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| 1 | Preliminary results pertaining to coseismic displacement and preseismic strain accumulation of the Lushan M_S7.0 earthquake,as reflected by GPS surveying显示文摘This paper presents the coseismic displacement and preseismic deformation fields of the Lushan MS7.0 earthquake that occurred on April 20,2013.The results are based on GPS observations along the Longmenshan fault and within its vicinity.The coseismic displacement and preseismic GPS results indicate that in the strain release of this earthquake,the thrust rupture is dominant and the laevorotation movement is secondary.Furthermore,we infer that any possible the rupture does not reach the earth’s surface,and the seismogenic fault is most likely one fault to the east of the Guanxian-Anxian fault.Some detailed results are obtainable.(1)The southern segment of the Longmenshan fault is locked preceding the Lushan earthquake.After the Wenchuan earthquake,the strain accumulation rate in the southeast direction accelerates in the epicenter of the Lushan earthquake,and the angle between the principal compressional strain and the seismogenic fault indicates that a sinistral deformation background in the direction of the seismogenic fault precedes the Lushan earthquake.Therefore,it is evident that the Wenchuan MS8.0 earthquake accelerated the pregnancy of the Lushan earthquake.(2)The coseismic displacements reflected by GPS data are mainly located in a region that is 230 km(NW direction)×100 km(SW direction),and coseismic displacements larger than 10 mm lie predominantly in a100-km region(NW direction).(3)On a large scale,the coseismic displacement shows thrust characteristics,but the associated values are remarkably small in the near field(within 70 km)of the earthquake fault.Meanwhile,the thrust movement in this70-km region does not correspond with the attenuation characteristics of the strain release,indicating that the rupture of this earthquake does not reach the earth’s surface.(4)The laevorotation movements are remarkable in the 50-km region,which is located in the hanging wall that is close to the earthquake fault,and the corresponding values in this case correlate with the attenuation characteristics of the strain release. | WU YanQiang JIANG ZaiSen WANG Min CHE Shi LIAO Hua LI Qiang LI Peng YANG YongLin XIANG HePing SHAO ZhiGang WANG WuXing WEI WenXin LIU XiaoXia | 2013 | Chinese Science Bulletin2013，58，28： | 33 |
| 2 | The principle of the positioning system based on communication satellites显示文摘It is a long dream to realize the communication and navigation functionality in a satellite system in the world. This paper introduces how to establish the system, a positioning system based on communication satellites called Chinese Area Positioning System (CAPS). Instead of the typical navigation satellites, the communication satellites are configured firstly to transfer navigation signals from ground stations, and can be used to obtain service of the positioning, velocity and time, and to achieve the function of navigation and positioning. Some key technique issues should be first solved; they include the accuracy position determination and orbit prediction of the communication satellites, the measur- ing and calculation of transfer time of the signals, the carrier frequency drift in communication satellite signal transfer, how to improve the geometrical configuration of the constellation in the system, and the integration of navigation & communication. Several innovative methods are developed to make the new system have full functions of navigation and communication. Based on the development of crucial techniques and methods, the CAPS demonstration system has been designed and developed. Four communication satellites in the geosynchronous orbit (GEO) located at 87.5°E, 110.5°E, 134°E, 142°E and barometric altimetry are used in the CAPS system. The GEO satellites located at 134°E and 142°E are decommissioned GEO (DGEO) satellites. C-band is used as the navigation band. Dual frequency at C1=4143.15 MHz and C2=3826.02 MHz as well as dual codes with standard code (CA code and precision code (P code)) are adopted. The ground segment consists of five ground stations; the master station is in Lintong, Xi’an. The ground stations take a lot of responsibilities, including monitor and management of the operation of all system components, determination of the satellite position and prediction of the satellite orbit, accomplishment of the virtual atomic clock measurement, transmission and receiving navigation signals to and from each satellite. In the north, the south, the east, the west and the center of Chinese main land, the function of CAPS demonstration system is checked and measured. In cars and on board the system is also checked and measured. The results are as follow: CA-code, horizontal positioning accuracy, 15-25 m (1σ), vertical, 1-3 m; P-code, horizontal positioning accuracy, 8-10 m (1σ), vertical, 1-3 m; velocity accuracy, CA-code, 0.13-0.30 m/s, P-code, 0.15-0.17 m/s; time accuracy, CA-code, 160 ns, P-code, 13 ns; determination accuracy of orbit ≤2 m. About 20 million US $ and two years are spent for the development of demonstration. A complete CAPS system is now being established. | AI GuoXiang SHI HuLi WU HaiTao LI ZhiGang GUO Ji | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 21 |
