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| 1 | Targets and molecular mechanisms of triptolide in cancer therapy显示文摘Triptolide(TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid(DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results. | Cuicui Meng Hongcheng Zhu Hongmei Song Zhongming Wang Guanhong Huang Defan Li Zhaoming Ma Jianhua Ma Qin Qin Xinchen Sun Jianxin Ma | 2014 | Chinese Journal of Cancer Research2014，26，5： | 16 |
| 2 | Effects of Tetrandrine on Apoptosis and Radiosensitivity of Nasopharyngeal Carcinoma Cell Line CNE显示文摘Tetrandrine 被知道然而,几乎不施加反肿瘤效果在鼻咽的癌房间上对它的效果被知道。在这研究,我们在鼻咽的癌房间线 CNE 测试了导致 tetrandrine 的 apoptosis 和放射敏感度并且调查了可能的机制。用流动 cytometry 和 DNA 电气泳动,我们发现 tetrandrine 能导致房间 apoptosis.Further , Bcl-2 mRNA 的水平减少了,盒子 mRNA 由使用反向的抄写聚合酶链 reaction.X-ray-induced G2 在 tetrandrine 的增加以后增加了,这被显示出拘捕被处理与 tetrandrine 废除,是由流动 cytometry 和有丝分裂的索引检测了。cyclinBl 蛋白质的累积和 Cdc2 tyrosine-15 和 Cdc25C serine-216 phosphorylation 的抑制在用蛋白质印迹分析与 tetrandrine 对待的照耀的房间被检测。总起来说,这些结果证明 tetrandrine 能导致 apoptosis 并且在 CNE 房间废除导致放射的 G2 拘捕。 | Xinchen SUN Ruizhi XU Yuxia DENG Hongyan CHENG Jun M Jiazhong JI Yingfeng ZHOU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，11： | 13 |
| 3 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 4 | XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer显示文摘DNA 修理能力(DRC ) 向基于铂的化疗与癌症房间的敏感被相关。我们假设那在 DNA 的基因多型性修理基因 XPA (干皮病 pigmentosum 组 A )和 XPG (干皮病 pigmentosum 组 G )( ERCC5 ,切除修理跨互补的组 5 ),它在 DNA 修理效率导致内部个人的差别,可以在先进非小的房间肺癌症( NSCLC )预言临床的反应到铂代理人病人。在这研究,我们发现 XPA A23G 多型性的 A G 变化显著地增加了反应到基于铂的化疗。在 XPG His46His 的多型性与减少的治疗回答被联系,但是不是统计上重要的。 | Jifeng Feng Xinchen Sun Ning Sun Shukui Qin Fan Li Hongyan Cheng Baoan Chen YuanDong Cao Jun Ma Lu Cheng Zuhong Lu Jiazhong Ji Yingfeng Zhou | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 8 |
| 5 | Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC显示文摘Epithelial–mesenchymal transition(EMT)is involved in both physiological and pathological processes.EMT plays an essential role in the invasion,migration and metastasis of tumours.Autophagy has been shown to regulate EMT in a variety of cancers but not in head and neck squamous cell carcinoma(HNSCC).Herein,we investigated whether autophagy also regulates EMT in HNSCC.Analyses of clinical data from three public databases revealed that higher expression of fibronectin-1(FN1)correlated with poorer prognosis and higher tumour pathological grade in HNSCC.Data from SCC-25 cells demonstrated that rapamycin and Earle’s balanced salt solution(EBSS)promoted autophagy,leading to increased FN1 degradation,while 3-methyladenine(3-MA),bafilomycin A1(Baf A1)and chloroquine(CQ)inhibited autophagy,leading to decreased FN1 degradation.On the other hand,autophagic flux was blocked in BECN1 mutant HNSCC Cal-27 cells,and rapamycin did not promote autophagy in Cal-27 cells;also in addition,FN1 degradation was inhibited.Further,we identified FN1 degradation through the lysosome-dependent degradation pathway using the proteasome inhibitor MG132.Data from immunoprecipitation assays also showed that p62/SQSTM1 participated as an autophagy adapter in the autophagy–lysosome pathway of FN1 degradation.Finally,data from immunoprecipitation assays demonstrated that the interaction between p62 and FN1 was abolished in p62 mutant MCF-7 and A2780 cell lines.These results indicate that autophagy significantly promotes the degradation of FN1.Collectively,our findings clearly suggest that FN1,as a marker of EMT,has adverse effects on HNSCC and elucidate the autophagy–lysosome degradation mechanism of FN1. | Xinchen Liu Lin Meng Xing Li Daowei Li Qilin Liu Yumeng Chen Xiangwei Li Wenhuan Bu Hongchen Sun | 2020 | International Journal of Oral Science2020，12，4： | 7 |
