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| 1 | 乳酸菌培养物的生长特性及其对豆奶质构和风味的影响显示文摘研究了Lactobacillus casei (LC), Lactobacillus helveticus (LH) and Lactobacillus rahmnosus (Lactobacillus casei subsp. rahmnosus 6013) (LR)生长特性及其对大豆奶酪风味的影响。研究表明,经过6 h的发酵,LC、LH和LR的菌落数分别增长至8.74、7.69和8.69 log (CFU/mL);37 ℃时,分别接种LC、LH、LR和添加有Glucono-δ-内酯(GDL)的大豆牛奶都明显出现可滴定酸度增加、pH减少的现象。这三种乳酸菌都能够利用大豆糖源。经质构分析发现,菌种可引起大豆牛奶质构发生变化,其凝乳的能力可与GDL媲美。菌种通过产酶、产酸而水解大豆蛋白,从而导致质构变化形成凝乳。这些菌种可释放18种游离氨基酸(FAA),其中包括可作为奶酪风味物质前体化合物的天门冬氨酸、异亮氨酸、亮氨酸、蛋氨酸、苯丙氨酸和缬氨酸。这些菌种均能利用大豆脂肪酸(FA),而在大豆凝乳中出现某些FA消失的现象表明所选的菌种还能分别完全消耗特定的FA。可见,这三种乳酸菌在大豆牛奶中可引起质感及风味前体物的变化,正是生产大豆奶酪所必需的效果,故选择它们作为制备大豆奶酪的适用菌种。 | Naveed Ahmad 李理 杨晓泉 宁正祥 Wazir Hussain Shah 王永华 陈泽华 | 2008 | 现代食品科技2008，24，4： | 12 |
| 2 | Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images显示文摘Super-resolution structured illumination microscopy(SR-SIM) provides an up to twofold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high-quality SR-SIM images critically depends on patterned illumination with high modulation contrast. Noisy raw image data(e.g., as a result of low excitation power or low exposure time), result in reconstruction artifacts. Here, we demonstrate deep-learning based SR-SIM image denoising that results in high-quality reconstructed images. A residual encoding–decoding convolutional neural network(RED-Net) was used to successfully denoise computationally reconstructed noisy SR-SIM images.We also demonstrate the end-to-end deep-learning based denoising and reconstruction of raw SIM images into high-resolution SR-SIM images. Both image reconstruction methods prove to be very robust against image reconstruction artifacts and generalize very well across various noise levels. The combination of computational image reconstruction and subsequent denoising via RED-Net shows very robust performance during inference after training even if the microscope settings change. | ZAFRAN HUSSAIN SHAH MARCEL MÜLLER TUNG-CHENG WANG PHILIP MAURICE SCHEIDIG AXEL SCHNEIDER MARK SCHÜTTPELZ THOMAS HUSER WOLFRAM SCHENCK | 2021 | Photonics Research2021，9，5： | 11 |
| 3 | NUMERICAL SIMULATION OF AN OSCILLATING FLOW PAST A CIRCULAR CYLINDER IN THE VICINITY OF A PLANE WALL显示文摘Oscillating flow around a circular cylinder in the vicinity of a plane wall was investigated by solving the two-dimensional incompressible Navier-Stokes equations with a finite element Galarkin residual method. The effect of the gap G D between the cylinder surface and the wall on the flow behavior was studied. For the case of G D ≤ 0.25, the periodicity in the flow is attributed to both the outer shear layer instability and the oscillating frequency. As G D > 0.25, vortex shedding occurs and the periodicity in the flow is mainly due to the competition of the oscillating frequency and the vortex shedding frequency from an isolated stationary cylinder. | SHAH Syed Bilal Hussain | 2008 | Journal of Hydrodynamics2008，20，5： | 7 |
| 4 | Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation显示文摘Dehydrating stresses trigger the accumulation of abscisic acid(ABA),a key plant stress-signaling hormone that activates Snf1-Related Kinases(SnRK2s)to mount adaptive responses.However,the regulatory circuits that terminate the SnRK2s signal relay after acclimation or post-stress conditions remain to be defined.Here,we show that the desensitization of the ABA signal is achieved by the regulation of OST1(SnRK2.6)protein stability via the E3-ubiquitin ligase HOS15.Upon ABA signal,HOS15-induced degradation of OST1 is inhibited and stabilized