| 3 | Age and genesis of the Shagou River terraces in eastern Qi-lian Mountains显示文摘The fluvial terrace sequence in eastern Qilian Mountains is a record of periodic uplift events of the Tibetan Plateau. Based on paleomagnetic dating, thermolumines-cence dating, radio carbon dating and loess-paleosol sequence on terraces, we preliminarily determine the ages of five major terraces of the Shagou River, northern side of the Qilian Mountains. The ages of five terraces were about 830, 418, 250,140 and 10 ka, respectively. Analysis on characteristics of terraces show that five major terraces were mainly tectonic genesis. Therefore, five major terraces recorded five strong rising events in the Qilian Mountains during the past 830 ka. The ages of those rising events are about the same as those terraces formation. Sub-terraces, constituting a main terrace, were perhaps mainly formed by climatic changes. | PAN Baotian WU Guangjian WANG Yixiang LIU Zhigang GUAN Qingyu | 2001 | Chinese Science Bulletin2001，46，6： | 18 |
| 4 | Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species显示文摘Magnolia grandiflora is an important medicinal,ornamental and horticultural plant species.The chloroplast(cp) genome of M.grandiflora was sequenced using a 454 sequencing platform and the genome structure was compared with other related species.The complete cp genome of M.grandiflora was 159623 bp in length and contained a pair of inverted repeats(IR) of 26563 bp separated by large and small single copy(LSC,SSC) regions of 87757 and 18740 bp,respectively.A total of 129 genes were successfully annotated,18 of which included introns.The identity,number and GC content of M.grandiflora cp genes were similar to those of other Magnoliaceae species genomes.Analysis revealed 218 simple sequence repeat(SSR) loci,most composed of A or T,contributing to a bias in base composition.The types and abundances of repeat units in Magnoliaceae species were relatively conserved and these loci will be useful for developing M.grandiflora cp genome vectors.In addition,results indicated that the cp genome size in Magnoliaceae species and the position of the IR border were closely related to the length of the ycf1 gene.Phylogenetic analyses based on 66 shared genes from 30 species using maximum parsimony(MP) and maximum likelihood(ML) methods provided strong support for the phylogenetic position of Magnolia.The availability of the complete cp genome sequence of M.grandiflora provides valuable information for breeding of desirable varieties,cp genetic engineering,developing useful molecular markers and phylogenetic analyses in Magnoliaceae. | LI XiWen GAO HuanHuan WANG YiTao SONG JingYuan HENRY Robert WU HeZhen HU ZhiGang YAO Hui LUO HongMei LUO Kun PAN HongLin CHEN ShiLin | 2013 | Science China(Life Sciences)2013，56，2： | 17 |
| 5 | Studies on aeroservoelasticity semi-physical simulation test for missiles显示文摘Missiles may be damaged when aeroservoelastic problem occurs,which is caused by the interaction of structure flexibility and flight control system.Because of the limit of wind tunnel test condition,numerical methods are mostly used in previous aeroservoelastic studies.However,series of assumptions and simplification on structures,aerodynamics and flight control systems are unavoidably introduced,and various nonlinear factors are also ignored,therefore,they result in considerable errors.A novel method called aeroservoelasticity semi-physical simulation test is proposed in this paper,which takes the flexible missile with control system as the test object.Vibration signals at several locations of the missile are measured by accelerometers,then corresponding unsteady aerodynamics is computed based on the fact that airflow at high Mach is nearly quasi-steady,and finally unsteady aerodynamics is exerted simultaneously by shakers at certain locations of the missile.The aeroservoelasticity semi-physical simulation test system can be constructed after the control system is closed.Open loop transfer function test and closed loop stability test are carried out in sequence.The test principle and method proposed in this paper are verified by the concordance between the results of numerical simulation and experiment. | WU ZhiGang CHU LongFei YUAN RuiZhi YANG Chao TANG ChangHong | 2012 | Science China(Technological Sciences)2012，55，9： | 14 |
