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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Zircon U-Pb dating on the Mesozoic volcanic suite from the Qingshan Group stratotype section in eastern Shandong Province and its tectonic significance显示文摘A geochronological study of zircon U-Pb on the volcanic rocks from the stratotype section of the Qingshan Group within the Jiaozhou Basin, eastern Shandong Province, is presented. The zircons were analyzed using the method of in situ ablation of a 193 nm excimer laser system coupled with an up to date ICP-MS system. Among the three formations of the Qingshan Group, zircons recovered from the lowest part of the Houkuang Fm. were dated at 106±2 Ma (95% confidence, the same below), whereas those from the lower and upper parts of the Shiqianzhuang Fm. were given ages of 105±4 Ma and 98±1 Ma, respectively. A spatially decreasing trend for the Mesozoic magmatic timing from west to east in the province is observed through comparing the data of this study with those by previous works on the Qingshan volcanic lavas occurring at western Shandong and within the Yishu fault zone. The Qingshan volcanic rocks are constituent of the 'Shoshonite Province' in East China. Exposed at most provinces of central East China along the Tan-Lu fault and the Yangtze fault zones, these volcanic suites are characterized by shoshonite and high-K calcalkalic rocks in lithology and thought to be correlated with the partial melting of continental mantle in genesis. It is also shown that the Qingshan potassic volcanic suite from eastern Shandong basins is distinctly younger than those from other ar-eas of the shoshonite province. By contrary, ages of the Mesozoic to Cenozoic alkaline basalts, sourced by asthenospheric mantle, from both northern Huaiyan basin and northern Dabie belt along the Tan-Lu fault zone and from the Ningwu, Lishui and Luzong basins along the Yangtze fault zone are observably older than those occurring within eastern Shandong. The revealed temporal and spatial patterns in magmatism for the two types of volcanic suites make an important geochronological con-straint on the Mesozoic to Cenozoic dynamic evolution model of the subcontinental lithosphere in East China. | LING WenLi XIE XianJun LIU XiaoMing CHENG JianPing | 2007 | Science China Earth Sciences2007，50，6： | 18 |
| 3 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 4 | Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer显示文摘胰腺的癌症是有导致世界范围的高死亡率的一个高变形的潜力的好攻击的恶意。尽管巨噬细胞有潜力杀死肿瘤房间并且对肿瘤得到有免疫力的回答,有证据,联系肿瘤的巨噬细胞(TAM ) 支持肿瘤前进并且压制 T 房间回答。CC-chemokine ligand 20 (CCL20 ) 并且它的唯一的受体 CC-chemokine 受体(CCR6 ) 6 被癌症房间为移植和转移利用并且在癌症的发展和前进起重要作用。最近的研究证明了 CCL20 的表示是在胰腺的癌症的 upregulated;然而, CCL20 的行动的机制尚待充分被阐明。在这研究,包括变形胰腺的癌症织物,在胰腺的癌症织物的 TAM 的 CCL20 的异常表示被检测。CCL20 表示比在胰腺的癌症房间排队的在巨噬细胞是更加更高的,特别地在 interleukin-4-treated (M2 ) 巨噬细胞。用胰腺的癌症房间的 Boyden 房间试金,我们发现 M2 巨噬细胞分泌的 CCL20 支持了胰腺的癌症房间的迁居,上皮间充质的转变,和侵略。RNA 干扰结果证明 CCR6 是为在胰腺的癌症房间的 CCL20 的受体,调停这些房间的增加的侵略性质由 CCL20 支持了。用一个老鼠模型,我们在在 vivo 支持胰腺的癌症生长和肝转移证实了 CCR6/CCL20 的角色。我们的调查结果在胰腺的癌症提供卓见进藏匿巨噬细胞的 CCL20 的重要角色并且含有 CCR6/CCL20 同样潜在的治疗学的目标。 | Bingyan Liu Yiping Jia Jun Ma Shaoqiu Wu Haosheng Jiang Yan Cao Xianjun Sun Xiang Yin Shuo Yan Mingyi Shang Aiwu Mao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 5 | Synthesis and characterization of LiNi_(0.95-x)Co_xAl_(0.05)O_2 for lithium-ion batteries显示文摘Samples of LiNi0.95?xCoxAl0.05O2 (x = 0.10 and 0.15) and LiNiO2, synthesized by the solid-state reaction at 725°C for 24 h from LiOH·H2O, Ni2O3, Co2O3, and Al(OH)3 under an oxygen stream, were characterized by TG-DTA, XRD, SEM, and electrochemical tests. Simultaneous doping of cobalt and aluminum at the Ni-site in LiNiO2 was tried to improve the cathode performance for lithium-ion batteries. The results showed that co-doping (especially, 5 at.% Al and 10 at.% Co) definitely had a large beneficial effect in increasing the capacity (186.2 mA?h/g of the first discharge capacity for LiNi0.85Co0.10Al0.05O2) and cycling behavior (180.1 mA?h/g after 10 cycles for LiNi0.85Co0.10Al0.05O2) compared with 180.7 mA?h/g of the first discharge capacity and 157.7 mA?h/g of the tenth discharge capacity for LiNiO2, respectively. Differen-tial capacity versus voltage curves showed that the co-doped LiNi0.95?xCoxAl0.05O2 had less intensity of the phase transitions than the pristine LiNiO2. | ZHU Xianjun ZHAN Hui LIU Hanxing ZHOU Yunhong | 2006 | Rare Metals2006，25，4： | 10 |
