|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targets and molecular mechanisms of triptolide in cancer therapy显示文摘Triptolide(TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid(DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results. | Cuicui Meng Hongcheng Zhu Hongmei Song Zhongming Wang Guanhong Huang Defan Li Zhaoming Ma Jianhua Ma Qin Qin Xinchen Sun Jianxin Ma | 2014 | Chinese Journal of Cancer Research2014，26，5： | 16 |
| 2 | Effects of Tetrandrine on Apoptosis and Radiosensitivity of Nasopharyngeal Carcinoma Cell Line CNE显示文摘Tetrandrine 被知道然而,几乎不施加反肿瘤效果在鼻咽的癌房间上对它的效果被知道。在这研究,我们在鼻咽的癌房间线 CNE 测试了导致 tetrandrine 的 apoptosis 和放射敏感度并且调查了可能的机制。用流动 cytometry 和 DNA 电气泳动,我们发现 tetrandrine 能导致房间 apoptosis.Further , Bcl-2 mRNA 的水平减少了,盒子 mRNA 由使用反向的抄写聚合酶链 reaction.X-ray-induced G2 在 tetrandrine 的增加以后增加了,这被显示出拘捕被处理与 tetrandrine 废除,是由流动 cytometry 和有丝分裂的索引检测了。cyclinBl 蛋白质的累积和 Cdc2 tyrosine-15 和 Cdc25C serine-216 phosphorylation 的抑制在用蛋白质印迹分析与 tetrandrine 对待的照耀的房间被检测。总起来说,这些结果证明 tetrandrine 能导致 apoptosis 并且在 CNE 房间废除导致放射的 G2 拘捕。 | Xinchen SUN Ruizhi XU Yuxia DENG Hongyan CHENG Jun M Jiazhong JI Yingfeng ZHOU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，11： | 13 |
| 3 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 4 | From a projective invariant to some new properties of algebraic hypersurfaces显示文摘Projective invariants are not only important objects in mathematics especially in geometry,but also widely used in many practical applications such as in computer vision and object recognition. In this work,we show a projective invariant named as characteristic number,from which we obtain an intrinsic property of an algebraic hypersurface involving the intersections of the hypersurface and some lines that constitute a closed loop. From this property,two high-dimensional generalizations of Pascal's theorem are given,one establishing the connection of hypersurfaces of distinct degrees,and the other concerned with the intersections of a hypersurface and a simplex. | LUO ZhongXuan ZHOU XinChen GU David XianFeng | 2014 | Science China Mathematics2014，57，11： | 8 |
| 5 | XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer显示文摘DNA 修理能力(DRC ) 向基于铂的化疗与癌症房间的敏感被相关。我们假设那在 DNA 的基因多型性修理基因 XPA (干皮病 pigmentosum 组 A )和 XPG (干皮病 pigmentosum 组 G )( ERCC5 ,切除修理跨互补的组 5 ),它在 DNA 修理效率导致内部个人的差别,可以在先进非小的房间肺癌症( NSCLC )预言临床的反应到铂代理人病人。在这研究,我们发现 XPA A23G 多型性的 A G 变化显著地增加了反应到基于铂的化疗。在 XPG His46His 的多型性与减少的治疗回答被联系,但是不是统计上重要的。 | Jifeng Feng Xinchen Sun Ning Sun Shukui Qin Fan Li Hongyan Cheng Baoan Chen YuanDong Cao Jun Ma Lu Cheng Zuhong Lu Jiazhong Ji Yingfeng Zhou | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 8 |
| 6 | Photocatalysis:an overview of recent developments and technological advancements显示文摘Photocatalysis,which is the catalyzation of redox reactions via the use of energy obtained from light sources,is a topic that has garnered a lot of attention in recent years as a means of addressing the environmental and economic issues plaguing society today.Of particular interest are photosynthesis can potentially mimic a variety of vital reactions,many of which hold the key to develop sustainable energy economy.In light of this,many of the technological and procedural advancements that have recently occurred in the field are discussed in this review,namely those linked to:(1)photocatalysts made from metal oxides,nitride,and sulfides;(2)photocatalysis via polymeric carbon nitride(PCN);and(3)general advances and mechanistic insights related to TiO2-based catalysts.The challenges and opportunities that have arisen over the past few years are discussed in detail.Basic concepts and experimental procedures which could be useful for eventually overcoming the problems associated with photocatalysis are presented herein. | Yuanxing Fang Yun Zheng Taofang Yong Chen Yaodong Zhu Qing Liang Hua Sheng Zhaosheng Li Chuncheng Chen Xinchen Wang | 2020 | Science China Chemistry2020，63，2： | 7 |
