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| 1 | Staged carotid artery angioplasty and stenting for patients with high-grade carotid stenosis with high risk of developing hyperperfusion injury:a retrospective analysis of 44 cases显示文摘Background:Hyperperfusion syndrome(HPS)is a rare but potentially a life-threatening complication after carotid artery angioplasty and stenting(CAS).Staged CAS has been an alternative to prevent HPS.Materials and methods:44 of 908 patients with high-grade internal carotid artery stenosis or near occlusion were at risk of HPS because of poor collateral flow and impaired cerebral blood flow(CBF).They were treated with first(stage 1),followed by a full CAS(stage 2)1 month later.Their 30-day outcomes were tabulated and analysed.Results:During follow-up,1 of the 44(2.2%)patients developed HPS immediately,3(7%)had postprocedural HPS(ie,transcranial Doppler(TCD)>120%)without clinical symptoms and 3(7%)required stenting at stage 1 for carotid dissections.After stage 1,there were significant improvement between the preprocedural and postprocedural CBF(0.98±0.06 vs 0.85±0.05,p<0.05),mean transit time(MTT;1.05±0.05 vs 1.15±0.05,p<0.05),time to peak(TTP;1.04±0.06 vs 1.20±0.06,p<0.05)on CT perfusion(CTP),and CBF(66.41±7.41 vs 44.44±6.43,p<0.05)on TCD.After stage 2,improvement was seen in CBF(1.01±0.07 vs 0.98±0.06,p<0.05),MTT(1.01±0.05 vs 1.05±0.05,p<0.05),TTP(0.99±0.06 vs 1.04±0.06,p<0.05)on CTP and CBF(66.41±7.41 vs 93.78±18.81,p<0.05)on TCD.2 had postoperative increase of middle cerebral artery mean flow velocity of 120%after stage 2 without clinical symptoms.Conclusion:Staged carotid artery stenting probably decreased the chance of developing HPS in this group of selected patients.Although requiring a 2-step intervention,staged CAS may be a safe and effective alternative. | Dapeng Mo Gang Luo Bo Wang Ning Ma Feng Gao Xuan Sun Xiaotong Xu Zhongrong Miao | 2016 | Stroke & Vascular Neurology2016，1，4： | 14 |
| 2 | Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer显示文摘Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. Here, we report the feasibility of this approach by SCNT of fibroblasts from a macaque monkey(Macaca fascicularis), in which a core circadian transcription factor BMAL1 was knocked out by clustered regularly interspaced short palindromic repeat/Cas9 gene editing(see accompanying paper).Out of 325 SCNT embryos transferred into 65 surrogate monkeys, we cloned five macaque monkeys with BMAL1 mutations in both alleles without mosaicism, with nuclear genes identical to that of the fibroblast donor monkey. Further peripheral blood m RNA analysis confirmed the complete absence of the wild-type BMAL1 transcript. This study demonstrates that the SCNT approach could be used to generate cloned monkeys from fibroblasts of a young adult monkeys and paves the way for the development of macaque monkey disease models with uniform genetic backgrounds. | Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun | 2019 | National Science Review2019，6，1： | 14 |
| 3 | BES1 Functions as the Co-regulator of D53-like SMXLs to Inhibit BRC1 Expression in Strigolactone-Regulated Shoot Branching in Arabidopsis显示文摘Shoot branching,determining plant architecture and crop yield,is critically controlled by strigolactones(SLs).However,how SLs inhibit shoot branching after its perception by the receptor complex remains largely obscure.In this study,using the transcriptomic and genetic analyss as well as biochemical studies,we reveal the key role of BES1 in the SL-regulated shoot branching.Wedemonstrate that BES1 and D53-like SMXLs,the substrates of SL receptor complex D14–MAX2,interact with each other to inhibit BRC1 expression,which specifically triggers the SL-regulated transcriptional network in shoot branching.BES1 directly binds the BRC1 promoter and recruits SMXLs to inhibit BRC1 expression.Interestingly,despite being the shared component by SL and brassinosteroid(BR)signaling,BES1 gains signal specificity through different mechanisms in response to BR and SL signals. | Jie Hu Yuanyuan Ji Xiaotong Hu Shiyong Sun Xuelu Wang | 2020 | Plant Communications2020，1，3： | 9 |
