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| 1 | NKX6.3 protects against gastric mucosal atrophy by downregulatingβ-amyloid production显示文摘BACKGROUND Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis.Thus, we hypothesized that transcription factor NKX6.3 might be involved in maintaining gastric epithelial homeostasis by regulating amyloid β(Aβ)production.AIM To determine whether NKX6.3 might protect against gastric mucosal atrophy by regulating Aβ production.METHODS We identified NKX6.3 depletion induced cell death by cell count and Western blot assay. Production and mechanism of Aβ oligomer were analyzed by enzymelinked immunosorbent assay, Western blot, immunoprecipitation, real-timequantitative polymerase chain reaction and immunofluorescence analysis. We further validated the correlation between expression of NKX6.3, Helicobacter pylori CagA, Aβ oligomer, apolipoprotein E(ApoE), and β-secretase 1(Bace1) in 55 gastric mucosae.RESULTS NKX6.3 depletion increased both adherent and floating cell populations in HFE-145 cells. Expression levels of cleaved caspase-3,-9, and poly ADP ribose polymerase were elevated in floating HFE-145^(shNKX6.3) cells. NKX6.3 depletion produced Aβ peptide oligomers, and increased expression of ApoE, amyloid precursor protein, Aβ, Bace1, low-density lipoprotein receptor, nicastrin, high mobility group box1, and receptor for advanced glycosylation end product proteins. In immunoprecipitation assay, γ-secretase complex was stably formed only in HFE-145^(shNKX6.3) cells. In gastric mucosae with atrophy, expression of Aβpeptide oligomer, ApoE, and Bace1 was detected and inversely correlated with NKX6.3 expression. Treatment with recombinant Aβ 1-42 produced Aβoligomeric forms and decreased cell viability in HFE-145^(shNKX6.3) cells. Additionally,NKX6.3 depletion increased expression of inflammatory cytokines and cyclooxygenase-2.CONCLUSION NKX6.3 inhibits gastric mucosal atrophy by regulating Aβ accumulation and inflammatory reaction in gastric epithelial cells. | Jung Hwan Yoon Yeon Soo Lee Olga Kim Hassan Ashktorab Duane T Smoot Suk Woo Nam Won Sang Park | 2019 | World Journal of Gastroenterology2019，25，3： | 6 |
| 2 | Consensus recommendations and review by an International Expert Panel on Interventions in Hepatocellular Carcinoma ( EPOIHCC )显示文摘 | Joong‐Won Park Deepak Amarapurkar Yee Chao Pei‐Jer Chen Jean‐Francois H. Geschwind Khean Lee Goh Kwang‐Hyub Han Masatoshi Kudo Han Chu Lee Rheun‐Chuan Lee Laurentius A. Lesmana Ho Yeong Lim Seung Woon Paik Ronnie T Poon Chee‐Kiat Tan Tawesak Tanwandee Gao | 2013 | Liver Int2013，，3： | 2 |
| 3 | End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients显示文摘AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis.RESULTS There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes. | Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | High Temperature Deformation Behavior of Carbon Steel in the Austenite and δ-Ferrite Regions显示文摘 | Seol D J Won Y M Yeo T J | 1999 | ISIJ International1999，39，1： | 1 |
| 6 | Giant magnetoresistance in La1-xSrxMnO2 films near room temperature 显示文摘 | JU H L K WON C LI Q GREENE R L VENKATESAN T | 1994 | Appl Phys Lett1994，65，16： | 1 |
| 7 | Powering fuel cells with CO via aqueous polyoxometalates and gold catalysts 显示文摘 | Won B K Voitl T Rodriguez-Rivera G J | 2004 | Science2004，305，： | 1 |
| 8 | Isolation and characterization of the lysozyme-encoding gene from the silkworm Bombyx mori显示文摘 | Won J L Paul T B | 1995 | Gene1995，161，19： | 1 |
| 9 | Effect of Cooling Rate on ZST,LIT and ZDT of Carbon Steels Near Melting Point显示文摘 | Won Y M Kim K H Yea T J | 1998 | ISIJ International1998，38，10： | 1 |
| 10 | Earth pressures on piles in a row due to lateral soil movements显示文摘 | Won P H Ito T | 1982 | Soils and Foundations1982，22，2： | 1 |
| 11 | Effect of hot isocratic pressing on the microstructure and mechanical properties of vitreous enamel coatings on low carbon steel 显示文摘 | Kim M T Chang S Y Won J B | 2006 | Surface Coatings Technology2006，54，6： | 1 |
| 12 | Effect of HIP process on the micro structural evolution of a nickel based superalloy 显示文摘 | KIM M T CHANG S Y WON J B | 2006 | Mater Sci Eng2006，441，： | 1 |
| 13 | A biomechanical comparison of modem anterior and posterior plate fixation of the cervical spine显示文摘 | Do Koh Y Lim T H Won You J | 2001 | Spine2001，26，1： | 1 |
| 14 | Analysis of solidification cracking using the specific crack susceptibility 显示文摘 | Won Y M Han H N and Yeo T | 2000 | ISIJ2000，40，2： | 1 |
| 15 | Effect of group IV elements on the cutting characteristics ofTi(C, N) cermet tools and reliability analysis显示文摘 | WON T K JUNE S P SHINHOO K | 2005 | Journal of Materials Processing Technology2005，166，： | 1 |
| 16 | Reproduction of an estuarine Diaphanosoma aspinosum under different salinities显示文摘 | Segwa S Won T Y | 1983 | Bull Plankton Soc Japan Nihon Purankuton Gakkaiho1983，34，1： | 1 |
| 17 | Effect of Cooling Rateon ZST, LIT and ZDT of Carbon Steels Near Melting Point显示文摘 | Won Y M Kim K H Yeo T J | 1998 | ISIJ International1998，38，10： | 1 |
| 18 | Synthetic chalcones as potential anti inflammatory and cancer chemopreventive agents 显示文摘 | Won S J Liu C T Tsao L T | 2005 | European Journal of Medicinal Chemistry2005，40，1： | 1 |
| 19 | Effects of intraoperative blood flow on the early patency of radiocephalic fistulus显示文摘 | Won T Jang JW Lee S | 2000 | Ann Vasc Surg2000，14，5： | 1 |
| 20 | Effects of intraoperative blood flow on the early patency of radiocephalic fistulas 显示文摘 | Won T Jang JW Lee S | 2000 | Ann Vasc Surg2000，14，5： | 1 |
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