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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB显示文摘Leptin 是首先涉及食物吸入和精力开销的规定的肽荷尔蒙。最近的研究建议了 leptin 是为包括动脉粥样硬化和高血压的心血管的疾病的风险因素之一。脉管的光滑的肌肉房间(VSMC ) 在动脉的内层的变厚并且脉管的改变起一个重要作用。在这研究,我们在 VSMC 房间周期规定和可能的小径上调查了 leptin 的效果。我们发现 leptin 刺激了 VSMC 增长并且增加了房间前进到 S 和 G2/M 阶段。cyclinD1 的表示, phosphorylated 细胞外的调整信号的 kinase 1/2 (ERK1/2 ) ,和原子因素(NF )-Bp65 被增加。有 leptin 对手三元组异种的房间的处理稀释了导致 leptin 的 ERK1/2 和 NF-B 激活。这些结果建议 leptin 由从 G1 把转变提升到 S 阶段和 ERK1/2 和 NF-B 小径刺激了 VSMC 增长可能贡献这行列。 | Fen Huang Xiaofang Xiong Huabin Wang Sha You Hesong Zeng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 20 |
| 4 | Application and interpretation of current autophagy inhibitors and activators显示文摘Autophagy 是主要细胞内部的降级系统,细胞质的材料被送到并且在 lysosome 降级了。作为为细胞质的蛋白质和细胞器的质量控制机制, autophagy 在许多人的疾病起重要作用,包括 neurodegenerative 疾病,癌症,心血管的疾病,糖尿病和传染、煽动性的疾病。ATG 基因的发现和涉及调整 autophagy 的发信号的小径的解剖极大地在这条 lysosomal 降级小径的出现和发展上充实我们的知识。除了它在降级的角色, autophagy 可以也支持与 apoptosis 不同的规划房间死亡的一种类型,称为的类型 II 规划了房间死亡。由于在房间死亡和疾病的特性的 autophagy 的双角色,在各种各样的疾病的 autophagy 的准确机制要求更多的调查。autophagy 禁止者和使活跃之物的申请将帮助我们在人的疾病理解 autophagy 的规定,并且提供卓见进指向 autophagy 的药的使用。在这评论,我们在 autophagy 禁止者和使活跃之物上总结最近的研究并且在人的疾病治疗讨论他们的申请的可能性。 | Ya-ping YANG Li-fang HU Hui-fen ZHENG Cheng-jie MAO Wei-dong HU Kang-ping XIONG Fen WANG Chun-feng LIU | 2013 | Acta Pharmacologica Sinica2013，34，5： | 10 |
| 5 | Stepwise sedation for elderly patients with mild/moderate COPD during upper gastrointestinal endoscopy显示文摘AIM: To investigate stepwise sedation for elderly patients with mild/moderate chronic obstructive pulmonary disease (COPD) during upper gastrointestinal (GI) endoscopy. METHODS: Eighty-six elderly patients with mild/moderate COPD and 82 elderly patients without COPD scheduled for upper GI endoscopy were randomly assigned to receive one of the following two sedation methods: stepwise sedation involving three-stage administration of propofol combined with midazolam [COPD with stepwise sedation (group Cs), and nonCOPD with stepwise sedation (group Ns)] or continuous sedation involving continuous administration of propofol combined with midazolam [COPD with continuous sedation (group Cc), and non-COPD with continuous sedation (group Nc)]. Saturation of peripheral oxygen (SpO 2 ), blood pressure, and pulse rate were monitored, and patient discomfort, adverse events, drugs dosage, and recovery time were recorded. RESULTS: All endoscopies were completed successfully. The occurrences of hypoxemia in groups Cs, Cc, Ns, and Nc were 4 (9.3%), 12 (27.9%), 3 (7.3%), and 5 (12.2%), respectively. The occurrence of hypoxemia in group Cs was significantly lower than that in group Cc (P < 0.05). The average decreases in value of SpO 2 , systolic blood pressure, and diastolic blood pressure in group Cs were significantly lower than those in group Cc. Additionally, propofol dosage and overall rate of adverse events in group Cs were lower than those in group Cc. Finally, the recovery time in group Cs was significantly shorter than that in group Cc, and that in group Ns was significantly shorter than that in group Nc (P < 0.001). CONCLUSION: The stepwise sedation method is effective and safer than the continuous sedation method for elderly patients with mild/moderate COPD during upper GI endoscopy. | Can-Xia Xu Xiong Chen Yan Jia Ding-Hua Xiao Hui-Fang Zou Qin Guo Fen Wang Xiao-Yan Wang Shou-Rong Shen Ling-Ling Tong Ke Cao Xiao-Ming Liu | 2013 | World Journal of Gastroenterology2013，19，29： | 5 |
