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| 1 | Ankylosing spondylitis: etiology, pathogenesis, and treatments显示文摘Ankylosing spondylitis(AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain;additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen(HLA)?B27 and the interleukin?23/17 axis.However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. | Wei Zhu Xuxia He Kaiyuan Cheng Linjie Zhang Di Chen Xiao Wang Guixing Qiu Xu Cao Xisheng Weng | 2019 | Bone Research2019，7，3： | 30 |
| 2 | Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure显示文摘Acute-on-chronic liver failure(ACLF)is a syndrome in which acute liver failure with extrahepatic organ failure occurs on chronic liver disease.Recently,liver transplantation is the only effective treatment for ACLF.There is still room for discussion on the optimal surgery timing for ACLF,perioperative infection prevention and control,and maintenance of nutrition and organ function.The Transplantation Immu-nology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association and Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Association invited relevant experts to discuss the perioperative management of ACLF liver transplantation in areas including surgery timing,organ protection,nutritional support,infection prevention and control,rehabilitation exercises,regulation of the internal environment,etc.An expert consensus was developed as reference for clinicians. | Transplantation Immunology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Society Guihua Chen Yang Yang Huimin Yi Jianrong Liu Pinglan Lu Lijuan Li Mingming Fan Xiaomeng Yi Haijin Lv Xuxia Wei | 2021 | Liver Research2021，5，2： | 3 |
| 3 | Association between interferon gamma receptor 1-56C/T gene polymorphism and tuberculosis susceptibility: a meta-analysis显示文摘 | Wang Wei Ren Weicong Zhang Xuxia Liu Yi Li Chuanyou | 2014 | Chinese Medical Journal2014，，21： | 3 |
| 4 | Dynamic organization of actin cytoskeleton during the polar-ity formation and germination of pollen protoplasts显示文摘The formation of the polarity of pollen proto-plast and the dynamics of actin cytoskeleton were observed by non-fixation, Alexa-Phalloidin probing and confocal laser scanning microscopy. Our results showed that the protoplast obtained from stored pollen contained numerous crystalline fusiform bodies to constitute a storage form of actin. When dormant pollen was hydrated, the actin cytoskeleton forms a fine network spreading uniformly in the protoplast. In the process of polarity formation and germination of pollen pro-toplast, actin filaments marshaled slowly to the brim, and then formed multilayer continuous actin filament bundles surrounding the cortical of the protoplast. When the proto-plast was exposed to actin filament-disrupting drugs, such as Latrunculin A and Cytochalasin D, continuously arranged actin bundles were disturbed and in this condition, the pro-toplast could not germinate. But when exposed to actin fila-ment stabiling drug-phalliodin, the dynamics of actin fila-ments in the protoplasts behaved normally and the proto-plasts could germinate normally. These results were also confirmed by the pharmacology experiments on pollen grains. And when Latrunculin A or Cytochalasin D was washed off, the ratio of pollen germination was resumed partly. All the results above show that the dynamic organiza-tion of the actin cytoskeleton are critical in the cell polarity formation and germination of pollen protoplast, and that the reorganization of actin cytoskeleton is mainly due to the re-arrangement of actin filament arrays. | XUXia ZIHuijun SUNYina RENHaiyun | 2004 | Chinese Science Bulletin2004，49，16： | 2 |
| 5 | Effects of different dietary selenium sources (selenium nanoparticle and selenomethionine ) on growth performance, muscle composition and glutathione peroxidase enzyme activity of cruclan carp ( Carassius attratus gibelio ) 显示文摘 | ZHOU Xuxia WANG Yanbo GU Qing | 2009 | Aquacul- ture2009，291，12： | 1 |