OST1 promotes the stress response.When the ABA signal terminates,protein phosphatases ABI1/2 promote rapid degradation of OST1 via HOS15.Notably,we found that even in the presence of ABA,OST1 levels are also depleted within hours of ABA signal onset.The unexpected dynamics of OST1 abundance are then resolved by systematic mathematical modeling,demonstrating a desensitizing feedback loop by which OST1-induced upregulation of ABI1/2 leads to the degradation of OST1.This model illustrates the complex rheostat dynamics underlying the ABA-induced stress response and desensitization. | Akhtar Ali Jae Kyoung Kim Masood Jan Haris Ali Khan Irfan Ullah Khan Mingzhe Shen Junghoon Park Chae Jin Lim Shah Hussain Dongwon Baek Kai Wang Woo Sik Chung Vicente Rubio Sang Yeol Lee Zhizhong Gong Woe Yeon Kim Ray ABressan Jose MPardo Dae-Jin Yun | 2019 | Molecular Plant2019，12，11： | 5 |
| 5 | Nitrogen(N) metabolism related enzyme activities,cell uitrastructure and nutrient contents as affected by N level and barley genotype显示文摘Development of the new crop cultivars with high yield under low nitrogen(N) input is a fundamental approach to enhance agricultural sustainability,which is dependent on the exploitation of the elite germplasm.In the present study,four barley genotypes(two Tibetan wild and two cultivated),differing in N use efficiency(NUE),were characterized for their physiological and biochemical responses to different N levels.Higher N levels significantly increased the contents of other essential nutrients(P,K,Ca,Fe,Cu and Mn),and the increase was more obvious for the N-efficient genotypes(ZD9 and XZ149).The observation of ultrastructure showed that chloroplast structure was severely damaged under low nitrogen,and the two high N efficient genotypes were relatively less affected.The activities of the five N metabolism related enzymes,i.e.,nitrate reductase(NR),glutamine synthetase(GS),nitrite reductase(NiR),glutamate synthase(GOGAT) and glutamate dehydrogenase(GDH) all showed the substantial increase with the increased N level in the culture medium.However the increased extent differed among the four genotypes,with the two N efficient genotypes showing more increase in comparison with the other two genotypes with relative N inefficiency(HXRL and XZ56).The current findings showed that a huge difference exists in low N tolerance among barley genotypes,and improvement of some physiological traits(such as enzymes) could be helpful for increasing N utilization efficiency. | Jawad Munawar Shah Syed Asad Hussain Bukhari ZENG Jian-bin QUAN Xiao-yan Essa Ali Noor Muhammad ZHANG Guo-ping | 2017 | Journal of Integrative Agriculture2017，16，1： | 4 |
| 6 | Antimicrobial chemical constituents from endophytic fungus Phoma sp.显示文摘Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma sp.and the tentative identification of their active constituents.Methods:The extract and compounds were screened for antimicrobial activity using the Agar Well Diffusion Method.Four compounds were purified using column chromatography and tlieir structures were assigned using~1H and~(13)C NMR spectra,DEPT,2D COSY,HMQC and HMBC experiments.Results:The ethyl acetate fraction of Phoma sp.showed good antifungal,antibacterial,and algicidal properties.One new dihydrofuran derivative,named phomafuranol(1),together with tliree known compounds,phomalacton(2),(3R)-5-hydroxymellein(3)and emodin(4)were isolated from the ethyl acetate fraction of Phoma sp.Preliminary studies indicated that phomalacton(2)displayed strong antibacterial,good