| 6 | Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice显示文摘Hepatic sinusoidal obstruction syndrome(HSOS)via exposure to pyrrolizidine alkaloids(PAs)is with high mortality and there is no effective treatment in clinics.Bear bile powder(BBP)is a famous traditional animal drug for curing a variety of hepatobiliary diseases such as cholestasis,inflammation,and fibrosis.Here,we aim to evaluate the protective effect of BBP against HSOS induced by senecionine,a highly hepatotoxic PA compound.Our results showed that BBP treatment protected mice from senecionine-induced HSOS dose-dependently,which was evident by improved liver histology including reduced infiltration of inflammatory cells and collagen positive cells,alleviated intrahepatic hemorrhage and hepatic sinusoidal endothelial cells,as well as decreased conventional serum liver function indicators.In addition,BBP treatment lowered matrix metalloproteinase 9 and pyrrole-protein adducts,two well-known markers positively associated with the severity of PA-induced HSOS.Further investigation showed that BBP treatment prevents the development of liver fibrosis by decreasing transforming growth factor beta and downstream fibrotic molecules.BBP treatment also alleviated senecionine-induced liver inflammation and lowered the pro-inflammatory cytokines,in which taurours-odeoxycholic acid played an important role.What’s more,BBP treatment also decreased the accumulation of hydrophobic bile acids,such as cholic acid,taurocholic acid,glycocholic acid,as well.We concluded that BBP attenuates senecionine-induced HSOS in mice by repairing the bile acids homeostasis,preventing liver fibrosis,and alleviating liver inflammation.Our present study helps to pave the way to therapeutic approaches of the treatment of PA-induced liver injury in clinics. | JIANG Kai-Yuan ZHANG Yi YE Xuan-Ling XIONG Fen CHEN Yan JIA Xia-Li ZHANG Yi-Xin YANG Li XIONG Ai-Zhen WANG Zheng-Tao | 2022 | Chinese Journal of Natural Medicines2022，20，4： | 2 |
| 7 | Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory,anti-oxidative and anti-proliferative effects显示文摘Inflammatory activation and oxidative stress promote the proliferation of vascular smooth muscle cells(VSMCs),which accounts for pathological vascular remodeling in hypertension.ELABELA(ELA)is the second endogenous ligand for angiotensin receptor-like 1(APJ)receptor that has been discovered thus far.In this study,we investigated whether ELA regulated VSMC proliferation and vascular remodeling in spontaneously hypertensive rats(SHRs).We showed that compared to that in Wistar-Kyoto rats(WKYs),ELA expression was markedly decreased in the VSMCs of SHRs.Exogenous ELA-21 significantly inhibited inflammatory cytokines and NADPH oxidase 1 expression,reactive oxygen species production and VSMC proliferation and increased the nuclear translocation of nuclear factor erythroid 2-related factor(Nrf2)in VSMCs.Osmotic minipump infusion of exogenous ELA-21 in SHRs for 4 weeks significantly decreased diastolic blood pressure,alleviated vascular remodeling and ameliorated vascular inflammation and oxidative stress in SHRs.In VSMCs of WKY,angiotensin II(Ang II)-induced inflammatory activation,oxidative stress and VSMC proliferation were attenuated by pretreatment with exogenous ELA-21 but were exacerbated by ELA knockdown.Moreover,ELA-21 inhibited the expression of matrix metalloproteinase 2 and 9 in both SHR-VSMCs and Ang II-treated WKY-VSMCs.We further revealed that exogenous ELA-21-induced inhibition of proliferation and PI3K/Akt signaling were amplified by the PI3K/Akt inhibitor LY294002,while the APJ receptor antagonist F13A abolished ELA-21-induced PI3K/Akt inhibition and Nrf2 activation in VSMCs.In conclusion,we demonstrate that ELA-21 alleviates vascular remodeling through anti-inflammatory,anti-oxidative and anti-proliferative effects in SHRs,indicating that ELA-21 may be a therapeutic agent for treating hypertension. | Chao Ye Zhi Geng Ling-li Zhang Fen Zheng Ye-bo Zhou Guo-qing Zhu Xiao-qing Xiong | 2022 | Acta Pharmacologica Sinica2022，43，10： | 1 |
