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| 1 | Analysis of ionospheric anomalies before the 2011 M_w 9.0 Japan earthquake显示文摘On March 11, 2011, a large earthquake of Mw=9.0 occurred near the east coast of Honshu, Japan. This paper investigates preearthquake ionospheric anomalies during the earthquake period, using data from global navigation satellite systems and ionosonde stations near the epicenter. A clear anomaly that occurred on March 8 lasted 6 hours. Eliminating ionospheric anomalies that may have been caused by solar activities and magnetic storms, we believe that a positive anomaly on March 8 was very possibly an ionospheric precursor. The affected ionospheric area on March 8, which is evident on a vertical total electron content distribution map, extended to 50° in longitude and 20° in latitude, with length ratio approximately 3:1. The anomaly peak arose from 15:00-19:00 LT, and its location did not coincide with the vertical projection of the epicenter, but was instead to its south. Corresponding ionospheric anomalies are also observed in the magnetically conjugated region. There were no obvious ionospheric anomalies in other parts of the world. To analyze changes in the ionospheric anomaly, computerized ionospheric tomography technology was used to invert the spatial and temporal distribution of electron density in the ionosphere. The ionospheric anomaly on March 8, 2011 is suggested to be an ionospheric precursor of the March 11 earthquake in Japan. | YAO YiBin CHEN Peng WU Han ZHANG Shun PENG WenFei | 2012 | Chinese Science Bulletin2012，57，5： | 14 |
| 2 | Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents显示文摘Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. | Jiabing Wang Lili Huang Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 3 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 4 | Zonal method solution of radiative heat transfer in a one-dimensional long roller-hearth furnace in CSP显示文摘A radiative heat transfer mathematical model for a one-dimensional long furnace was set up in a through-type roller-hearth furnace (TTRHF) in compact strip production (CSP). To accurately predict the heat exchange in the furnace, modeling of the complex gas energy-balance equation in volume zones was considered, and the heat transfer model of heating slabs and wall lines was coupled with the radiative heat transfer model to identify the surface zonal temperature. With numerical simulation, the temperature fields of gas, slabs, and wall lines in the furnace under one typical working condition were carefully accounted and analyzed. The fundamental theory for analyzing the thermal process in TTRHF was provided. | Wenfei Wu Yanhui Feng Xinxin Zhang | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 4 |
| 5 | Efficacy of Rebixiao Chinese herbal tablets and Chinese formula granules in acute gout arthritis patients:a randomized,multicenter,double-blind,controlled trial显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of Rebixiao(RBX)Chinese herbal tablets(CHT)and Chinese formula granules(CFG)in the treatment of acute gout arthritis(AGA).METHODS:This randomized,multicenter,double-blind,controlled trial included 165 AGA patients with the damp-heat symptom pattern who were randomly divided into an RBX CHT group and an RBX CFG group and treated for 7 d at three centers.The total effective rates of the joint symptom score,Traditional Chinese Medicine(TCM)symptoms score,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)were used to evaluate the clinical efficacy.Safety assessments were also performed.RESULTS:Of the 165 enrolled patients,147 completed the clinical observation.There was no difference in baseline between the two groups.The total effective rates of the joint symptom score were 94.36%and 97.36%,and the total effective rates of the TCM symptoms score were 95.77%and 97.36%in the CFG group and CHT group,respectively.No statistical difference was found between the two groups(P>0.05).Additionally,ESR and CRP were similar in both groups(P>0.05).Furthermore,treatment efficacy regarding TCM and joint symptoms,the ESR,and CRP were consistent within each center and among the different centers(P>0.05).In addition,the incidence of adverse events was 4.22%and 2.63%in the CFG group and CHT group,respectively,and no