| 6 | Progress of regional oceanography study associated with western boundary current in the South China Sea显示文摘Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The possible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (~0.1 ms-1 ) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 ms-1 , and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed. | WANG DongXiao LIU QinYan XIE Qiang HE ZhiGang ZHUANG Wei SHU YeQiang XIAO XianJun HONG Bo WU XiangYu SUI DanDan | 2013 | Chinese Science Bulletin2013，58，11： | 10 |
| 7 | Relationship between the Flow Blockage of Tip Leakage Vortex and its Evolutionary Procedures inside the Rotor Passage of a Subsonic Axial Compressor显示文摘The near casing flow fields inside the rotor passage of a 1.5 stage axial compressor with different blade-loading levels and tip gap sizes were measured by using stereoscopic particle image velocimetry(SPIV). Based on a carefully defined blockage extracting method, the variations of blockage parameter inside the blade passage were analyzed. It was found that the variation of blockage parameter appeared as a non-monotonic behavior inside the blade passage in most cases. This non-monotonic behavior became much more remarkable as the blade loading increases or mass flow rate decreases.The variations of the blockage parameter inside the blade passage had close relation to the evolutionary procedures of the tip leakage vortex(TLV). The destabilization of the TLV caused a rapid increasing of the blockage parameter. After the TLV lost the features of a concentrated streamwise vortex,the blockage parameter usually got a peak value. And then, because of the intense turbulent mixing between the TLV low momentum flow and its surrounding flows, the flow deficit inside the TLV recovered. | DU Hui YU Xianjun ZHANG Zhibo LIU Baojie | 2013 | Journal of Thermal Science2013，22，6： | 7 |
| 8 | Analysis of CVC roll contour and determination of roll crown显示文摘Mathematical analysis of continuous variable crown (CVC) roll contour used in CSP production line was conducted and the roll contour function of CVC roll was obtained. The validation with actual CVC roll contour shows that the calculation values of the roll contour function and the actual roll contour parameters given by equipment provider are the same, which proves that the roll contour function of CVC rolls given in this article is correct. The nonlinear relationship between the roll crown of CVC rolls and roll shift amounts was deduced. The concept of crown extremum was given. | Guang Xu Xianjun Liu Jiarong Zhao Junwei Xiong | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 7 |
| 9 | 为细菌的房间的一个非凡的紧、敏感的光可切换的基因表达式系统显示文摘 | Chen, Xianjun Liu, Renmei Ma, Zhengcai Xu, Xiaopei Zhang, Haoqian Xu, Jianhe Ouyang, Qi Yang, Yi | 2016 | Cell Research2016，26，7： | 7 |
| 10 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 11 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
| 12 | Wearable CNT/Ti_(3)C_(2)T_(x)MXene/PDMS composite strain sensor with enhanced stability for real-time human healthcare monitoring显示文摘Strain sensors with good stability are vital to the development of wearable healthcare monitoring systems.However,the design of strain sensor with both duration stability and environmental stability is still a challenge.In this work,we propose an ultra-stable and washable strain sensor by embedding a coupled composite film of carbon nanotube(CNT)and Ti_(3)C_(2)T_(x) MXene into polydimethylsiloxane(PDMS)matrix.The composite strain sensor with embedded microstructure and uneven surface makes it conformal to skin,while the CNT/MXene sensing layer exhibits a resistance sensitive to strain.This sensor shows reliable responses at different frequencies and with long-term cycling durability(over 1,000 cycles).Meanwhile,the CNT/MXene/PDMS composite strain sensor provides the advantages of superior anti-interference to temperature change and water washing.The results