| 6 | Electrochemical reduction of CO_2 to CO using graphene oxide/carbon nanotube electrode in ionic liquid/acetonitrile system显示文摘Electrochemical reduction of CO_2 to CO is an interesting topic. In this work, we prepared metal-free electrodes by depositing graphene oxide(GO), multi-walled carbon nanotube(MWCNT), and GO/MWCNT composites on carbon paper(CP) using electrophoretic deposition(EPD) method. The electrodes were characterized by different methods, such as X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS). The electrochemical reduction of CO_2 to CO was conducted on the electrodes in 1-butyl-3-methylimidazolium tetrafluoroborate([Bmim]BF4)/acetonitrile(Me CN) electrolyte, and the composition of the electrolyte influenced the reaction significantly. It was demonstrated that GO/MWCNT-CP electrode was very effective for the reaction in IL(90 wt%)/Me CN binary mixture, the Faradaic efficiency of CO and current density were even higher than those on Au and Ag electrodes in the same electrolyte. | Qinggong Zhu Jun Ma Xinchen Kang Xiaofu Sun Jiayin Hu Guanying Yang Buxing Han | 2016 | Science China Chemistry2016，59，5： | 5 |
| 7 | A novel multifunctional nanocomposite C225-conjugated Fe3O4/Ag enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy显示文摘放射疗法是为鼻咽的癌的主要处理,上皮的起源的一个恶意的肿瘤。在这个过程,有高敏感的 tracer 为在放射疗法的诊断成像是枢轴的。这里,我们设计了新奇的多功能的磁性的银 nanocomposite, Fe3O4/Ag 结合了受体特定的抗体(C225 ) 到一个表皮的生长因素,它能潜在地经由磁性的回声成像为同步癌症治疗和诊断被使用。Fe3O4/Ag/C225 的特征被传播电子显微镜学决定,精力散 X 光检查光谱学,紫外系列,并且动态轻散布。结果证明 Fe3O4/Ag/C225 nanoparticles 在水里球形、分散很好。C225 的活动被保存 80% 在 Fe3O4/Ag/C225 nanoparticles。Futhermore,我们在 vitro 为人的鼻咽的癌房间线(CNE ) 测试了 nanocomposite 的 cytotoxicity 和放射敏感度。MTT 分析表明 Fe3O4/Ag/C225 能在一个剂量依赖者和时间依赖者举止禁止 CNE 的增长。clonogenic 试金显示与 X 光检查治疗相结合的 Fe3O4/Ag/C225 能增加 CNE 的敏感到照耀。在一篇摘要,新奇多功能的 nanocomposite Fe3O4/Ag/C225 可能是为对待的潜在的 radiosensitizer 诽谤在诊所的肿瘤。 | Di Zhao Xinchen Sun Jinglong Tong Jun Ma Xiaodong Bu Ruizhi Xu Renhua Fan | 2012 | Acta Biochimica et Biophysica Sinica2012，44，8： | 3 |
| 8 | Polymorphisms in hMSH2 and hMLH1 and response to platinum-based chemotherapy in advanced non-small-cell lung cancer patients显示文摘基于铂的 chemotherapeutics 是为先进 non-small-cell 肺癌症(NSCLC ) 的最普通的政体病人。然而,在临床的治疗识别铂抵抗是困难的。基因因素被认为代表药功效的重要决定因素。在这研究,我们调查了是否在人的傻瓜相当或相同的事物 2 的单个核苷酸的多型性(SNP )(hMSH2 ) 和人的 mutL 相当或相同的事物(hMLH1 ) 1 在先进 NSCLC 病人与肿瘤反应被联系用汉语的收到的基于铂的化疗人口。完全,有先进 NSCLC 的 96 个病人习惯性地与基于 cisplatin 或基于 carboplatin 的化疗被对待。三维(3D ) , polyacrylamide 基于胶化的 DNA microarray 方法被用来与外部淋巴细胞评估 hMSH2 gIVS12-6T/C 和 hMLH1-1151T/A 的遗传型。我们发现有对有 hMSH2 gIVS12-6T/C 多型性的基于铂的化疗的治疗反应的一个显著地增加的机会。3D polyacrylamide 基于胶化的 DNA microarray 方法精确、高产量、便宜,对在人口的 SNP genotyping 的大规模特别合适。 | Hongyan Cheng Ning Sun Xinchen Sun Baoan Chen Fan Li Jifeng Feng Lu Cheng Yuandong Cao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 2 |
| 9 | A Facile Band Alignment of Polymeric Carbon Nitride Semiconductors to Construct Isotype Heterojunctions显示文摘 | Jinshui Zhang Mingwen Zhang Rui‐Qing Sun Xinchen Wang | 2012 | Angew Chem Int Ed2012，，40： | 1 |
| 10 | Combination of two multiplex genome-edited soybean varieties enables customization of protein functional properties显示文摘Dear Editor,Soybean(Glycine max)is a major source of plant-based protein for people worldwide,providing a healthy,affordable,and environmentally friendly alternative to animal-based protein(Montgomery,2003).It has been estimated that there are currently over 12000 food products that contain soy protein(Montgomery,2003).Different food applications of soy protein require distinct properties that affect its function and sensory features.For instance,the sensory quality of soymilk is significantly affected by protein emulsibility,whereas tofu quality is determined by protein-gelling ability(Kinsella,1979). | Mengyan Bai Cuicui Yuan Huaqin Kuang Qian Sun Xinchen Hu Luning Cui Wenxin Lin Chunyan Peng Peng Yue Shikui Song Zebin Guo Yuefeng Guan | 2022 | Molecular Plant2022，15，7： | 1 |
