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| 1 | Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging显示文摘Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary hepatic malignancy.This study was designed to investigate the value of computed tomography(CT)spectral imaging in differentiating HCC from hepatic hemangioma(HH)and focal nodular hyperplasia(FNH).Methods:This was a retrospective study of 51 patients who underwent spectral multiple-phase CT at 40–140 keV during the arterial phase(AP)and portal venous phase(PP).Slopes of the spectral curves,iodine density,water density derived from iodine-and water-based material decomposition images,iodine uptake ratio(IUR),normalized iodine concentration,and the ratio of iodine concentration in liver lesions between AP and PP were measured or calculated.Results:As energy level decreased,the CT values of HCC(n=31),HH(n=17),and FNH(n=7)increased in both AP and PP.There were significant differences in IUR in the AP,IUR in the PP,normalized iodine concentration in the AP,slope in the AP,and slope in the PP among HCC,HH,and FNH.The CT values in AP,IUR in the AP and PP,normalized iodine concentration in the AP,slope in the AP and PP had high sensitivity and specificity in differentiating HH and HCC from FNH.Quantitative CT spectral data had higher sensitivity and specificity than conventional qualitative CT image analysis during the combined phases.Conclusions:Mean CT values at low energy(40–90 keV)and quantitative analysis of CT spectral data(IUR in the AP)could be helpful in the differentiation of HCC,HH,and FNH. | Weixia Li Ruokun Li Xiangtian Zhao Xiaozhu Lin Yixing Yu Jing Zhang Kemin Chen Weimin Chai Fuhua Yan | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 6 |
| 2 | Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer therapy.However,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications.Herein,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor microenvironment.We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection.Meanwhile,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose.By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo.We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2022 | Nano Research2022，15，2： | 1 |
| 3 | Therapeutic endoscopy of localized gastric varices: pretherapy screening and posttreatment evaluation with MDCT portography显示文摘 | Hui Zhu Bei Shi Manavendra Upadhyaya Zhiyuan Wu Xiaozhu Lin Yunlin Wu Kemin Chen | 2010 | Abdominal Imaging2010，，1： | 1 |
| 4 | Laser Raman Spectrum of Optical Fiber And the Measurement of Temperature Field in Space显示文摘 | Zhang Zaixuan Liu Tianfu Chen Xiaozhu | 1994 | Proceedings of SPIE-The Information Society for Optical Engineering1994，2321，： | 1 |
| 5 | Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression显示文摘Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process.Binary Tet-On system has been widely employed to regulate transgenic expression by doxycycline.Previous pig models with tetracycline regulatory elements were generated through random integration.This process often resulted in uncertain expression and unpredictable phenotypes,thus hindering their applications.Here,by precise knock-in of binary Tet-On 3G elements into Rosa26 and Hipp11 locus,respectively,a double knock-in reporter pig model was generated.We characterized excellent properties of this system for controllable transgenic expression both in vitro and in vivo.Two att P sites were arranged to flank the td Tomato to switch reporter gene.Single or multiple gene replacement was efficiently and faithfully achieved in fetal fibroblasts and nuclear transfer embryos.To display the flexible application of this system,we generated a pig strain with Dox-inducing h KRASexpression through phiC31 integrase-mediated cassette exchange.After eight months of Dox administration,squamous cell carcinoma developed in the nose,mouth,and scrotum,which indicated this pig strain could serve as an ideal large animal model to study tumorigenesis.Overall,the established pig models with controllable and switchable transgene expression system will provide a facilitating platform for transgenic and biomedical research. | Qin Jin Xiaoyu Yang Shixue Gou Xiaoyi Liu Zhenpeng Zhuang Yanhui Liang Hui Shi Jiayuan Huang Han Wu Yu Zhao Zhen Ouyang Quanjun Zhang Zhaoming Liu Fangbing Chen Weikai Ge Jingke Xie Nan Li Chengdan Lai Xiaozhu Zhao Jiaowei Wang Meng Lian Lei Li Longquan Quan Yinghua Ye Liangxue Lai Kepin Wang | 2022 | Science China(Life Sciences)2022，65，11： | 1 |
| 6 | Study of Urban and Rural Construction Land Change Based on Small Scale in Dafang显示文摘This paper is to examine the urban and rural construction land data of Dafang between basic year and final year based on country scale and spatial econometrics,and analyze its spatial pattern and change feature. According to the results,the construction lands in all the villages of Dafang County showed strong spatial autocorrelation and significant spatial cluster. After the analysis of local Moran's I,the construction lands in 381 villages of 36 counties presented strong activity. The original small-scale villages were gradually enlarging,which will not only gradually benefit local development,but also be in accordance with the strategy of ' one city,one district,eight parks'. | Xiaozhu CHEN | 2014 | Asian Agricultural Research2014，6，8： | 0 |
| 7 | Erratum to:Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Erratum to Nano Research 2022,15(2):1554–1563 https://doi.org/10.1007/s12274-021-3701-8 Figure 3(d)in the original paper contained duplicated micrographs(BPQDs+NIR)for different xenografts(B16 vs.CNE-2).This error did not affect any of the conclusions from the published paper. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2023 | Nano Research2023，16，1： | 0 |