| 7 | Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC显示文摘Epithelial–mesenchymal transition(EMT)is involved in both physiological and pathological processes.EMT plays an essential role in the invasion,migration and metastasis of tumours.Autophagy has been shown to regulate EMT in a variety of cancers but not in head and neck squamous cell carcinoma(HNSCC).Herein,we investigated whether autophagy also regulates EMT in HNSCC.Analyses of clinical data from three public databases revealed that higher expression of fibronectin-1(FN1)correlated with poorer prognosis and higher tumour pathological grade in HNSCC.Data from SCC-25 cells demonstrated that rapamycin and Earle’s balanced salt solution(EBSS)promoted autophagy,leading to increased FN1 degradation,while 3-methyladenine(3-MA),bafilomycin A1(Baf A1)and chloroquine(CQ)inhibited autophagy,leading to decreased FN1 degradation.On the other hand,autophagic flux was blocked in BECN1 mutant HNSCC Cal-27 cells,and rapamycin did not promote autophagy in Cal-27 cells;also in addition,FN1 degradation was inhibited.Further,we identified FN1 degradation through the lysosome-dependent degradation pathway using the proteasome inhibitor MG132.Data from immunoprecipitation assays also showed that p62/SQSTM1 participated as an autophagy adapter in the autophagy–lysosome pathway of FN1 degradation.Finally,data from immunoprecipitation assays demonstrated that the interaction between p62 and FN1 was abolished in p62 mutant MCF-7 and A2780 cell lines.These results indicate that autophagy significantly promotes the degradation of FN1.Collectively,our findings clearly suggest that FN1,as a marker of EMT,has adverse effects on HNSCC and elucidate the autophagy–lysosome degradation mechanism of FN1. | Xinchen Liu Lin Meng Xing Li Daowei Li Qilin Liu Yumeng Chen Xiangwei Li Wenhuan Bu Hongchen Sun | 2020 | International Journal of Oral Science2020，12，4： | 7 |
| 8 | Electrochemical reduction of CO_2 to CO using graphene oxide/carbon nanotube electrode in ionic liquid/acetonitrile system显示文摘Electrochemical reduction of CO_2 to CO is an interesting topic. In this work, we prepared metal-free electrodes by depositing graphene oxide(GO), multi-walled carbon nanotube(MWCNT), and GO/MWCNT composites on carbon paper(CP) using electrophoretic deposition(EPD) method. The electrodes were characterized by different methods, such as X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS). The electrochemical reduction of CO_2 to CO was conducted on the electrodes in 1-butyl-3-methylimidazolium tetrafluoroborate([Bmim]BF4)/acetonitrile(Me CN) electrolyte, and the composition of the electrolyte influenced the reaction significantly. It was demonstrated that GO/MWCNT-CP electrode was very effective for the reaction in IL(90 wt%)/Me CN binary mixture, the Faradaic efficiency of CO and current density were even higher than those on Au and Ag electrodes in the same electrolyte. | Qinggong Zhu Jun Ma Xinchen Kang Xiaofu Sun Jiayin Hu Guanying Yang Buxing Han | 2016 | Science China Chemistry2016，59，5： | 5 |
| 9 | Determination of hexabromocyclododecanes in sediments from the Haihe River in China by an optimized HPLC–MS–MS method显示文摘Hexabromocyclododecanes(HBCDs),a new type of persistent organic pollutants widely used as brominated flame retardants,have attracted wide attention due to their increasing level and toxicity. A method based on high-performance liquid chromatography mass spectrometry(HPLC–MS–MS)in electrospray ionization mode has been developed by optimization of various parameters,which effectively improved the separation degree and responsive intensity of α-,β-and γ-HBCD isomers. The concentrations and distribution profiles of three HBCD isomers were investigated in sediments from the Haihe River in China.It was observed that the concentrations of HBCDs varied in the range of 0.4–58.82 ng/g,showing a decreasing trend along the flow direction,possibly due to attenuation and biodegradation along the flow direction of the Haihe River. The distribution profile of α-,β-,γ-HBCD was 7.91%–88.6%,0–91.47%,and 0.62%–42.83%,respectively. Interestingly,α-HBCD dominated in most sample sites. This was different from the distribution profile in commercial industrial products,which might be attributed to the