antifungal and antialgal activities.Similarly(3R)-5-hydroxymellein(3)and emodin(4)showed good antifungal,antibacterial and algicidal properties.Conclusions:Antimicrobial activities of the ethyl acetate fraction of the endophytic fungus Phoma sp.and isolated compounds clearly demonstrate that Phoma sp.and its active compounds represent a great potential for the food,cosmetic and pharmaceutical industries. | Hidayat Hussain Ines Kock Ahmed Al-Harrasi Ahmed Al-Rawahi Ghulam Abbas Ivan R.Green Afzal Shah Amin Badshah Muhammad Saleem Siegfried Draeger Barbara Schulz Karsten Krohn | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，9： | 3 |
| 7 | Bed planting of wheat(Triticum aestivum L.)improves nitrogen use efficiency and grain yield compared to flat planting显示文摘Conventional flat planting is commonly used for growing wheat in Pakistan and the crop is irrigated by flood irrigation, but it leads to ineffective use of applied nitrogen owing to poor aeration and leaching and volatilization losses. The practice also results in greater crop lodging, lower water use efficiency, and crusting of the soil surface. In contrast, bed planting of wheat not only saves water but improves fertilizer use efficiency and grain yield. Three years of pooled data from the present study showed that wheat planting on beds and nitrogen application at 120 kg ha-1produced 15.06% higher grain yield than flat planting at the same nitrogen rate. Similarly, 25.04%, 15.02%, 14.59%, and 29.83% higher nitrogen uptake, nitrogen use, and agronomic and recovery efficiencies, respectively, were recorded for bed compared to flat planting. Wheat planting on beds with a nitrogen application of80 kg ha-1gave a yield similar to that of flat planting with 120 kg ha-1nitrogen. However,the economic return was 29% higher in bed planting as compared to flat planting, when nitrogen was applied at 120 kg ha-1. | Abdul Majeed Atif Muhmood Abid Niaz Shahid Javid Zahid Ashfaq Ahmad Syed Shahid Hussain Shah Asrar Hussain Shah | 2015 | The Crop Journal2015，3，2： | 3 |
| 8 | Hydrometallurgical leaching and kinetic modeling of low-grade manganese ore with banana peel in sulfuric acid显示文摘Manganese was leached from a low-grade manganese ore(LGMO)using banana peel as the reductant in a dilute sulfuric acid medium.The effects of banana peel amount,H2SO4 concentration,reaction temperature,and time on Mn leaching from the complex LGMO were studied.A leaching efficiency of~98%was achieved at a leaching time of 2 h,banana peel amount of 4 g,leaching temperature of 120°C,manganese ore amount of 5 g,and sulfuric acid concentration of 15vol%.The phase,microstructural,and chemical analyses of LGMO samples before and after the leaching process confirmed the successful leaching of manganese.Furthermore,the leaching process followed the shrinking core model and the leaching rate was controlled by a surface chemical reaction(1−(1−x)^1/3=kt)mechanism with an apparent activation energy of 40.19 kJ·mol^−1. | Sajjad Ali Yaseen Iqbal Inamullah Khan Ansar Ullah Muhammad Sadiq Muhammad Fahad Khizar Hussain Shah | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，2： | 3 |
| 9 | 眼血流的变化对青光眼病情进展的影响(英文)显示文摘青光眼是由多种因素引起的神经退行性疾病,眼压过高会损害视神经而导致永久性视力丧失。虽然青光眼的基本病理生理机制尚未确定,但眼组织如视神经,视网膜,脉络膜以及虹膜的血流改变是青光眼发病的重要危险因素。由于不同因素所引发的视神经损害的有限认知,测量方法和治疗方面缺乏,人们对青光眼的理解存在障碍。尽管研究人员在不断地积累证据,力证眼血流的变化在青光眼发病机制中起着重要的作用,但大部分情况下,对于眼血流的变化和青光眼的患病风险之间的关系,他们都持有多样甚至矛盾的结论。本文中,我们回顾了青光眼的不同方面以及眼血流在疾病发展中的影响。 | Sher Zaman Safi Mamoona Noreen Muhammad Imran Yasir Waheed Muhammad Imran Amir Miraj Ul Hussain Shah Nawshad Muhammad | 2017 | 国际眼科杂志2017，17，3： | 3 |
