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| 1 | International consensus statement on robotic hepatectomy surgery in 2018显示文摘The robotic surgical system has been applied in liver surgery. However,controversies concerns exist regarding a variety of factors including the safety,feasibility, efficacy, and cost-effectiveness of robotic surgery. To promote the development of robotic hepatectomy, this study aimed to evaluate the current status of robotic hepatectomy and provide sixty experts' consensus and recommendations to promote its development. Based on the World Health Organization Handbook for Guideline Development, a Consensus Steering Group and a Consensus Development Group were established to determine the topics, prepare evidence-based documents, and generate recommendations. The GRADE Grid method and Delphi vote were used to formulate the recommendations. A total of 22 topics were prepared analyzed and widely discussed during the 4 meetings. Based on the published articles and expert panel opinion, 7 recommendations were generated by the GRADE method using an evidence-based method, which focused on the safety, feasibility, indication,techniques and cost-effectiveness of hepatectomy. Given that the current evidences were low to very low as evaluated by the GRADE method, further randomized-controlled trials are needed in the future to validate these recommendations. | Rong Liu Go Wakabayashi Hong-Jin Kim Gi-Hong Choi Anusak Yiengpruksawan Yuman Fong Jin He Ugo Boggi Roberto I Troisi Mikhail Efanov Daniel Azoulay Fabrizio Panaro Patrick Pessaux Xiao-Ying Wang Ji-Ye Zhu Shao-Geng Zhang Chuan-Dong Sun Zheng Wu Kai-Shan Tao Ke-Hu Yang Jia Fan Xiao-Ping Chen | 2019 | World Journal of Gastroenterology2019，25，12： | 23 |
| 2 | Recent advances and future challenges for massive MIMO channel measurements and models显示文摘The emerging fifth generation(5G) wireless communication system raises new requirements on spectral efficiency and energy efficiency. A massive multiple-input multiple-output(MIMO) system, equipped with tens or even hundreds of antennas, is capable of providing significant improvements to spectral efficiency,energy efficiency, and robustness of the system. For the design, performance evaluation, and optimization of massive MIMO wireless communication systems, realistic channel models are indispensable. This article provides an overview of the latest developments in massive MIMO channel measurements and models. Also, we compare channel characteristics of four latest massive MIMO channel models, such as receiver spatial correlation functions and channel capacities. In addition, future challenges and research directions for massive MIMO channel measurements and modeling are identified. | Cheng-Xiang WANG Shangbin WU Lu BAI Xiaohu YOU Jing WANG Chih-Lin I | 2016 | Science China(Information Sciences)2016，59，2： | 16 |
| 3 | Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years'experience of National Cancer Center in China显示文摘Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer.Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics(FIGO) Ib–IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed.The median follow-up was 70 months.Results: Of all the patients,61.6% of the cases received adjuvant therapy,with 5-year disease-free survival(DFS)of 92.1% and 5-year overall survival(OS) of 95.0%.In multivariate analysis,differentiation of G3(P<0.05),lymph node metastasis(LNM,P<0.05) and lymphovascular space invasion(LVSI,P<0.05) were independent predictors for OS,while LNM(P<0.05),deep stroma invasion(DSI,P<0.05) and LVSI(P<0.05) were independent factors for DFS.The samples were stratified by histologic type,and cervical squamous cell carcinoma(SCC) was found to share the same independent factors except for differentiation of OS.As to patients with cervical adenocarcinoma/adenosquamous carcinoma(AC/ASC),differentiation was the independent predictor of OS(P<0.05); and LVSI of DFS(P<0.05).Of 236 patients with high-risk