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| 1 | Genetically modified foods in China and the United States:A primer of regulation and intellectual property protection显示文摘Food is a basic and personal necessity to human.Safety of food is a prime factor to consider apart from nutrition,quality and cost.Genetically modified(GM)foods first came on the market in 1994.Yet safety,transparency and traceability ofGMfoods are still under hot debate.Nonetheless,the market of GM foods is huge and attractive.Regulatory affairs and intellectual property(IP)are two critical factors affecting the development and commercial success of a food product.This article will take a look at the GM food technology and regulatory framework for GM foods in China and the United States.This article will also discuss the unique patent issues and non-patent IP tools for safeguarding the technology in these two countries. | Alice Yuen-Ting Wong Albert Wai-Kit Chan | 2016 | Food Science and Human Wellness2016，5，3： | 4 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 4 | Development of a Questionnaire to Measure the Level of Reflective Thinking显示文摘 | David Kember Doris Y. P. Leung Alice Jones Alice Yuen Loke Jan McKay Kit Sinclair Harrison Tse Celia Webb Frances Kam Yuet Wong Marian Wong Ella Yeung | 2000 | Assessment & Evaluation in Higher Education2000，，4： | 2 |
| 5 | Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript显示文摘 | Alemi Mansour Prigione Alessandro Wong Alice | 2007 | Free Radical Biology & Medicine2007，42，： | 1 |
| 6 | Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in Human ovarian cancer cells显示文摘 | Alice S Wong T | 2006 | Endocrinology2006，147，： | 1 |
| 7 | Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts显示文摘 | Gino Cortopassi Steven Danielson Mansour Alemi Shan Shan Zhan Warren Tong Valerio Carelli Andrea Martinuzzi Sangot Marzuki Kari Majamaa Alice Wong | 2006 | Mitochondrion2006，，4： | 1 |
| 8 | Stanniocalcin-2 promotes epithelial–mesenchymal transition and invasiveness in hypoxic human ovarian cancer cells显示文摘 | Alice Y.S. Law Chris K.C. Wong | 2010 | Experimental Cell Research2010，，20： | 1 |
| 9 | Risk assessment for human consumption of perfluorinated compound-contaminated freshwater and marine fish from Hong Kong and Xiamen显示文摘 | Yin G. Zhao Hin T. Wan Alice Y.S. Law Xi Wei Ye Q. Huang John P. Giesy Ming H. Wong Chris K.C. Wong | 2011 | Chemosphere2011，，2： | 1 |
| 10 | Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis显示文摘 | Susan Shuxin Wang Kam Lun Hon Alice Pik‐shan Kong Henry Nga‐hin Pong Gary Wing‐kin Wong Ting Fan Leung | 2014 | Pediatr Allergy Immunol2014，，1： | 1 |
| 11 | Risk assessment for human consumption of perfluorinated compound-contaminated freshwater and marine fish from Hong Kong and Xiamen显示文摘 | Yin G. Zhao Hin T. Wan Alice Y.S. Law Xi Wei Ye Q. Huang John P. Giesy Ming H. Wong Chris K.C. Wong | 2011 | Chemosphere2011，，2： | 1 |
| 12 | Does different exercise have the same effect of health promotion for the elderly?Comparison of training-speci?c effect of Tai Chi and swimming on motor control 显示文摘 | Alice M K Wong Shih-Wei C Shu-Chun H Ching L Hsieh-Ching C Wei-Hsien H Carl P C etal | 2011 | Archives of Gerontology and Geriatrics2011，53，： | 1 |
| 13 | Plasma apolipoprotein A1 as a biomarker for Parkinson disease显示文摘 | Judy K. Qiang Yvette C. Wong Andrew Siderowf Howard I. Hurtig Sharon X. Xie Virginia M.‐Y. Lee John Q. Trojanowski Dora Yearout James B. Leverenz Thomas J. Montine Matt Stern Susan Mendick Danna Jennings Cyrus Zabetian Ken Marek Alice S. Chen‐Plotkin | 2013 | Ann Neurol2013，，1： | 1 |