| 10 | Why more research needs to be done on echinococcosis in Pakistan显示文摘Background:Echinococcosis has a worldwide geographical distribution with endemic foci on every inhabited continent.Due to the frequent outbreaks in different parts of Pakistan in the recent past,echinococcosis is being described as a neglected tropical disease and is considered one of the most neglected parasitic diseases in the country.In endemic regions,predominantly settings with limited resources,there are high numbers of echinococcosis patients,as these communities do not have access to appropriate treatment.In Pakistan,there are limited reports on echinococcosis.The disease is prevalent in human and livestock,but this has not been sufficiently explored yet.Pakistan is an agricultural country and due to the disease’s zoonotic mode of transmission,there is a dire need of future research on it.The present paper is an effort to highlight the importance of echinococcosis in Pakistan.Discussion:There is a dire need for future research on echinococcosis in Pakistan as very few investigations had been carried out on this topic thus far.The prevalence of the disease in neighbouring countries highlights that Pakistan might be at severe risk of this zoonotic infection and further supports the need for more research.In Pakistan,the majority of the population lives in rural areas with limited acess to proper hygienic/sanitary facilities.These conditions favour the outbreak of diseases such as echinococcosis.The limited available data could result in higher outbreaks in the future,and thus cause the already weak healthcare system to overburden.The country has a meagre annual budget for health,which is being spent on known infections such as polio,dengue fever and hepatic viral infections.A proper surveillance system for echinococcosis is required across the country as treatment is usually expensive,complicated and may require extensive surgery and/or prolonged drug therapy.Development of new/novel drugs and other treatment modalities receives very little,if any,attention.Prognostic awareness programmes against this infection involve deworming of the infected animals,improved food inspection and slaughterhouse hygiene,and public education campaigns.Conclusion:Future research on echinococcosis is anticipated to demonstrate whether the epidemiology,diagnosis and recombinant vaccines/antibodies relating to echinococcosis can meet the quality standards(purity,potency,safety and efficacy)defined by the World Health Organization.Research work should be carried out on the epidemiology and serodiagnosis of echinocossis in the different areas of Pakistan,which will be useful for the proper eradication of echinococcosis in this region.The health department should implement awareness-raising campaigns for the general public in order to reduce the burden of disease. | Haroon Ahmed Shahzad Ali Muhammad Sohail Afzal Abid Ali Khan Hamid Raza Zaheer Hussain Shah Sami Simsek | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 11 | SCH 503034, a Novel Hepatitis C Virus Protease Inhibitor, Plus Pegylated Interferon α-2b for Genotype 1 Nonresponders显示文摘 | Christoph Sarrazin Regine Rouzier Frank Wagner Nicole Forestier Dominique Larrey Samir K. Gupta Musaddeq Hussain Amrik Shah David Cutler Jenny Zhang Stefan Zeuzem | 2007 | Gastroenterology2007，，4： | 2 |