| 6 | Gut-liver axis:gut microbiota in shaping hepatic innate immunity显示文摘Gut microbiota play an essential role in shaping immune cell responses. The liver was continuously exposed to metabolic products of intestinal commensal bacterial through portal vein and alteration of gut commensal bateria was always associated with increased risk of liver inflammation and autoimmune disease. Considered as a unique immunological organ, the liver is enriched with a large number of innate immune cells. Herein, we summarize the available literature of gut microbiota in shaping the response of hepatic innate immune cells including NKT cells, NK cells, γδ T cells and Kupffer cells during health and disease. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of innate immune cell-related liver disease. | xunyao wu zhigang tian | 2017 | Science China(Life Sciences)2017，60，11： | 13 |
| 7 | Rapid afterslip and short-term viscoelastic relaxation following the 2008 M_W7.9 Wenchuan earthquake显示文摘Significant postseismic deformation of the 2008 M W 7.9 Wenchuan earthquake has been observed from GPS data of the first 14 days after the earthquake. The possible mechanisms for the rapid postseismic deformation are assumed to be afterslip on the earthquake rupture plane and viscoelastic relaxation of coseismiclly stress change in the lower crust or upper mantle. We firstly use the constrained least squares method to find an afterslip model which can fit the GPS data best. The afterslip model can explain near-field data very well but shows considerable discrepancies in fitting far-field data. To estimate the effect due to the viscoelastic relaxation in the lower crust, we then ignore the contribution from the afterslip and attempt to invert the viscosity structure beneath the Longmenshan fault where the Wenchuan earthquake occurred from the postseismic deformation data. For this purpose, we use a viscoelastic model with a 2D geometry based on the geological and seismological observations and the coseismic slip distribution derived from the coseismic GPS and InSAR data. By means of a grid search we find that the optimum viscosity is 9×10 18 Pa·s for the middle-lower crust in the Chengdu Basin, 4×10 17 Pa·s for the middle-lower crust in the Chuanxi Plateau and 7×10 17 Pa·s for the low velocity zone in the Chuanxi plateau. The viscoelastic model explains the postseismic deformation observed in the far-field satisfactorily, but it is considerably worse than the afterslip model in fitting the near-fault data. It suggests therefore a hybrid model including both afterslip and relaxation effects. Since the viscoelastic model produces mainly the far-field surface deformation and has fewer degree of freedoms (three viscosity parameters) than the afterslip model with a huge number of source parameters, we fix the viscositiy structure as obtained before but redetermine the afterslip distribution using the residual data from the viscoelastic modeling. The redetermined afterslip distribution becomes physically more reasonable; it is more localized and exhibits a pattern spatially complementary with the coseismic rupture distribution. We conclude that the aseismic fault slip is responsible for the near-fault postseismic deformation, whereas the viscoelastic stress relaxation might be the major cause for the far-field postseismic deformation. | Zhigang Shao Rongjiang Wang Yanqiang Wu Langping Zhang | 2011 | Earthquake Science2011，24，2： | 12 |
| 8 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 9 | Methods of rapid orbit forecasting after maneuvers for geostationary satellites显示文摘A geostationary(GEO) satellite may serve as a navigation satellite,but there is a problem that maneuvers frequently occur and the forces are difficult to model.Based on the technique of determining satellite orbits by transfer,a predicted orbit with high accuracy may be achieved by the method of statis-tical orbit determination in case of no maneuver force.The predicted orbit will soon be invalid after the maneuver starts,and it takes a long time to get a valid orbit after the maneuver ends.In order to improve ephemeris usability,the method of rapid orbit forecasting after maneuvers is studied.First,GEO satellite movement is analyzed in case of maneuvers based on the observation from the orbit meas-urement system by transfer.Then when a GEO satellite is in the free status just after maneuvers,the short arc observation is used to forecast the orbit.It is assumed that the common system bias and biases of each station are constant,which can be obtained from orbit determination with long arc observations.In this way,only 6 orbit elements would be solved by the method of statistical orbit determination,and the ephemeris with high accuracy may be soon obtained.Actual orbit forecasting with short arc observation for SINOSAT-1 satellite shows that,with the tracking network available,the precision of the predicted orbit(RMS of O-C) can reach about 5 m with 15 min arc observation,and about 3 m with 30 min arc observation. | YANG XuHai LI ZhiGang FENG ChuGang GUO Ji SHI HuLi AI GuoXiang WU FengLei QIAO RongChuan | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 10 |
