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| 1 | Soil Microbial Community Structure in Diverse Land Use Systems:A Comparative Study Using Biolog,DGGE,and PLFA Analyses显示文摘Biolog,16S rRNA gene denaturing gradient gel electrophoresis(DGGE) ,and phospholipid fatty acid(PLFA) analyses were used to assess soil microbial community characteristics in a chronosequence of tea garden systems(8-,50-,and 90-year-old tea gardens) ,an adjacent wasteland,and a 90-year-old forest. Biolog analysis showed that the average well color development(AWCD) of all carbon sources and the functional diversity based on the Shannon index decreased(P < 0.05) in the following order:wasteland > forest > tea garden. For the DGGE analysis,the genetic diversity based on the Shannon index was significantly lower in the tea garden soils than in the wasteland. However,compared to the 90-year-old forest,the tea garden soils showed significantly higher genetic diversity. PLFA analysis showed that the ratio of Gram positive bacteria to Gram negative bacteria was significantly higher in the tea garden soils than in the wasteland,and the highest value was found in the 90-year-old forest. Both the fungal PLFA and the ratio of fungi to bacteria were significantly higher in the three tea garden soils than in the wasteland and forest,indicating that fungal PLFA was significantly affected by land-use change. Based on cluster analysis of the soil microbial community structure,all three analytical methods showed that land-use change had a greater effect on soil microbial community structure than tea garden age. | XUE Dong YAO Huai-Ying GE De-Yong HUANG Chang-Yong | 2008 | Pedosphere2008，18，5： | 56 |
| 2 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 3 | Optimal operation of electricity, natural gas and heat systems considering integrated demand responses and diversified storage devices显示文摘In recent years, the increasing penetration level of renewable generation and combined heat and power(CHP) technology in power systems is leading to significant changes in energy production and consumption patterns. As a result, the integrated planning and optimal operation of a multi-carrier energy(MCE) system have aroused widespread concern for reasonable utilization of multiple energy resources and efficient accommodation of renewable energy sources. In this context, an integrated demand response(IDR) scheme is designed to coordinate the operation of power to gas(P2 G) devices, heat pumps,diversified storage devices and flexible loads within an extended modeling framework of energy hubs. Subsequently, the optimal dispatch of interconnected electricity,natural gas and heat systems is implemented considering the interactions among multiple energy carriers by utilizing the bi-level optimization method. Finally, the proposed method is demonstrated with a 4-bus multi-energy systemand a larger test case comprised of a revised IEEE 118-bus power system and a 20-bus Belgian natural gas system. | Linna NI Weijia LIU Fushuan WEN Yusheng XUE Zhaoyang DONG Yu ZHENG Rui ZHANG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 30 |
| 4 | 美国山核桃在云南的引种研究进展及发展前景显示文摘总结了云南53a来对美国山核桃引种、选种、生物学特性、生态适应性、苗木繁殖、丰产栽培、虫害防治的研究进展和示范推广情况。认为美国山核桃市场潜力大,在云南栽培效益高、适栽区域广、符合该省经济林树种结构调整需要,将来定会得到大力推广发展。 | 习学良 XI XUE LIANG 范志远 FAN ZHI YUAN 董润泉 DONG RUN QUAN 张雨 ZHANG YU | 2001 | 江西林业科技2001，，6： | 25 |