| 12 | Mango Leaf Disease Identification Using Fully Resolution Convolutional Network显示文摘Due to the high demand for mango and being the king of all fruits,it is the need of the hour to curb its diseases to fetch high returns.Automatic leaf disease segmentation and identification are still a challenge due to variations in symptoms.Accurate segmentation of the disease is the key prerequisite for any computer-aided system to recognize the diseases,i.e.,Anthracnose,apicalnecrosis,etc.,of a mango plant leaf.To solve this issue,we proposed a CNN based Fully-convolutional-network(FrCNnet)model for the segmentation of the diseased part of the mango leaf.The proposed FrCNnet directly learns the features of each pixel of the input data after applying some preprocessing techniques.We evaluated the proposed FrCNnet on the real-time dataset provided by the mango research institute,Multan,Pakistan.To evaluate the proposed model results,we compared the segmentation performance with the available state-of-the-art models,i.e.,Vgg16,Vgg-19,and Unet.Furthermore,the proposed model’s segmentation accuracy is 99.2%with a false negative rate(FNR)of 0.8%,which is much higher than the other models.We have concluded that by using a FrCNnet,the input image could learn better features that are more prominent and much specific,resulting in an improved and better segmentation performance and diseases’identification.Accordingly,an automated approach helps pathologists and mango growers detect and identify those diseases. | Rabia Saleem Jamal Hussain Shah Muhammad Sharif Ghulam Jillani Ansari | 2021 | Computers, Materials & Continua2021，，12： | 2 |
| 13 | Assessment of quadriceps muscle thickness using bedside ultrasonography by nurses and physicians in the intensive care unit:Intra- and inter-operator agreement显示文摘BACKGROUND Data regarding the agreement among multiple operators for measurement of quadriceps muscle thickness by bedside ultrasonography(USG)are sparse.AIM To statistically assess the agreement among 5 operators for measurement of quadriceps muscle thickness on bedside USG.METHODS This was a cross-sectional observational study.The 5 operators of varied experience(comprised of 1 critical care consultant,2 fellows,and 2 nurses)independently measured quadriceps muscle thickness in triplicate for 45 critically ill patients each,using USG.Intra-and interrater agreement rates among the 5 operators were assessed using intraclass correlation coefficient(ICC)and expressed with 95%confidence interval(CI).RESULTS The 5 operators produced a total of 135 readings and 675 observations for ICC calculations to determine the intraoperator and interoperator variations respectively.For intraoperator agreement,the overall ICC(95%CI)was 0.998(0.997,0.999)for operator 1,0.998(0.997,0.999)for operator 2,0.997(0.995,0.999)for operator 3,0.999(0.998,0.999)for operator 4,and 0.998(0.997,0.999)for operator 5.For interoperator agreement,the overall ICC(95%CI)was 0.977(0.965,0.986;P<0.001)for reading 1,0.974(0.960,0.984;P<0.001)for reading 2,and 0.975(0.961,0.985;P<0.001)for reading 3.CONCLUSION USG measurement of quadriceps muscle thickness was not dependent on clinical experience,supporting training for nurses in it. | Rohit Kumar Tajamul Hussain Shah Vijay Hadda Pawan Tiwari Saurabh Mittal Karan Madan Maroof Ahmad Khan Anant Mohan | 2019 | World Journal of Critical Care Medicine2019，8，7： | 2 |
| 14 | TLR4 polymorphisms and disease susceptibility显示文摘 | Mamoona Noreen Muhammad Ali A. Shah Sheeba Murad Mall Shazia Choudhary Tahir Hussain Iltaf Ahmed Syed Fazal Jalil Muhammad Imran Raza | 2012 | Inflammation Research2012，，3： | 2 |