inter-transformation and different degradation rates of the three HBCD isomers. The potential ecological risk of HBCDs in sediment was characterized under the two-tiered procedure of the European Medicines Evaluation Agency for environmental risk assessment. Although the HBCDs in the selected section of the Haihe River presented 'no risk' in the sediment compartment,its risk in sediment cannot be neglected since sediment is one of the important sinks and reservoirs of pollutants. | Yanhui Zhao Qianqian Li Xue Miao Xinchen Huang Binke Li Guijin Su Minghui Zheng | 2017 | Journal of Environmental Sciences2017，29，5： | 5 |
| 10 | Ultraviolet Light Assisted Hierarchical Porous Fe2O3 Catalyzing Heterogeneous Fenton Degradation of Tetracycline Under Neutral Condition with a Low Requirement of H2O2显示文摘The hierarchical porous Fe2O3 particles as a novel ultraviolet light assisted heterogeneous Fenton catalysts were synthesized by bio-template synthesis method using iron nitrate as precursor at high temperature of around 550℃.The hierarchical porous structured Fe2O3 was endowed with a large surface area and abundant pore volume,leading to the exposure of more active sites and rapid mass transfer.The synergistic effect of UV irradiation and hie-rarchical porous Fe2O3 improved the photo-degradation efficiency of Tetracycline(TC).The degradation efficiency of Fe203 catalyzing UV-Fenton system reached 97.4%after 60 min reaction,which was more substantial than Fe2O3 catalyzing Fenton system(7.6%)and UV/H2O2 system(59.2%).Moreover,the hierarchical porous Fe2O3 catalyzing UV-Fenton system exhibited an extremely wide pH range(from 3.0 to 9.0,from mildly acidic to slightly alkaline)for efficient degradation of TC.Simultaneously,the extraordinary higher degradation efficiency was based on 10 mmol/L H2O2 concentration,which was low requirement for H2O2,Further,the hierarchical porous Fe2O3 can be used for five consecutive cycles with over 95%of the original degradation efficiency.Ultraviolet light assisted heterogeneous Fenton reaction in the hierarchical porous Fe2O3 improved the·OH and O2·^-production and Fe(III)/Fe(II)redox cycle,which consequently achieved an excellent degradation rate. | LIN Xinchen XIE Feng YU Xiaodan TANG Xin GUAN Heda CHEN Yu FENG Wei | 2019 | Chemical Research in Chinese Universities2019，35，2： | 5 |
| 11 | Photocatalytic degradation of benzene in gas phase by nanostructured BiPO_4 catalysts | Baihua Long Jianhui Huang Xinchen Wang | 2012 | Progress in Natural Science:Materials International2012，22，6： | 4 |
| 12 | Impacts of climate change and human activities on water resources in the Ebinur Lake Basin, Northwest China显示文摘Changing climatic conditions and extensive human activities have influenced the global water cycle.In recent years,significant changes in climate and land use have degraded the watershed ecosystem of the Ebinur Lake Basin in Xinjiang,Northwest China.In this paper,variations of runoff,temperature,precipitation,reference evapotranspiration,lake area,socio-economic water usage,groundwater level and water quality in the Ebinur Lake Basin from 1961 to 2015 were systematically analyzed by the Mann-Kendall test methods(M-K)mutation test,the cumulative levelling method,the climate-sensitive method and land-use change index.In addition,we evaluated the effects of human activities on land use change and water quality.The results reveal that there was a significant increase in temperature and precipitation from 1961 to 2015,despite a decrease in reference evapotranspiration.The Wenquan station was not significantly affected by human activities as it is situated at a higher altitude.Runoff at this station increased significantly with climate warming.In contrast,runoff at the Jinghe station was severely affected by numerous human activities.Runoff decreased without obvious fluctuations.The contributions of climate change to runoff variation at the Jinghe and Wenquan stations were 46.87%and 58.94%,respectively;and the contributions of human activities were 53.13%and 41.06%,respectively.Land-use patterns in the basin have changed significantly