| 5 | Isolation and characterization of insecticidal activity of (Z)- asarone from Acorus calamus L.显示文摘Acorus 省藤属的植物 L 的杀虫活性。对 Sitophilus zeamais Motschulsky 的成年人的导出根茎的材料被使用抵抗性方法和接触毒性检验。A 的生物学上活跃的成分。省藤属的植物根茎被分开并且识别。结果证明乙醇 A 提取。省藤属的植物有强壮的抵抗性和接触效果到 S。zeamais 和 A 的活跃成分。省藤属的植物被分光镜的分析作为(Z)-asarone 描绘。从测试的回答与暴露时间和剂量变化了。在抵抗性测试,乙醇 A 提取。省藤属的植物在 629.08 og/cmpo 有 93.92% 抵抗性但是仅仅 71.38% 在 157.27 og/cmpo 在处理以后的 12 h。作为一个对比,(Z)-asarone 在 314.54 og/cmpo 显示出 84.50% 抵抗性并且 77.02% 在 78.63 og/cmpo 在处理以后的 12 h。在滤纸散开测试,乙醇 A 提取。省藤属的植物引起了 95.56% 和 17.78% 死亡到 S。在 314.54 og/cmpo 和 78.63 og/ cmpo 的 zeamais 在处理以后的 4 天,当(Z)-asarone 分别地在 40.89 og/cmpo 和 15.73 og/cmpo 引起了 100.00% 和 15.56% 死亡时。这些结果显示 A 的杀虫活性。省藤属的植物摘录可能由于(Z)-asarone。 | Yingjuan Yao Wanlun Cai Changju Yang Dong Xue Yanzhang Huang | 2008 | Insect Science2008，15，3： | 22 |
| 6 | Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells显示文摘AIM:To investigate whether umbilical cord human mesenchymal stem cell(UC-MSC)was able to differentiate into neural stem cell and neuron in vitro.·METHODS:The umbilical cords were obtained from pregnant women with their written consent and the approval of the Clinic Ethnics Committee.UC-MSC were isolated by adherent culture in the medium contains 20%fetal bovine serum(FBS),then they were maintained in the medium contain 10%FBS and induced to neural cells in neural differentiation medium.We investigated whether UC-MSC was able to differentiate into neural stem cell and neuron in vitro by using flow cytometry,reverse transcriptase-polymerase chain reaction(RT-PCR)and immunofluorescence(IF)analyzes.·RESULTS:A substantial number of UC-MSC was harvested using the tissue explants adherent method at about 2wk.Flow cytometric study revealed that these cells expressed common markers of MSCs,such as CD105(SH2),CD73(SH3)and CD90.After induction of differentiation of neural stem cells,the cells began to form clusters;RT-PCR and IF showed that the neuron specific enolase(NSE)and neurogenic differentiation 1-positive cells reached 87.3%±14.7%and 72.6%±11.8%,respectively.Cells showed neuronal cell differentiation after induced,including neuron-like protrusions,plump cell body,obviously and stronger refraction.RT-PCR and IF analysis showed that microtubule-associated protein 2(MAP2)and nuclear factor-M-positive cells reached 43.1%±10.3%and 69.4%±19.5%,respectively.·CONCLUSION:Human umbilical cord derived MSCscan be cultured and proliferated in vitro and differentiate into neural stem cells,which may be a valuable source for cell therapy of neurodegenerative eye diseases. | Song Chen Wei Zhang Ji-Ming Wang Hong-Tao Duan Jia-Hui Kong Yue-Xin Wang Meng Dong Xue Bi Jian Song | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 22 |
| 7 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 8 | The Yanshan orogeny and late Mesozoic multi-plate convergence in East Asia—Commemorating 90th years of the “Yanshan Orogeny”显示文摘The Yanshan movement/orogeny has been proposed for 90 years, which is of special significance in the history of geological research in China. This study conducted a review by synthesizing major achievements regarding episodic deformation features, sedimentary and magmatic records of the Yanshan orogeny in China, and clarified the episodic tectono-magmatism and its geodynamic origins. The tectonic implications of the Yanshan orogeny are discussed in the context of global plate tectonics and supercontinent reconstruction. Lines of evidence from structural, sedimentary and magmatic data suggest that the Yanshan orogeny represents a regional-scale tectonic event that affected the entire China continent in late Mesozoic period. Numerous age and structural constraints consistently indicate that the Yanshan orogeny was initiated in the Jurassic(at ~170±5 Ma). and was characterized by alternating stages of crustal shortening at ~170–136 Ma, crustal extension at ~135–90 Ma, and weak shortening at ~80 Ma. The 170–136 Ma crustal shortening was reflected in the generation of two regional stratigraphic unconformities(the Tiaojishan and Zhangjiakou unconformities), which were initially named the A and B episodes of 'the Yanshan Orogeny' by Mr.Wong Wenhao in 1928. Geodynamically, the Yanshan orogeny in East Asia was associated with nearly coeval oceanic subduction and continental convergence in the Paleo-Pacific, Neo-Tethys, and Mongol-Okhotsk tectonic domains. As a consequence, three giant accretionary-collisional tectonic systems were formed along the continental margins of East Asia, i.e., the Mongol-Okhotsk, Bangonghu-Nujiang, and SE China subduction-and collision-related accretionary systems. The Yanshan orogeny induced widespread crustal-scale folding and thrusting, tectonic reactivation of long-lived zones of crustal weakness,and extensive magmatism and mineralization in intraplate regions. Based on the time principle of supercontinent assembly and break-up, we propose that the mid-Late Jurassic multi-plate convergence in East Asia might represent the initiation of the assembly of the Amasia supercontinent, and the Yanshan orogeny might be the first 'stirrings' that is a prerequisite for the birth of the Amasia supercontinent. | Shuwen DONG Yueqiao ZHANG Hailong LI Wei SHI Huaimin XUE Jianhua LI Shiqi HUANG Yongchao WANG | 2018 | Science China Earth Sciences2018，61，12： | 21 |
| 9 | Effect of lime application on microbial community in acidic tea orchard soils in comparison with those in wasteland and forest soils显示文摘Lime application is a conventional technology to control acidification in tea orchard soils. We investigated the effect of lime application on soil microbial community diversity in the soils of three tea orchards, wasteland and forest. The BIOLOG data showed that both the average well color development of all carbon sources and the functional diversity index increased with the liming rate in the tea orchards and the forest, but decreased in the wasteland. The phospholipid fatty acid (PLFA) analysis showed that the structural diversity index of soil microbial community increased with the liming rate in all the tea orchards, the wasteland and the forest. Lime application also increased the soil-bacterial PLFA content in all the soils. Soil fungal and actinomycete PLFAs in the tea orchards showed an increasing trend from 0 to 3.2 g CaCO 3 /kg application and then a decreasing trend from 3.2 to 6.4 g CaCO 3 /kg application. The principal component analysis of BIOLOG and PLFA data suggested that lime application had a significant effect on soil microbial community structure, and land use had a greater effect on soil microbial community structure compared to lime application. | Dong Xue Xiangdong Huang Huaiying Yao Changyong Huang | 2010 | Journal of Environmental Sciences2010，22，8： | 20 |
| 10 | Fast magnetic reconstruction of the portal vein with allogeneic blood vessels in canines显示文摘BACKGROUND:The resection and reconstruction of large vessels,including the portal vein,are frequently needed in tumor resection.Warm ischemia before reconstruction might have deleterious effects on the function of some vital organs and therefore,how to reconstruct the vessels quickly after resection is extremely important.The present study was to introduce a new type of magnetic compression anastomosis(MCA)device to establish a quick non-suture anastomosis of