| 14 | Developing Curricula to Encourage Students to Write Reflective Journals显示文摘 | David Kember Alice Jones Alice Loke Jan McKay Kit Sinclair Harrison Tse Celia Webb Frances Wong Marian Wong Po Wa Yan Ella Yeung | 1996 | Educational Action Research1996，，3： | 1 |
| 15 | Pain relief by applying transcutaneous electrical nerve stimulation (TENS) on acupuncture points during the first stage of labor: A randomized double-blind placebo-controlled trial显示文摘 | An-Shine Chao Angel Chao Tzu-Hao Wang Yu-Cheng Chang Hsiu-Huei Peng Shuenn-Dyh Chang Anne Chao Chee-Jen Chang Chyong-Huey Lai Alice M.K. Wong | 2007 | Pain2007，，3： | 1 |
| 16 | Gonadotropins and Ovarian Cancer显示文摘 | Jung-Hye Choi Alice S. T. Wong He-Feng Huang Peter C. K. Leung | 2007 | Endocrine Reviews2007，，4： | 1 |
| 17 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
| 18 | 伊森伯格管理学院商业创新中心显示文摘这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的扩建和部分翻新使伊森伯格管理学院现有的空间扩大了近一倍. | Alice Cladet Amina Blacksher Barbara Stallone Beat Schenk Cheyenne Vandevoorde Daniel Kidd Davide Maggio Deborah Campbell Denys Kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily Mohr Fabian Lorenz Francesca Portesine Ibrahim Salman Jan Leenknegt Justyna Mydlak Kai-Uwe Bergmann Kristoffer Negendahl Ku Hun Chung Linda Halim Lucas Hong Manon Otto Maria Eugenia Dominguez Mustafa Khan Nicolas Gustin Pei Pei Yang Peter Lee Seoyoung Shin Simon Lee Terrence Chew Tianqi Zhang Tore Banke Yehezkiel Wiliardy Yixin Li Max Touhey Laurian Ghinitoiu 曲鸿(译) | 2019 | 城市环境设计2019，0，2： | 0 |
| 19 | Shuangyang——The Hometown of Chinese Sika Deer显示文摘The name of Shuangyang derives from the Lake of Shuangyang.Many foreign tourists have begun to discover what a multitude of Chinese tourists have long been aware of:that the vast continental expanse of China can dish up a host of interesting wintertime travel destinations,ranging from'haute culture'tours to ski holidays tours | Alice Wong | 2017 | China's Foreign Trade2017，，1： | 0 |
| 20 | The synergy of Helicobacter pylori and lipid metabolic disorders in induction of Th17-related cytokines in human gastric cancer显示文摘Aim:To study the impact of Helicobacter pylori(H.pylori)and lipid metabolic disorder on the expression of Th17-related cytokines in gastric cancer(GC).Methods:GC specimens were randomly collected from 42 patients,of whom 15 had H.pylori infection and 27 were without.Tumor RNA was extracted for reverse transcription quantitative polymerase chain reaction quantification of gene expression.Results:The mRNA levels of interleukin(IL)-6 and leptin,which are known to regulate Th17 differentiation,were upregulated by 20 and 6 folds,respectively,in H.pylori-infected compared to uninfected patients.IL-17A and granulocyte-macrophage colony-stimulating factor,two cytokines produced by Th17 cells,were 5-and 6-fold higher in tumors with H.pylori infection,respectively.Consistently,RORγt,a transcription factor regulating Th17 differentiation,was increased 6-fold in H.pylori-positive vs.negative tumors.Further elevation of RORγt was seen in advanced H.pylori-associated tumors.In addition,H.pylori infection was also associated with enhanced expression of CXCL1(5 folds),chemotactic factor capable of driving bone marrow-derived immature myeloid cells.Interestingly,we observed that H.pylori-associated increase of IL-17A was enhanced in the group with higher plasma triglycerides.Conclusion:The findings demonstrate a cross-talk and synergistic role of H.pylori infection and abnormal lipid metabolism in GC development,at least partly via cooperative induction of Th17 differentiation and activation. | Jie Liu Han Wang Gang Chen Mo Yang Zhi-Xian Wu Russell Erick Ericksen Alice Sze Tsai Wong Weiping Han Jin-Zhang Zeng | 2017 | Journal of Cancer Metastasis and Treatment2017，3，1： | 0 |
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