|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Accuracy of three-dimensional seismic ground response analysis in time domain using nonlinear numerical simulations显示文摘To provide appropriate uses of nonlinear ground response analysis for engineering practice, a three-dimensional soil column with a distributed mass system and a time domain numerical analysis were implemented on the Open Sees simulation platform. The standard mesh of a three-dimensional soil column was suggested to be satisfied with the specified maximum frequency. The layered soil column was divided into multiple sub-soils with a different viscous damping matrix according to the shear velocities as the soil properties were significantly different. It was necessary to use a combination of other one-dimensional or three-dimensional nonlinear seismic ground analysis programs to confirm the applicability of nonlinear seismic ground motion response analysis procedures in soft soil or for strong earthquakes. The accuracy of the three-dimensional soil column finite element method was verified by dynamic centrifuge model testing under different peak accelerations of the earthquake. As a result, nonlinear seismic ground motion response analysis procedures were improved in this study. The accuracy and efficiency of the three-dimensional seismic ground response analysis can be adapted to the requirements of engineering practice. | Liang Fayun Chen Haibing Huang Maosong | 2017 | Earthquake Engineering and Engineering Vibration2017，16，3： | 6 |
| 2 | Genome Analysis of Dasineura jujubifolia Toursvirus 2,A Novel Ascovirus显示文摘So far,ascoviruses have only been identified from Lepidoptera host insects and their transmission vectors-endoparasitic wasps.Here,we reported the first finding of a complete novel ascovirus genome from a Diptera insect,Dasineura jujubifolia.Initially,sequence fragments with homology to ascoviruses were incidentally identified during metagenomic sequencing of the mitochondria of D.jujubifolia(Cecidomyiidae,Diptera)which is a major pest on Ziziphus jujuba.Then a full circular viral genome was assembled from the metagenomic data,which has an A+T percentage of 74%and contains 142,600 bp with 141 open reading frames(ORFs).Among the 141 ORFs,37 were conserved in all sequenced ascoviruses(core genes)including proteins predicted to participate in DNA replication,gene transcription,protein modification,virus assembly,lipid metabolism and apoptosis.Multi-gene families including those encode for baculovirus repeated open reading frames(BROs),myristylated membrane proteins,RING/U-box E3 ubiquitin ligases,and ATP-binding cassette(ABC)transporters were found in the virus genome.Phylogenetic analysis showed that the newly identified virus belongs to genus Toursvirus of Ascoviridae,and is therefore named as Dasineura jujubifolia toursvirus 2(DjTV-2a).The virus becomes the second reported species of the genus after Diadromus pulchellus toursvirus 1(DpTV-1a).The genome arrangement of DjTV-2a is quite different from that of DpTV-1a,suggesting these two viruses separated in an early time of evolution.The results suggest that the ascoviruses may infect a much broader range of hosts than our previous knowledge,and shed lights on the evolution of ascoviruses and particularly on that of the toursviruses. | Jun Wang Minglu Yang Haibing Xiao Guo-Hua Huang Fei Deng Zhihong Hu | 2020 | Virologica Sinica2020，35，2： | 4 |