between 1990 and 2015:urban and rural constructed lands,saline-alkali land,bare land,cultivated land,and forest land have expanded,while areas under grassland,lake,ice/snow and river/channel have declined.Human activities have dramatically intensified land degradation and desertification.From 1961 to 2015,both the inflow into the Ebinur Lake and the area of the lake have declined year by year;groundwater levels have dropped significantly,and the water quality has deteriorated during the study period.In the oasis irrigation area below the runoff pass,human activities mainly influenced the utilization mode and quantity of water resources.Changes in the hydrology and quantity of water resources were driven primarily by the continuous expansion of cultivated land and oasis,as well as the growth of population and the construction of hydraulic engineering projects.After 2015,the effects of some ecological protection projects were observed.However,there was no obvious sign of ecological improvement in the basin,and some environmental problems continue to persist.On this basis,this study recommends that the expansion of oasis should be limited according to the carrying capacity of the local water bodies.Moreover,in order to ensure the ecological security of the basin,it is necessary to determine the optimal oasis area for sustainable development and improve the efficiency of water resources exploitation and utilization. | WANG Yuejian GU Xinchen YANG Guang YAO Junqiang LIAO Na | 2021 | Journal of Arid Land2021，13，6： | 3 |
| 13 | Effective Removal of Tetracycline by Using Biochar Supported Fe3O4 as a UV-Fenton Catalyst显示文摘Novel Fe3O4-decorate hierarchical porous carbon skeleton derived from maize straw(Fe3O4@MSC)was synthesized by a facile co-precipitation process and a calcination process,which was developed as a UV assisted heterogeneous Fenton-like catalyst.The as-synthesized catalysts were characterized via X-ray powder diffraction(XRD), scanning electron microscope(SEM),transmission electron microscope(TEM),Brunauer-Emmet-Teller(BET)and vibrating sample magnetometer(VSM)at room temperature.The morphology and structure analysis revealed that the as-prepared Fe3O4@MSC retained the original pore morphology of the maize straw material.The non-uniform poly- hedral Fe3O4 grew on the whole surface of the MSC,which reduced the aggragation of Fe3O4 and provided more active sites to strengthen the UV-assisted Fenton-like reaction.As a result,the tetracycline(TC)degradation efficiency after 40 min reaction and total organic carbon(TOC)removal efficiency after 2 h reaction of Fe3O4@MSC catalyzing UV-Fenton system reached 99.2%and 72.1%,respectively,which were more substantial than those of Fe3O4@MSC/H2O2(31.5%and 2%),UV/H2O2 system(68%and 23.4%)and UV/Fe3O4/H2O2(80% and 37.5%).The electron spin resonance(ESR)results showed that the ·OH played an important role in the catalytic reaction.A possible degradation pathway of TC was proposed on the basis of the identified intermediates.Overall,the UV assisted heterogeneous Fenton-like process in Fe3O4@MSC improved the cycle of Fe^3+/Fe^2+ and activated the interfacial catalytic site,which eventually realized the enhancement of degradation and mineralization to tetracycline. | YU Xiaodan LIN Xinchen LI Weiguang FENG Wei | 2019 | Chemical Research in Chinese Universities2019，35，1： | 3 |
| 14 | An artificial chromosome for data storage显示文摘DNA digital storage provides an alternative for information storage with high density and long-term stability.Here,we report the de novo design and synthesis of an artificial chromosome that encodes two pictures and a video clip.The encoding paradigm utilizing the superposition of sparsified error correction codewords and pseudo-random sequences tolerates base insertions/deletions and is well suited to error-prone nanopore sequencing for data retrieval.The entire 254 kb sequence was 95.27%occupied by encoded data.The Transformation-Associated Recombination method was used in the construction of this chromosome from DNA fragments and necessary autonomous replication sequences.The stability was demonstrated by transmitting the data-carrying chromosome to the 100 th generation.This study demonstrates a data storage method using encoded artificial chromosomes via in vivo assembly for write-once and stable replication for multiple retrievals,similar to a compact disc,with potential in economically massive data distribution. | Weigang Chen Mingzhe Han Jianting Zhou Qi Ge Panpan Wang Xinchen Zhang Siyu Zhu Lifu Song Yingjin Yuan | 2021 | National Science Review2021，8，5： | 3 |