| 8 | Sorption of Cu(lI) and Cd(II) by extraceUuar polymeric substances(EPS) from Aspergillus fumigates 显示文摘 | Yurong Yin Yongyou Hu Fen Xiong | 2011 | Intemational Biodeterioration and Biodegradation2011，65，： | 1 |
| 9 | Sorption Of Cu( I ) and Cd(I ) by extracellular polymeric substances(EPS) from Asporgillus lumigates 显示文摘 | YIN YURONG HONG YONGYOU XIONG FEN | 2011 | International Biodeterioration & Biodegradation2011，65，： | 1 |
| 10 | CRYSTAL STRUCTURE OF BINUCLEAR Y(Ⅲ) COMPLEX WITH p-METHYLBENZOIC ACID, Y_2(p-CH_3C_6H_4COO)_6(C_(12)H_8N_2)_2显示文摘Y2(p-CH3C6H4COO)6(C12H8N2)2, Mr=1349.08, triclinic, space group P, a=13.00(3), b=19.743(2), c=12.754(3)A, α=97.94(1), β=106.24(2), γ=91.66(1)°, V=3177(1)3, Z=2, Dc=1.41gcm-3, λ(MoKα)=0.71069, μ=18.92 cm-1, F(ooo)=1384, T=295K, final R=0.073 for 6504 observed reflections with Ⅰ>36(Ⅰ). There are two nonidentical binuclear molecules with different bridging connection patterns in a cell. One has four bridging carboxyl groups bound two Y(Ⅲ) ions and another only has two. The Y-Y distance is 4.196 for the former and 5.302 for the latter respectively. | Rui Fen WANG(Department of Chemistry, Eebei Normal College, Shijiazhuang, 050000)Lin Pei JIN~*, Ming Zhao WANG (Department of Chemistry, Beijing Normal University, Beijing, 100875) Guan Liang CAI, Shi Xiong LIU, Jin Ling HUANG (Department of Chemistry, Fuzhou University, Fuzhou, 350002) | 1991 | Chinese Chemical Letters1991，2，11： | 1 |
| 11 | Bio-inspired untethered fully soft robots in liquid actuated by induced energy gradients显示文摘Soft robotics with new designs,fabrication technologies and control strategies inspired by nature have been totally changing our view on robotics.To fully exploit their potential in practical applications,untethered designs are preferred in implementation.However,hindered by the limited thermal/mechanical performance of soft materials,it has been always challenging for researchers to implement untethered solutions,which generally involve rigid forms of high energy-density power sources or high energy-density processes.A number of insects in nature,such as rove beetles,can gain a burst of kinetic energy from the induced surface-energy gradient on water to return to their familiar habitats,which is generally known as Marangoni propulsion.Inspired by such a behavior,we report the agile untethered mobility of a fully soft robot in liquid based on induced energy gradients and also develop corresponding fabrication and maneuvering strategies.The robot can reach a speed of 5.5 body lengths per second,which is 7-fold more than the best reported,0.69(body length per second),in the previous work on untethered soft robots in liquid by far.Further controlling the robots,we demonstrate a soft-robot swarm that can approach a target simultaneously to assure a hit with high accuracy.Without employing any high energy-density power sources or processes,our robot exhibits many attractive merits,such as quietness,no mechanical wear,no thermal fatigue,invisibility and ease of robot fabrication,which may potentially impact many fields in the future. | Liang Xiong Lyu Fen Li Kang Wu Pan Deng Seung Hee Jeong Zhigang Wu Han Ding | 2019 | National Science Review2019，6，5： | 1 |