| 11 | Association between poly-morphisms of ercc1 and xpd and clinical response to platinum-based chemotherapy in advanced non-small cell lung cancer显示文摘 | Fan Li Xinchen Sun Ning Sun | 2010 | Am J Clin Oncol2010，33，5： | 1 |
| 12 | Metal-free activation of dioxygen by graphene/g-C3N4 nanocomposites: functional dyads for selective oxidation of saturated hydrocarbons 显示文摘 | Li Xinhao Chen Jiesheng Wang Xinchen Sun Jianhua Antonietti Markus | 2011 | Journal of the American Chemical Society2011，133，21： | 1 |
| 13 | A Facile Band Alignment of Polymeric Carbon Nitride Semiconductors to Construct Isotype Heterojunctions显示文摘 | Jinshui Zhang Mingwen Zhang Rui‐Qing Sun Xinchen Wang | 2012 | Angew Chem Int Ed2012，，40： | 1 |
| 14 | Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients显示文摘 | Xinchen Sun Fan Li Ning Sun Qin Shukui Chen Baoan Feng Jifeng Cheng Lu Lu Zuhong Cheng Hongyan Cao YuanDong Ji Jiazhong Zhou Yingfeng | 2008 | Lung Cancer2008，，2： | 1 |
| 15 | Report of China's innovation increase and research growth in radiation oncology显示文摘Aims: To investigate the research status of radiation oncology in China through survey of literature in international radiation oncology journals and retrospectively compare the outputs of radiation oncology articles of the three major regions of China—Mainland(ML), Taiwan(TW) and Hong Kong(HK).Methods: Radiation oncology journals were selected from 'oncology' and 'radiology, nuclear & medical image' category from Science Citation Index Expand(SCIE). Articles from the ML, TW and HK were retrieved from MEDLINE. The number of total articles, clinical trials, case reports, impact factors(IF), institutions and articles published in each journals were conducted for quantity and quality comparisons.Results: A total 818 articles from 13 radiation oncology journals were searched, of which 427 are from ML, 259 from TW, and 132 from HK. Ninety-seven clinical trials and 5 case reports are reported in China. Accumulated IF of articles from ML(1,417.11) was much higher than that of TW(1,003.093) and HK(544.711), while the average IF of articles from ML is the lowest.Conclusions: The total number of articles from China especially ML increased significantly in the last decade. The number of articles published from the ML has exceeded those from TW and HK. However, the quality of articles from TW and HK is better than that from ML. | Hongcheng Zhu Xi Yang Qin Qin Kangqi Bian Chi Zhang Jia Liu Hongyan Cheng Xinchen Sun | 2014 | Chinese Journal of Cancer Research2014，26，3： | 0 |
| 16 | Identification and verification of aging-related lncRNAs for prognosis prediction and immune microenvironment in patients with head and neck squamous carcinoma显示文摘Aging is highly associated with tumor formation and progression.However,little research has explored the association of aging-related lncRNAs(ARLs)with the prognosis and tumor immune microenvironment(TIME)of head and neck squamous cell carcinoma(HNSCC).RNA sequences and clinicopathological data of HNSCC patients and normal subjects were downloaded from The Cancer Genome Atlas.In the training group,we used Pearson correlation,univariate Cox regression,least absolute shrinkage/selection operator regression analyses,and multivariate Cox regression to build a prognostic model.In the test group,we