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您的检索式：作者名="Hongsong Dong"
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| 1 | The effect of collagen hydrogels on chondrocyte behaviors through restricting the contraction of cell/hydrogel constructs显示文摘Collagen is a promising material for tissue engineering,but the poor mechanical properties of collagen hydrogels,which tend to cause contraction under the action of cellular activity,make its application challengeable.In this study,the amino group of type I collagen(Col I)was modified with methacrylic anhydride(MA)and the photo-crosslinkable methacrylate anhydride modified type I collagen(CM)with three different degrees of substitution(DS)was prepared.The physical properties of CM and Col I hydrogels were tested,including micromorphology,mechanical properties and degradation properties.The results showed that the storage modulus and degradation rate of hydrogels could be adjusted by changing the DS of CM.In vitro,chondrocytes were seeded into these four groups of hydrogels and subjected to fluorescein diacetate/propidium iodide(FDA/PI)staining,cell counting kit-8(CCK-8)test,histological staining and cartilage-related gene expression analysis.In vivo,these hydrogels encapsulating chondrocytes were implanted subcutaneously into nude mice,then histological staining and sulfated glycosaminoglycan(sGAG)/DNA assays were performed.The results demonstrated that contraction of hydrogels affected behaviors of chondrocytes,and CM hydrogels with suitable DS could resist contraction of hydrogels and promote the secretion of cartilage-specific matrix in vitro and in vivo. | Longpeng Dong Qingli Liu Yongli Gao Hengxing Jia Wenling Dai Likun Guo Hongsong Fan Yujiang Fan Xingdong Zhang | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
| 2 | In vitro resistance to interferon-alpha of hepatitis B virus with basic core promoter double mutation显示文摘 | Yan Wang Lai Wei Dong Jiang Xu Cong Ran Fei Hongsong Chen Jiang Xiao Yu Wang | 2007 | Antiviral Research2007，，2： | 1 |
| 3 | Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer therapy.However,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications.Herein,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor microenvironment.We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection.Meanwhile,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose.By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo.We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2022 | Nano Research2022，15，2： | 1 |
| 4 | Erratum to:Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Erratum to Nano Research 2022,15(2):1554–1563 https://doi.org/10.1007/s12274-021-3701-8 Figure 3(d)in the original paper contained duplicated micrographs(BPQDs+NIR)for different xenografts(B16 vs.CNE-2).This error did not affect any of the conclusions from the published paper. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2023 | Nano Research2023，16，1： | 0 |
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