| 4 | Spatial correlation-based characterization of acoustic emission signal-cloud in a granite sample by a cube clustering approach显示文摘To extract more in-depth information of acoustic emission(AE)signal-cloud in rock failure under triaxial compression,the spatial correlation of scattering AE events in a granite sample is effectively described by the cube-cluster model.First,the complete connection of the fracture network is regarded as a critical state.Then,according to the Hoshen-Kopelman(HK)algorithm,the real-time estimation of fracture con-nection is effectively made and a dichotomy between cube size and pore fraction is suggested to solve such a challenge of the one-to-one match between complete connection and cluster size.After,the 3D cube clusters are decomposed into orthogonal layer clusters,which are then transformed into the ellip-soid models.Correspondingly,the anisotropy evolution of fracture network could be visualized by three orthogonal ellipsoids and quantitatively described by aspect ratio.Besides,the other three quantities of centroid axis length,porosity,and fracture angle are analyzed to evaluate the evolution of cube cluster.The result shows the sample dilatancy is strongly correlated to four quantities of aspect ratio,centroid axis length,and porosity as well as fracture angle.Besides,the cube cluster model shows a potential pos-sibility to predict the evolution of fracture angle.So,the cube cluster model provides an in-depth view of spatial correlation to describe the AE signal-cloud. | Dongjie Xue Zepeng Zhang Cheng Chen Jie Zhou Lan Lu Xiaotong Sun Yintong Liu | 2021 | International Journal of Mining Science and Technology2021，31，4： | 5 |
| 5 | Changes and correlation of microorganism and flavor substances during persimmon vinegar fermentation显示文摘To investigate the microbial diversity and the change of the flavor substances during the traditional natural persimmon vinegar fermentation,two group samples from alcohol fermentation stage(A)and acetic acid fermentation stage(B)were analyzed.The results showed that Burkholderia,Lactobacillus,Acetobacter,Komagataeibacter were the main bacteria,and the major fungi were Saccharomyces,Hanseniaspora,Hortaea,and Cladosporium at the genus level.The contents of flavonoids and polyphenols in B increased by 17.91%and 26.59%compared with A,respectively.The superoxide anion scavenging activity significantly increased by 20.15%.The contents of total free amino acids were 5709.99±410.36 mg/L and 5736.16±472.02 mg/L,and the total contents of 9 organic acids were 19.89±1.20 g/L and 33.77±2.49 g/L in samples A and B,respectively.Pearson correlation analysis showed that 11 flavor compounds were related to Lactobacillus and Leuconostoc;8 and 10 compounds were respectively related to Komagataeibacter and Acetobacter;13 and 19 flavor compounds were respectively associated with Saccharomyces and Monascus.Orthogonal Partial Least Square(OPLS)model showed that the contents of Leu,Lys,and lactic acid were mainly associated with fungi,andγ-aminobutyric acid(GABA)content was correlated with Lactobacillus,Acetobacter,Leuconostoc,and Saccharomyces.This study revealed the relationship between microbial diversity and flavor compounds in persimmon vinegar produced by spontaneous fermentation.The results can provide a theoretical support for the safety and health assessment of persimmon vinegar. | Dahong Wang Mengyang Wang Luwei Cao Xiaotong Wang Jianrui Sun Jiangfeng Yuan Shaobin Gu | 2022 | Food Bioscience2022，46，2： | 4 |
| 6 | Mitochondrial replacement in macaque monkey offspring by first polar body transfer显示文摘Dear Editor,Mitochondrial DNA(mtDNA)mutations are materally inherited to the offspring and mitochondrial replacement therapy(MRT)provides.a promising approach for preventing mtDNA-related 1,2 diseases.First polar body transfer(PB1T)has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.However,generation of primate offspring using PB1T has not been reported.Here,we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey(Macaca fascicularis),a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT. | Zhanyang Wang Yuzhuo Li Xianfa Yang Yan Wang Yanhong Nie Yuting Xu Xiaotong Zhang Yong Lu Tikui Zhang Qiming Liu Naihe Jing Zhen Liu Qiang Sun | 2021 | Cell Research2021，31，2： | 4 |
