩机快正在成为一颗大担心,,煤气的汽轮机引擎的使用尽最大努力产生并且在军人,工业增加。以便减少传统的可伸缩方法的分析表演错误,为估计多级式的轴的流动压缩机的特征的一个新可伸缩方法被建议。这个新奇方法基于引擎制造商提供的试验性、部分的数据。拿密度变化的效果进说明,我们介绍平均无穷小的阶段概念,并且从而把压缩进程划分成相应于无穷小的阶段的无穷小的进程的一个无限的数字。随后,我们采用改正的雷纳兹类比方法让可压缩的流动计算以便与类似标准保证好一些的依从。确认检查证明建议方法有足够的精确预言多级式的轴的流动压缩机的离开设计表演特征。 | MA Wentong LIU Yongwen SU Ming | 2007 | Chinese Journal of Mechanical Engineering2007，20，6： | 3 |
| 5 | PTEN’s regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia显示文摘 | Cheng Zhiyong Liang Wentong Yang Xiaoyang Pan Ling | 2012 | Medical Oncology2012，，2： | 2 |
| 6 | Concept and design of super junction devices显示文摘The super junction(SJ) has been recognized as the 'milestone' of the power MOSFET, which is the most important innovation concept of the voltage-sustaining layer(VSL). The basic structure of the SJ is a typical junction-type VSL(J-VSL) with the periodic N and P regions. However, the conventional VSL is a typical resistance-type VSL(R-VSL) with only an N or P region. It is a qualitative change of the VSL from the R-VSL to the JVSL, introducing the bulk depletion to increase the doping concentration and optimize the bulk electric field of the SJ. This paper firstly summarizes the development of the SJ, and then the optimization theory of the SJ is discussed for both the vertical and the lateral devices, including the non-full depletion mode, the minimum specific on-resistance optimization method and the equivalent substrate model. The SJ concept breaks the conventional'silicon limit' relationship of R_(on)∝V_B^(2.5), showing a quasi-linear relationship of R_(on)∝V_B^(1.03). | Bo Zhang Wentong Zhang Ming Qiao Zhenya Zhan Zhaoji Li | 2018 | Journal of Semiconductors2018，39，2： | 2 |
| 7 | The role of gut microbiota and its metabolites short-chain fatty acids in food allergy显示文摘Emerging evidence indicated that the increase in food allergy(FA)over the past few decades was associated with the abnormal compositional and metabolic changes of gut microbiota.Gut microbiota played a vital role in maintaining the homeostasis of the immune system and the dysbiosis of gut microbiota promoted the occurrence of FA.Recent research suggested that short-chain fatty acids(SCFAs),the main metabolites derived from gut microbiota,contributed to FA protection.Herein,we provided a comprehensive review on the relationship between gut microbiota and FA.The multifaceted mechanisms underlymg beneficial effects of gut microbiota composition/metabolites on the regulation of diverse cellular pathways in intestinal epithelial cells,dendritic cells,innate lymphoid cells,T cells,B cells and mast cells in the immune system were discussed systematically.These findings emphasized the positive function of gut microbiota in FA and provided novel ideas for the treatment or prevention of FA in the future. | Chen Chen Chenglong Liu Ke Zhang Wentong Xue | 2023 | Food Science and Human Wellness2023，12，3： | 2 |
| 8 | Establishment and Application of a SYBR Green I Real-time Quantitative PCR Assay for the Detection of LAT Gene of Pseudorabies Virus in Bama Miniature Pigs显示文摘[Objective] This study aimed to establish a rapid,sensitive and specific SYBR Green I real-time quantitative PCR assay for the detection of latent pseudorabies virus( PRV) infection. [Method]SYBR Green I real-time quantitative PCR conditions and system for early detection of latent pseudorabies virus infection were optimized and compared with conventional PCR to investigate the sensitivity and specificity. Subsequently,the established assay was applied to detect different clinical samples. [Result]The sensitivity of SYBR Green I real-time quantitative PCR assay( 52 copies / μl) was 1 000 times higher than that of conventional PCR( 5. 2 × 104 copies / μl) and the detection time was shortened by 1 /2. The established assay could be used to detect PRV but could not be used to detect PCV2,PPV,CSFV or PRRSV. Various tissues were collected from Bama miniature pigs with latent PRV infection under sterile conditions for real-time PCR detection. Results showed that viral copy number in the brain,nasal swab,inguinal lymph node,liver,lung and spleen was above 20,while PRV was not detected in the kidney and heart tissues. [Conclusion]The established SYBR Green I real-time quantitative PCR assay for PRV LAT detection was specific,sensitive and rapid,which could be used for pathogen monitoring,epidemiological investigation and quantitative study of PRV. | Sufang LU Guangjun GUO Ling MO Feng WEI Bingmei DONG Wentong ZHANG Zhiqiang SHEN | 2015 | Agricultural Biotechnology2015，4，3： | 2 |