the portal vein after resection in canines.METHODS:The new MCA device consists of a pair of titanium alloy and neodymium-ferrum-boron magnet(Ti-Nd Fe B)composite rings.The Nd Fe B magnetic ring as a core of the device was hermetically sealed inside the biomedical titanium alloy case.Twelve canines were divided into two groups:a MCA group in which the end-to-end anastomoses was made with a new device after resection in the portal vein and a traditional manual suture(TMS)group consisted of 6 canines.The anastomosis time,anastomotic patency and quality were investigated at week 24 postoperatively.RESULTS:The portal vein was reconstructed successfully in all of the animals and they all survived.The duration of portal vein anastomosis was significantly shorter in the MCA group than in the TMS group(8.16±1.25 vs 36.24±2.17 min,P<0.05).Portography and ultrasound showed that the blood flow was normal without angiostenosis or thrombosis in all of the canines.Hematoxylin-eosin staining and electron microscope scanning showed in contrast to the TMS group,MCA anastomotic intimal was much smoother with more regularly arranged endothelial cells at week 24 postoperatively. | Shan-Pei Wang Xiao-Peng Yan Fei Xue Ding-Hui Dong Xu-Feng Zhang Feng Ma Hao-Hua Wang Yi Lv | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 20 |
| 11 | APPLICATION OF WHOLE BODY DIFFUSION WEIGHTED MR IMAGING FOR DIAGNOSIS AND STAGING OF MALIGNANT LYMPHOMA显示文摘Objective To evaluate the clinical impact of whole body diffusion weighted imaging (WB-DWI) on diagnosis and staging of malignant lymphoma. Methods Thirty-one patients with suspected lymphadenopathy were enrolled. WB-DWI was performed by using short TI inversion recovery echo-planar imaging sequence with free breathing and built-in body coil. Axial T2- weighted imaging images of the same location were used as reference. The results of WB-DWI were compared with pathological results and other imaging modalities. The mean apparent diffusion coefficient (ADC) values of different kinds of lymph nodes were compared. Results WB-DWI was positive in all 18 cases with lymphoma, 5 cases with metastatic lymph nodes and 4 of 8 cases with benign lymphadenopathy. The mean ADC value of lymphomatous, metastatic and benign lymph nodes was (0.87 ± 0.17) × 10-3, (0.98 ± 0.09) × 10-3 and (1.20 ± 0.10) × 10-3 mm2/s. There was significant difference in ADC value between benign lymph nodes and other two groups (P < 0.01). The sensitivity, specificity and accuracy of WB-DWI in diagnosis of lymphoma were 100% (18/18), 30.8% (4/13) and 71.0% (22/31). When an ADC value of 1.08 × 10-3 mm2/s was used as the threshold value for differentiating malignant from benign lymph nodes, the best results were obtained with sensitivity of 87.8% and specificity of 91.3%. Sixteen of eighteen cases (88.9%) of lymphoma were accurately staged in accordance with clinical staging. Conclusions WB-DWI is a sensitive, but less specific technique for diagnosis of lymphoma. It is difficult to differentiate lymphomatous from metastatic lymph nodes using WB-DWI. However, it is a valuable imaging modality for staging of patients with malignant lymphoma. | Shuo Li Hua-dan Xue Jian Li Fei Sun Bo Jiang Dong Liu Hong-yi Sun Zheng-yu Jin | 2008 | Chinese Medical Sciences Journal2008，23，3： | 18 |
