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| 1 | One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients显示文摘The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. | Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai | 2016 | Science China(Life Sciences)2016，59，7： | 18 |
| 2 | NASICON-structured Na3.1Zr1.95Mg0.05Si2PO12 solid electrolyte for solid-state sodium batteries显示文摘Using stable inorganic solid electrolyte to replace organic liquid electrolyte could significantly reduce potential safety risks of rechargeable batteries. Na-superionic conductor(NASICON)-structured solid electrolyte is one of the most promising sodium solid electrolytes and can be employed in solid-state sodium batteries. In this work, a NASICONstructured solid electrolyte Na_(3.1)Zr_(1.95)Mg_(0.05)Si_2PO_(12) was synthesized through a facile solid-state reaction, yielding high sodium-ionic conductivity of 1.33×10^(-3) S·cm^(-1) at room temperature. The results indicate that Mg^(2+)is a suitable and economical substitution ion to replace Zr^(4+), and this synthesis route can be scaled up for powder preparation with low cost. In addition to electrolyte material preparation, solid-state batteries with Na_(3.1)Zr_(1.95)Mg_(0.05)Si_2PO_(12) as electrolyte were assembled. A specific capacity of 57.9 mAh·g^(-1) is maintained after 100 cycles under a current density of 0.5 C rate at room temperature. The favorable cycling performance of the solid-state battery suggests that Na_(3.1)Zr_(1.95)Mg_(0.05)Si_2PO_(12) is an ideal electrolyte candidate for solid-state sodium batteries. | Jing Yang HongLi Wan ZhiHua Zhang GaoZhan Liu XiaoXiong Xu YongSheng Hu Xia-Yin Yao | 2018 | Rare Metals2018，37，6： | 10 |
| 3 | Ecological risk assessment of Cd and other heavy metals in soil-rice system in the karst areas with high geochemical background of Guangxi,China显示文摘Karst areas are widely distributed in China,and the soil derived in these areas is enriched with trace elements and has the typical characteristics of high geochemical background.Therefore,soil ecological risk has gradually attracted extensive attention.In this study,1090 sets of rice grains and paired rhizosphere soils were collected as research objects from the outcropped karst areas of carbonate rocks in Guangxi,and the concentration characteristics and influencing factors of heavy metals,such as Cd and As,in rice grains and the corresponding soils were studied.According to the Chinese Soil Environmental Quality Standard(GB 15618-2018),the proportion of karstic soil samples in Guangxi with heavy metal(As,Cd,Cr,Cu,Hg,Ni,Pb and Zn)concentrations that exceed the standard risk screening values was generally greater than that of surface soils in China or non-karstic soils in Guangxi.Notably,Cd and As were the most prominently enriched heavy metals in soils.According to the Chinese Food Safety Standard(GB 2762-2017),Pb in rice grains from the studied area did not exceed the standard;the exceedance rates of Cr,Hg,and inorganic As were only about 1%;and the exceedance rate of Cd was 12.5%.Soil Cd concentration increased gradually whereas the concentration and exceedance rate of Cd in rice grains decreased gradually with the increase of soil pH.Specifically,the exceedance rate of Cd in rice grains was only 4%when soil pH>6.5.The results indicated that the risk screening values of Cd element in the Chinese Soil Environmental Quality Standard are not satisfactorily applicable to the ecological risk assessment of Cd in karstic soils.Therefore,the recommended threshold values for the safe utilization and risk control of Cd in karstic soils was proposed so as to provide a basis for soil environmental quality hierarchization,pollution risk control and land safety zoning of agricultural land in karst areas in China. | Qiong YANG Zhongfang YANG Qizuan ZHANG Xu LIU Xiaoxiong ZHUO Tiansheng WU Lei WANG Xueji WEI Junfeng JI | 2021 | Science China Earth Sciences2021，64，7： | 5 |
| 4 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 5 | Nanosized silicon - based composite derived by in situ mechanochemical reduction for lithium ion batteries 显示文摘 | YANG Xuelin WEN Zhaoyin XU Xiaoxiong | 2007 | J Power Sources2007，164，2： | 1 |
| 6 | Detection of scene-irrelevant head movements via eye-head coordination information显示文摘Background Accurate motion tracking in head-mounted displays(HMDs)has been widely used in immersive VR interaction technologies.However,tracking the head motion of users at all times is not always desirable.During a session of HMD usage,users may make scene-irrelevant head rotations,such as adjusting the head position to avoid neck pain or responding to distractions from the physical world.To the best of our knowledge,this is the first study that addresses the problem of scene-irrelevant head movements.Methods We trained a classifier to detect scene-irrelevant motions using temporal eye head-coordinated information sequences.To investigate the usefulness of the detection results,we propose a technique to suspend motion tracking in HMDs where scene-irrelevant motions are detected.Results/Conclusions Experimental results demonstrate that the scene-relevancy of movements can be detected using eye-head coordination information,and that ignoring scene-irrelevant head motions in HMDs improves user continuity without increasing sickness or breaking immersion. | Xiaoxiong FAN Yun CAI Yufei YANG Tianxing XU Yike Li Songhai ZHANG Fanglue ZHANG | 2021 | Virtual Reality & Intelligent Hardware2021，3，6： | 0 |
| 7 | Protein-based nanocarriers for efficient Etoposide delivery and cancer therapy显示文摘Etoposide,a DNA damage-inducing agent,is widely used for malignant tumors.However,insufficient solubility,poor bioavailability and adverse events limited the treatment outcomes and prognosis.To address this,we here developed a novel biosynthetic and unfolded protein nanocarrier to load and deliver Etoposide.Compared with the pristine agent,the loading efficiency of the nanoformulated drug increased four times and the half-life time increased to 17.6 h with controlled release of the Etoposide for 6 days.The half-maximal inhibitory concentration at 48 h was lower than that at 24 h,suggesting a long-acting anti-tumor property.Moreover,the anti-tumor performance in rat models was significantly enhanced by improving solubility and cellular internalization.Additionally,immunogenicity and adverse toxicologic effects such as kidney and liver toxicity were significantly weakened.Therefore,the assembly strategy enables etoposide with higher efficacy,bioavailability,and safety,and has great potential in the comprehensive treatment of malignant tumors. | Bo Wang Xiaoxiong Xu Bo Li Zheng Wei Shuang Lu Jingjing Li Kai Liu Hongjie Zhang Fan Wang Yang Yang | 2023 | Nano Research2023，16，8： | 0 |
| 8 | Data Fusion about Serviceability Reliability Prediction for the Long-Span Bridge Girder Based on MBDLM and Gaussian Copula Technique显示文摘This article presented a new data fusion approach for reasonably predicting dynamic serviceability reliability of the long-span bridge girder.Firstly,multivariate Bayesian dynamic linear model(MBDLM)considering dynamic correlation among the multiple variables is provided to predict dynamic extreme deflections;secondly,with the proposed MBDLM,the dynamic correlation coefficients between any two performance functions can be predicted;finally,based on MBDLM and Gaussian copula technique,a new data fusion method is given to predict the serviceability reliability of the long-span bridge girder,and the monitoring extreme deflection data from an actual bridge is provided to illustrated the feasibility and application of the proposed method. | Xueping Fan Guanghong Yang Zhipeng Shang Xiaoxiong Zhao Yuefei Liu | 2021 | Structural Durability & Health Monitoring2021，15，1： | 0 |
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