| 7 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 8 | Hd1,Ghd7,and DTH8 synergistically determine the rice heading date and yield-related agronomic traits显示文摘Heading date determines the seasonal and regional adaptation of rice(Oryza sativa L.)varieties and is mainly controlled by photoperiod sensitivity(PS).The core heading date genes Hd1,Ghd7,DTH8,and PRR37 act synergistically in regulating the PS.In this study,we systematically analyze the heading date,PS,and agronomic traits of eight homozygous lines with various combinations of Hd1,Ghd7,and DTH8 alleles in the prr37 background under long-day(LD)and short-day(SD)conditions,respectively.We find that Hd1 alone promotes heading,regardless of the day length.However,under LDs,Hd1 suppresses flowering,in coordination with functional Ghd7 or with Ghd7 and DTH8.These loci cooperate to negatively regulate the Ehd1-Hd3 a/RFT1 pathway and delay heading.Under SDs,Hd1 competes with various heading suppressors to promote heading.Therefore,the dual function of Hd1 is vital for PS.The lines carrying Hd1 alone show reduced plant height with fewer primary and secondary branches in panicles.Lines carrying Ghd7 and DTH8(with hd1)show delayed heading and improve agronomic traits.Overall,our results reveal the regulation of rice PS flowering by the core heading date genes and their effects on agronomic traits,providing valuable information for the selection of rice varieties for adaptation to different light and temperature conditions. | Kangli Sun Minghui Huang Wubei Zong Dongdong Xiao Chen Lei Yanqiu Luo Yingang Song Shengting Li Yu Hao Wanni Luo Bingqun Xu Xiaotong Guo Guangliang Wei Letian Chen Yao-Guang Liu Jingxin Guo | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 9 | Embedded whispering-gallery mode microsphere resonator in a tapered hollow annular core fiber显示文摘We propose and demonstrate a tapered hollow annular core fiber (HACF) coupler for excitation of whisperinggallery modes (WGMs) of an embedded microsphere resonator. The coupler is simply fabricated by fusion splicing of a segment of HACF with the single-mode fiber (SMF), and then improved by tapering the splicing joint to reduce the cone-apex angle. Therefore, the coupling efficiency from the SMF to the HACF is enhanced to excite various WGMs via evanescent field coupling. Normal positive, negative symmetrical Lorentzian and asymmetric Fano line shapes can be obtained by varying the resonator size and location. Another interesting phenomenon is observed that a higher Q-factor mode in a lower Q-factor mode has a contrast as high as 58. Temperature sensing with good stability is also demonstrated. This embedded WGM microsphere resonator in the tapered HACF is expected to promote environmental adaptability in practical applications due to its simplicity and | JIAWEI WANG XIAOBEI ZHANG MING YAN LEI YANG FENGYU HOU WEN SUN XIAOTONG ZHANG LIBO YUAN HAI XIAO TINGYUN WANG | 2018 | Photonics Research2018，6，12： | 4 |
| 10 | The effect of cephalexin in influencing the pharmacokinetics of a novel drug–5’-valyl-cytarabine hydrochloride显示文摘The aim of this study is to investigate the pharmacokinetics of 5′-valyl-cytarabine hydrochloride(OPC) when co-administered with cephalexin, which are both the substrates of PepT 1.The drugs were administered orally by gavage. Blood samples were collected from the orbital plexus of the rats after oral administration of drug solutions. A new high-performance liquid chromatographic method was validated and used for determination of the two drugs. Pharmacokinetic parameters were calculated using DAS 2.1.1 software with noncompartmental analysis. After oral administration of OPC and co-administration of OPC and cephalexin,there were significant differences in the main pharmacokinetic parameters. The main pharmacokinetic parameters for the OPC group and the co-administrative group were as follows:AUC0-10(18,168.7 ± 2561.4) ng·h/ml and(13,448.5 ± 2544.73) ng·h/ml, AUC0-∞(18,683.1 ± 3066.5)ng·h/ml and(13,721.1 ± 2683.0) ng·h/ml, Cmax(6654.8 ± 481.3) ng/ml and(4765.1 ± 928.9) ng/ml, respectively. The results showed that the bioavailability of OPC could be reduced when co-administered with cephalexin, suggesting that the efficacy of a novel drug might be reduced when it came to combination use of β-lactam antibiotics. | Xiaotong Song Yinghua Sun Chenyao Zhao Zhonggui He | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，2： | 2 |