| 12 | Dynamic modeling of a hose-drogue aerial refueling system and integral sliding mode backstepping control for the hose whipping phenomenon显示文摘Dynamic modeling of a hose-drogue aerial refueling system(HDARS) and an integral sliding mode backstepping controller design for the hose whipping phenomenon(HWP) during probe-drogue coupling are studied. Firstly, a dynamic model of the variable-length hose-drogue assembly is built for the sake of exploiting suppression methods for the whipping phenomenon.Based on the lumped parameter method, the hose is modeled by a series of variable-length links connected with frictionless joints. A set of iterative equations of the hose's three-dimensional motion is derived subject to hose reeling in/out, tanker motion, gravity, and aerodynamic loads accounting for the effects of steady wind, atmospheric turbulence, and tanker wake. Secondly,relying on a permanent magnet synchronous motor and high-precision position sensors, a new active control strategy for the HWP on the basis of the relative position between the tanker and the receiver is proposed. Considering the strict-feedback configuration of the permanent magnet synchronous motor, a rotor position control law based on the backstepping method is designed to insure global stability. An integral of the rotor position error and an exponential sliding mode reaching law of the current errors are applied to enhance control accuracy and robustness. Finally,the simulation results show the effectiveness of the proposed model and control laws. | Wang Haitao Dong Xinmin Xue Jianping Liu Jiaolong | 2014 | Chinese Journal of Aeronautics2014，27，4： | 17 |
| 13 | Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion显示文摘AIM: To assess the effect of notoginsenoside R1 on hepatic microcirculatory disturbance induced by gut ischemia/reperfusion (I/R) in mice.METHODS: The superior mesenteric artery (SMA) of C57/BL mice was ligated for 15 min to induce gut ischemia followed by 30-min reperfusion. In another set of experiments, R1 was continuously infused (10 mg/kg per hour) from 10 min before I/R until the end of the investigation to study the influence of R1 on hepatic microcirculatory disturbance induced by gut I/R. Hepatic microcirculation was observed by inverted microscopy, and the vascular diameter, red blood cell (RBC) velocity and sinusoid perfusion were estimated. Leukocyte rolling and adhesion were observed under a laser confocal microscope. Thirty and 60 min after reperfusion, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate transaminase (AST) in peripheral blood were determined. The expression of adhesion molecules CD11b/CD18 in neutrophils and tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) in plasma were evaluated by flow cytometry. E-selectin and intercellular adhesion molecule-1 (ICAM-1) in hepatic tissue were examined by immunofluorescence. RESULTS: After gut I/R, the diameters of terminal portal venules and central veins, RBC velocity and the number of perfused sinusoids were decreased, while the leukocyte rolling and adhesion, the expression of E-selectin in hepatic vessels and CD18 in neutrophils, IL-6, MCP-1, LDH, ALT and AST were increased. R1 treatment attenuated these alterations except for IL-6 and MCP-1.CONCLUSION: R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury. The effect of R1 is related to its inhibition of leukocyte rolling and adhesion by inhibiting the expression of E-selectin in endothelium and CD18 in neutrophils. | Wei-Xing Chen Fang Wang, Yu-Ying Liu, Qing-Jiang Zeng, Kai Sun, Xin Xue, Xiang Li, Ji-Ying Yang, Li-Hua An,Bai-He Hu, Jin-Hui Yang, Chuan-She Wang, Zhi-Xin Li, Lian-Yi Liu, Yan Li, Jun Zheng, Fu-Long Liao, Dong Han,Jing-Yu Fan, Jing-Yan Han Fang Wang Yu-Ying Liu Qing-Jiang Zeng Kai Sun Xin Xue Xiang Li Ji-Ying Yang Li-Hua An Bai-He Hu Jin-Hui Yang Chuan-She Wang Zhi-Xin Li Lian-Yi Liu Yan Li Jun Zheng Fu-Long Liao Dong Han Jing-Yu Fan Jing-Yan Han | 2008 | World Journal of Gastroenterology2008，14，1： | 17 |