| 6 | The nisin-controlled gene expression system: construction, application and improvements显示文摘 | ZHOU Xuxia LI Weifn MA Guoxia | 2006 | Biotechnology Advances2006，24，3： | 1 |
| 7 | Effects of different dieta-ry selenium sources(selenium nanoparticle and selenomethionine)on growth performance,muscle composition and glutathione peroxi-dase enzyme activity of crucian carp(Carassius auratus gibelio)显示文摘 | Zhou Xuxia Wang Yanbo Gu Qing | 2009 | Aquaculture2009，291，： | 1 |
| 8 | Low-bandgap conjugated polymers based on benzodipyrrolidone with reliable unipolar electron mobility exceeding 1 cm^(2) V^(-1)s^(-1)显示文摘The employment of an intrinsic quinoidal building block,benzodipyrrolidone(BDP),on constructing conjugated polymers(PBDP-2F and PBDP-2CN)with high electron mobility and unipolar transport characteristic in polyethylenimine ethoxylated(PEIE)modified organic field-effect transistors(OFETs)is reported.The intrinsic quinoidal characteristic and excellent coplanarity of BDP can lower the lowest unoccupied molecular orbital(LUMO)levels and improve ordered interchain packing of the resulting polymers in solid states,which are favorable for electron-injection and transport.By using PEIE as the interlayer to block the hole injection,unipolar n-type transport characteristics with high electron mobility of 0.58 and 1.01 cm^(2) V^(-1)s^(-1)were achieved by the OFETs based on PBDP-2F and PBDP-2CN,respectively.More importantly,the extracted mobilities are highly reliable with the reliability factor of above 80%.To the best of our knowledge,PBDP-2CN is the very first quinoid-based conjugated polymer with reliable electron mobility exceeding 1 cm^(2) V^(-1)s^(-1).This work represents a significant step in exploring intrinsic quinoidal CPs for application in n-channel OFETs and logic complementary circuits. | Mingqun Yang Tian Du Xuxia Zhao Xuelong Huang Langheng Pan Shuting Pang Haoran Tang Zhongxiang Peng Long Ye Yunfeng Deng Mingliang Sun Chunhui Duan Fei Huang Yong Cao | 2021 | Science China Chemistry2021，64，7： | 1 |
| 9 | Characterization of Extensively Drug-Resistant Myeobaeterium tuberculosis Clinical Isolates in China 显示文摘 | Zhaogang San Yanjie Chao Xuxia Zhang | 2008 | Journal of clinical microbiology2008，46，： | 1 |
| 10 | Effect of probiotic on larvae shrimp (Penaeus vannameO based on water quality, survival rate and digestive enzyme activities显示文摘 | Zhou Xuxia Wang Yanbo Li Weifen | 2009 | Aquaculture2009，287，34： | 1 |
| 11 | The gasification reactivity of unburned carbon present in gasification slag from entrained-flow gasifier 显示文摘 | Xu Shengqi Zhou Zhijie Gao Xuxia | 2009 | Fuel Processing Technology2009，90，9： | 1 |
| 12 | Apidaecin-type peptides: Biodiversity, structure-function relationships and mode of action显示文摘 | LI Weifen MA Guoxia ZHOU Xuxia | 2006 | Peptides2006，27，9： | 1 |
| 13 | 显示文摘 | XUXia(徐霞) YEZun-Zhong(叶尊忠) WUJian(吴坚) YINGYi-Bin(应义斌) | | 分析化学0，，： | 1 |
| 14 | AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans显示文摘 | Qi Li Zhongjing Su Xiaoyuan Xu Gefei Liu Xuhong Song Ruijian Wang Xuxia Sui Ting Liu Xiaolan Chang Dongyang Huang | 2012 | Proceedings of the National Academy of Sciences2012，，35： | 1 |