factors,there was no significant difference in survival between concurrent chemoradiotherapy(CCRT,n=195),radiotherapy(RT,n=24),and chemotherapy(CT,n=17).Among the 190 patients with LNM who underwent CCRT,124 cases showed improved DFS after sequential CT(P=0.118),with a recurrence rate decrease of 14%,though the difference was not statistically significant.Patients with single intermediate-risk factors like DSI or LVSI were found to partially benefit from adjuvant therapy,but the difference was not statistically significant.Conclusions: LNM,LVSI,DSI and differentiation were found to be independent prognostic factors for operable cervical cancer.Aggressive postoperative adjuvant therapy based on single risk factors in Chinese National Cancer Center could benefit survival.CCRT+CT outperformed CCRT in high-risk patients.For patients with single non-high-risk factor,the role of adjuvant therapy needs to be further discussed. | Tong Shu Dan Zhao Bin Li Yating Wang Shuanghuan Liu Pingping Li Jing Zuo Ping Ba i RongZhang Lingying Wu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 12 |
| 4 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 5 | Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management显示文摘Chronic hepatitis B(CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to complications, such as cirrhosis, liver failure and hepatocellular carcinoma(HCC). Liver transplantation(LT) is considered gold standard for treatment of hepatitis B virus(HBV)-related liver failure and HCC. However, post-transplant viral reactivation can be detrimental to allograft function, leading to poor survival. Prophylaxis with high-dose hepatitis B immunoglobulin(HBIG) and anti-viral drugs have achieved remarkable progress in LT by suppressingviral replication and improving long-term survival. The combination of lamivudine(LAM) plus HBIG has been for many years the most widely used. However, life-long HBIG use is both cumbersome and costly, whereas long-term use of LAM results in resistant virus. Recently, in an effort to develop HBIG-free protocols, high potency nucleos(t)ide analogues, such as Entecavir or Tenofovir, have been tried either as monotherapy or in combination with low-dose HBIG with excellent results. Current focus is on novel antiviral targets, especially for covalently closed circular DNA(ccc DNA), in an effort to eradicate HBV infection instead of viral suppression. However, there are several other molecular mechanisms through which HBV may reactivate and need equal attention. The purpose of this review is to address post-LT HBV reactivation, its risk factors, underlying molecular mechanisms, and recent advancements and future of anti-viral therapy. | Ranjit Chauhan Shilpa Lingala Chiranjeevi Gadiparthi Nivedita Lahiri Smruti R Mohanty Jian Wu Tomasz I Michalak Sanjaya K Satapathy | 2018 | World Journal of Hepatology2018，10，3： | 5 |
| 6 | STELLADELIN D,A NEW CYCLIC UNDECAPEPTIDE FROM STELLARIA DELAVAYI显示文摘STELLADELIND,ANEWCYCLICUNDECAPEPTIDEFROMSTELLARIADELAVAYI￥YuRuiZHAO;JunZHOU;XianKaiWANG;XiaoLinHUANG;HouMingWU;ChangXiangCHEN... | Yu Rui ZHAO Jun ZHOU Xian Kai WANG Xiao Lin HUANG Hou Ming WU Chang Xiang CHENG (Depepartment of Medicinal Chemistry of Natural Products,School ofPharmacy, West China University of Medical Sciences,Chengdu, 610041)(Laboratory of Phytochemistry,Kunming I | 1996 | Chinese Chemical Letters1996，7，3： | 4 |
| 7 | Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a T aiwanese population显示文摘 | Wen‐Hung Hsu Sophie SW Wang Hsiang‐Yao Shih Meng‐Chieh Wu Yi‐Yu Chen Fu‐Chen Kuo Hui‐Ying Yang Shun‐Li Chiu Koung‐Shing Chu Kuang‐I Cheng Deng‐Chyang Wu I‐Cheng Lu | 2013 | Journal of Digestive Diseases2013，，3： | 3 |