| 3 | Supersaturation induced by Itraconazole/Soluplus micelles provided high GI absorption in vivo显示文摘To investigate the effect of supersaturation induced by micelle formation during dissolution on the bioavailability of itraconazole(ITZ)/Soluplus~? solid dispersion. Solid dispersions prepared by hot melt extrusion (HME) were compressed into tablets directly with other excipients. Dissolution behavior of ITZ tablets was studied by dissolution testing and the morphology of micelles in dissolution media was studied using transmission electron microscopy (TEM). Drug transferring from stomach into intestine was simulated to obtain a supersaturated drug solution. Bioavailability studies were performed on the ITZ tablets and Sporanox~? in beagle dogs. The morphology of micelles in the dissolution media was observed to be spherical in shape, with an average size smaller than 100 nm. The supersaturated solutions formed by Soluplus~? micelles were stable and no precipitation took place over a period of 180 min. Compared with Sporanox~?, ITZ tablets exhibited a 2.50-fold increase in the AUC (0–96) of ITZ and a 1.95-fold increase in its active metabolite hydroxyitraconazole (OHITZ) in the plasma of beagle dogs. The results obtained provided clear evidence that not only the increase in the dissolution rate in the stomach, but also the supersaturation produced by micelles in the small intestine may be of great assistance in the successful development of poorly water-soluble drugs. The micelles formed by Soluplus~? enwrapped the molecular ITZ inside the core which promoted the amount of free drug in the intestinal cavity and carried ITZ through the aqueous boundary layer(ABL), resulting in high absorption by passive transportation across biological membranes. The uptake of intact micelles through pinocytosis together with the inhibition of P-glycoprotein-mediated drug efflux in intestinal epithelia contributed to the absorption of ITZ in the gastrointestinal tract. These results indicate that HME with Soluplus~?, which can induce supersaturation by micelleformation, may be of great assistance to the successful development of poorly watersoluble drugs. | Yue Zhong Guanghui Jing Bin Tian Hao Huang Yuanyuan Zhang Jingxin Gou Xing Tang Haibing He Yanjiao Wang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，2： | 3 |
| 4 | Geochemical characteristics of hadal sediment in the northern Yap Trench显示文摘Two sediment cores were retrieved in the hadal zone of the Yap Trench,and their concentrations of six major elements Mg,Al,Ca,Ti,Mn and Fe and nine trace elements Sr,Ba,Pb,V,Cr,Co,Ni,Cu and Zn were determined in inductively coupled plasma atomic emission spectrometry(ICP-AES).According to the vertical distribution profiles of the 15 elements,the correlation of their concentrations,the ratios of Ni/Co,V/Cr,Fe/Al,and Ti/Al,and morphological characteristics of the sediment samples,the implications of the depositional environment and the sediment provenance were analyzed.The results show that the ratio of Ni/Co in all depths of the two sediment cores were below 5,and the ratio of V/Cr were lower than 2,indicating that the depositional environment of the hadal zone in the trench was oxidative and might have inflow of the Antarctic bottom oxygen-rich water.The sediment samples on the eastern side of the trench were siliceous mud mainly composed of diatoms,radiolarian,and sponge needles from surface to deep layer.The vertical profile of the elements,the concentration of TOC and the fossil record indicated that the sediment sample from station Dive113 was well mixed from surface to bottom layer.Based on the correlation of concentrations of the elements,the morphological characteristics of the sediment,and the ratios of Fe/Al and Ti/Al,we inferred that the sediment in the hadal zone of the trench had terrestrial,volcanic,biological,and authigenic sources.Major source of the sediment in the eastern side of the trench were terrestrial;whereas the sediment in the western side of the trench received more volcaniclastic input. | HUANG Yuhuan SUN Chengjun YANG Guipeng YUE Xin’an JIANG Fenghua CAO Wei YIN Xiaofei GUO Chaonan NIU Jiaohong DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 3 |
