|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model显示文摘人的间充质的干细胞(hMSCs ) 装家到肿瘤地点并且禁止肿瘤细胞的生长。很少对内在的分子的机制被知道连接 hMSCs 到肿瘤房间的指向的抑制。在这研究,我们从 hMSCs 用一个动物移植模型,一个合作文化系统和调节媒介在二根人的 hepatoma 房间线(H7402 和 HepG2 ) 上调查了 hMSCs 的效果。当 SCID 老鼠与 H7402 细胞和 Z3 hMSCs 的一个相等的数字被注射时,动物移植研究证明肿瘤形成的潜伏的时间被延长并且肿瘤尺寸更小。当 co 有教养时与 Z3 房间, H7402 细胞增殖减少了,增加的 apoptosis,和 Bcl-2 的表示, c-Myc,原子抗原(PCNA ) 和 survivin 低是的增殖的房间调整了。在有调节媒介的处理源于 Z3 hMSC 文化以后, H4702 房间出现了减少的形成殖民地的能力和减少的增长。Immunoblot 分析证明 beta-catenin, Bcl-2, c-Myc, PCNA 和 survivin 表示是在 H7402 和 HepG2 房间调整的 down。总起来说,我们的调查结果证明 hMSCs 禁止 H7402 和 HepG2 人的肝癌症房间线的恶意的显型,它包括增长,形成殖民地的能力和 oncogene 表示试管内和体内。而且,我们的研究提供表明小径的 Wnt 可以在调停 hMSC 的指向和肿瘤房间抑制有一个角色的证据。 | Ling Qiao Zhili Xu Tiejun Zhao Zhigang Zhao Mingxia Shi Robert C Zhao Lihong Ye Xiaodong Zhang | 2008 | Cell Research2008，18，4： | 68 |
| 2 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 3 | Determination of metastable zone and induction time of analgin for cooling crystallization显示文摘The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol–aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time(t_(ind)) data. Homogeneous nucleation tended to occur when the supersaturation is high, whereas heterogeneous nucleation was more likely to occur when the supersaturation is low. | Ling Zhou Zhao Wang Meijing Zhang Mingxia Guo Shijie Xu Qiuxiang Yin | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 7 |
| 4 | Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients显示文摘Dear Editor,In late December 2019,an outbreak of severe pneumonia caused by an unknown etiological agent was initially reported in Wuhan,China,and then quickly spread throughout China and even abroad(Zhu et al.,2020).Swift control measures and etiological investigations were conducted by the Chinese government,physicians and researchers,and by using high throughput sequencing and virological testing,the mysterious pneumonia pathogen was shown to be a novel coronavirus(SARS-CoV-2)capable of person-to-person transmission(Zhu et al.,2020).Coronaviruses are a group of non-segmented,enveloped and positive-sense RNA viruses that belong to the subfamily of Coronavirinae in the family of Coronavirdiae and order of Nidovirales. | Dachuan Lin Lei Liu Mingxia Zhang Yunlong Hu Qianting Yang Jiubiao Guo Yongchao Guo Youchao Dai Yuzhong Xu Yi Cai Xinchun Chen Zheng Zhang Kaisong Huang | 2020 | Science China(Life Sciences)2020，63，4： | 6 |
| 5 | Brief Introduction to a Unique Edible Bolete---Phlebopus portentosus in Southern China显示文摘 | Chunxia Zhang Mingxia He Jing Liu Xinjing Xu Yang Cao Feng Gao Yiwei Fang Wenbing Wang Yun Wang | 2017 | Journal of Agricultural Science and Technology(B)2017，7，6： | 6 |
| 6 | MiR-147b inhibits cell viability and promotes apoptosis of rat H9c2 cardiomyocytes via down-regulating KLF13 expression显示文摘最近, microRNAs (miRNAs ) 被显示了在心失败的过程包含。这研究试图在老鼠 H9c2 cardiomyocytes 调查 miR-147b 的功能的角色并且探索内在的分子的机制。H9c2 房间的房间生存能力被 MTT 试金检测。房间 apoptosis 被流动 cytometry 检测。miR-147b 和 KLF13 mRNA 的表示被量的即时 PCR 检测。在 miR-147b 和 KLF13 之间的关系被双酶的记者试金验证。蛋白质层次被西方的污点分析检测。它被发现那 H 2 O 2 禁止了房间生存能力并且以一种集中依赖者方式支持了 H9c2 房间的房间 apoptosis。MiR-147b overexpression miR-147b 压制了房间生存能力并且在 H9c2 房间增加了 apoptosis,当击倒时在 H 2 O 2-treated H9c2 房间。酶记者试金并且在功能的试金显示出的 vitro,那 KLF13 是 miR-147b,和 KLF13 的一个下游的目标在 H9c2 房间的击倒的压制的房间生存能力和导致的 apoptosis。KLF13 的强制表示在 H9c2 房间在房间生存能力和 apoptosis 上恢复了 miR-147b overexpression 的效果。MiR-147b 在 apoptosis 相关的蛋白质上调制了 miR-147b overexpression 的 apoptosis 相关的蛋白质,和效果的表示层次层次被 KLF13 的强制表示在 H9c2 房间阻止。在里面 vivo 实验证明 miR-147b 是起来调整的,并且 KLF13 在从有长期的心失败的老鼠的心肌的纸巾是下面调整的。一起, miR-147b 禁止生存能力并且由在 H9c2 房间指向 KLF13 支持房间 apoptosis,它可以与心失败的致病被联系。 | Mingxia Gu Jing Wang Yi Wang Yanjuan Xu Yingqiang Zhang Weiqing Wu Shuping Liao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 6 |