| 9 | 节段性小肠移植手术中采用自体髂内血管进行血管重建显示文摘背景:本研究旨在评估自体髂内动静脉可否用于异体及自体节段性小肠移植手术的血管重建。方法:2011年1月至2019年1月间34例小肠移植患者纳入研究,其中19例为亲属活体移植,15例为自体移植。收集患者临床资料、血管重建类型及术后并发症进行分析。结果:全组男性20例,女性14例,中位年龄35岁。在34例小肠移植中,22例(64.7%,其中异体移植和自体移植各11例)采用自体髂内动脉脉进行血管重建,12例(35.3%)直接行血管吻合。血管重建耗时(21˘6)min。与直接吻合组相比,血管重建组患者手术总时长(530˘226 vs 440˘116 min,P=0.208)和冷缺血时间(159˘49 vs 125˘66 min,P=0.097)均有延长的趋势,但差异并未达到统计学意义。直接吻合组术后血栓形成发生率较血管重建组有增高的趋势(16.7%vs 0%,P=0.118)。中位随访36.9个月,无一例出现静脉狭窄或假性动脉瘤。19例异体移植患者中,4例(21.1%)发生急性排斥反应,1例(5.2%)出现慢性排斥反应。结论:本组数据显示,采用自体髂内动静脉进行血管重建可有力促进小肠移植的开展,同时有望降低术后血管并发症的风险。 | Guosheng Wu Yinglun Wu Mian Wang Wentong Zhang Chaoxu Liu Tingbo Liang | 2021 | Gastroenterology Report2021，9，4： | 2 |
| 10 | Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy显示文摘Metastasis remains the primary cause for mortality of breast cancer.Despite advances in current therapeutic agents,patients with metastatic breast cancer still have poor prognoses.Tumor hypoxia,a key microenvironment factor,is emerging as an attractive target to prevent metastasis and is also involved with resistance to phototherapy.Here,we show an effective nanotherapeutic approach based on manganese dioxide-coated polydopamine nanocarriers to trigger robust anti-tumor and anti-metastasis responses against metastatic breast cancer by supplemental oxygenation and multimodal imaging-guided phototherapies.In cancer cells,the produced oxygen by the developed nanoplatform decreases the expression of hypoxia-inducible factors 1 a to inhibit tumor metastasis,and enhances the efficacy of photodynamic therapy.This nanotherapeutic approach enables the combined photodynamic/photothermal treatments with great inhibition on cell migration and invasion in vitro.Moreover,the nanotherapeutics effectively suppresses primary tumor progress and inhibits lung metastasis in v ivo in a breast cancer mouse model with satisfying biosafety.This study suggests that the tumor hypoxia-targeting nanotherapeutics have great potential for preventing and treating metastatic cancers. | Jialing Hu Fuan Wang Feng Liu Wentong Sun Qunying Jiang Yahua Liu Yun Zhao Xiaoqing Liu | 2020 | Nano Research2020，13，4： | 1 |
| 11 | Analysis of an efficientrule-based motion planning system for simulating human crowds显示文摘 | Xiong Muzhou Lees M Cai Wentong | 2010 | The Visual Computer2010，26，5： | 1 |
| 12 | An Alternative Time Management Mechanism for Distributed Simulations 显示文摘 | Wentong Cai Stephen J Turner Bu-Sung Lee Junlan Zhou | 2005 | ACM Transactions on Modeling and Computer Simulation (TOMACS) (S1049-3301)2005，15，2： | 1 |
| 13 | Immortalized mouse dental papilla mesenchymal cells preserve odontoblastic phenotype and respond to bone morphogenetic protein 2显示文摘 | Feng Wang Li-An Wu Wentong Li Yuan Yang Feng Guo Qingping Gao Hui-Hsiu Chuang Lisa Shoff Wei Wang Shuo Chen | 2013 | In Vitro Cellular & Developmental Biology - Animal2013，，： | 1 |
| 14 | Time-space consistency in large-scale distributed virtual environment 显示文摘 | Zhou Suiping Cai Wentong Lee B S | 2004 | ACM Transactions on Modeling and Computer Simu- lation2004，14，1： | 1 |
| 15 | Effect of inoculating lactic acid bacteria starter cultures on the nitrite concentration of fermenting Chinese paocai显示文摘 | YAN Pingrnei XUE Wentong ZHANG Hui | 2008 | Food Control2008，12，： | 1 |
| 16 | Adaptive weighted leastsquare support vector machine regression integrated withoutlier detection and its application in QSAR 显示文摘 | Wentong Cui Xuefeng Yan | 2009 | Chemo-metrics and Intelligent Laboratory Systems2009，98，： | 1 |
| 17 | Structural Evo- lution of LC4 Alloy in Making Thixotropic Billet by SIMA Method显示文摘 | Luo Soujing Tian Wentong Zhang Guangan | 2001 | Transactions of Nonferrous Metals Society of China2001，11，： | 1 |
| 18 | The preparation of quaternized polysulfone membrane for low pressure reverse osmosis显示文摘 | Hao Jihua Wang Wentong Yang Puchen | 1991 | Desalination1991，38，13： | 1 |
| 19 | Application of adaptive Grey predictor based algorithm to boiler drum level control:Energy Conversion and Management显示文摘 | Yu Nanhua Ma Wentong Su Ming | 2006 | Elsevier2006，，： | 1 |
| 20 | Adaptive weighted least square support vector machine regression integrated with outlier detection and its application in QSAR显示文摘 | Cui Wentong Yan Xuefeng | 2009 | Chemometrics and Intelligent Laboratory Sysmms2009，98，2： | 1 |
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