demonstrate less than 10%resistance changes as the temperature rises from-20 to 80℃or after sonication in water for 120 min,respectively.The composite sensor is applied to monitor human joint motions,such as bending of finger,wrist and elbow.Moreover,the simultaneous monitoring of the electrocardiogram(ECG)signal and joint movement while riding a sports bicycle is demonstrated,enabling the great potential of the as-fabricated sensor in real-time human healthcare monitoring. | Xiaowen Xu Yucheng Chen Pei He Song Wang Kai Ling Longhui Liu Pengfei Lei Xianjun Huang Hu Zhao Jianyun Cao Junliang Yang | 2021 | Nano Research2021，14，8： | 5 |
| 13 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 14 | Preparation of layered oxide Li(Co_(1/3)Ni_(1/3)Mn_(1/3))O_2 via the sol-gel process显示文摘获得同质的分层的氧化物李(Co1/3Ni1/3Mn1/3 ) 是的 O2 锂插入积极电极材料,把柠檬性的酸用作一个 chelating 代理人的大音阶的第五音胶化过程被使用。材料李(Co1/3Ni1/3Mn1/3 ) O2 在不同锻烧温度被综合。XRD 实验显示分层的李(Co1/3Ni1/3Mn1/3 ) O2 材料能在 800 的更低的温度被综合 ? 琠? 楢整漠吗? | ZHANG Wen LIU Hanxing HU Chen ZHU Xianjun LI Yanxi | 2008 | Rare Metals2008，27，2： | 4 |
| 15 | Neighbor Detection-Based Spectrum Sensing Algorithm in Distributed Cognitive Radio Networks显示文摘Security issues of spectrum sensing have drawn a lot of attentions in Cognitive radio networks(CRNs).Malicious users can mislead the network to make wrong decision about the states of channels by tampering spectrum sensing data.To defense against Spectrum sensing data falsification(SSDF) attack,we propose a neighbor detection-based spectrum sensing algorithm in distributed CRNs,which can detect attackers with the help of neighbors during spectrum sensing to improve the accuracy of decision making.The proposed scheme can also guarantee the connectivity of the network.Simulation results illustrate that the proposed scheme can defense against SSDF attacks effectively and reach the unified information of spectrum sensing data. | PEI Qingqi LI Hongning LIU Xianjun | 2017 | Chinese Journal of Electronics2017，26，2： | 4 |
| 16 | Applying accurate gradients of seismic wave reflection coefficients (SWRC) to the inversion of seismic wave velocities显示文摘Through solving the Zoeppritz's partial derivative equations, we have obtained accurate partial derivatives of reflected coefficients of seismic wave with respect to Pand S-wave velocities.With those partial derivatives, a multi-angle inversion is developed for seismic wave velocities.Numerical examples of different formation models show that if the number of iterations goes over 10, the relative error of inversion results is less than 1%, whether or not there is interference among the reflection waves.When we only have the reflected seismograms of P-wave, and only invert for velocities of P-wave, the multi-angle inversion is able to obtain a high computation precision.When we have the reflected seismograms of both P-wave and VS-wave, and simultaneously invert for the velocities of P-wave and VS-wave, the computation precisions of VS-wave velocities improves gradually with the increase of the number of angles, but the computation precision of P-wave velocities becomes worse.No matter whether the reflected seismic waves from the different reflection interface are coherent or non-coherent, this method is able to achieve a higher computation precision.Because it is based on the accurate solution of the gradient of SWRCs without any additional restriction, the multi-angle inversion method can be applied to seismic inversion of total angles.By removing the difficulties caused by simplified Zoeppritz formulas that the conventional AVO technology struggles with, the multiangle inversion method extended the application range of AVO technology and improved the computation precision and speed of inversion of seismic wave velocities. | LIU FuPing MENG XianJun XIAO JiaQi WANG YuMei SHEN GuoQiang | 2012 | Science China Earth Sciences2012，55，12： | 3 |