| 7 | Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics显示文摘Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy. | Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 5 |
| 8 | The template preparation and characterization of three new shapes of titania nanometer-array systems显示文摘A two-step anodization process was used to prepare highly ordered porous anodic alu- mina template (PAA). The template method was combined with the sol-electrophoresis deposition and sol-gel method to synthesize three types of nano- meter-array systems. The titania nano-arrays have a high specific surface area. The sol-gel template method was also applied to prepare the rod-shaped titania nanowire-arrays. The diameter of titania nanometer-array is about 50 nm; the length is about 20 μm; and the distance of neighboring two nanowires is about 100 nm. Through controlling the pore depth of the template, the membrane with peri- odical modulating titania nanodots was prepared. The diameter of the nanodots on the membrane surface was about 75 nm and the dot distance was about 100 nm. Also a compact structure has been found on the back face of the membrane. The sol-electrophoresis template method was used to prepare the nanowire-array system with the shape of string of candied haws. The diameter of nanowires was about 75 nm and the length was about 20 μm. The periodic concave-convex structures were found in each nanowire and the shape looked like string of candied haws. The three types of nano-array systems have a high specific surface area. It can be predicted that this type of surface modulating array system will have new properties and effects that are different from those of common membranes, nanodots and nanowires. | TIAN Yuming XU Mingxia LIU Xiangzhi GE Lei | 2006 | Chinese Science Bulletin2006，51，12： | 4 |
| 9 | miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn’s disease显示文摘 | Yu Chen Xiaochun Meng Chengxiao Wang Ying Liu Liwei Tang Mingxia Zheng Chundi Xu Jian Song | 2013 | Biochemical and Biophysical Research Communications2013，，： | 2 |
| 10 | miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn’s disease显示文摘 | Yu Chen Chengxiao Wang Ying Liu Liwei Tang Mingxia Zheng Chundi Xu Jian Song Xiaochun Meng | 2013 | Biochemical and Biophysical Research Communicatio2013，，1： | 2 |
| 11 | Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis显示文摘Impairment of glucose(Glu)uptake and storage by skeletal muscle is a prime risk factor for the development of metabolic diseases.Heterogeneous nuclear ribonucleoprotein A1(hnRNP Al)is a highly abundant RNA-binding protein that has been implicated in diverse cellular functions.The aim of this study was to investigate the function of hnRNP A1 on muscle tissue insulin sensitivity and systemic Glu homeostasis.Our results showed that conditional deletion of hnRNP Al in the muscle gave rise to a severe insulin resistance phenotype in mice fed a high-fat diet(HFD).Conditional knockout mice fed a HFD showed exacerbated obesity,insulin resistance,and hepatic steatosis.In vitro interference of hnRNP Al in C2C12 myotubes impaired insulin signal transduction and inhibited Glu uptake,whereas hnRNP Al overexpression in C2C12 myotubes protected against insulin resistance induced by supraphysiological concentrations of insulin.The expression and stability of glycogen synthase(gysl)mRNA were also decreased in the absence of hnRNP A l.Mechanistically,hnRNP Al interacted with gys l and stabilized its mRNA,thereby promoting glycogen synthesis and maintaining the insulin sensitivity in muscle tissue.Taken together,our findings are the first to show that reduced expression of hnRNP Al in skeletal muscle affects the metabolic properties and systemic insulin sensitivity by inhibiting glycogen synthesis. | Mingxia Zhao Lihong Shen Zijun Ouyang Manru Li Guoliang Deng Chenxi Yang Wei Zheng Lingdong Kong Xuefeng Wu Xudong Wu Wenjie Guo Ye Yin Qiang Xu Yang Sun | 2020 | Journal of Molecular Cell Biology2020，12，4： | 2 |