| 15 | BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis显示文摘 | Jian Li Sihan Lv Xinchen Qiu Jiamin Yu Junkun Jiang Yalan Jin Wenxuan Guo| Ruowei Zhao Zhen-Ning Zhang Chao Zhang Bing Luan | 2018 | Protein & Cell2018，9，11： | 3 |
| 16 | A reduced combustion kinetic model for the methanol-gasoline blended fuels on SI engines.显示文摘A reduced combustion kinetic model for the methanol-gasoline blended fuels for SI engines was developed. Sensitivity analysis and rate constant variation methods were used to optimize the kinetic model. Flame propagation, shock-tube and jet-stirred reactor systems were modeled in CHEMKIN. The laminar flame speed, ignition delay time and change in concentrations of species were simulated using the reduced kinetic model. The simulation results of reduced chemical mechanism agreed well with the relevant experimental data published in the literature. The experimental investigations on engine bench were also carried out. The in-cylinder pressure and exhaust emissions were obtained by using a combustion analyzer and an FTIR(Fourier transform infrared spectroscopy) spectrometer. Meanwhile, an engine in-cylinder CFD model was established in AVL FIRE and was coupled with the proposed reduced chemical mechanism to simulate the combustion process of methanol-gasoline blends. The simulated combustion process showed good agreement with the engine experimental results and the predicted emissions were found to be in accordance with the FTIR results. | LING XinChen WU Feng YAO DongWei | 2016 | Science China(Technological Sciences)2016，59，1： | 3 |
| 17 | A novel multifunctional nanocomposite C225-conjugated Fe3O4/Ag enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy显示文摘放射疗法是为鼻咽的癌的主要处理,上皮的起源的一个恶意的肿瘤。在这个过程,有高敏感的 tracer 为在放射疗法的诊断成像是枢轴的。这里,我们设计了新奇的多功能的磁性的银 nanocomposite, Fe3O4/Ag 结合了受体特定的抗体(C225 ) 到一个表皮的生长因素,它能潜在地经由磁性的回声成像为同步癌症治疗和诊断被使用。Fe3O4/Ag/C225 的特征被传播电子显微镜学决定,精力散 X 光检查光谱学,紫外系列,并且动态轻散布。结果证明 Fe3O4/Ag/C225 nanoparticles 在水里球形、分散很好。C225 的活动被保存 80% 在 Fe3O4/Ag/C225 nanoparticles。Futhermore,我们在 vitro 为人的鼻咽的癌房间线(CNE ) 测试了 nanocomposite 的 cytotoxicity 和放射敏感度。MTT 分析表明 Fe3O4/Ag/C225 能在一个剂量依赖者和时间依赖者举止禁止 CNE 的增长。clonogenic 试金显示与 X 光检查治疗相结合的 Fe3O4/Ag/C225 能增加 CNE 的敏感到照耀。在一篇摘要,新奇多功能的 nanocomposite Fe3O4/Ag/C225 可能是为对待的潜在的 radiosensitizer 诽谤在诊所的肿瘤。 | Di Zhao Xinchen Sun Jinglong Tong Jun Ma Xiaodong Bu Ruizhi Xu Renhua Fan | 2012 | Acta Biochimica et Biophysica Sinica2012，44，8： | 3 |
| 18 | Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation显示文摘The transcription factor CONSTANS(CO)integrates day-length information to induce the expression of florigen FLOWERING LOCUS T(FT)in Arabidopsis.We recently reported that the C-terminal CCT domain of CO forms a complex with NUCLEAR FACTOR-YB/YC to recognize multiple cis-elements in the FT promoter,and the N-terminal tandem B-box domains form a homomultimeric assembly.However,the mechanism and biological function of CO multimerization remained unclear.Here,we report that CO takes on a head-to-tail oligomeric configuration via its B-boxes to mediate FT activation in long days.The crystal structure of B-boxesCOreveals a closely connected tandem B-box fold forming a continuous head-to-tail assembly through unique CDHH zinc fingers.Mutating the key residues involved in CO oligomerization resulted in a non-functional CO,as evidenced by the inability to rescue co mutants.By contrast,a transgene encoding a human p53-derived tetrameric peptide in place of the B-boxesCOrescued co mutant,emphasizing the essential role of BboxesCO-mediated oligomerization.Furthermore,we found that the four TGTG-bearing cis-elements in FT proximal promoter are required for FT activation in long days.Our results suggest that CO forms a multimer to bind to the four TGTG motifs in the FT promoter to mediate FT activation. | Xiaolin Zeng Xinchen Lv Rui Liu Hang He Shiqi Liang Lixian Chen Fan Zhang Liu Chen Yuehui He Jiamu Du | 2022 | Journal of Integrative Plant Biology2022，64，3： | 2 |
