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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Prevalence of amblyopia among preschool children in central south China显示文摘AIM: To determine the prevalence and factors associated with amblyopia among children aged 30-83 mo in central south of China.METHODS: A population-based, cross-sectional study was conducted in children aged 30-83 mo in Changsha(an urban city) and Zhangjiajie(a rural area) in central south of China. Clinical examinations including ocular alignment, ocular motility, visual acuity(VA), prism cover test, cycloplegic refraction, slit lamp examination and fundus examination were performed by trained study ophthalmologists and optometrists. Unilateral amblyopia was defined as a 2-line difference between eyes with VA<20/32 in the worse eye and with coexisting anisometropia [≥1.00 D spherical eutivalent(SE) for hyperopia, ≥3.00 D SE for myopia, and ≥1.50 D for astigmatism], strabismus, or past or present visual axis obstruction. Bilateral amblyopia was defined as VA in both eyes <20/40(≥ 48-month-old) and <20/50(< 48-month-old), with coexisting hyperopia ≥4.00 D SE, myopia ≤-6.00 D SE, and astigmatism ≥2.50 D, or past or present visual axis obstruction.RESULTS: There were 8042 children enrolled and 7713 children were screened. The amblyopia prevalence in children aged 30-83 mo was 1.09%(95% confidence interval, 0.86%-1.35%) with no age(P=0.81), gender(P=0.46) or area distribution(P=0.93) differences. Of these, 0.68% were unilateral cases and 0.41% were bilateral cases. Underlying causes included anisometropia(40%), binocular refractive error(36%), strabismus(14%) and deprivation(10%). Hyperopia combined with astigmatism was the frequent refractive error for ametropic and anisometropic amblyopia.CONCLUSION: In this rural and urban Chinese population, 1.09% of children with 30-83 mo of age had amblyopia, a prevalence rate similar to that of many other studies. Anisometropia and refractive error are the most common causes of unilateral and bilateral amblyopia respectively. | Yun-Ping Li Meng-Wen Zhou Susan H Forster Si-Ying Chen Xin Qi Hui-Ming Zhang Jing Luo | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 5 |
| 3 | Structural basis of the Norrin-Frizzled 4 interaction显示文摘 | Guobo Shen Jiyuan Ke Zhizhi Wang Zhihong Cheng Xin Gu Yuquan Wei Karsten Melcher H Eric Xu Wenqing Xu | 2015 | Cell Research2015，25，9： | 3 |
| 4 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 5 | Superhydrophobic silica nanocomposite coating by a low-temperature process显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of American Ceramic Society2004，87，9： | 1 |
| 6 | Superhydrophobie silica nanocom-poaite coating by a low-temperature proeess显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of the Ameri-Call Ceramic Socienty2004，87，9： | 1 |
| 7 | Induction of cold hardiness by salt stress involves synthesis of cold and abscisic acid responsive proteins in Pmato显示文摘 | Ryu S tS Costa A Xin Z G Li P H | 1995 | Plant Cell Physiol1995，36，： | 1 |
| 8 | Exploring the Black Box: An Analysis of Work Group Diversity, Conflict, and Performance显示文摘 | PELLED L H EISENHARDT K M XIN K R | 1999 | Administrative Science Quarterly1999，44，1： | 1 |
| 9 | Species-area relationship explained by the joint effects of dispersal limita- tion and habit heterogeneity显示文摘 | GUO C S MING J Y XIN H U | 2009 | Ecology2009，90，11： | 1 |
| 10 | Effeet of CO2/N2 addition to supercritical methanol on reactivities and fuel qualities in bindiesel prnduetion 显示文摘 | Imahara H Xin Jiayu Saka S | 2009 | Fuel2009，88，7： | 1 |
| 11 | Possible use of ail and foxA polymorphisms fordetecting pathogenic Yersinia enterocolitica 显示文摘 | Ying H Xin W Cui Z | 2010 | BMC Microbiol2010，10，： | 1 |
| 12 | Aging adversely impacts biological properties of human bone marrow-derived mesenchymal stem cel s:implications for tissue engineering heart valve construction显示文摘 | Xin Y Wang YM Zhang H | | 0，，03： | 1 |
| 13 | Deep desulfurization of model gasoline by adsorption on mesoporous CeMCM-41 显示文摘 | KE T XIN H | 2010 | Pet Sci Technol2010，28，6： | 1 |
| 14 | Annealing hardening in detwinning deformation of Mg-3AHZn alloy显示文摘 | YC Xin XJ Zhou HW Chen JF Nie H Zhang YY Zhang Qg Liu | 2014 | Materials Science and Engineering:A2014，594，： | 1 |
| 15 | HIV testing among men who have sex with men in China:a systematic review and meta-analysis显示文摘 | Zou H Hu N Xin Q | 2012 | AIDS Behav2012，16，7： | 1 |
| 16 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 17 | Analysis of the phases developed by laser uitriding Ti-6Al-4V alloys显示文摘 | Xin H Watson L M | 1997 | Acta Materialia1997，，45： | 1 |
| 18 | Proteome analysis of maize seeds: the effect of artificial ageing 显示文摘 | Xin X Lin X H Zhou YC | 2011 | Physiologia Planta- rum2011，143，： | 1 |
| 19 | Improving the oral bioavilability of albendazole in rabbits by the solid dispersion technique显示文摘 | Nanori Kohri Yasuko Yamayoshi Xin H | 1999 | J Pharm Pharmacol1999，51，： | 1 |
| 20 | A new approach to UVblocking treatment for cotton fabrics 显示文摘 | Xin J H Daoud WA Kong YY | 2004 | Textile Research Journal2004，74，2： | 1 |
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