difference was observed between the two groups(P>0.05).CONCLUSION:RBX CFG and CHT have significant and similar efficacy in the treatment of AGA,and CFG did not increase adverse side effects. | Wang Shasha Zhang Ying Dai Min Yang Min Leng Wenfei Peng Xiufeng Li Guojun Yang Jinbing Gan Jianping Zhu Fenglin Li Yanping Wu Bin | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 6 | Mathematical Model and Its Application of Radial Effective Thermal Conductivity for Coil Heat Transfer in HPH Furnace显示文摘Temperature uniformity of steel coils in High Performance Hydrogen bell-type annealing furnace has a significant effect on their quality and production. The hot rolled coil can be considered as a periodically laminated material composed of steel layers and interface layers in radial direction. A new formula for the radial effective thermal conductivity has been proposed, which is based on surface characteristic, strip thickness and compressive stress of the rolled coil. Furthermore, it has been used to develop a heat transfer mathematical model for steel coils in the HPH furnace. The calculated annealing curves using this mathematical model are in good agreement with the experimental data. | Wenfei Wu Fan Yu Xinxin Zhang Yi Zuo | 2002 | Journal of Thermal Science2002，11，2： | 2 |
| 7 | Size-resolved effective density of submicron particles during summertime in the rural atmosphere of Beijing, China显示文摘Particle density is an important physical property of atmospheric particles.The information on high time-resolution size-resolved particle density is essential for understanding the atmospheric physical and chemical aging processes of aerosols particles.In the present study,a centrifugal particle mass analyzer(CPMA) combined with a differential mobility analyzer(DMA) was deployed to determine the size-resolved effective density of 50 to 350 nm particles at a rural site of Beijing during summer 2016.The measured particle effective densities decreased with increasing particle sizes and ranged from 1.43 to 1.55 g/cm^3,on average.The effective particle density distributions were dominated by a mode peaked at around 1.5 g/cm^3 for 50 to350 nm particles.Extra modes with peaks at 1.0,0.8,and 0.6 g/cm3 for 150,240,and 350 nm particles,which might be freshly emitted soot particles,were observed during intensive primary emissions episodes.The particle effective densities showed a diurnal variation pattern,with higher values during daytime.A case study showed that the effective density of Aitken mode particles during the new particle formation(NPF) event decreased considerably,indicating the significant contribution of organics to new particle growth. | Kai Qiao Zhijun Wu Xiangyu Pei Qianyun Liu Dongjie Shang Jing Zheng Zhuofei Du Wenfei Zhu Yusheng Wu Shengrong Lou Song Guo Chak K.Chan Ravi Kant Pathak Mattias Hallquist Min Hu | 2018 | Journal of Environmental Sciences2018，30，11： | 2 |
| 8 | A new hybrid method—combined heat flux method with Monte-Carlo method to analyze thermal radiation显示文摘A new hybrid method, Monte-Carlo-Heat-Flux (MCHF) method, was presented to analyze the radiative heat transfer of participating medium in a three-dimensional rectangular enclosure using combined the Monte-Carlo method with the heat flux method. Its accuracy and reliability was proved by comparing the computational results with exact results from classical 'Zone Method'. | Zengwu Zhao Daqiang Cang Wenfei Wu Yike Li Baowei Li | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 2 |
| 9 | Versatile subtypes of pericytes and their roles in spinal cord injury repair,bone development and repair显示文摘Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit(NVU),pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury(SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics. | Sipin Zhu Min Chen Yibo Ying Qiuji Wu Zhiyang Huang Wenfei Ni Xiangyang Wang Huazi Xu Samuel Bennett Jian Xiao Jiake Xu | 2022 | Bone Research2022，10，2： | 2 |
| 10 | Adding regular expressions to graph reachability and pattern queries显示文摘发现边不同类型是的在图是逐渐地普通的,显示许多关系。为如此的图,我们建议 reachability 询问的一个类和图模式,一个边与某个形式的一个正规表达式在被指定的一个类,表示经由各种各样的类型的边的一张数据图的连接。另外,我们定义图模式基于图模拟的一个修订观点匹配。在在象社会网络那样的新兴的应用的图上,我们证明这些询问能够比他们的传统的对应物发现更理智的信息。更好静止,他们的增加的富有表达力的力量不与额外的复杂性来。确实,(1 ) 我们调查他们的抑制和最小化问题,并且证明这些基本问题在 reachability 询问的二次的时间并且在模式询问的立方的时间。(2 ) 我们为回答 reachability 询问开发一个算法,在至于他们的传统的对应物的二次的时间。(3 ) 我们为评估图模式询问提供二个立方时间的算法,与图模式经由 subgraph 同晶型匹配的 NP 完全性对比。(4 ) 这些算法的有效性和效率试验性地用真实数据和合成数据被验证。 | Wenfei FAN Jianzhong LI Shuai MA Nan TANG Yinghui WU | 2012 | Frontiers of Computer Science2012，6，3： | 2 |