| 19 | MoO_(x) and V_(2)O_(x) as hole and electron transport layers through functionalized intercalation in normal and inverted organic optoelectronic devices显示文摘To achieve fabrication and cost competitiveness in organic optoelectronic devices that include organic solar cells(OSCs)and organic light-emitting diodes(OLEDs),it is desirable to have one type of material that can simultaneously function as both the electron and hole transport layers(ETLs and HTLs)of the organic devices in all device architectures(i.e.,normal and inverted architectures).We address this issue by proposing and demonstrating Cs-intercalated metal oxides(with various Cs mole ratios)as both the ETL and HTL of an organic optoelectronic device with normal and inverted device architectures.Our results demonstrate that the new approach works well for widely used transition metal oxides of molybdenum oxide(MoOx)and vanadium oxide(V_(2)O_(x)).Moreover,the Cs-intercalated metaloxide-based ETL and HTL can be easily formed under the conditions of a room temperature,water-free and solution-based process.These conditions favor practical applications of OSCs and OLEDs.Notably,with the analyses of the Kelvin Probe System,our approach of Cs-intercalated metal oxides with a wide mole ratio range of transition metals(Mo or V)/Cs from 1:0 to 1:0.75 can offer significant and continuous work function tuning as large as 1.31 eV for functioning as both an ETL and HTL.Consequently,our method of intercalated metal oxides can contribute to the emerging large-scale and low-cost organic optoelectronic devices. | Xinchen Li Fengxian Xie Shaoqing Zhang Jianhui Hou Wallace CH Choy | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 20 | Chemokines and Chemokine Receptors as Novel Therapeutic Targets in Rheumatoid Arthritis (RA):Inhibitory Effects of Traditional Chinese Medicinal Components显示文摘Chemokines belong to a large family of inflammatory cytokines responsible for migration and accumulation of leukocytes at inflammatory sites. Over the past decade, accumulating evidence indicated a crucial role for chemokines and chemokine receptors in the pathophysiology of rheumatoid arthritis (RA). RA is a chronic autoimmune disease in which the synovial tissue is heavily infiltrated by leukocytes. Chemokines play an important role in the infiltration, localization, retention of infiltrating leukocytes and generation of ectopic germinal centers in the inflamed synovium. Recent evidence also suggests that identification of inhibitors directly targeting chemokines or their receptors may provide a novel therapeutic strategy in RA. Traditional Chinese medicinals (TCMs) have a long history in the treatment of inflammatory joint disease. The basis for the clinical benefits of TCM remains largely unclear. Our studies have led to the identification of numerous novel chemokine/chemokine receptor inhibitors present in anti-inflammatory TCMs. All of these inhibitors were previously reported by other researchers to have anti-arthritic effect, which may be attributable, at least in part, to their inhibitory effect on chemokine and/or chemokine receptor. Therefore, identification of agents capable of targeting chemokine/chemokine receptor interactions has suggested a mechanism of action for several TCM components and provided a means of identifying additional anti-RA TCM. Thus, this approach may lead to the discovery of new inhibitors of chemokines or chemokine receptors that can be used to treat diseases associated with inappropriately overactive chemokine mediated inflammatory reactions. Cellular & Molecular Immunology. 2004;1(5):336-342. | XinChen JoostJ.Oppenheim O.M.ZackHoward | 2004 | Cellular & Molecular Immunology2004，1，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员