| 11 | Accelerated plasma degradation of organic pollutants in milliseconds and examinations by mass spectrometry显示文摘The rapid degradation of organic pollutants,process monitoring and online controlling to obtain advanced products and decreased by-products are great and challenging tasks in environmental treatments.Herein,an accelerated plasma degradation in milliseconds was achieved by combining electrospray-based acceleration and plasma-based degradation.Taking the degradation of chloroaniline as an example,97%of the degradation can be achieved in milliseconds.The velocity distribution of droplets was determined to be 40-50 m/s after being degraded for 0.30 ms,which exhibited different degradation behaviors in different milliseconds.Simultaneously,by virtue of the real-time and on-line detection ability of ambient mass spectrometry,intermediates,by-products and advanced products were monitored.Therefore,degradation mechanisms for different degradation times were proposed,which would provide theoretical guidance on obtaining efficient and green degradation.The fabrication,examining and understanding of accelerated plasma degradation not only enlarged application of accelerated reactions,but also promoted green and efficient degradation for environmental treatments. | Hua Lu Yiyan Yin Jianghui Sun Weixiang Li Xiaotong Shen Xiujuan Feng Jin Ouyang Na Na | 2021 | Chinese Chemical Letters2021，32，11： | 2 |
| 12 | Land use and land cover classification using Chinese GF-2 multispectral data in a region of the North China Plain显示文摘The newly launched GF-2 satellite is now the most advanced civil satellite in China to collect high spatial resolution remote sensing data.This study investigated the capability and strategy of GF?2 multispectral data for land use and land cover (LULC) classification in a region of the North China Plain.The pixel-based and object-based classifications using maximum likelihood (MLC) and support vector machine (SVM) classifiers were evaluated to determine the classification strategy that was suitable for GF?2 multispectral data.The validation results indicated that GF-2 multispectral data achieved satisfactory LULC classification performance,and object-based classification using the SVM classifier achieved the best classification accuracy with an overall classification accuracy of 94.33% and kappa coefficient of 0.911.Therefore,considering the LULC classification performance and data characteristics,GF-2 satellite data could serve as a valuable and reliable high-resolution data source for land surface monitoring.Future works should focus on improving LULC classification accuracy by exploring more classification features and exploring the potential applications of GF-2 data in related applications. | Kun JIA Jingcan LIU Yixuan TU Qiangzi LI Zhiwei SUN Xiangqin WEI Yunjun YAO Xiaotong ZHANG | 2019 | Frontiers of Earth Science2019，13，2： | 2 |
| 13 | Clean Synthesis of adipic acid by direct oxidation of cyclohexene in the absence of phase transfer agents显示文摘 | Heng Jiang Hong Gong Zhonghua Yang Xiaotong Zhang Zhaolin Sun | 2002 | Reaction Kinetics and Catalysis Letters2002，，2： | 1 |
| 14 | Traffic Flow Statistics Method Based on Deep Learning and Multi-Feature Fusion显示文摘Traffic flow statistics have become a particularly important part of intelligent transportation.To solve the problems of low real-time robustness and accuracy in traffic flow statistics.In the DeepSort tracking algorithm,the Kalman filter(KF),which is only suitable for linear problems,is replaced by the extended Kalman filter(EKF),which can effectively solve nonlinear problems and integrate the Histogram of Oriented Gradient(HOG)of the target.The multi-target tracking framework was constructed with YOLO V5 target detection algorithm.An efficient and longrunning Traffic Flow Statistical framework(TFSF)is established based on the tracking framework.Virtual lines are set up to record the movement direction of vehicles to more accurate and detailed statistics of traffic flow.In order to verify the robustness and accuracy of the traffic flow statistical framework,the traffic flow in different scenes of actual road conditions was collected for verification.The experimental validation shows that the accuracy of the traffic statistics framework reaches more than 93%,and the running speed under the detection data set in this paper is 32.7FPS,which can meet the real-time requirements and has a particular significance for the development of intelligent transportation. | Liang Mu Hong Zhao Yan Li Xiaotong Liu Junzheng Qiu Chuanlong Sun | 2021 | Computer Modeling in Engineering & Sciences2021，，11： | 1 |