| 14 | Study of angiogenesis induced by metastatic and non-metastatic liver cancer by corneal micropocket model in nude mice显示文摘METHODSCornealmicropocketswerecreatedinnudemice.Tumortissuesandlivertissueswereimplantedintothecornealmicropockets.Angiogenes... | SUN Hui Chuan, LI Xiao Ming, XUE Qiong, CHEN Jun, GAO Dong Mei and TANG Zhao You | 1999 | World Journal of Gastroenterology1999，5，2： | 17 |
| 15 | Prognosis-related classifi cation and dynamic monitoring of immune status in patients with sepsis:A prospective observational study显示文摘BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation. | Jun Yin Yao Chen Jun-ling Huang Lei Yan Zhong-shu Kuang Ming-ming Xue Si Sun Hao Xiang Yan-yan Hu Zhi-min Dong Chao-yang Tong Chun-xue Bai Zhen-ju Song | 2021 | World Journal of Emergency Medicine2021，12，3： | 16 |
| 16 | MR DIFFUSION WEIGHTED IMAGING FOR EVALUATION OF RADIOTHERAPEUTIC EFFECTS ON RABBIT VX2 TUMOR MODEL显示文摘Objective To investigate the feasibility of magnetic resonance (MR) diffusion weighted imaging (DWI) for evaluation of radiotherapeutic effects on rabbit VX2 tumor model. Methods Sixteen New Zealand white rabbits received a subcutaneous implantation of VX2 tumor cell suspension 0.5 mL (4×107 cells/mL) in their right thighs to set up tumor model. And 2 weeks later they were randomly divided into therapy group (Group T, n = 10) and control group (Group C, n = 6). Group T received radiotherapy at a single dose of 10 Gy. MR imaging (MRI) scan including short TI inversion recovery echo-planar imaging DWI, T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI) sequences were performed 1 day prior to as well as 1 day, 2 days, 3 days and 7 days after radiotherapy. Group C received only MRI scan at the same time points without any treatment. MRI appearance on T2WI, T1WI, and DWI images was compared and tumor volume was calculated. Apparent diffusion coefficient (ADC) values of the tumor were evaluated in all cases. HE staining was used for pathological study. Results Necrosis (n = 8) and hemorrhage (n = 2) were seen gradually on T2WI and T1WI images of Group T after time point of day 2 after irradiation. In Group C, no obvious necrosis was found until day 7. There was no significant difference in tumor volume between the two groups before radiotherapy. After radiotherapy, tumors in Group T showed a gradual growth but not as obvious as Group C. There was a significant difference in tumor volume between the two groups from day 2 on (P < 0.05). ADC value changed dramatically right from the 1st day after radio- therapy in Group T [(0.99 ± 0.15) ×10-3 mm2/s for 1 day before radiotherapy, (1.23 ± 0.08) ×10-3, (1.45 ± 0.07) ×10-3, (1.63 ± 0.06) ×10-3, and (2.02 ± 0.18) ×10-3 mm2/s for day 1, 2, 3, and 7]; and ADC value had no significant changes after radiotherapy in Group C except day 7 [(1.07 ± 0.08) ×10-3 mm2/s for 1 day before radiotherapy, (1.03 ± 0.04) × 10-3, (1.05 ± 0.02) ×10-3, (1.05 ± 0.05) ×10-3, and (0.95 ± 0.07) ×10-3 mm2/s for day 1, 2, 3, and 7]. There was significant difference in ADC value between the two groups for each time point after radiotherapy (P < 0.01). Pathological study showed that the number of viable tumor cells in Group T decreased 1 day after radiotherapy, and the inflammatory cell infiltration was marked and almost all viable tumor cells disappeared by day 7 after radiotherapy. Conclusions DWI is a new promising technique for monitoring radiotherapy outcomes. ADC value may give a prior clue on physiological changes of radiotherapy before routine MRI could tell. | Shuo Li Hua-dan Xue Xin-hai Wang Fei Sun Bo Jiang Dong Liu Jing Lei Zheng-yu Jin | 2008 | Chinese Medical Sciences Journal2008，23，3： | 15 |