| 12 | Ferroelectric engineering of two-dimensional group-Ⅳ monochalcogenides:The effects of alloying and strain显示文摘In this work,we studied the stability and ferroelectricity of twodimensional(2D)group-IV monochalcogenides MX(M=Ge,Sn,or Pb;X=S,Se,or Te).Two competing crystal structures of these 2D compounds have been considered,including the rippled crystal structure with a space group of Pmn21,which can be obtained from exfoliation,and the P3m1 hexagonal crystal structure containing the X-M-M-X building blocks.We find that the total energies of the rippled phases of PbX,SnS and SnSe are lower than those of the corresponding hexagonal phases;particularly,the rippled phases of SnS and SnSe exhibit spontaneous polarizations and ferroelectricity.On the other hand,the hexagonal phases of GeX and SnTe are energetically more stable than the corresponding rippled phases;because the hexagonal phases are centrosymmetric,these 2D compounds are non-ferroelectric.To engineer the ferroelectricity of 2D group-Ⅳmonochalcogenides,we have investigated the effects of alloying and equibiaxial strain.Based on density functional theory calculations,we find that the rippled phases of GeX and SnTe can be stabilized via Pb alloying to achieve ferroelectricity.In addition,it is also found that equibiaxial tensile strain gives rise to ferroelectricity in the rippled phases of 2D PbX compounds. | Fen Xiong Xilin Zhang Zhen Lin Yue Chen | 2018 | Journal of Materiomics2018，4，2： | 1 |
| 13 | Fouling process and anti-fouling mechanisms of dynamic membrane assisted by photocatalytic oxidation under sub-critical fluxes显示文摘Membrane fouling is often considered as a hindrance for the application of microfiltration/ultrafiltration(MF/UF) for drinking water production. A novel process of photocatalytic membrane reactor/dynamic membrane(PMR/DM), operating in a continuous mode under sub-critical flux, was proposed for the mitigation of membrane fouling caused by humic acids(HAs) in water. The mechanism of membrane fouling alleviation with synergistic photocatalytic oxidation and dynamic layer isolating effect was comprehensively investigated from the characterization of foulant evolution responsible for the reversible and irreversible fouling. The results showed that the PMR/DM utilized photocatalytic oxidation to enhance the porosity and hydrophilicity of the fouling layer by converting the high molecular weight(MW) and hydrophobic HA molecules with carboxylic functional groups and aromatic structures into low-MW hydrophilic or transphilic fractions, including tryptophan-like or fulvic-like substances. The fouling layer formed in the PMR/DM by combination of photocatalytic oxidation and DM running at a sub-critical flux of 100 L·h^-1·m^-2, was more hydrophilic and more porous, resulting in the lowest trans-membrane pressure(TMP) growth rates, as compared to the processes of ceramic membrane(CM), DM and PMR/CM.Meanwhile, the dynamic layer prevented the foulants, particularly the high-MW hydrophobic fractions,from contacting the primary membrane, which enabled the membrane permeability to be restored easily. | Tao Yang Fen Liu Houfeng Xiong Qiyong Yang Fushan Chen Changchao Zhan | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 1 |