| 8 | Numerical prediction experiment on Typhoon Maggie (9903)显示文摘The movement of Typhoon Maggie (9903) in June 1999 is one of the rare cases ever seen in the history. At 00U on June 6 Maggie was located at about 70 km to the southwest of Taiwan. When it arrived at the coastal region of Shanwei City (22.8N, 116.5E), it turned suddenly to move southwestward along the southern China coastal line. De June 7 Maggie finally turned to move northward, making landfall to the north of Shangchuan Island. The experimental numerical prediction system on typhoon movement that was designed based on MM5 is proved quite successful for the 48h prediction of Maggie’s movement and rainfall. The mean prediction error of typhoon track is 81 km for 0-24 h and 74 km for 24-48 h. The location of typhoon center in the initial field of the model is approximately 100 km away from the actual observations. In order to modify the location of typhoon center, a bogus typhoon was intro- duced into the model and the prediction of typhoon track was improved in 0-24 h time interval. But the prediction error was enlarged in 24-36 h. We also performed a sensitivity experiment of changing the land of southern China into the ocean. It is found that the orientation of South China coastal line and the topography have no obvious effect on the movement of Typhoon Maggie. | Fong Soi Kun, Wu Chisheng, Hao I Pan, Lam Kin Hang Ku Chi Meng, Wang Anyu, Lin Wenshi (1. Macao Meteorological and Geophysical Bureau, Macao, China 2. Department of Atmospheric Sciences, Zhongshan University, Guangzhou 510275, China) | 2001 | Acta Oceanologica Sinica2001，20，2： | 3 |
| 9 | The role of advanced paternal age in modern reproductive medicine显示文摘 | Christopher Wu Larry I Lipshultz Jason R Kovac | 2016 | Asian Journal of Andrology2016，18，3： | 3 |
| 10 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 11 | A review of the Euplotidae (Hypotrichida, Ciliophora)显示文摘 | Curds C R Wu I C H | 1983 | Bull Br Mus Nat Hist1983，44，： | 3 |
| 12 | Genotypes and Viremia of Hepatitis B and D Viruses Are Associated With Outcomes of Chronic Hepatitis D Patients显示文摘 | Chien–Wei Su Yi–Hsiang Huang Teh–Ia Huo Hsuan Hui Shih I–Jane Sheen Su–Wen Chen Pui–Ching Lee Shou–Dong Lee Jaw–Ching Wu | 2006 | Gastroenterology2006，，6： | 3 |
| 13 | Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury显示文摘 | Wang, YX Cheung, PT Shen, GX Bhatia, I Wu, EX Qiu, DQ Khong, PL | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 14 | LC-MS-based lipidomic analysis in distinguishing patients with nonalcoholic steatohepatitis from nonalcoholic fatty liver显示文摘Background: Nonalcoholic fatty liver disease(NAFLD) is one of the main liver diseases, and its pathologic profile includes nonalcoholic fatty liver(NAFL) and nonalcoholic steatohepatitis(NASH). However, there is no reliable non-invasive parameter in distinguishing NASH from NAFL in clinical practice. The present study was to find a non-invasive way to differentiate these two categories of NAFLD via lipidomic analysis. Methods: Lipidomic analysis was used to determine the changes of lipid moieties in blood from 20 NAFL and 10 NASH patients with liver biopsy. Liver histology was evaluated after hematoxylin and eosin staining and Masson’s trichrome staining. The profile of lipid metabolites in correlation with steatosis, inflammation, hepatocellular necroptosis, fibrosis, and NAFLD activity score(NAS) was analyzed. Results: Compared with NAFL patients, NASH patients had higher degree of steatosis, ballooning degeneration, lobular inflammation. A total of 434 different lipid molecules were identified, which were mainly composed of various phospholipids and triacylglycerols. Many lipids, such as phosphatidylcholine(PC)(P-22:0/18:1), sphingomyelin(SM)(d14:0/18:0), SM(d14:0/24:0), SM(d14:0/22:0), phosphatidylethanolamine(PE)(18:0/22:5), PC(O-22:2/12:0), and PC(26:1/11:0) were elevated in the NASH group compared to those in the NAFL group. Specific analysis revealed an overall lipidomic profile shift from NAFL to NASH, and identified valuable lipid moieties, such as PCs [PC(14:0/18:2), PE(18:0/22:5) and PC(26:1/11:0)] or plasmalogens [PC(O-22:0/0:0), PC(O-18:0/0:0), PC(O-16:0/0:0)], which were significantly altered in NASH patients. In addition, PC(14:0/18:2), phosphatidic acid(18:2/24:4) were