| 8 | Division of Township Grade System and Scope of Influence:A Case Study of Dafang County显示文摘At the township level,combining Voronoi diagram and breaking point theory,this paper divides township grade system and its scope of influence in Dafang County of Guizhou Province,and discusses the grade system from small scale perspective.Results show that Dafang County takes Dafang Town as the center,Dashi Town in the north and Shachang Township in the east as auxiliary part,Sanyuan Township,Zhuyuan Township,Babao Township,Pudi Township,Lihua Township,and Dingxin Township as cooperative part,to drive development of 36 townships in Dafang County.Thus,it basically reflects township grade of Dafang County,accords with current development situation,provides certain reference value for system planning and economic zoning of small scale regions,and it is able to improve the accuracy of scope division by completing attribute data and revision of many methods. | Xiaozhu CHEN | 2013 | Asian Agricultural Research2013，5，9： | 0 |
| 9 | Soil Phosphorus Composition and Phosphatase Activities along Altitudes of Alpine Tundra in Changbai Mountains,China显示文摘Alpine tundra ecosystems have specific vegetation and environmental conditions that may affect soil phosphorus(P) composition and phosphatase activities. However, these effects are poorly understood. This study used Na OH-EDTA extraction and solution31 P nuclear magnetic resonance(NMR) spectroscopy to determine soil P composition and phosphatase activities, including acid phosphomonoesterase(Ac P), phosphodiesterase(PD) and inorganic pyrophosphatase(IPP), in the alpine tundra of the Changbai Mountains at seven different altitudinal gradients(i.e., 2000 m, 2100 m, 2200 m, 2300 m, 2400 m, 2500 m, and 2600 m). The results show that total P(TP), organic P(OP), OP/TP, Na OH-EDTA extracted P and AcP, PD, and IPP activities over the altitude range of 2500–2600 m are significantly lower than those below 2400 m. The dominant extracted form of P is OP(73%–83%) with a large proportion of monoesters(65%–72%), whereas inorganic P is present in lower proportions(17%–27%). The activity of Ac P is significantly positively correlated with the contents of soil OP, total carbon(TC), total nitrogen(TN), and TP(P < 0.05), indicating that the Ac P is a more sensitive index for responding P nutrient storage than PD and IPP. Soil properties, P composition, and phosphatase activities decrease with increased altitude and soil p H. Our results indicate that the distribution of soil P composition and phosphatase activities along altitude and Ac P may play an important role in P hydrolysis as well as have the potential to be an indicator of soil quality. | YANG Xiaozhu WEI Kai CHEN Zhenhua CHEN Lijun | 2016 | Chinese Geographical Science2016，26，1： | 0 |
| 10 | A Study on the Value Change of Land Ecosystem Services in Huangguoshu Scenic Area显示文摘Land use and ecological service influence and constrain each other and the quantitative research on the value change of ecosystem services and land use in Huangguoshu scenic area can help to provide a scientific basis for the harmonious development of special ecology,society and economy in Huangguoshu scenic area. This paper analyzes the value change of land ecosystem services in Huangguoshu scenic area during 2009- 2012,and explores important issues and focus in the land planning and development of Huangguoshu scenic area. The results show that the value of woodland ecosystem services is highest in Huangguoshu scenic area,accounting for nearly 70% of the total value,and there was a slight decline in the total value of ecosystem services in Huangguoshu scenic area during the four years,mainly due to the internal restructuring of agriculture and expansion of construction land. In the future development of Huangguoshu scenic area,it is necessary to economically and intensively use construction land,pay attention to the maintenance and improvement of land ecological environment,and focus on the protection of woodland,pasture land and other types of ecological land,so as to improve the overall regional land ecosystem services. | Xiaozhu CHEN | 2016 | Asian Agricultural Research2016，8，5： | 0 |
| 11 | Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A variants显示文摘Base editor-mediated C-to-T base conversion obviates the requirements of double-strand breaks,thereby showing promise as a tool for disease modeling and gene therapy(Gaudelli et al.,2017;Rees and Liu 2018).The most actively used base editor comprises a Cas9 nickase(nCas9)with cytidine deaminase and fused uracil DNA glycosylase inhibitor at the carboxy terminus of nCas9 to inhibit uracil N-glycosylase effects(Pearl,2000;Kunz et al.,2009;Rees and Liu 2018). | Meng Lian Fangbing Chen Xingyun Huang Xiaozhu Zhao Shixue Gou Nan Li Qin Jin Hui Shi Yanhui Liang Jingke Xie Weikai Ge Zhenpeng Zhuang Jiaowei Wang Yinghua Ye Yi Yang Kepin Wang Liangxue Lai Han Wu | 2021 | Journal of Genetics and Genomics2021，48，1： | 0 |
| 12 | The Land Use Change in the Scenic Area:A Case Study of Huangguoshu显示文摘Based on information entropy theory and ecological footprint theory,we analyze the changes in land use and land ecological carrying capacity in Huangguoshu scenic area during 2009- 2012. The results show that the area of arable land and construction land was relatively increased while the area of grassland and woodland was relatively reduced in Huangguoshu scenic area during 2009- 2012,and the information entropy showed a wavy change. It indicates that the land use in the study area poses increasing pressure on the ecological environment,and there is a need to strengthen ecological protection and achieve the coordinated development of land use and ecological environment construction. | Xiaozhu CHEN | 2015 | Asian Agricultural Research2015，7，8： | 0 |
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