| 14 | Status and Development Strategies of Grassland Agriculture: A Case Study of Dafang County显示文摘In order to better promote the development of grassland husbandry in the Bijie experimental area and promote industrial poverty alleviation and rural revitalization strategies,the development status of grassland agriculture in developed countries( USA,Netherlands and France) and China is summarized. By learning from the successful experience of grassland agricultural development at home and abroad,combined with the survey results of grassland agriculture in Dafang County of Bijie experimental area,the development of grassland agriculture in Dafang County of Bijie experimental area is analyzed,and corresponding development strategies are put forward. | Jiahai WU Wenzhong CHEN Feng XUE Xiaodong LI Jun XIONG Fen LOU Guangji CHEN Qiong MOU | 2019 | Asian Agricultural Research2019，11，6： | 1 |
| 15 | Sorption of Cu (Ⅱ) and Cd(Ⅱ) by extracelluar polymeric substances (EPS) from Aspergillusfumigates显示文摘 | Yin Yurong Hu Yongyou Xiong Fen | 2011 | International Biodeterioration and Biodegradation2011，65，7： | 1 |
| 16 | Prediction of Ocular Irritancy of 26 Chemicals and 26 Cosmetic Products with Isolated Rabbit Eye (IRE) Test显示文摘Objective This study aims to establish and evaluate the methodology of isolated rabbit eye (IRE) test.Methods IRE test was performed according to modifications of the in vitro toxicology (INVITTOX) Protocol No.85:Rabbit enucleated eye test by European Centre for the Validation of Alternative Methods (ECVAM),and then 26 chemicals and 26 cosmetic products were tested in both in vitro IRE and in vivo Draize tests.A statistical analysis was conducted to determine the relevance of the IRE test to the data generated in the Draize test.Results IRE test was established successfully in our laboratory.It was shown that ranking correlation and class concordance were fairly well between the IRE test and the Draize test for 26 reference chemicals (Fisher's Exact Test χ 2 =51.314,P<0.001;McNemar P=0.261;Gamma=0.960,P<0.001;Kappa=0.843,P<0.001) and 26 cosmetic products (Fisher's Exact Test χ 2 =15.522,P<0.001;McNemar P=0.311;Gamma=0.967,P<0.001;Kappa=0.611,P<0.001).Conclusion IRE test was established successfully for in vitro testing of eye irritation as an alternative to Draize test. | GUO Xiang YANG Xing Fen YANG Ying HANS Raabe CAI Jing Heng XUE Jin Yu TAN Xiao Hua XIE Xiao Ping XIONG Xi Kun HUANG Jun Ming | 2012 | Biomedical and Environmental Sciences2012，25，3： | 1 |
| 17 | Machining performance of Ti-Al-Si-N coated inserts 显示文摘 | CHEN L WANG S Q DU Y ZHOU S Z GANG T FEN J C CHANG K K LI Y W XIONG X | 2010 | Surface and Coatings Technology2010，205，2： | 1 |
| 18 | Interaction and functional- ity of mixed myofibrillar and enzyme - hydrolyzed soy pro- reins 显示文摘 | FEN( Jianlin XIONG Youling | 2003 | J Food Sci2003，68，3： | 1 |
| 19 | Therapeutic potential of bright light therapy for the non-motor symptoms in Parkinson's disease显示文摘To the Editor:Alterations of circadian rhythms seem to be the casual contribution to sleep disturbances,depression,and other non-motor symptoms in Parkinson's disease(PD).[1,2]By restoring the circadian rhythm,bright light therapy(BLT)might be a potentially new treatment option for PD.However,no studies have conclusively demonstrated the effects of BLT on the non-motor symptoms in PD. | Yun Shen Siyi Gong Yulu Liu Jie Li Kangping Xiong Chengjie Mao Yali Wang Dan Li Fen Wang Hua Hu Chunfeng Liu | 2022 | Chinese Medical Journal2022，，2： | 0 |