| 10 | Progress of regional oceanography study associated with western boundary current in the South China Sea显示文摘Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The possible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (~0.1 ms-1 ) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 ms-1 , and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed. | WANG DongXiao LIU QinYan XIE Qiang HE ZhiGang ZHUANG Wei SHU YeQiang XIAO XianJun HONG Bo WU XiangYu SUI DanDan | 2013 | Chinese Science Bulletin2013，58，11： | 10 |
| 11 | Identification of the state-space model and payload mass parameter of a flexible space manipulator using a recursive subspace tracking method显示文摘The on-orbit parameter identification of a space structure can be used for the modification of a system dynamics model and controller coefficients. This study focuses on the estimation of a system state-space model for a two-link space manipulator in the procedure of capturing an unknown object, and a recursive tracking approach based on the recursive predictor-based subspace identification(RPBSID) algorithm is proposed to identify the manipulator payload mass parameter. Structural rigid motion and elastic vibration are separated, and the dynamics model of the space manipulator is linearized at an arbitrary working point(i.e., a certain manipulator configuration).The state-space model is determined by using the RPBSID algorithm and matrix transformation. In addition, utilizing the identified system state-space model, the manipulator payload mass parameter is estimated by extracting the corresponding block matrix. In numerical simulations, the presented parameter identification method is implemented and compared with the classical algebraic algorithm and the recursive least squares method for different payload masses and manipulator configurations. Numerical results illustrate that the system state-space model and payload mass parameter of the two-link flexible space manipulator are effectively identified by the recursive subspace tracking method. | Zhiyu NI Jinguo LIU Zhigang WU Xinhui SHEN | 2019 | Chinese Journal of Aeronautics2019，32，2： | 8 |
| 12 | Advances in statistical mechanics of rock masses and its engineering applications显示文摘To efficiently link the continuum mechanics for rocks with the structural statistics of rock masses,a theoretical and methodological system called the statistical mechanics of rock masses(SMRM)was developed in the past three decades.In SMRM,equivalent continuum models of stressestrain relationship,strength and failure probability for jointed rock masses were established,which were based on the geometric probability models characterising the rock mass structure.This follows the statistical physics,the continuum mechanics,the fracture mechanics and the weakest link hypothesis.A general constitutive model and complete stressestrain models under compressive and shear conditions were also developed as the derivatives of the SMRM theory.An SMRM calculation system was then developed to provide fast and precise solutions for parameter estimations of rock masses,such as full-direction rock quality designation(RQD),elastic modulus,Coulomb compressive strength,rock mass quality rating,and Poisson’s ratio and shear strength.The constitutive equations involved in SMRM were integrated into a FLAC3D based numerical module to apply for engineering rock masses.It is also capable of analysing the complete deformation of rock masses and active reinforcement of engineering rock masses.Examples of engineering applications of SMRM were presented,including a rock mass at QBT hydropower station in northwestern China,a dam slope of Zongo II hydropower station in D.R.Congo,an open-pit mine in Dexing,China,an underground powerhouse of Jinping I hydropower station in southwestern China,and a typical circular tunnel in Lanzhou-Chongqing railway,China.These applications verified the reliability of the SMRM and demonstrated its applicability to broad engineering issues associated with jointed rock masses. | Faquan Wu Jie Wu Han Bao Bo Li Zhigang Shan Deheng Kong | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，1： | 8 |
| 13 | Study on gust alleviation control and wind tunnel test显示文摘Aircraft are inevitably affected by gust during flight,which disturbs the regular operations of pilots and worsens the ride quality.In more grievous cases,flight mission cannot be completed and the flight safety may be disserved.In order to improve the ride quality and the fatigue life of the plane structure under the affect of gust,it is necessary to explore and validate the gust alleviation schemes.Through the low-speed wind tunnel test,the gust alleviation active control technology applied to elastic aircraft is studied.For a large-type passenger plane configuration with high aspect ratio wing,a test system was designed and three gust alleviation control schemes with PID controllers were proposed.Finally the gust alleviation control low-speed wind tunnel test was carried out in the FD-09 wind tunnel.Test results showed that at certain speed and gust frequency,all of the 3 control schemes can alleviate the acceleration at fuselage and wing-tip to a certain extent,as well as the bending moment of wing-root.The gust alleviation control scheme,which uses aileron,elevator and canard as control surfaces synthetically,gives the most satisfying gust alleviation effect. | WU ZhiGang CHEN Lei YANG Chao | 2013 | Chinese Science Bulletin2013，58，7： | 7 |
