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| 1 | Downregulation of miR-130a contributes to cisplatin resistance in ovarian cancer cells by targeting X-linked inhibitor of apoptosis (XIAP) directly显示文摘MicroRNAs (miRNAs ) 是短的,高度保存了小非编码的 RNA 分子,它 post-transcriptionally 调整基因表示并且在多样的生物进程起关键作用。最近的研究证明了 miRNAs 的 dysregulation 可能调制癌症房间的电阻到化学疗法的代理人。为了在人的卵巢的癌症房间在 cisplatin 电阻的发展调查 miR-130a 的可能的角色,衬里 A2780,我们由量的即时反向的抄写聚合酶链反应在房间计算了 microRNA-130a (miR-130a ) 的表达式。结果证明 miR-130a 在 cisplatin 抵抗的卵巢的癌症房间是显著地下面调整的。MTT 试金和流动 cytometry (FCM ) 结果证明 miR-130a 的在表示上调整了 apoptotic 活动,并且从而 cisplatin chemosensitivity,在卵巢的癌症房间。而且,我们发现 miR-130a 能直接指向 XIAP,并且参予 apoptosis 的规定。miR-130a 的起来规定在 XIAP mRNA 层次和蛋白质层次导致了重要减少。XIAP 在卵巢的癌症房间线 A2780 在 cisplatin 抵抗起一个重要作用。我们的调查结果建议 miR-130a 能在卵巢的癌症房间线 A2780 在 cisplatin 抵抗的发展起一个作用,至少部分地由经由指向 XIAP 的 apoptosis 的调整。 | Xi'an Zhang Lingna Huang Yinglin Zhao Wuhong Tan | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 16 |
| 2 | A high-quality chromosome-level genome assembly reveals genetics for important traits in eggplant显示文摘Eggplant(Solanum melongena L.)is an economically important vegetable crop in the Solanaceae family,with extensive diversity among landraces and close relatives.Here,we report a high-quality reference genome for the eggplant inbred line HQ-1315(S.melongena-HQ)using a combination of Illumina,Nanopore and 10X genomics sequencing technologies and Hi-C technology for genome assembly.The assembled genome has a total size of~1.17 Gb and 12 chromosomes,with a contig N50 of 5.26 Mb,consisting of 36,582 protein-coding genes.Repetitive sequences comprise 70.09%(811.14 Mb)of the eggplant genome,most of which are long terminal repeat(LTR)retrotransposons(65.80%),followed by long interspersed nuclear elements(LINEs,1.54%)and DNA transposons(0.85%).The S.melongena-HQ eggplant genome carries a total of 563 accession-specific gene families containing 1009 genes.In total,73 expanded gene families(892 genes)and 34 contraction gene families(114 genes)were functionally annotated.Comparative analysis of different eggplant genomes identified three types of variations,including singlenucleotide polymorphisms(SNPs),insertions/deletions(indels)and structural variants(SVs).Asymmetric SV accumulation was found in potential regulatory regions of protein-coding genes among the different eggplant genomes.Furthermore,we performed QTL-seq for eggplant fruit length using the S.melongena-HQ reference genome and detected a QTL interval of 71.29–78.26 Mb on chromosome E03.The gene Smechr0301963,which belongs to the SUN gene family,is predicted to be a key candidate gene for eggplant fruit length regulation.Moreover,we anchored a total of 210 linkage markers associated with 71 traits to the eggplant chromosomes and finally obtained 26 QTL hotspots.The eggplant HQ-1315 genome assembly can be accessed at http://eggplant-hq.cn.In conclusion,the eggplant genome presented herein provides a global view of genomic divergence at the whole-genome level and powerful tools for the identification of candidate genes for important traits in eggplant. | Qingzhen Wei Jinglei Wang Wuhong Wang Tianhua Hu Haijiao Hu Chonglai Bao | 2020 | Horticulture Research2020，7，1： | 12 |
| 3 | The emergence, development and regional differences of mixed farming of rice and millet in the upper and middle Huai River Valley, China显示文摘Mixed farming of rice and millet is one of the basic agricultural modes in the upper and middle Huai River Valley(HRV). According to the latest data, this agricultural mode appeared during the middle and late Peiligang Culture(7.8–7.0 ka BP) in the upper HRV, and then became a common subsistence economy in the end of the Neolithic(5.0–4.0 ka BP) in both the upper and middle HRV. However, it is still not clear how this mixed farming developed in the upper HRV after its occurrence, nor are the regional differences in the