| 11 | Study of the heat transfer in high performance hydrogen belltype annealing furnaces显示文摘 | Zuo Yi Wu Wenfei Zhang Xinxin | 2001 | Heat Treating Asian Research2001，30，8： | 1 |
| 12 | Zonal method solution of radiative heat transfer in a one- dimensional long roller-hearth furnace in CSP 显示文摘 | WU Wenfei FENG Yanhui ZHANG Xinxin | 2007 | Journal of University of Science and Technology Beijing: Mineral Metallurgy Materials (Eng Ed)2007，14，4： | 1 |
| 13 | The decoupling between gas exchange and water potential of Cinnamomum camphora seedlings during drought recovery and its relation to ABA accumulation in leaves显示文摘气候变化将改变降雨格局,从而导致极端干旱事件增多。然而,树木如何协调生理和生化响应来应对干旱-恢复的机制仍不清楚。本研究探讨了干旱-恢复过程中树木生理与生化特征的耦联关系。我们首先将香樟(Cinnamomum camphora)盆栽幼苗种植在水分充足的条件下,然后通过停止浇水以达到干旱处理的目的。当幼苗胁迫至轻度干旱(气孔关闭)和中度干旱(ψxylem=−1.5 MPa)时,分别对其进行复水处理。在干旱及复水4天过程中,我们测定了香樟叶片水势、气体交换、脱落酸以及非结构性碳水化合物的变化规律。我们发现干旱强度在很大程度上决定了香樟的生理与生化响应,并影响其干旱后恢复。轻度干旱导致气孔关闭,并引起叶片脱落酸累积和水势下降,而中度干旱可进一步引起叶片脯氨酸累积和非结构性碳水化合物的变化。干旱强度的增加会导致气体交换恢复滞后,但对水势的恢复无显著影响。另外,干旱与复水过程中水势与气体交换之间的关系存在较大差异:即干旱过程中水势与气体交换存在很强的耦联关系,而这种耦联关系在复水过程中并不存在,其主要原因是由于叶片脱落酸累积,从而延缓了气孔导度的恢复。综上,本研究结果表明,脱落酸可能是导致香樟旱后气孔导度恢复滞后的主要影响因素。此外,干旱强度对树木生理和生化的恢复具有显著影响。 | Honglang Duan Defu Wang Xiaohua Wei Guomin Huang Houbao Fan Shuangxi Zhou Jianping Wu Wenfei Liu David TTissue Songze Wan | 2020 | Journal of Plant Ecology2020，13，6： | 1 |
| 14 | NLFM Interference Suppressing Based on Time-Varying AR Modeling and Adaptive IIR Notch Filter显示文摘 | FENG Jining YANG Xiaobo DIAO Zhejun GONG Wenfei WU Siliang | 2011 | Chinese Journal of Electronics2011，20，4： | 1 |
| 15 | Bandgap engineering of tetragonal phase CuFeS_(2)quantum dots via mixed-valence single-atomic Ag decoration for synergistic Cr(VI)reduction and RhB degradation显示文摘Bandgap engineering through single-atom site binding on semiconducting photocatalyst can boost the intrinsic activity,selectivity,carrier separation,and electron transport.Here,we report a mixed-valence Ag(0)and Ag(I)single atoms co-decorated semiconducting chalcopyrite quantum dots(Ag/CuFeS_(2)QDs)photocatalyst.It demonstrates efficient photocatalytic performances for specific organic dye(rhodamine B,denoted as RhB)as well as inorganic dye(Cr(VI))removal in water under natural sunlight irradiation.The RhB degradation and Cr(VI)removal efficiencies by Ag/CuFeS_(2)QDs were 3.55 and 6.75 times higher than those of the naked CuFeS_(2)QDs at their optimal pH conditions,respectively.Besides,in a mixture of RhB and Cr(VI)solution under neutral condition,the removal ratio has been elevated from 30.2%to 79.4%for Cr(VI),and from 95.2%to 97.3%for RhB degradation by using Ag/CuFeS_(2)QDs after 2 h sunlight illumination.The intrinsic mechanism for the photocatalytic performance improvement is attributed to the narrow bandgap of the single-atomic Ag(I)anchored CuFeS_(2)QDs,which engineers the electronic structure as well as expands the optical light response range.Significantly,the highly active Ag(0)/CuFeS_(2)and Ag(I)/CuFeS_(2)effectively improve the separation efficiency of the carriers,thus enhancing the photocatalytic performances.This work presents a highly efficient single atom/QDs photocatalyst,constructed through bandgap engineering via mixed-valence single noble metal atoms binding on semiconducting QDs.It paves the way for developing high-efficiency single-atom photocatalysts for complex pollutions removal in dyeing wastewater environment. | Yangzi Shangguan Yuanhao Zhou Renji Zheng Xuezhen Feng Qiuyue Ge Ranhao Wang Dazhong Yang Wenfei Wei Xiaoyong Wu Jia Lin Hong Chen | 2021 | Chinese Chemical Letters2021，32，11： | 1 |
| 16 | Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats显示文摘 | Wenfei Tan Xuezhao Cao Junke Wang Huangwei Lv Binyang Wu Hong Ma | 2010 | European Journal of Anaesthesiology2010，，9： | 1 |
| 17 | A study of heat transfer in high-performance hydrogen bell-type annealing furnaces 显示文摘 | Zuo Yi Wu Wenfei Zhang Xinxin | 2001 | Heat Transfer-Asian Research2001，30，8： | 1 |
| 18 | A study of heat transfer in high-performance hydrogen bell-type annealing furnaces显示文摘 | Zuo Yi Wu Wenfei Zhang Xinxin | 2001 | Heat Transfer-Asian Research2001，3，8： | 1 |