| 14 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
| 15 | Structural Nonlinear Flutter Characteristics Analysis for an Actuator-fin System with Dynamic Stiffness显示文摘The flutter characteristics of an actuator-fin system are investigated with structural nonlinearity and dynamic stiffness of the electric motor. The component mode substitution method is used to establish the nonlinear governing equations in time domain and frequency domain based on the fundamental dynamic equations of the electric motor and decelerator. The existing describing function method and a proposed iterative method are used to obtain the flutter characteristics containing preload freeplay nonlinearity when the control command is zero. A comparison between the results of frequency domain and those of time domain is studied. Simulations are carried out when the control command is not zero and further analysis is conducted when the freeplay angle is changed. The results show that structural nonlinearity and dynamic stiffness have a significant influence on the flutter characteristics. Limit cycle oscillations (LCOs) are observed within linear flutter boundary. The response of the actuator-fin system is related to the initial disturbance. In the nonlinear condition, the amplitude of the control command has an influence on the flutter characteristics. | YANG Ning WU Zhigang YANG Chao | 2011 | Chinese Journal of Aeronautics2011，24，5： | 7 |
| 16 | Gene Expression Profiling in Apoptotic K562 Cells Treated by Homoharringtonine显示文摘基因薄片技术被用来在 homoharringtonine 导致的 apoptotic K562 房间决定基因表达侧面。mRNAs 被发现显著地被换掉的 44 的表达式在与能够同时检测 14,218 不同人的 mRNA 种类的一块基因芯片屏蔽以后被识别。这些基因, 17 是起来调整的, 27 是下面调整的。他们中的大多数被发现与 apoptosis, oncogenes,或肿瘤抑制有关。有改变的基因表达的几基因,例如人的转变生长因素贝它可诱导的早蛋白质基因( TIEG ),在调整蛋白质上面的 维生素 D3 1 基因( VDUP1 ), RNA 有约束力的主题蛋白质 4 基因( RBM4 )和 v-myc myelocytomatosis 病毒的癌基因相当或相同的事物( C-MYC ),被RNA 印迹分析证实。根据在这些 apoptotic 房间的动态基因表达模式,激活的转变生长因素贝它和肿瘤坏死因素发信号小径在导致 homoharringtonine 的 apoptosis 起一个重要作用。TIEG 显著地在 apoptosis 正式就职以后被改变,它应该为 apoptosis 信号传播是批评的。 | Wei JINX Jiong WU Zhigang ZHUANG Junjie Li Fei FEI Genhong DI Ying CHEN Ming YAO Zhimin SHAO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 17 | Identification of nonlinear multi-degree-of freedom structures based on Hilbert transformation显示文摘The modeling method and identified method adapted to multi-degree-of-freedom structures with strucrural nonlinearities are established.The component mode synthesis method is used to establish the nonlinear governing equations by extending the connected relationships.Based on the modeling method,the Hilbert transform method is applied to identify the nonlinear stiffness of multi-degree-of-freedom structures.Nonlinear analysis and identification of a typical folding wing configuration with three freeplay hinges are investigated.The nonlinear governing equation is established based on present methods and the computing results of different stiffness are checked by finite element programming.In order to illustrate the influence of the nonlinearities,the frequency response characteristics of the structure are analyzed and Hilbert transform is performed.The Hilbert transform identification method is utilized to identify the nonlinear stiffness of nonlinear hinges in the time domain and several parametric studies are performed.In addition,the comparison of response is made to illustrate the feasibility of the methods.The results show that the extending component mode synthesis method in the present work can be used to establish the governing equation with structural nonlinearities.Based on the modeling method,the Hilbert transform identified method can be extended to multi-degree-of-freedom structures accurately. | WU ZhiGang YANG Ning YANG Chao | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，9： | 6 |