evaluated the model.Multivariate Cox regression was done to screen out independent prognostic factors,with which we constructed a nomogram.Afterward,we demonstrated the predictive value of the risk scores based on the model and the nomogram using time-dependent receiver operating characteristics.Gene set enrichment analysis,immune correlation analysis,and half-maximal inhibitory concentration were also performed to reveal the different landscapes of TIME between risk groups and to predict immuno-and chemo-therapeutic responses.The most important LINC00861 in the model was examined in HNE1,CNE1,and CNE2 nasopharyngeal carcinoma cell lines and transfected into the cell lines CNE1 and CNE2 using the LINC00861-pcDNA3.1 construct plasmid.In addition,CCK-8,Edu,and SA-β-gal staining assays were conducted to test the biofunction of LINC00861 in the CNE1 and CNE2 cells.The signature based on nine ARLs has a good predictive value in survival time,immune infiltration,immune checkpoint expression,and sensitivity to multiple drugs.LINC00861 expression in CNE2 was significantly lower than in the HNE1 and CNE1 cells,and LINC00861 overexpression significantly inhibited the proliferation and increased the senescence of nasopharyngeal carcinoma cell lines.This work built and verified a new prognostic model for HNSCC based on ARLs and mapped the immune landscape in HNSCC.LINC00861 is a protective factor for the development of HNSCC. | QING GAO YUJING SHI YUANYUAN SUN SHU ZHOU ZEYUAN LIU XINCHEN SUN XIAOKE DI | 2023 | Oncology Research2023，31，1： | 0 |
| 17 | Yanggan Jiangmei Formula alleviates hepatic inflammation and lipid accumulation in non-alcoholic steatohepatitis by inhibiting the NF-κB/NLRP3 signaling pathway显示文摘The role of NF-κB and the NLRP3 inflammasome in the chronic inflammatory microenvironment of non-alcoholic steatohepatitis(NASH)has been posited as crucial.The Yanggan Jiangmei Formula(YGJMF)has shown promise in ameliorating hepatic steatosis in NASH patients,yet its pharmacological mechanisms remain largely unexplored.This study was conducted to investigate the efficacy of YGJMF in NASH and to elucidate its pharmacological underpinnings.To simulate NASH both in vivo and in vitro,high-fat-diet(HFD)rats and HepG2 cells stimulated with free fatty acids(FFAs)were utilized.The severity of liver injury and lipid deposition was assessed using serum indicators,histopathological staining,micro-magnetic resonance imaging(MRI),and the liver-tomuscle signal intensity ratio(SIRL/M).Furthermore,a combination of enzyme-linked immunosorbent assay(ELISA),immunohistochemistry(IHC),immunofluorescence,real-time quantitative polymerase chain reaction(RT-qPCR),and Western blotting analyses was employed to investigate the NF-κB/NLRP3 signaling pathway and associated cytokine levels.The results from liver pathology,MRI assessments,and biochemical tests in rat models demonstrated YGJMF’s significant effectiveness in reducing liver damage and lipid accumulation.Additionally,YGJMF markedly reduced hepatocyte inflammation by downregulating inflammatory cytokines in both liver tissue and serum.Furthermore,YGJMF was found to disrupt NF-κB activation,consequently inhibiting the assembly of the NLRP3 inflammasome in both the in vitro and in vivo models.The preliminary findings of this study suggest that YGJMF may alleviate hepatic steatosis and inhibit the NF-κB/NLRP3 signaling pathway,thereby exerting anti-inflammatory effects in NASH. | WU Yuanyuan ZHOU Jingwen ZUO Xinchen KUANG Yufeng SUN Lixia ZHANG Xiaolong | 2024 | Chinese Journal of Natural Medicines2024，22，3： | 0 |
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