| 15 | Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives显示文摘Nanocarriers have emerged as a promising cancer drug delivery strategy.Multi-drug resistance caused by overexpression of multiple-drug excretion transporters in tumor cells is the major obstacle to successful chemotherapy.Vitamin E derivatives have many essential functions for drug delivery applications,such as biological components that are hydrophobic,stable,water-soluble enhancing compounds,and anticancer activity.In addition,vitamin E derivatives are also effective mitocan which can overcome multi-drug resistance by binding to P glycoproteins.Here,we developed a carboxymethyl chitosan/vitamin E succinate nano-micellar system(O-CMCTS-VES).The synthesized polymers were characterized by Fourier Transform IR,and 1H NMR spectra.The mean sizes of O-CMCTS-VES and DOX-loaded nanoparticles were around 177 nm and 208 nm.The drug loading contents were 6.1%,13.0%and 10.6%with the weight ratio of DOX to O-CMCTS-VES corresponding 1:10,2:10 and 3:10,and the corresponding EEs were 64.3%,74.5%and 39.7%.Cytotoxicity test,hemolysis test and histocompatibility test showed that it had good biocompatibility in vitro and in vivo.Drug release experiments implied good pH sensitivity and sustained-release effect.The DOX/O-CMCTS-VES nanoparticles can be efficiently taken up by HepG2 cancer cells and the tumor inhibition rate is up to 62.57%.In the in vivo study by using H22 cells implanted Balb/C mice,DOX/O-CMCTS-VES reduced the tumor volume and weight efficiently with a TIR of 35.58%.The newly developed polymeric micelles could successfully be utilized as a nanocarrier system for hydrophobic chemotherapeutic agents for the treatment of solid tumors. | Xiaotong Chen Junxiang Gu Le Sun Wenya Li Lili Guo Zhiyang Gu Litong Wang Yan Zhang Wangwang Zhang Baoqin Han Jing Chang | 2021 | Bioactive Materials2021，6，10： | 1 |
| 16 | Study on Quantitative Structure–Retention Relationships for Hydrocarbons in FCC Gasoline显示文摘 | Xiaotong Zhang Ling Ding Zhaolin Sun Lijuan Song Ting Sun | 2009 | Chromatographia (-)2009，，3： | 1 |
| 17 | Clean Synthesis of adipic acid by direct oxidation of cyclohexene in the absence of phase transfer agents显示文摘 | Heng Jiang Hong Gong Zhonghua Yang Xiaotong Zhang Zhaolin Sun | 2002 | Reaction Kinetics and Catalysis Letters2002，，2： | 1 |
| 18 | Selective alkylation of phenol with tert -butyl alcohol catalyzed by Br?nsted acidic imidazolium salts显示文摘 | Jianzhou Gui Hongyan Ban Xiaohui Cong Xiaotong Zhang Zhide Hu Zhaolin Sun | 2004 | A, Chemical2004，，1： | 1 |
| 19 | Investigation on Modification of NaY Zeolite and Its Behaviors in Selective Adsorptive Desulfurization of FCC gasoline显示文摘NaY zeolite was modified with oxalic acid, and Ce(IV)Y(1) zeolite was obtained via liquid phase ion exchange between the modified NaY zeolite and cerium nitrate. The Ce(IV)Y(2) zeolite was obtained via liquid phase ion exchange between NaY zeolite and cerium nitrate. The performance of two Y zeolites [Ce(IV)Y(1) and Ce(IV)Y(2)] was compared through static selective adsorptive desulfurization of FCC gasoline at room temperature and normal pressure. The sulfur compounds and contents of the FCC gasoline were analyzed by microcoulometry and GC-SCD chromatogram. The results showed that the effect of adsorptive desulfurization of FCC gasoline achieved by Ce(IV)Y(1) zeolite was better than that of Ce(IV)Y(2) zeolite. The rate for adsorptive desulfurization of FCC gasoline by Ce(IV)Y(1) zeolite and Ce(IV)Y(2) zeolite was 85.0% and 62.4%, respectively. The Ce(IV)Y(1) zeolite could adsorb DMTs, which could not be adsorbed by Ce(IV)Y(2) zeolite. The rate of regeneration of extruded Ce(IV)Y(1)zeolite was 95.5%. | Zhu Heli Song Lijuan Gao Xiang Wang Hongguo Zhang Xiaotong Sun Zhaolin (Liaoning Key Laboratory of Petrochemical Engineering, Liaoning University of Petroleum and Chemical Technology, Fushun 113001) | 2009 | China Petroleum Processing & Petrochemical Technology2009，11，1： | 1 |
| 20 | Pyrolysis of Huang Tu Miao coal over faujasite zeolite and supported transition metal catalysts显示文摘 | Shuang Li Jingsheng Chen Ting Hao Wenbin Liang Xiaotong Liu Ming Sun Xiaoxun Ma | 2013 | Journal of Analytical and Applied Pyrolysis2013，，： | 1 |
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