| 12 | CRISPR-Cas adaptive immune systems in Sulfolobales:genetic studies and molecular mechanisms显示文摘CRISPR-Cas systems provide the small RNA-based adaptive immunity to defend against invasive genetic elements in archaea and bacteria.Organisms of Sulfolobales,an order of thermophilic acidophiles belonging to the Crenarchaeotal Phylum,usually contain both type I and typeⅢCRISPR-Cas systems.Two species,Saccharolobus solfataricus and Sulfolobus islandicus,have been important models for CRISPR study in archaea,and knowledge obtained from these studies has greatly expanded our understanding of molecular mechanisms of antiviral defense in all three steps:adaptation,expression and crRNA processing,and interference.Four subtypes of CRISPR-Cas systems are common in these organisms,including I-A,I-D,Ⅲ-B,andⅢ-D.These cas genes form functional modules,e.g.,all genes required for adaptation and for interference in the I-A immune system are clustered together to form aCas and i Cas modules.Genetic assays have been developed to study mechanisms of adaptation and interference by different CRISPR-Cas systems in these model archaea,and these methodologies are useful in demonstration of the protospacer-adjacent motif(PAM)-dependent DNA interference by I-A interference modules and multiple interference activities byⅢ-B Cmr systems.Ribonucleoprotein effector complexes have been isolated for SulfolobalesⅢ-B andⅢ-D systems,and their biochemical characterization has greatly enriched the knowledge of molecular mechanisms of these novel antiviral immune responses. | Zhenxiao Yu Suping Jiang Yuan Wang Xuhui Tian Pengpeng Zhao Jianan Xu Mingxia Feng Qunxin She | 2021 | Science China(Life Sciences)2021，64，5： | 2 |
| 13 | 显示文摘 | Ge Lei Xu Mingxia Fang Haibo | 2006 | Journal of Sol-Gel Sci- ence and Technology2006，40，1： | 1 |
| 14 | Synthesis and characterization of the Pd/In VO4-TiO2 co-doped thin films with visible light photocatalyric activities显示文摘 | GE Lei XU Mingxia FANG Haibo | 2006 | Appl Surf Sci2006，253，4： | 1 |
| 15 | Preparation and characterization of silver and indium vanadate co-doped TiO2 thin films as visible-light-activated photocatalyst显示文摘 | GE Lei XU Mingxia FANG Haibo | 2006 | J Sol Gel Sci Technol2006，40，1： | 1 |
| 16 | Synthesis and photocatalytic properties of InVO4 sol containing nanocrystals by mild hydrothermal processing显示文摘 | FANG Haibo XU Mingxia GE Lei | 2006 | Trans Nonfer Met al Soci Chin2006，16，27： | 1 |
| 17 | Ti-MCM-41 supported phosphotungstic acid: An effectiveand environmentally benign catalyst for epoxidation ofstyrene 显示文摘 | Wang Guangjian Liu Guangqing Xu Mingxia ei al | 2008 | Appl Surf Sci2008，255，5： | 1 |
| 18 | Regularity control of porous anodic alumina and photodegradation activity of highly ordered titania nanostructures 显示文摘 | Liu Xiangzhi Xu Mingxia Tian Yuming | 2006 | Transactions of Nonferrous Metals Society of China2006，16，1： | 1 |
| 19 | Regularity control of porous anodic alumina and photodegradation activity of highly ordered titania nanostructures显示文摘 | LIU Xiangzhi XU Mingxia TIAN Yuming | 2006 | Trans Nonferrous Met Soc China2006，16，： | 1 |
| 20 | 显示文摘 | Ge Lei Xu Mingxia Fang Haibo | 2006 | Applied Surface Science2006，253，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员