| 19 | Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice显示文摘In vertebrates,the type 1 parathyroid hormone receptor(PTH1R)is a critical regulator of skeletal development and homeostasis;however,how it is modulated is incompletely understood.Here we report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralizes the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult bone.Single-cell profiling reveals that Kindlin-2 loss increases the proportion of osteoblasts,but not mesenchymal stem cells,chondrocytes and fibroblasts,in non-hematopoietic bone marrow cells,with concomitant depletion of osteoblasts on the bone surfaces,especially those stimulated by PTH.Furthermore,haploinsufficiency of Kindlin-2 and Pth1r genes,but not that of either gene,in mice significantly decreases basal and,to a larger extent,PTH-stimulated bone mass,supporting the notion that both factors function in the same genetic pathway.Mechanistically,Kindlin-2 interacts with the C-terminal cytoplasmic domain of PTH1R via aa 474–475 and Gsα.Kindlin-2 loss suppresses PTH induction of cAMP production and CREB phosphorylation in cultured osteoblasts and in bone.Interestingly,PTH promotes Kindlin-2 expression in vitro and in vivo,thus creating a positive feedback regulatory loop.Finally,estrogen deficiency induced by ovariectomy drastically decreases expression of Kindlin-2 protein in osteocytes embedded in the bone matrix and Kindlin-2 loss essentially abolishes the PTH anabolic activity in bone in ovariectomized mice.Thus,we demonstrate that Kindlin-2 functions as an intrinsic component of the PTH1R signaling pathway in osteoblastic cells to regulate bone mass accrual and homeostasis. | Xuekun Fu Bo Zhou Qinnan Yan Chu Tao Lei Qin Xiaohao Wu Sixiong Lin Sheng Chen Yumei Lai Xuenong Zou Zengwu Shao Meiqing Wang Di Chen Wenfei Jin Youqiang Song Huiling Cao Ge Zhang Guozhi Xiao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 20 | Responses of intra-annual runoff to forest recovery patterns in subtropical China显示文摘Forest recovery plays a critical role in regulating eco-hydrological processes in forested watersheds.However,characteristics of the intra-annual runoff variation associated with different forest recovery patterns remain poorly understood.In this study,three forest change periods were identified,the baseline period(1961-1985),reforestation period(1986-2000)and fruit tree planting period(2001-2016).We selected the magnitude of seasonal runoff(wet and dry seasons)and distribution characteristics,i.e.,non-uniformity coefficient(C_(v)),complete accommodation coefficient(C_(r)),concentration ratio(C_(n)),concentration period(C_(d)),absolute variation ratio(ΔR)and relative variation ratio(C_(max)).The pair-wise approach evaluated the intra-annual runoff variation characteristics between forest change periods.Results indicate that reforestation decreased wet season runoff and increased dry season runoff.In contrast,fruit tree planting increased wet season runoff and had no significant effect on dry season runoff.For intra-annual runoff distribution characteristics,reforestation significantly reduced the C_(v),C_(r),C_(n)and C_(max).Distribution of the intra-annual runoff in the fruit tree planting period was not significantly different from the baseline.We concluded that reforestation reduced the occurance of extreme water conditions in wet and dry seasons and effectively increased the stability of the intra-annual runoff.In contrast,fruit tree planting increased instability and fluctuation of the intra-annual runoff after reforestation.The characteristics of the intra-annual runoff to fruit tree planting was similar to those of the baseline.Therefore,adopting fruit tree planting practices to regulate intra-annual runoff characteristics may not be a practical approach,and impacts of different reforestation practices should be ascertained in our study region.The implications of this study should guide regional land-water management,and this study adds to the understanding of the impacts gained in forest cover on hydrology. | Zhipeng Xu Wenfei Liu Qiang Li Jianping Wu Honglang Duan Guomin Huang Yizao Ge | 2021 | Journal of Forestry Research2021，32，4： | 0 |
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