| 17 | Probucol attenuates atrial autonomic remodeling in a canine model of atrial fibrillation produced by prolonged atrial pacing显示文摘背景我们假设氧化应力和发炎可以玩的那增加的 atrial 在 atrial 神经在 atrial 纤维性颤动(AF ) 期间发芽和异构的同情的 hyperinnervation 的一个重要角色。测试假设,我们检验了有 probucol 的抗氧化剂和反煽动性的处理是否稀释在 AF 的一个犬的模型的自治改变由延长快速的正确 atrial 踱步生产了的 atrial。21 条狗被划分成一个假冒操作组,一个控制组和一个 probucol 组的方法。在控制组和 probucol 组的狗经历了每分钟在 400 敲击踱步的正确 atrial 因为在踱步直到踱步的快速的 atrial 停止了以前,在 probucol 的 6 个星期,和那些 1 个星期组织收到的 probucol。在 6 星期的快速的 atrial 踱步以后,包括的一般性质离开了 atrial AF 的结构和功能, atrial hemodynamics 和 inducibility 和持续时间在所有这些组被测量。Atrial 氧化压力标记和浆液 C 反应的蛋白质(CRP ) 集中被估计。神经在正确 atrial 发芽和同情的神经分布的度前面的墙(RAAW ) 和左 atrial 前面的墙(LAAW ) 被 immunohistochemistry 确定, atdal 新肾上素内容也被检测。在 RAAW 和 LAAW 的 Atrial 贝它神经生长因素(beta-NGF ) mRNA 和蛋白质表示被即时量的 RT-PCR 并且分别地的西方的弄污估计。结果 Atrial tachypacing 导致了重要神经发芽和异构的同情的 hyperinnervation,并且神经发芽和 hyperinnervation 的大小比在 LAAW 在 RAAW 是更高的。Atrial beta-NGF mRNA 和蛋白质层次显著地在 RAAW 和 LAAW 被增加,并且 beta-NGF 表示的 upregulation 比在在控制组的 LAAW 在 RAAW 是更大的。beta-NGF 蛋白质水平断然在所有组与同情的神经的密度被相关。Probucol 减少了氧化应力由 atrial tachypacing 引起了的 CRP 集中和稀释 atrial 的增加。另外, probucol 能有效地禁止 atrial beta-NGF upregulation,显著地稀释 atrial 神经发芽和异构的同情的 hyperinnervation,并且戏剧性地减少 AF 的 inducibility 和持续时间。beta-NGF 的 atrial 在表示上可能由增加的氧化应力和发炎引起了的结论可以是位于 atrial 下面的主要机制在 AF 期间的自治改变。Probucol 稀释 atrial 由它的抗氧化剂和反煽动性的行动的可能的自治改变。 | GONG Yong-tai LI Wei-min LI Yue YANG Shu-sen SHENG Li YANG Ning SHAN Hong-bo XUE Hong-jie LIU Wei YANG Bao-feng DONG De-li LI Bao-xin | 2009 | Chinese Medical Journal2009，，1： | 15 |
| 18 | A Comparative miRNAome Analysis Reveals Seven Fiber Initiation-Related and 36 Novel miRNAs in Developing Cotton Ovules显示文摘越来越多的 microRNAs (miRNAs ) 被显示了在工厂开发的进程起关键规章的作用。这里,我们使用了高产量的定序与计算分析结合了在纤维开始期间从野类型的高地棉花和无纤维的异种的小卵描绘 miRNAomes。与北弄污和 RACEPCR 相结合的比较 miRNAome 分析揭示了开始相关的 miRNAs 在棉花表示了的七纤维小卵和这些 miRNAs 的试验性地验证的目标涉及不同细胞的回答和新陈代谢的过程,包括 transcriptional 规定,植物生长素和赤霉素信号 transduction,肌动朊捆,和木质素生合成。这份报纸描述由在棉花小卵表示协调纤维开始回答的这些 miRNAs 组成的一个复杂规章的网络。另外, 36 新奇 miRNAs 和二保存 miRNAs 最新被识别,将近加倍已知的棉花 miRNA 家庭的数字到 78 的一个总数。而且,改变复杂子单元的染色质和拼接的因素第一次被显示出是 miRNA 的 pre-mRNA 指向。到我们的知识,这研究是纤维的第一系统的调查在发展中的棉花小卵的开始相关的 miRNAs 和他们的目标,在棉花加深我们 miRNAs 的重要规章的功能的理解纤维开始。 | Zheng-Ming Wang Wei Xue Chun-Juan Dong Long-Guo Jin Shao-Min Bian Chuan Wang Xiu-Yun Wu Jin-Yuan Liu | 2012 | Molecular Plant2012，5，4： | 15 |
| 19 | Clinical profiles and outcomes of acute type A aortic dissection and intramural hematoma in the current era: lessons from the first registry of aortic dissection in China显示文摘Background::Acute type A aortic dissection(ATAAD)and acute type A intramural hematoma(ATAIMH)are life-threatening diseases with high mortality.To better understand their clinical features in the Chinese population,we analyzed the data from the first Registry of Aortic Dissection in China(Sino-RAD)to promote the understanding and management of the diseases.Methods::All patients with ATAAD and ATAIMH enrolled in Sino-RAD from January 1,2012 to December 31,2016 were involved.The data of patients’selection,history,symptoms,management,outcomes,and postoperation complications were analyzed in the study.The continuous variables were compared using the Student’s t test for normal distributions and the Mann-Whitney U test for non-normal distributions.Categorical