development of mixed farming between the upper and middle HRV during the Neolithic completely understood. In this paper, flotation and starch analyses were conducted on samples from eight archaeological sites in the upper and middle HRV. The results indicate that the mixed farming of rice and millet first appeared in the later phase of the middle Neolithic in the regions of the Peiligang Culture, then developed quite rapidly in the late Neolithic(6.8–5.0 ka BP), finally becoming the main subsistence economy at the end of the Neolithic in the upper HRV. However, there are obvious differences in the emergence and development of agriculture between the middle and upper HRV. Rice farming was the only agricultural system during the middle Neolithic, lasting until the end of the Neolithic, when mixed farming appeared in the middle HRV. Furthermore, although mixed farming appeared in both the upper and middle HRV during the end of the Neolithic, the roles of rice, foxtail millet and broomcorn millet in the subsistence economy were not the same. In general, millet was more widely cultivated than rice in the upper HRV, but rice occupied the same or a slightly more prominent position in the middle HRV at the end of the Neolithic. These results are significant for understanding the process of agricultural development and transformation, as well as human adaptation to climatic and cultural variability duringthe Neolithic. | YANG YuZhang CHENG ZhiJie LI WeiYa YAO Ling LI ZhanYang LUO WuHong YUAN ZengJian ZHANG Juan ZHANG JuZhong | 2016 | Science China Earth Sciences2016，59，9： | 11 |
| 4 | Plant food sources and stone tools' function at the site of Shunshanji based on starch grain analysis显示文摘The upper-middle Huai River valley(HRV) is located in the transition zone in the middle of eastern China. Previous studies have shown that the past populations in the upper HRV obtained plant food through gathering and cultivation of both rice and millet during the middle Neolithic. However, for the middle HRV it is not very clear what methods were used by humans to obtain plant food in that time. In this paper, starch grain analysis was carried out on 17 stone tools and 29 cauldron pottery sherds unearthed at Shunshanji(8.5–7.0 kyr BP), which is known as the earliest Neolithic site in the middle HRV excavated so far. Here, ancient starches from Coix lacryma-jobi, Triticeae, Oryza sativa, Trichosanthes kirilowii and one unidentified specie were recovered. This study contributes to the limited knowledge of food strategies as observed in the middle HRV. It demonstrates that both gathering and cultivation of rice took place during the middle-Neolithic. Among the identified species, Coix lacryma-jobi appears to have been the main plant food at Shunshanji. Moreover, it is clear that Oryza sativa was not consumed as much as other plant species according to the occurrence frequency of different starch grains. Starch grains were also found on the used surfaces of grinding stone implements as well as pestles, which means that these stone tools were used for food processing. In addition, axes from Shunshanji may also have been used for food processing as well as wood working because starches were also found on the edge of axes. Information about subsistence strategies and tool use at Shunshanji will also be helpful to understanding the utilization of plants and agricultural development in the middle HRV during the early-middle Neolithic period. | YANG YuZhang LI WeiYa YAO Ling CHENG ZhiJie LUO WuHong ZHANG JuZhong LIN LiuGen GAN HuiYuan YAN Long | 2016 | Science China Earth Sciences2016，59，8： | 9 |
| 5 | A Prediction Model for Railway Transportation Sofety and Its Application显示文摘APredictionModelforRailwayTransportationSofetyandItsApplicationLiuDongming,WangWuhong(CollegeofManagementEngineering,Southwes... | Liu Dongming, Wang Wuhong (College of Management Engineering, Southwest Jiaotong University,) Chengdu 610031,China | 1994 | Journal of Modern Transportation1994，11，1： | 3 |