| 20 | Relevant detection indicator of prethrombotic state in patients with primary hypertension显示文摘BACKGROUND Hypertension is a common chronic disease that affects many people worldwide.Only a few reports related to the exploration of relevant indicators of the prethrombotic state in patients with primary hypertension(PH)in clinical settings were available.AIM To detect prethrombotic state-related indicators in patients with PH and analyze their differences in different patient populations to provide a laboratory basis for the clinical prevention and control of hypertensive thrombotic diseases.METHODS The general data of patients with PH who attended the Department of Cardiovascular Medicine,The First Affiliated Hospital of Jiangxi Medical College,from January 2022 to December 2022 were collected retrospectively.The patients were divided into three groups of 40 patients each according to the Grade of PH:Grade 1,Grade 2,and Grade 3 hypertension experimental group.The baseline data of 40 volunteers,who underwent physical examination in our hospital but were not diagnosed with PH during the same period,were included in the control group.The relevant indicators of prethrombotic state of the participants were compared,and mainly included inflammation-related indicators,hemorheology-related indicators,and coagulation function related indicators.The relationship between the aforementioned indicators and the progression of PH was analyzed.RESULTS No significant differences were observed in age,sex,diabetes mellitus,smoking history,drinking history,body mass index,New York Heart Association functional classification,or the course of hypertension among the four groups(P>0.05).The expressions of high-sensitivity C-reactive protein(hs-CRP),thrombomodulin(TM),hematocrit(Hct),erythrocyte sedimentation rate(ESR),P-selectin on platelet surface(CD62P),and fibrinogen(FIB)in the control group wereGrade 1 hypertension group>Grade 2 hypertension group>Grade 3 hypertension group,and the difference was statistically significant(P<0.05).The results of the multivariate logistic regression model showed that the expression of hs-CRP,TM,Hct,ESR,CD62P,PLT,APTT,PT,TT,and FIB in the included participants was related to the progression of PH.Among these,high expression of hs-CRP,TM,Hct,ESR,CD62P,APTT,PT,and TT,and low expression of PLT and FIB were risk factors for PH(OR>1,P<0.05).The results of the receiver operating characteristic curve analysis showed that the area under the curve of hs-CRP,TM,ESR,CD62P,APTT,PT,TT,and FIB for the prediction of PH were>0.80,and the prediction value was ideal.Linear correlation analysis with bivariate Spearman showed that hs-CRP,TM,Hct,ESR,CD62P,APTT,PT,and TT were positively correlated with each other(r>0,P<0.05);PLT and FIB were negatively correlated with hs-CRP,TM,Hct,ESR,CD62P,APTT,PT,and TT(r<0,P<0.05);and PLT and FIB were positively correlated(r>0,P<0.05).Linear correlation analysis using bivariate Spearman showed that hs-CRP,TM,Hct,ESR,CD62P,and FIB were positively correlated with each other(r>0,P<0.05),whereas PLT,APTT,PT,and TT were negatively correlated with hs-CRP,TM,Hct,ESR,CD62P,and FIB(r<0,P<0.05).There was a positive correlation between PLT,APTT,PT,and TT(r>0,P<0.05).CONCLUSION The relevant indicators of the prethrombotic state in patients with PH,such as hs-CRP,TM,Hct,ESR,CD62P,PLT,APTT,PT,TT,and FIB,showed differences.High expression of hs-CRP,TM,Hct,ESR,CD62P,and FIB,and low expression of PLT,APTT,PT,and TT are the keys to the occurrence,progression,and thrombotic state of PH.Based on the above serum indicators’expression in patients,targeted interventions can be administered to patients with abnormal expression levels to control the progression of their disease and reduce the risk of developing a prethrombotic state. | Jie Luo Tuo Yang Lan Ding Jian-Hui Xiong Teng Ying Fen Xu | 2023 | World Journal of Clinical Cases2023，11，24： | 0 |
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