variables were compared using the Chi-square test or Fisher exact test.Results::A total of 1582 patients with ATAAD and 130 patients with ATAIMH were included.The mean age of all patients was 48.4 years.Patients with ATAAD were significantly younger than patients with ATAIMH(48.9 years vs.55.6 years,P<0.001).For the total cohort,males were dominant,but the male ratio of patients with ATAAD was significantly higher compared to those with ATAIMH(P=0.01).The time range from the onset of symptom to hospitalization was 2.0 days.More patients of ATAIMH had hypertension than that of ATAAD(82.3%vs.67.6%,P<0.05).Chest and back pain were the most common clinical symptoms.Computerized tomography(CT)was the most common initial diagnostic imaging modality.84.7%received surgical treatment and in-hospital mortality was 5.3%.Patients with ATAAD mainly received surgical treatment(89.6%),while most patients with ATAIMH received medical treatment(39.2%)or endovascular repair(35.4%).Conclusions::Our study suggests that doctors should comprehensively use clinical examination and genetic background screening for patients with ATAAD and ATAIMH and further shorten the time range from symptoms onset to intervention,achieving early diagnosis and treatment,thereby reducing the mortality rate of patients with aortic dissection in China.We should standardize the procedures of aortic dissection treatment and improve people’s understanding.Meanwhile,the curing and transferring efficiency should also be improved. | Wei-Xun Duan Wei-Guang Wang Lin Xia Chao Xue Bo Yu Kai Ren Wei Yi Hong-Liang Liang Xiao-Chao Dong Jian Zuo Jin-Cheng Liu Shi-Qiang Yu Ding-Hua Yi | 2021 | Chinese Medical Journal2021，，8： | 15 |
| 20 | Topographic differentiations of biological soil crusts and hydraulic properties in fixed sand dunes, Tengger Desert显示文摘Biological soil crusts(BSCs) play an important role in surface soil hydrology. Soils dominated with moss BSCs may have higher infiltration rates than those dominated with cyanobacteria or algal BSCs. However, it is unnown whether improved infiltration in moss BSCs is accompanied by an increase in soil hydraulic conductivity or water retention capacity. We investigated this question in the Tengger Desert, where a 43-year-old revegetation program has promoted the formation of two distinct types of BSCs along topographic positions, i.e. the moss-dominated BSCs on the interdune land and windward slopes of the fixed sand dunes, and the algal-dominated BSCs on the crest and leeward slopes. Soil water retention capacity and hydraulic conductivity were measured using an indoor evaporation method and a field infiltration method. And the results were fitted to the van Genuchten–Mualem model. Unsaturated hydraulic conductivities under greater water pressure(<–0.01 MPa) and water retention capacities in the entire pressure head range were higher for both crust types than for bare sand. However, saturated and unsaturated hydraulic conductivities in the near-saturation range(>–0.01 MPa) showed decreasing trends from bare sand to moss crusts and to algal crusts. Our data suggested that topographic differentiation of BSCs significantly affected not only soil water retention and hydraulic conductivities, but also the overall hydrology of the fixed sand dunes at a landscape scale, as seen in the reduction and spatial variability in deep soil water storage. | Zhi Shan ZHANG Yong Le CHEN Bin Xing XU Lei HUANG Hui Juan TAN Xue Jun DONG | 2015 | Journal of Arid Land2015，7，2： | 13 |
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