| 5 | Distribution characteristics of lipids in hadal sediment in the Yap Trench显示文摘In this study,cored sediment samples collected by the Jiaolong Submersible at 6779 m depth from the hadal zone of the Yap Trench in May 2016 were sliced in 1-cm interval from top to bottom,and lipids in each sediment layer were quantitatively and qualitatively analyzed.The vertical distribution profiles of the lipids in the sediment sample,their main existing forms,and their possible sources were investigated.The results show that the concentration of lipid in the surface sediment was the highest with the carbon number from 12 to 27,dominated by medium and short-chain lipids.The total concentration of fatty acids in surface sediment was much higher than those in the offshore and deep-sea areas,being up to 325.77μg/g due to the funnel effect caused by the“V”terrain of the trench.Fatty acid 18:0 was the most abundant lipids in the sediment sample.Abnormal high concentrations of fatty acid 18:1ω7 and alkanes indicated the existence of hydrothermal fluids in the study area.In addition,saturated fatty acids and monounsaturated fatty acids existed mainly in free form,and polyunsaturated fatty acids existed mainly in bound form.Most of the alkanes were in bound form,and their major source was autochthounous input.The carbon number of alcohols in the sediment sample ranged from 12 to 20,mainly existed in bound form.The source of fatty acids was mainly autochthonous input,and the neutral lipids had both marine and terrestrial origin.This is the first study of lipids in hadal sediment of the Yap Trench.The results will promote deeper understanding of organic carbon cycle in marine environment. | YAN Yixin SUN Chengjun HUANG Yuhuan CAO Wei JIANG Fenghua YANG Guipeng DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 2 |
| 6 | Tracking the multiple-step formation of an iron(Ⅲ) complex and its application in photodynamic therapy for breast cancer显示文摘A tandem reaction of pyridin-2-ylmethanamine(L1′) with 8-hydroxyquinoline-2-carbaldehyde(HL1) assisted by FeCl_3 was observed to give the new nitrogen heterocycle HL3(HL3=2-(imidazo[1,5-a]pyridin-3-yl)quinolin-8-ol) as its Fe(Ⅲ) complex,[Fe(L3)Cl_2](Fe1). Electrospray ionization mass spectrometry(ESI-MS) reveals its formation involves three steps:(1) coordination of both HL1 and L1′ to Fe,(2) aldehyde-amine coupling, and(3) ring closure. The results of electronic absorption spectroscopy, cyclic voltammetry, and density functional theory(DFT) calculations show the proximity of the optical transition energy to that of the excitation of ~3O_2 to ~1O_2, which prompted us to explore its application as a photosensitizer for photodynamic therapy(PDT). Photo-toxicity studies show that Fe1 exhibits the highest anti-proliferation efficiency in human breast cancer MDA-MB-231 cells under light irradiation. Moreover, studies with orthotopic models of breast cancer further expounded the anti-tumor activity of Fe1 with no significant toxicity to other organs and low retention in the body. | Zhong-Hong Zhu Qian Hu Hui-Ling Pan Yuexing Zhang Haibing Xu Mohamedally Kurmoo Jin Huang Ming-Hua Zeng | 2019 | Science China Chemistry2019，62，6： | 2 |
| 7 | Synthesis of(co-) Polyethylene with Broad Molecular Weight Distribution by the Heterogenous Ziegler-Natta Catalysts via One-Pot Strategy 显示文摘 | Liu Zhi Zhang Xinli Huang Haibing | 2012 | JlndEngChem2012，，18： | 1 |
| 8 | Underground water Cherenkov muon detector array with the Tibet air shower array for gamma-ray astronomy in the 100 TeV region显示文摘 | M. Amenomori S. Ayabe X. J. Bi D. Chen S. W. Cui Danzengluobu L. K. Ding X. H. Ding C. F. Feng Zhaoyang Feng Z. Y. Feng X. Y. Gao Q. X. Geng H. W. Guo H. H. He M. He K. Hibino N. Hotta Haibing Hu H. B. Hu J. Huang Q. Huang H. Y. Jia F. Kajino K. Kasahara | 2007 | Astrophysics and Space Science (-)2007，，1： | 1 |