positively correlated with NAS;whereas PC(18:0/0:0) was correlated positively with fibrosis score. Conclusions: The present study revealed overall lipidomic profile shift from NAFL to NASH, identified valuable lipid moieties which may be non-invasive biomarkers in the categorization of NAFLD. The correlations between lipid moieties and NAS and fibrosis scores indicate that these lipid biomarkers may be used to predict the severity of the disease. | Zhong-Hua Wang Kenneth I Zheng Xiao-Dong Wang Jin Qiao Yang-Yang Li Li Zhang Ming-Hua Zheng Jian Wu | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 2 |
| 15 | A NEW CYCLOPEPTIDE FROM ARENARIA JUNCEA显示文摘A NEW CYCLOPEPTIDE FROM ARENARIA JUNCEAANEWCYCLOPEPTIDEFROMARENARIAJUNCEAYuRuiZHAO;JunZHOU;XianKaiWANG;XiaoLinHUANG;HouMingWU... | Yu Rui ZHAO Jun ZHOU Xian Kai WANG Xiao Lin HUANG Hou Ming WU Tong Fang ZHAO(Department of Medicinal Chemistry of Natural Products, School of Pharmacy, West China University of Medical Sciences. Chengdu, 610041)(Laboratory of Phytochemistry, Kunming I | 1994 | Chinese Chemical Letters1994，5，9： | 2 |
| 16 | Feasibility of Shortening 14‐day Hybrid Therapy While Maintaining an Excellent Helicobacter pylori Eradication Rate显示文摘 | Jeng‐Yih Wu Ping‐I Hsu Deng‐Chyang Wu David Y. Graham Wen‐Ming Wang | 2014 | Helicobacter2014，，3： | 2 |
| 17 | The aging burden of hospitalization for heart failure in Chinese populations:evidence from the Macao Heart Failure Study显示文摘Objective To assess the aging burden of hospitalization for heart failure in Chinese populations in Macao.Methods The Macao Heart Failure Study consists of patients hospitalized with a diagnosis of acute heart failure(AHF)at Centro Hospitalar Conde de São Januário(the only public hospital that provides medical care for the approximately 600,000 residents of Macao)from January 2014 to December 2016.First,we investigated the relationship between socioeconomic development and epidemiological characteristics of HF in Macao.Then we assessed the patients’clinical features and outcomes according to the age groups.Results A total of 967 patients were included in the final analysis.The median age at admission was 82 years old.The advanced age at the admission of HF in Macao was significantly associated with a high-income level and the aging population structure.Marked heterogeneity existed in the epidemiological characteristics,clinical features,utilization of evidence-based therapies,short-and long-term outcomes,and prognostic utility of clinical variables among the different age groups.Conclusion Rapid economic development and significantly aging populations have produced a profound impact on the epidemiological characteristics of HF in Chinese populations.Acute decompensated heart failure(ADHF)is predominantly a disease of the elderly in Macao,and a significant heterogeneity exists in the clinical features,managements,and outcomes among different age groups.Age-based risk stratification models and multidisciplinary HF teams are urgently needed to improve the management and outcomes of hospitalized heart failure(HHF)patients. | Zhi-Nan LU Mario Evora Edmundo Lao Man Ieng Pun Weng Hong Pun Monica Pon Kong Chu Pui I Ieong Toi-Meng Mok Yong-Jian WU | 2020 | Journal of Geriatric Cardiology2020，17，9： | 2 |
| 18 | 查看详情显示文摘 | Wu A Vilarinho P M Salvado I M M | | 0，，： | 2 |
| 19 | The Efficacy of Second‐Line Anti‐ Helicobacter pylori Therapy Using an Extended 14‐Day Levofloxacin/Amoxicillin/Proton‐Pump Inhibitor Treatment – A Pilot Study显示文摘 | Seng‐Kee Chuah Wei‐Chen Tai Pin‐I Hsu Deng‐Chyang Wu Keng‐Liang Wu Chung‐Mou Kuo Yi‐Chun Chiu Ming‐Luen Hu Yeh‐Pin Chou Yuan‐Hung Kuo Chih‐Ming Liang King‐Wah Chiu Tsung‐Hui Hu | 2012 | Helicobacter2012，，5： | 2 |
| 20 | Quantitative analysis of the temperature effect on the radiation crosslinking and scission of polyethylene macromolecules显示文摘 | Shyichuk A Shyichuk I Wu G Z | 2001 | J Polym Sci Part A-Polym Chem2001，39，10： | 1 |
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