| 18 | Possible mechanism underlying analgesic effect of Tuina in rats may involve piezo mechanosensitive channels within dorsal root ganglia axon显示文摘OBJECTIVE: To demonstrate the analgesic effect of Tuina mainly from mechanically sensitive ion channels in peripheral myelinated nerve fibers.METHODS: A total of 40 healthy and pathogen-free adult male Sprague-Dawley rats were used in the study [weight:(220.0 ± 1.4) g, Shanghai Slac Laboratory Animal Co., Ltd., Shanghai, China; license No. Shanghai ICP 05033115]. The rats were housed in cages with free access to water and food in a temperature-controlled room [(22 ± 1) ℃] and12-h/12-h light-dark cycle. Thirty-two rats were randomly divided into five groups: naive, sham, chronic compression of dorsal root ganglion(CCD), Tuina(7 d) and Tuina(21 d). CCD rat model was established via unilateral DRG compression by'L'liked steel bar. Chinese Tuina treatment was accepted once per day. Behavior monitoring of paw withdrawal threshold(PWT) and paw withdrawal latency(PWL) were tested. The expression of Piezo1 and Piezo2 in myelinated nerve fiber were analyzed by immunohistochemistry and Western-blotting.RESULTS: There was a high expression of Piezo2 and a low expression of Piezo1 in the naive and CCD groups. In contrast, the expression of Piezo2 was down regulated and Piezo1 was increased after a period of Tuina. There was significant difference(P ≤ 0.05) between the groups.CONCLUSION: Our findings suggest that Tuina therapy can increase the expression of Piezo2 and decrease the expression of Piezo1 in the test rats.The different changes in the expressions of Piezo1 and Piezo2 may play an important role in alleviating CCD-induced allodynia and hyperalgesia. | Song Pengfei Lin Zhigang Zhu Qingguang Jiang Shichao Zhang Hao Cheng Yanbin Sun Wuquan Wu Zhiwei Zhou Xin Lv Zhizhen Fang Min | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 6 |
| 19 | Characterization of glucose-6-phosphate dehydrogenase deficiency and identification of a novel haplotype 487G>A/IVS5-612(G>C) in the Achang population of southwestern China显示文摘The prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency and its gene mutations were studied in the Achang population from Lianghe County in Southwestern China. We found that 7.31% (19 of 260) males and 4.35% (10 of 230) females had G6PD deficiency. The molecular analysis of G6PD gene exons 2―13 was performed by a PCR-DHPLC-Sequencing or PCR-Sequencing. Sixteen inde-pendent subjects with G6PD Mahidol (487G>A) and the new polymorphism IVS5-612 (G>C), which combined into a novel haplotype, were identified accounting for 84.2% (16/19). And 100% Achang G6PD Mahidol were linked to the IVS5-612 C. The percentage of G6PD Mahidol in the Achang group is close to that in the Myanmar population (91.3% 73/80), which implies that there are some gene flows between Achang and Myanmar populations. Interestingly, G6PD Canton (1376G>T) and G6PD Kaiping (1388G>A), which were the most common G6PD variants from other ethnic groups in China, were not found in this Achang group, suggesting that there are different G6PD mutation profiles in the Achang group and other ethnic groups in China. Our findings appear to be the first documented report on the G6PD genetics of the AChang people, which will provide important clues to the Achang ethnic group origin and will help prevention and treatment of malaria in this area. | YANG YinFeng, ZHU YueChun, LI DanYi, LI ZhiGang, Lü HuiRu, WU Jing, TANG Jing & TONG ShuFen Department of Biochemistry, Faculty of Basic Medicine, Kunming University of Medical Sciences, Kunming 650031, China These authors contributed equally to this work | 2007 | Science China(Life Sciences)2007，50，4： | 6 |
| 20 | PbGA2ox8 induces vascular-related anthocyanin accumulation and contributes to red stripe formation on pear fruit显示文摘Fruit with stripes,which are generally longitudinal,can occur naturally,but the bioprocesses underlying this phenomenon are unclear.Previously,we observed an atypical anthocyanin distribution that caused red-striped fruit on the spontaneous pear bud sport“Red Zaosu”(Pyrus bretschneideri Rehd.).In this study,comparative transcriptome analysis of the sport and wild-type“Zaosu”revealed that this atypical anthocyanin accumulation was tightly correlated with abnormal overexpression of the gene-encoding gibberellin(GA)2-beta-dioxygenase 8,PbGA2ox8.Consistently,decreased methylation was also observed in the promoter region of PbGA2ox8 from“Red Zaosu”compared with“Zaosu”.Moreover,the GA levels in“Red Zaosu”seedlings were lower than those in“Zaosu”seedlings,and the application of exogenous GA4 reduced abnormal anthocyanin accumulation in“Red Zaosu”.Transient overexpression of PbGA2ox8 reduced the GA4 level and caused anthocyanin accumulation in pear fruit skin.Moreover,the presence of red stripes indicated anthocyanin accumulation in the hypanthial epidermal layer near vascular branches(VBs)in“Red Zaosu”.Transient overexpression of PbGA2ox8 resulting from vacuum infiltration induced anthocyanin accumulation preferentially in calcium-enriched areas near the vascular bundles in pear leaves.We propose a fruit-striping mechanism,in which the abnormal overexpression of PbGA2ox8 in“Red Zaosu”induces the formation of a longitudinal array of anthocyanin stripes near vascular bundles in fruit. | Rui Zhai Zhigang Wang Chengquan Yang Kui Lin-Wang Richard Espley Jianlong Liu Xieyu Li Zhongying Wu Pengmin Li Qingmei Guan Fengwang Ma Lingfei Xu | 2019 | Horticulture Research2019，6，1： | 5 |
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