| 9 | Assessment of International GNSS Service Global Ionosphere Map products over China region based on measurements from the Crustal Movement Observation Network of China显示文摘The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of GIM products in data-sparse regions is of paramount importance.In this study,measurements from the Crustal Movement Observation Network of China(CMONOC)are leveraged to evaluate the suitability of IGS-GIM products over China region in 2013-2014.The indices of mean error(ME),root mean square error(RMSE),and normalized RMSE(NRMSE)are then utilized to quantify the accuracy of IGS-GIM products.Results revealed distinct local time and latitudinal dependencies in IGS-GIM errors,with substantially high errors at nighttime(NRMSE:39%)and above 40°latitude(NRMSE:49%).Seasonal differences also emerged,with larger equinoctial deviations(NRMSE:33.5%)compared with summer(20%).A preliminary analysis implied that the irregular assimilation of sparse IGS observations,compounded by China’s distinct geomagnetic topology,may manifest as error variations.These results suggest that modeling based solely on IGS-GIM observations engenders inadequate representations across China and that a thorough examination would proffer the necessary foundation for advancing regional total electron content(TEC)constructions. | Jin Hu HaiBing Ruan FuQing Huang ShengYang Gu XianKang Dou | 2024 | Earth and Planetary Physics2024，8，2： | 1 |
| 10 | Microstructures and mechanical properties of A12 03 - ZrO2 - C refractories using silicon, microsilica or their combination as additive 显示文摘 | Fan Haibing Li Yawei Huang Yupeng | 2012 | Mater Sci Eng A2012，545，： | 1 |
| 11 | Vertical variations of dissolved carbohydrates in the North Yap Trench显示文摘The concentrations of dissolved monosaccharides(MCHO),polysaccharides(PCHO),and total carbohydrates(TCHO)in the seawater samples collected from the north of the Yap Trench in the western Pacific Ocean were measured by 2,4,6-tripyridine-s-triazine(TPTZ)spectrophotometry method.The results show that the concentrations of MCHO,PCHO,and TCHO ranged from 4.6 to 22.1μmol C/L,3.5 to 27.3μmol C/L,and 13.8 to 36.3μmol C/L,respectively.In different sampling stations,the concentrations of MCHO,PCHO,and TCHO with water depth showed complex variation patterns.In the study area,the maximum concentrations of MCHO,PCHO,and TCHO occurred in the euphotic layer and the minimum concentrations occurred in mesopelagic seawater layer.Generally,the concentrations of MCHO,PCHO,and TCHO decreased with water depth from the euphotic layer to the hadal zone.The average value of PCHO/TCHO was higher than the average value of MCHO/TCHO,indicating that PCHO was the main component of TCHO in north of the Yap Trench. | GUO Chaonan SUN Chengjun YANG Guipeng ZHANG Honghai CHEN Yan YIN Xiaofei JIANG Fenghua HUANG Yuhuan NIU Jiaohong DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 1 |
| 12 | Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their high stability,easy preparation,and tunable catalytic properties,especially in the field of cancer therapy.However,the unfavorable catalytic effects of nanozymes in the acidic tumor microenvironment have limited their applications.Herein,we developed a biomimetic erythrocyte membrane-camouflaged ultrasmall black phosphorus quantum dots(BPQDs)nanozymes that simultaneously exhibited an exceptional near-infrared(NIR)photothermal property and dramatically photothermal-enhanced glucose oxidase(GOx)-like activity in the acidic tumor microenvironment.We demonstrated the engineered BPQDs gave a photothermal conversion efficiency of 28.9%that could rapidly heat the tumor up to 50℃ while effectively localized into tumors via homing peptide iRGD leading after intravenously injection.Meanwhile,the significantly enhanced GOx-like activity of BPQDs under NIR irradiation was capable of catalytical generating massive toxic reactive oxygen species via using cellular glucose.By combining the intrinsic photothermal property and the unique photothermal-enhanced GOx-like catalytic activity,the developed BPQDs were demonstrated to be an effective therapeutic strategy for inhibiting tumor growth in vivo.We believe that this work will provide a novel perspective for the development of nanozymes in tumor catalytic therapy. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2022 | Nano Research2022，15，2： | 1 |