| 6 | The rapid uncertainty prediction of the ocean-acoustic coupled model显示文摘 | CUI Baolong DA Lianglong GUO Wuhong ZHAO Jianxin | 2018 | Chinese Journal of Acoustics2018，37，4： | 2 |
| 7 | Capturing uncertainties of the underwater acoustic environment based on an ocean-acoustic coupled model显示文摘Considering the uncertain effects of temporal and spatial changes in the marine environment on the underwater acoustic environment,we established an ocean-acoustic coupled numerical model and performed a parallel calculation.This model incorporated acoustic calculations into the dynamic ocean,thereby achieving a dynamic forecasting and assessment of the acoustic environment.Furthermore,we adopted the ensemble prediction method to predict the vertical structure of temperature in a classic cross-section,the sound speed of the cross-section of the investigated sea area,and transmission losses.We gave the prediction errors of the sound speed profile as well as the 90%probability interval of transmission losses and the uncertainty histograms of the sound speeds,transmission losses,and sonar ranges at different depths and frequencies.The results reflected the influence of marine temporal and spacial variations on the uncertainties of the underwater acoustic environment,and the results also quantified the uncertainties of the underwater acoustic environment parameters.The experimental results indicate that the method used in this study is able to delineate and quantify the uncertainties of the underwater acoustic environment caused by marine dynamic changes. | DA Lianglong GUO Wuhong ZHAO Jianxin FAN Peiqin | 2015 | Chinese Journal of Acoustics2015，34，3： | 2 |
| 8 | Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and antiangiogenic activities in gender-specific gene expression in Keshan disease显示文摘 | He Shulan Tan Wuhong Wang Sen Wu Cuiyan Wang Pan Wang Bin Su Xiaohui Zhao Junjie Guo Xiong Xiang Youzhang | 2014 | Chinese Medical Journal2014，，1： | 2 |
| 9 | Comparative analysis of alternative splicing, alternative polyadenylation and the expression of the two KIN genes from cytoplasmic male sterility cabbage ( Brassica oleracea L. var. capitata L.)显示文摘 | Peng Tao Xiaoyun Huang Biyuan Li Wuhong Wang Zhichen Yue Juanli Lei Xinmin Zhong | 2014 | Molecular Genetics and Genomics2014，，3： | 1 |
| 10 | Preparation and characterization of three-dimensionally ordered macroporous yttria stabilized zirconia by aqueous organic gel route显示文摘 | ZHAO Jiupeng Ll Yao XIN Wuhong | 2008 | J Solid State Chem2008，181，2： | 1 |
| 11 | Metabolism of arachidonic acid by the cytochrome P450 enzyme in patientswith chronic Keshan disease and dilated cardiomyopathy显示文摘 | Bing Zhou Shulan He Xi Wang Xiaolong Zhen Xiaohui Su Wuhong Tan | 2016 | Biomedical Reports2016，，： | 1 |
| 12 | Genome-wide identification and characterization of aquaporin genes ( AQP s) in Chinese cabbage ( Brassica rapa ssp. pekinensis )显示文摘 | Peng Tao Xinmin Zhong Biyuan Li Wuhong Wang Zhichen Yue Juanli Lei Weiling Guo Xiaoyun Huang | 2014 | Molecular Genetics and Genomics2014，，6： | 1 |
| 13 | A Safety-basedApproaching Behavioural Model with Various Driving Characteris-tics 显示文摘 | Wang Wuhong Zhang Wei Guo Hongwei | 2011 | Transportation Research Part C: Emerging Technologies2011，19，6： | 1 |
| 14 | 显示文摘 | WANGJuan(王娟) XUYun-Hua(许云华) WUHong(吴宏) | | HotWorkingTechnol(RejiagongGongyi)0，，： | 1 |
| 15 | A safety-based approaching behavioural model with various driving characteristics显示文摘 | WUHONG WANG | 2011 | Beijing Institute of Technol- ogy2011，56，24： | 1 |