| 15 | Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway显示文摘Mesenchymal stromal cells(MSCs)have been considered a promising alternative for treatment of acute respiratory distress syndrome(ARDS).However,there is significant heterogeneity in their therapeutic efficacy,largely owing to the incomplete understanding of the mechanisms underlying the therapeutic activities of MSCs.Here,we hypothesize that the cholinergic antiinflammatory pathway(CAP),which is recognized as a neuroimmunological pathway,may be involved in the therapeutic mechanisms by which MSCs mitigate ARDS.Using lipopolysaccharide(LPS)and bacterial lung inflammation models,we found that inflammatory cell infiltration and Evans blue leakage were reduced and that the expression levels of choline acetyltransferase(ChAT)and vesicular acetylcholine transporter(VAChT)in lung tissue were significantly increased 6 hours after MSC infusion.When the vagus nerve was blocked orα7 nicotinic acetylcholine(ACh)receptor(α7nAChR)-knockout mice were used,the therapeutic effects of MSCs were significantly reduced,suggesting that the CAP may play an important role in the effects of MSCs in ARDS treatment.Our results further showed that MSC-derived prostaglandin E2(PGE2)likely promoted ACh synthesis and release.Additionally,based on the efficacy of nAChR andα7nAChR agonists,we found that lobeline,the nicotinic cholinergic receptor excitation stimulant,may attenuate pulmonary inflammation and alleviate respiratory symptoms of ARDS patients in a clinical study(ChiCTR2100047403).In summary,we reveal a previously unrecognized MSC-mediated mechanism of CAP activation as the means by which MSCs alleviate ARDS-like syndrome,providing insight into the clinical translation of MSCs or CAP-related strategies for the treatment of patients with ARDS. | Xiaoran Zhang Xuxia Wei Yiwen Deng Xiaofeng Yuan Jiahao Shi Weijun Huang Jing Huang Xiaoyong Chen Shuwei Zheng Jieying Chen Keyu Chen Ruiming Xu Hongmiao Wang Weiqiang Li Shiyue Li Huimin Yi Andy Peng Xiang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 16 | PTHrP is a novel mediator for TGF-β-induced apoptosis显示文摘 | Yanna Cao Weili Zhang Xuxia Gao Guohua Zhang Miriam Falzon Courtney M. Townsend Mark R. Hellmich Tien C. Ko | 2013 | Regulatory Peptides2013，，： | 1 |
| 17 | Service Function Chain Orchestration across Multiple Clouds显示文摘Network function virtualization is a new network concept that moves network functions from dedicated hardware to software-defined applications running on standard high volume severs. In order to accomplish network services, traffic flows are usually processed by a list of network functions in sequence which is defined by service function chain. By incorporating network function virtualization in inter-data center(DC) network, we can use the network resources intelligently and deploy network services faster. However, orchestrating service function chains across multiple data centers will incur high deployment cost, including the inter-data center bandwidth cost, virtual network function cost and the intra-data center bandwidth cost. In this paper, we orchestrate SFCs across multiple data centers, with a goal to minimize the overall cost. An integer linear programming(ILP) model is formulated and we provide a meta-heuristic algorithm named GBAO which contains three modules to solve it. We implemented our algorithm in Python and performed side-by-side comparison with prior algorithms. Simulation results show that our proposed algorithm reduces the overall cost by at least 21.4% over the existing algorithms for accommodating the same service function chain requests. | Xuxia Zhong Ying Wang Xuesong Qiu | 2018 | China Communications2018，15，10： | 1 |
| 18 | Apidaecin-type peptides: biodiversity, structure-function relationships and mode of action显示文摘 | LI Weifen MA Guoxia ZHOU Xuxia | 2006 | Peptides2006，27，9： | 1 |
| 19 | Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis显示文摘 | Rongqin Huang Liang Han Jianfeng Li Shuhuan Liu Kun Shao Yuyang Kuang Xing Hu Xuxia Wang Hao Lei Chen Jiang | 2011 | Biomaterials2011，，22： | 1 |
| 20 | Antitumor activity of a sulfated polysaccharide from Enteromorpha intestinalis targeted against hepatoma through mitochondrial pathway显示文摘 | Xuxia Wang Ying Chen Jingjie Wang Zhenxiong Liu Shuguang Zhao | 2014 | Tumor Biology2014，，2： | 1 |
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