| 13 | Characteristics of the fault-related rocks, fault zones and the principal slip zone in the Wenchuan Earthquake Fault Scientific Drilling Project Hole-1 (WFSD-1)显示文摘 | Haibing Li Huan Wang Zhiqin Xu Jialiang Si Junling Pei Tianfu Li Yao Huang Sheng-Rong Song Li-Wei Kuo Zhiming Sun Marie-Luce Chevalier Dongliang Liu | 2012 | Tectonophysics2012，，： | 1 |
| 14 | A goat poxvirus-vectored peste-des-petits-ruminants vaccine induces long-lasting neutralization antibody to high levels in goats and sheep显示文摘 | Weiye Chen Sen Hu Linmao Qu Qianqian Hu Qian Zhang Haibing Zhi Kehe Huang Zhigao Bu | 2010 | Vaccine2010，，30： | 1 |
| 15 | Formation mechanism of cobalt-gradient structure in WC-Co hard alloy显示文摘 | Yong Liu Haibing Wang Jiangao Yang Baiyun Huang Zhengyi Long | 2004 | Journal of Materials Science2004，，13： | 1 |
| 16 | Properties of paper mill sludge–wood fiber–HDPE composites after exposure to xenon-arc weathering显示文摘We used paper mill sludge(PMS) to substitute for part of the wood fibers(WF) used to reinforce high density polyethylene(HDPE).The resulting composites were subjected to xenon-arc weathering.The composite filled with limited PMS(under 10 %) had mechanical properties and aging resistance similar to those without PMS.The composites containing more PMS faded and cracked more readily than those without PMS.Based on the carbonyl index,crystallinity,and wood index,PMS appeared to accelerate the degradation of composites during weathering.Adding PMS to WF–HDPE composites reduced the weathering resistance,and this reduction was not significant if the PMS content did not exceed 20 % of the wood fibers.Therefore,PMS could be used as a reinforcement in wood-plastic composites at levels less than20 % of the wood fiber content. | Xiaohui Yang Xianquan Zhang Weihong Wang Haibing Huang Shujuan Sui | 2015 | Journal of Forestry Research2015，26，2： | 1 |
| 17 | Development of Super-Synchronization Speed Control Assembly in Two 80 MVA Motor Generators of HL-2A Tokamak显示文摘 | LI Huajun DU Chang XUAN Weimin PEN Jianfei HU Haotian LIU Lin KANG Li XU Lirong HUANG Zhaorong WANG Fen WANG Xiaoping WANG Haibing | 2005 | Southwestern Institute of Physics Annual Report2005，，1： | 0 |
| 18 | Erratum to:Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy显示文摘Erratum to Nano Research 2022,15(2):1554–1563 https://doi.org/10.1007/s12274-021-3701-8 Figure 3(d)in the original paper contained duplicated micrographs(BPQDs+NIR)for different xenografts(B16 vs.CNE-2).This error did not affect any of the conclusions from the published paper. | Hui Ding Daji Wang Haibing Huang Xiaozhu Chen Jie Wang Jinjie Sun Jianlin Zhang Lu Lu Beiping Miao Yanjuan Cai Kelong Fan Yongtian Lu Hongsong Dong Xiyun Yan Guohui Nie Minmin Liang | 2023 | Nano Research2023，16，1： | 0 |
| 19 | Why Is Shinzo Abe so Eager to Improve Relations with China?显示文摘Japanese Prime Minister Shinzo Abe has maintained a tough stance onChina since he took office.Not only has his administration antagonized China over sensitive issues such as territorial disputes but it has also launched a public opinion war,exaggerating the China threat to the international community.Abe’s government has also been trying to | Huang Dahui Xing Haibing | 2014 | Contemporary International Relations2014，24，6： | 0 |
| 20 | Crisis Public Diplomacy in China显示文摘Due to the current domestic situation and trend of development, China should strive to promote internal harmony and progress, and improve strategic coordination with all major powers and the peripheral countries. It should study seriously the theories and practices of crisis public diplomacy, consolidate fundamental strategic capabilities, and enhance its ability to execute relevant programs. | Huang Zhong Tang Xiaosong Xing Haibing | 2014 | Contemporary International Relations2014，24，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员