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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Transduction of human catalase mediated by an HIV-1 tat protein basic domain and arginine-rich peptides into mammalian cells 显示文摘 | LI H J JAE H B WON S E | 2001 | Free Radical Biology & Medicine2001，31，11： | 1 |
| 3 | Testosterone causes simultaneous decrease of i and tension in rabbit coronary arteries:by opening voltage dependent potassium channels显示文摘 | Won E Won J Kwon S | 2003 | Yonsei Med J2003，44，6： | 1 |
| 4 | Fibroblast growth factors : biol- ogy, function, and application for tissue regeneration 显示文摘 | Yun YR Won JE Jeon E | 2010 | J Tis- sue Eng2010，2010，21： | 1 |
| 5 | Changes in S-allylcysteine contents and physicochemical properties of black garlicduring heat treatment显示文摘 | BAE S E CHO S Y WON Y D | 2014 | LWT-Food Science and Technology2014，55，： | 1 |
| 6 | Diagnosis and management of endometrial polyps: a critical review of the literature 显示文摘 | Salim S Won H Nesbitt-Hawes E | 2011 | J Minim Invasive Gynecol2011，18，5： | 1 |
| 7 | Dynamic contrast- enhanced MR renography for renal function evaluation in ureteropelvic junction obstruction: feasibility study显示文摘 | Krepkin K Won E Ramaswamy K | 2014 | Am J Roentgenol2014，202，： | 1 |
| 8 | Successful outcome following prenatal intervention in a female fetus with bladder outlet obstruction显示文摘 | Won HS Shim JY | 2005 | Epub ahead of print2005，，： | 1 |
| 9 | Synthesis, spinning and mechanical properties of poly(p-phenylene benzobisoxazole)显示文摘 | Choe E Won Kim Sang Nim | 1981 | Macromolecule1981，14，4： | 1 |
| 10 | Studies on the analysis of Benzo (a) pyrene and its metabolites in biological samples by using high performance liquid chromatograpy/fluorescence detection and gas chromatography/mass spectrometry 显示文摘 | Won L Hye S S Jee E H | 2003 | Bull Korean Chem Soc2003，24，5： | 1 |
| 11 | Autism spectrum disorder causes,mech-anisms,and treatments:focus on neuronal synapses显示文摘 | Won H Mah W Kim E | 2013 | Front Mol Neurosci2013，6，： | 1 |
| 12 | Clinical significance of microbleeds in subcortical vascular dementia 显示文摘 | Won S S Hwa L B Kim E J | 2007 | Stroke2007，38，6： | 1 |
| 13 | Diagnosis andmanagement of endometrial polyps:a critical review of theliterature显示文摘 | Salim S Won H Nesbitt-Hawes E | 2011 | J Minim Invasive Gynecol2011，18，： | 1 |
| 14 | Soft solution route to directionally grown ZnO nanorod arrays on Si wafer: roomtemperature ultraviolet laser显示文摘 | Choy J H Jang E S Won J H | 2003 | Adv Mater2003，15，22： | 1 |
| 15 | A comparative studyof the different analytical methods for analysis of S-allylcysteine in black garlic by HPLC显示文摘 | Bae E S Cho S Y Won Y D | 2012 | LWT-Food Scienceand Technology2012，46，： | 1 |
| 16 | Transduction of human catalase mediated by an HIV-1 tat protein basic domain and argininerich peptides into mammalian cells显示文摘 | Li H J Jae H B Won S E | 2001 | Free Radical Biol Med2001，31，11： | 1 |
| 17 | Epidermal growth factor increases prostaglandin E2 production via ERK1/2 MAPK and NF-kappaB pathway in fibroblast like synoviocytes from patients with rheumatoid arthritis 显示文摘 | Nah SS Won HJ Ha E | 2010 | Rheumatol Int2010，30，4： | 1 |
| 18 | Transduction of human catalase mediated by an HIV-1 tat protein basic domain and arginine-rich peptides into mammalian cells显示文摘 | LI H J JAE H B WON S E | 2001 | Free Radical Biology & Medicine2001，31，11： | 1 |
| 19 | Evaluation of the potential impact of polluted sediments using Manila clam Ruditapes philippinarum :bioaccumulation and biomarker responses 显示文摘 | WON E J HONG S RA K | 2012 | Environmental Science and Pollution Research2012，19，7： | 1 |
| 20 | Urinary TractSymptoms (LUTS) Secondary to Benign Prostatic Hy-perplasia CBPH) and LUTS/BPH with Erectile Dys-function in Asian Men: A Systematic Review Focusingon Tadalafil显示文摘 | Park H J Won J E Sorsaburu S | 2013 | World J Mens Health2013，31，3： | 1 |
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