| 17 | Predicting geogenic groundwater fluoride contamination throughout China显示文摘Endemic fluorosis exists in almost all provinces of China.The long-term ingestion of groundwater containing high concentrations of fluoride is one of the main causes of fluoro-sis.We used artificial neural network to model the relationship between groundwater fluo-ride concentrations from throughout China and environmental variables such as climatic,geological.and soil parameters as proxy predictors.The results show that the accuracy and area under the receiver operating characteristic curve of the model in the test dataset are 80.5%and 0.86%,respectively,and climatic variables are the most effective predictors.Based on the artificial neural network model,a nationwide prediction risk map of fluoride concen-trations exceeding 1.5 mg/L with a 0.5×0.5 arc minutes resolution was generated.The high risk areas are mainly located in western provinces of Xinjiang,Tibet,Qinghai,and Sichuan,and the northern provinces of Inner Mongolia,Hebei and Shandong.The total number of people estimated to be potentially at risk of fluorosis due to the use of untreated high flu-oride groundwater as drinking water is about 89 million,or 6%of the population.The high fluoride groundwater risk map helps the authorities to prioritize areas requiring mitigation measures and thus facilitates the implementation of water improvement and defluorida-tion projects. | Hailong Cao Xianjun Xie Yanxin Wang Hongxing Liu | 2022 | Journal of Environmental Sciences2022，34，5： | 3 |
| 18 | Energy sources identify metabolic phenotypes n pancreatic cancer显示文摘 | Chen Liang Yi Qin Bo Zhang Shunrong Ji Si Shi Wenyan Xu Jiang Liu Jinfeng Xiang Dingkong Liang Qiangsheng Hu Liang Liu Chen Liu Guopei Luo Quanxing Ni Jin xu Xianjun Yu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 19 | Down-regulation of GPR137 expression inhibits proliferation of colon cancer cells显示文摘G 联合蛋白质的受体(GPR ) 是高度与 oncogenesis 和癌症转移有关。G 联合蛋白质的受体(GPR137 ) 137 大约 10 年以前开始作为新奇孤儿 GPR 被报导。一些孤儿 GPR 在人的癌症被含有。这研究的目的是在人的结肠癌调查 GPR137 的角色。GRP137 的表示层次被量的聚合酶链反应和西方的污点分析在不同结肠癌房间线分析。调停 Lentivirus 的短发卡 RNA 明确地被设计在结肠癌房间将 GPR137 表示击倒。房间生存能力被 methylthiazoletetrazolium 和殖民地形成试金测量。另外,房间周期特征被流动 cytometry 调查。GRP137 表示在不同层次在所有七根结肠癌房间线被观察。GPR137 的 mRNA 和蛋白质层次在在 lentivirus 感染以后的 HCT116 和 RKO 房间是下面调整的。GPR137 的调停 Lentivirus 的 silencing 减少了增长率和殖民地数字。在导致的两根房间线的 GPR137 击倒在 G 0/G1 阶段的房间周期拘捕。这些结果显示 GPR137 在结肠癌房间增长起一个重要作用。GPR137 在结肠癌房间的信号 transduction 小径上的效果的更好的理解可以提供卓见进结肠癌的新奇基因治疗。 | Kai Zhang Zhen Shen Xianjun Liang Tongjun Liu Tiejun Wang Yang Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 3 |
| 20 | High valence metals engineering strategies of Fe/Co/Ni-based catalysts for boosted OER electrocatalysis显示文摘Electrocatalysis for the oxygen evolution reactions(OER)has attracted much attention due to its important role in water splitting and rechargeable metal-air batteries.Therefore,designing highly efficient and low-cost catalysts for OER process is essential as the conventional catalysts still rely on precious metals.Transition metal-based compounds have been widely investigated as active OER catalysts,and renewed interest in the high valence metals engineered compounds has been achieved for superior catalytic activity and stability.However,an in-depth understanding of the construction strategies and induced effects for the high valence metals engineered catalysts is still lacking and desired.In this review,we have summarized the construction strategies of high valence metals as dopants or formed heterostructures with the iron/cobalt/nickel(Fe/Co/Ni)-based catalysts.Then the induced effects on Fe/Co/Ni-based catalysts by incorporating high valence metals,e.g.,accelerating the surface reconstruction,forming amorphous structure,generating vacancies/defects,and acting as stabilizers,are highlighted.The impacts of high valence metals on OER performance are elucidated based on different elements,including molybdenum(Mo),tungsten(W),cerium(Ce),vanadium(V),chromium(Cr),manganese(Mn),niobium(Nb),zirconium(Zr).The correlations of construction strategies,induced effects,catalytic activity and OER reaction pathways are elaborated.Finally,the remaining challenges for further enhancements of OER performance induced by high valence metals are presented. | Lu Li Xianjun Cao Juanjuan Huo Junpeng Qu Weihua Chen Chuntai Liu Yufei Zhao Hao Liu Guoxiu Wang | 2023 | Journal of Energy Chemistry2023，，1： | 3 |
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