| 16 | Quorum sensing in Gram-negative bacteria显示文摘Bacteria can communicate with each other by means of signal molecules to coordinate the behavior of the entire community, and the mechanism is referred to as quorum sensing (QS). Signal systems enable bacteria to sense the size of their densities by monitoring the concentration of the signal molecules. Among Gram-negative bacteria N-acyl-L-homoserine lactone (acyl-HSL)-dependent quorum sensing systems are particularly widespread. These systems are used to coordinate expression of phenotypes that are fundamental to the interaction of bacteria with each other and with their environment and particularly higher organisms, covering a variety of functions ranging from pathogenic to symbiotic interactions. The detailed knowledge of these bacterial communication systems has opened completely new perspectives for controlling undesired microbial activities. | WUHong SONGZhijun NielsHOIBY MichaelGIVSKOV | 2004 | Progress in Natural Science:Materials International2004，14，5： | 1 |
| 17 | Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells显示文摘Ginsenoside Rh3(GRh3)is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors.However,its antitumor role remains to be elucidated.The aim of this study is to explore the mechanisms underlying the tumor suppressive activity of GRh3 from the perspective of pyroptosis and ferroptosis.GRh3 eliminates colorectal cancer(CRC)cells by activating gasdermin D(GSDMD)-dependent pyroptosis and suppressing solute carrier family 7 member 11(SLC7A11),resulting in ferroptosis activation through the Stat3/p53/NRF2 axis.GRh3 suppresses nuclear factor erythroid 2-related factor 2(NRF2)entry into the nucleus,leading to the decrease of heme oxygenase 1(HO-1)expression,which in turn promotes NOD-like receptor thermal protein domain associated protein 3(NLRP3)and caspase-1 expression.Finally,caspase-1 activates GSDMD-dependent pyroptosis.Furthermore,GRh3 prevents NRF2 from entering the nucleus,which suppresses SLC7A11,causing the depletion of glutathione(GSH)and accumulation of iron,lipid reactive oxygen species(ROS)and malondialdehyde(MDA),and eventually leading to ferroptosis in CRC cells.In addition,GRh3 effectively inhibits the proliferation of CRC cells in vitro and in nude mouse models.Collectively,GRh3 triggers pyroptotic cell death and ferroptotic cell death in CRC cells via the Stat3/p53/NRF2 axis with minimal harm to normal cells,showing great anticancer potential. | Yingchao Wu Dajin Pi Shuyao Zhou Zhongjia Yi Yangyang Dong Wuhong Wang Huan Ye Yiliu Chen Qian Zuo Mingzi Ouyang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 1 |
| 18 | Research on Wireless Video Monitoring System显示文摘 | Zhao Hong Yang Peng Gong Ren-bin Liang Xi-jun Wuhong Wang | 2013 | Advances in Mechanical Engineering2013，，： | 1 |
| 19 | Person-independent expression recognition based on person-similarity weighted expression feature显示文摘A new method to extract person-independent expression feature based on higher-order singular value decomposition (HOSVD) is proposed for facial expression recognition. Based on the assumption that similar persons have similar facial expression appearance and shape, the person-similarity weighted expression feature is proposed to estimate the expression feature of test persons. As a result, the estimated expression feature can reduce the influence of individuals caused by insufficient training data, and hence become less person-dependent. The proposed method is tested on Cohn-Kanade facial expression database and Japanese female facial expression (JAFFE) database. Person-independent experimental results show the superiority of the proposed method over the existing methods. | Huachun Tan Yujin Zhang Hao Chen Yanan Zhao Wuhong Wang | 2010 | Journal of Systems Engineering and Electronics2010，21，1： | 1 |
| 20 | Modeling lane-keeping behavior of bicyclists using survival analysis aooroach显示文摘 | GUO Hongwei WANG Wuhong GUO Weiwei | 2013 | Discrete Dynamics in Nature and Society2013，，3： | 1 |
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