| 15 | Development of multi-physics numerical simulation model to investigate thermo-mechanical fatigue crack propagation in an autofrettaged gun barrel显示文摘In this research,a detailed multi-physics study has been carried out by numerically simulating a solid fractured gun barrel for 20 thermo-mechanical cycles.The numerical model is based on thermal effects,mechanical stress fields and fatigue crack mechanics.Elastic-plastic material data of modified AISI 4340 at temperatures ranging from 25 to 1200℃and at strain rates of 4,16,32 and 48 s^(-1) was acquired from high-temperature compression tests.This was used as material property data in the simulation model.The boundary conditions applied are kept similar to the working gun barrel during continuous firing.A methodology has been provided to define thermo-mechanically active surface-to-surface type interface between the crack faces for a better approximation of stresses at the crack tip.Comparison of results from non-autofrettaged and autofrettaged simulation models provide useful information about the evolution of strains and stresses in the barrel at different points under combined thermo-mechanical loading cycles in both cases.The effect of thermal fatigue under already induced compressive yield due to autofrettage and the progressive degradation of the accumulated stresses due to thermo-mechanical cyclic loads on the internal surface of the gun barrel(mimicking the continuous firing scenario)has been analyzed.Comparison between energy release rate at tips of varying crack lengths due to cyclic thermo-mechanical loading in the non-autofrettaged and autofrettaged gun has been carried out. | Naveed Hussain Faisal Qayyum Riffat Asim Pasha Masood Shah | 2021 | Defence Technology(防务技术)2021，17，5： | 2 |
| 16 | Endoscopic ligation vs. sclerotherapy in adults with extrahepatic portal venous obstruction: a prospective randomized study显示文摘 | Showkat Ali Zargar Gul Javid Bashir Ahmad Khan Omar Javid Shah Ghulam Nabi Yattoo Altaf Hussain Shah Ghulam Mohammad Gulzar Jaswinder Singh Nisar Ahmad Shah Hakim Mohamad Shafi | 2005 | Gastrointestinal Endoscopy2005，，1： | 1 |
| 17 | 并发糖尿病和甲状腺功能亢进对雄性动物睾丸和附睾组织形态学及类固醇激素合成的作用(英文)显示文摘目的:评估糖尿病和甲状腺功能亢进对雄性动物睾丸和附睾组织形态学及类固醇激素合成的影响,并初步探讨其作用机制。创新点:以小鼠为模型,首次研究并发糖尿病和甲状腺功能亢进对雄性哺乳动物睾丸、附睾发育和类固醇激素合成的影响。方法:32只ICR品系小鼠分为四组:对照组(C)、糖尿病组(D)、糖尿病+甲亢组(DH)和甲亢组(H)。D组小鼠以200 mg/kg剂量单次腹膜内注射链脲佐菌素(STZ),诱导糖尿病成功。另对其中一半以0.3 mg/kg剂量每天注射甲状腺素,组成DH组。小鼠试验结束后,采集睾丸、附睾和血液,并离心分离获得血清。睾丸和附睾用4%(0.04 g/ml)多聚甲醛固定,并用苏木精-伊红染色法(H&E)观察睾丸和附睾组织形态学变化,用放射免疫测定(RIA)试剂盒检测血清中睾酮、促甲状腺激素(TSH)、胰岛素、甲状腺素(T4)和三碘甲状腺原氨酸(T3)的含量并进行分析。结论:D和DH组小鼠的体重、睾丸和附睾的重量显著降低。相比于正常甲亢或糖尿病小鼠,DH组中血糖水平显著升高。甲状腺激素可能是通过改变糖尿病患者的血清血糖水平对血糖稳态产生瞬时影响。组织形态学分析结果显示,在DH和H组小鼠睾丸中,输精管管腔增大,上皮厚度减少,睾丸生殖干细胞发生萎缩性变化。DH组小鼠的附睾头呈现主细胞压实、纤毛、脂质空泡化和炎症浸润现象。在附睾尾部观察到了小管完整性受损、透明细胞聚积和细胞脱落,并发现圆形精子。对于DH和H组,甲亢提高了小鼠血清睾酮水平,并损害了附睾的组织形态。总之,本试验模拟了多腺体自身免疫综合征对雄性繁殖的影响,这将有助于更好地了解男性并发糖尿病和甲亢患者不育的原因。 | Nazar Ali KOREJO Quan-wei WEI Atta Hussain SHAH Fang-xiong SHI | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，11： | 1 |
| 18 | Enhanced angiotensin II-induced activation of Na^ + , K^+ -ATPase in the proximal tubules of obese Zucker rats 显示文摘 | Shah S Hussain T | 2006 | Clin Exp Hypertens2006，28，1： | 1 |
| 19 | Storage of wheat with ears显示文摘 | SHAH W H KAUSAR T HUSSAIN A | 2002 | Pakistan Journal of Agricultural Research2002，17，3： | 1 |
| 20 | Persistent hyperinsuli- naemic hypoglycaemia in infancy 显示文摘 | Shah P Demirbilek H Hussain K | 2014 | Semin Pediatr Surg2014，23，2： | 1 |
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